Journal
NATURE CELL BIOLOGY
Volume 18, Issue 3, Pages 238-245Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3309
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Funding
- Juvenile Diabetes Research Foundation (JDRF)
- National Pancreatic Cancer Canada Foundation
- Pancreas Centre British Columbia
- Canadian Institutes of Health Research
- National Institutes of Health [DK05192, DK104143, DK078803, DK068471]
- Helmsley Charitable Trust
- JDRF
- California Institute for Regenerative Medicine
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Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.
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