Journal
NATURE
Volume 538, Issue 7624, Pages 183-192Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature19764
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Funding
- US National Institute of Health [R01GM101420-01A1]
- Swiss NSF [P300P3_151179]
- Keith Murdoch Fellowship via the American Australian Association
- Life Sciences Research Foundation Fellowship - Good Ventures
- Broad Institute
- Ragon Institute fellowship
- Swiss National Science Foundation (SNF) [P300P3_151179] Funding Source: Swiss National Science Foundation (SNF)
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Intracellular delivery of materials has become a critical component of genome-editing approaches, ex vivo cell-based therapies, and a diversity of fundamental research applications. Limitations of current technologies motivate development of next-generation systems that can deliver a broad variety of cargo to diverse cell types. Here we review in vitro and ex vivo intracellular delivery approaches with a focus on mechanisms, challenges and opportunities. In particular, we emphasize membrane-disruption-based delivery methods and the transformative role of nanotechnology, microfluidics and laboratory-on-chip technology in advancing the field.
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