Journal
NATURE
Volume 529, Issue 7586, Pages 298-306Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature17038
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Funding
- US National Institutes of Health [CA163167, CA129243]
- Congressionally Directed Medical Research Programs of the US Department of Defense, Cancer Center Support Grant [P30 CA008748]
- Center for Metastasis Research of the Memorial Sloan Kettering Cancer Center
- Austrian Science Fund [J3013]
- Austrian Science Fund (FWF) [J3013] Funding Source: Austrian Science Fund (FWF)
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Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as latent tumour-initiating seeds and eventually breaking out to replace the host tissue. They make metastasis a highly inefficient process. However, once metastases have been established, current treatments frequently fail to provide durable responses. An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
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