Journal
NATURE
Volume 541, Issue 7635, Pages 102-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature20789
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Funding
- Swiss National Science Foundation [P2ZHP3_151609]
- Fonds National de la Recherche Luxembourg [AFR7883116]
- Lawrence Ellison Medical Foundation [U54CA155626]
- Glenn Foundation for Medical Research
- National Institutes of Health (NIH) [1R01AG044346]
- Ligue Nationale contre le Cancer
- Novo Nordisk Foundation [NNF13OC0007939]
- Swiss National Science Foundation (SNF) [P2ZHP3_151609] Funding Source: Swiss National Science Foundation (SNF)
- Novo Nordisk Fonden [NNF13OC0007939] Funding Source: researchfish
- Villum Fonden [00007292] Funding Source: researchfish
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Ageing is driven by a loss of transcriptional and protein homeostasis(1-3) and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction associated with age therefore have the potential to reduce overall disease risk in the elderly. Precursor mRNA (pre-mRNA) splicing is a fundamental link between gene expression and the proteome, and deregulation of the splicing machinery is linked to several age-related chronic illnesses(4,5). However, the role of splicing homeostasis in healthy ageing remains unclear. Here we demonstrate that pre-mRNA splicing homeostasis is a biomarker and predictor of life expectancy in Caenorhabditis elegans. Using transcriptomics and in-depth splicing analysis in young and old animals fed ad libitum or subjected to dietary restriction, we find defects in global pre-mRNA splicing with age that are reduced by dietary restriction via splicing factor 1 (SFA-1; the C. elegans homologue of SF1, also known as branchpoint binding protein, BBP). We show that SFA-1 is specifically required for lifespan extension by dietary restriction and by modulation of the TORC1 pathway components AMPK, RAGA-1 and RSKS-1/S6 kinase. We also demonstrate that overexpression of SFA-1 is sufficient to extend lifespan. Together, these data demonstrate a role for RNA splicing homeostasis in dietary restriction longevity and suggest that modulation of specific spliceosome components may prolong healthy ageing.
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