Journal
NATURE
Volume 535, Issue 7610, Pages 56-64Publisher
NATURE RESEARCH
DOI: 10.1038/nature18846
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Funding
- US National Institute of Diabetes and Digestive and Kidney Diseases NIDDK [R01-DK085025]
- Swedish Research Council
- Novo Nordisk Foundation
- European Research Council [615362-METABASE]
- NNF Center for Basic Metabolic Research [Bäckhed Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0008163] Funding Source: researchfish
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It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.
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