Related references
Note: Only part of the references are listed.Loss of VPS1 3C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy
Suzanne Lesage et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2016)
Structural disorder of monomeric α-synuclein persists in mammalian cells
Francois-Xavier Theillet et al.
NATURE (2016)
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
Frank Soldner et al.
NATURE (2016)
Identification of TMEM230 mutations in familial Parkinson's disease
Han-Xiang Deng et al.
NATURE GENETICS (2016)
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
Dominic M. Walsh et al.
NATURE REVIEWS NEUROSCIENCE (2016)
Prions and Protein Assemblies that Convey Biological Information in Health and Disease
David W. Sanders et al.
NEURON (2016)
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
Joseph R. Mazzulli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
Carla F. Bento et al.
NATURE COMMUNICATIONS (2016)
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Martin Steger et al.
ELIFE (2016)
Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
Emmy H. Rannikko et al.
BMC NEUROSCIENCE (2015)
Conditional depletion of intellectual disability and Parkinsonism candidate geneATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
Aline Dubos et al.
HUMAN MOLECULAR GENETICS (2015)
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
Joao P. L. Daher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Autophagosome dynamics in neurodegeneration at a glance
Yvette C. Wong et al.
JOURNAL OF CELL SCIENCE (2015)
α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
Lauren R. Kett et al.
JOURNAL OF NEUROSCIENCE (2015)
A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
Linan Chen et al.
JOURNAL OF NEUROSCIENCE (2015)
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
Fu-Lei Tang et al.
JOURNAL OF NEUROSCIENCE (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Michael Lazarou et al.
NATURE (2015)
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders
Scott A. Small et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
Alicia M. Pickrell et al.
NEURON (2015)
Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Nripesh Dhungel et al.
NEURON (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation
Shijun Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Reina N. Fuji et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
Ulf Dettmer et al.
NATURE COMMUNICATIONS (2015)
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Changyoun Kim et al.
CELL REPORTS (2015)
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N
L. N. Munsie et al.
HUMAN MOLECULAR GENETICS (2015)
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
Amaia M. Arranz et al.
JOURNAL OF CELL SCIENCE (2015)
Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology
Gabrielle R. Wilson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)
Thomas C. Suedhof
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease
Ian Martin et al.
CELL (2014)
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation
Ian J. McGough et al.
CURRENT BIOLOGY (2014)
Autophagy and human disease: emerging themes
Jaime L. Schneider et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)
Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
Mark W. Dodson et al.
DISEASE MODELS & MECHANISMS (2014)
DNAJC13 mutations in Parkinson disease
Carles Vilarino-Gueell et al.
HUMAN MOLECULAR GENETICS (2014)
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
Elpida Tsika et al.
HUMAN MOLECULAR GENETICS (2014)
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
Stephanie M. Y. Kong et al.
HUMAN MOLECULAR GENETICS (2014)
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
Ghazaleh Ashrafi et al.
JOURNAL OF CELL BIOLOGY (2014)
ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein
Taiji Tsunemi et al.
JOURNAL OF NEUROSCIENCE (2014)
Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes
Laura A. Volpicelli-Daley et al.
MOLECULAR BIOLOGY OF THE CELL (2014)
Pharmacological chaperones stabilize retromer to limit APP processing
Vincent J. Mecozzi et al.
NATURE CHEMICAL BIOLOGY (2014)
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls et al.
NATURE GENETICS (2014)
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
Emiko Miura et al.
NEUROBIOLOGY OF DISEASE (2014)
A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
Franziska Richter et al.
NEUROTHERAPEUTICS (2014)
LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32
Dieter Waschbuesch et al.
PLOS ONE (2014)
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Michelle Rothaug et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
Jacqueline Burre et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
Yvette C. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandria Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Biogenesis of Lysosomes and Lysosome-Related Organelles
J. Paul Luzio et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
Eun-Jin Bae et al.
NATURE COMMUNICATIONS (2014)
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy
Eszter Zavodszky et al.
NATURE COMMUNICATIONS (2014)
α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
Hien T. Tran et al.
CELL REPORTS (2014)
Genetics and genomics of Parkinson's disease
Michelle K. Lin et al.
GENOME MEDICINE (2014)
Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan et al.
CELL (2013)
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
Lisa Fellner et al.
