Journal
NATURE CELL BIOLOGY
Volume 18, Issue 5, Pages 463-465Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3349
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Wnt/beta-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/beta-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
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