Interaction of Atorvastatin-loaded magnetic iron oxide nanoparticles with DNA

The present work aims to tether magnetic iron oxide nanoparticles onto a statin drug, Atorvastatin, in its free- and beta-cyclodextrin-encapsulated form. The binding behavior of magnetic iron oxide nanoparticles tethered and beta-cyclodextrin-encapsulated Atorvastatin to calf thymus DNA is studied by UV-Visible and fluorescence spectroscopy. The docking poses of Atorvastatin to beta-cyclodextrin and DNA prove their binding toward the isopropyl and pyrrole moiety, respectively. The tethering of magnetic iron oxide nanoparticles and the encapsulation of beta-cyclodextrin do not affect Atorvastatin's binding strength toward DNA. The formation of the supramolecular ternary complex from free- and magnetic iron oxide nanoparticles tethered to Atorvastatin can be achieved with beta-cyclodextrin and DNA for the drug's better dissolution, bioavailability, and in-vivo medical applications.

Automated summary

This study investigates the binding behavior of magnetic iron oxide nanoparticles tethered to Atorvastatin and beta-cyclodextrin-encapsulated Atorvastatin to calf thymus DNA. The results show that the tethering and encapsulation do not affect the binding strength of Atorvastatin with DNA, suggesting the potential of forming a supramolecular ternary complex for improved drug performance.