GLIA (2013)
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)
Olena Korvatska et al.
HUMAN MOLECULAR GENETICS (2013)
Mutation in the SYNJ1 Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
Marialuisa Quadri et al.
HUMAN MUTATION (2013)
The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
Catharine E. Krebs et al.
HUMAN MUTATION (2013)
MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneratione
Ashley S. Harms et al.
JOURNAL OF NEUROSCIENCE (2013)
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Mathias Jucker et al.
NATURE (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
100 years of Lewy pathology
Michel Goedert et al.
NATURE REVIEWS NEUROLOGY (2013)
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk
David A. MacLeod et al.
NEURON (2013)
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
Florence Clavaguera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons
Chee Yeun Chung et al.
SCIENCE (2013)
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Changyoun Kim et al.
NATURE COMMUNICATIONS (2013)
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein
He-Jin Lee et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Sandra Maday et al.
JOURNAL OF CELL BIOLOGY (2012)
The immunology of neurodegeneration
Eva Czirr et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Marija Usenovic et al.
JOURNAL OF NEUROSCIENCE (2012)
A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism
Simon Edvardson et al.
PLOS ONE (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology
Herve Rhinn et al.
NATURE COMMUNICATIONS (2012)
Parkinson's Disease and Parkinsonism: Neuropathology
Dennis W. Dickson
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
VPS35 Mutations in Parkinson Disease
Carles Vilarino-Gueell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Joseph R. Mazzulli et al.
CELL (2011)
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
Martin C. Herzig et al.
HUMAN MOLECULAR GENETICS (2011)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
Michael A. Nalls et al.
LANCET (2011)
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
Tim Bartels et al.
NATURE (2011)
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
Harvey T. McMahon et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Mechanisms of mitophagy
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
NEURON (2011)
Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
Chuong B. Do et al.
PLOS GENETICS (2011)
The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates
Beidong Liu et al.
CELL (2010)
Prion-like disorders: blurring the divide between transmissibility and infectivity
Mimi Cushman et al.
JOURNAL OF CELL SCIENCE (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani et al.
NEURON (2010)
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Jacqueline Burre et al.
SCIENCE (2010)
α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
Aaron D. Gitler et al.
NATURE GENETICS (2009)
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake et al.
NATURE GENETICS (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simon-Sanchez et al.
NATURE GENETICS (2009)
Rab GTPases as coordinators of vesicle traffic
Harald Stenmark
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
Eugene V. Mosharov et al.
NEURON (2009)
Clearance and deposition of extracellular α-synuclein aggregates in microglia
He-Jin Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Synuclein activates microglia in a model of Parkinson's disease
Xiaomin Su et al.
NEUROBIOLOGY OF AGING (2008)
Functional architecture of the retromer cargo-recognition complex
Aitor Hierro et al.
NATURE (2007)
Carrier screening for Gaucher disease - Lessons for low-penetrance, treatable diseases
Shachar Zuckerman et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)
'Rejuvenation' protects neurons in mouse models of Parkinson's disease
C. Savio Chan et al.
NATURE (2007)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Mechanisms of Parkinson's disease linked to pathological α-synuclein:: New targets for drug discovery
Virginia M. -Y. Lee et al.
NEURON (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Antony A. Cooper et al.
SCIENCE (2006)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
α-synuclein cooperates with CSPα in preventing neurodegeneration
S Chandra et al.
CELL (2005)
A combinatorial code for the interaction of α-synuclein with membranes
S Kubo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
W Zhang et al.
FASEB JOURNAL (2005)
Proteolysis: from the lysosome to ubiquitin and the proteasome
A Ciechanover
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
CN Arighi et al.
JOURNAL OF CELL BIOLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Parkinsonism among Gaucher disease carriers
O Goker-Alpan et al.
JOURNAL OF MEDICAL GENETICS (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Yeast cells provide insight into alpha-synuclein biology and pathobiology
TF Outeiro et al.
SCIENCE (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
Colocalization of tau and alpha-synuclein epitopes in Lewy bodies
T Ishizawa et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
KA Conway et al.
SCIENCE (2001)
α-synuclein gene haplotypes are associated with Parkinson's disease
M Farrer et al.
HUMAN MOLECULAR GENETICS (2001)
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-β family of receptor serine-threonine kinases
WT Parks et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)
Share Paper
