Journal
NATURE
Volume 529, Issue 7586, Pages 307-315Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature17039
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Funding
- US National Institutes of Health
- Alliance for Lupus Research
- Lymphoma and Leukemia Society
- Superfund Basic Research Program
- Stand Up to Cancer
- European Research Council
- Alpe d'HuZes/KWF
- Netherlands Research Council NWO
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Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
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