☆ 4.6 Article

COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition

NPJ VACCINES (2023)

Related references

Note: Only part of the references are listed.

Review Pediatrics

SARS-CoV-2 infection in children and implications for vaccination

Jordan Nathanielsz et al.

Summary: This article provides an up-to-date account of SARS-CoV-2 infections in children and discusses the direct and indirect effects of COVID-19 on children. It highlights the increased risk of infection in children due to the emergence of variants of concern and the implementation of childhood immunization programs globally to mitigate the impact.

PEDIATRIC RESEARCH (2023)

Add to Collection

Article Gastroenterology & Hepatology

Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Siew C. Ng et al.

Summary: This study identified specific gut microbiota markers associated with improved immune response and reduced adverse events following COVID-19 vaccines, suggesting that microbiota-targeted interventions may complement the effectiveness of vaccines.

GUT (2022)

Add to Collection

Article Obstetrics & Gynecology

Neutralizing Antibodies and Cytokines in Breast Milk After Coronavirus Disease 2019 (COVID-19) mRNAVaccination

Vignesh Narayanaswamy et al.

Summary: This study found that lactating women who received mRNA-based COVID-19 vaccines exhibited immune responses in their breast milk, which could be transferred to breastfeeding infants. The antibodies in breast milk were able to neutralize the spike protein of SARS-CoV-2 and its variants. This suggests the potential for passive immunity against COVID-19 in breastfed infants.

OBSTETRICS AND GYNECOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Lactation-dependent vertical transmission of natural probiotics from the mother to the infant gut through breast milk

Ce Qi et al.

Summary: Key anaerobic gut-associated bacteria are transmitted from the mother to the infant's gut during lactation, particularly in the colostrum phase. Other bacteria, such as Streptococcus salivarius, Bifidobacterium longum, and Lactobacillus gasseri, can also be transferred between the maternal gut, breast milk, and newborn gut depending on specific amplicon sequence variants. This suggests that targeted isolation of key microorganisms from breast milk could be used to manipulate the microbiota of either breast milk or newborns for promoting neonatal health.

FOOD & FUNCTION (2022)

Add to Collection

Article Pediatrics

Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination

Bridget E. Young et al.

Summary: The study found that there were differences in antibody responses in human milk between parents with COVID-19 infection and those who received mRNA vaccination, with infection leading to a highly variable IgA-dominant response and vaccination leading to an IgG-dominant response. However, both groups showed human milk that exhibited neutralization activity against live SARS-CoV-2 virus.

JAMA PEDIATRICS (2022)

Add to Collection

Article Immunology

Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women

Kee Thai Yeo et al.

Summary: The majority of lactating mothers had detectable SARS-CoV-2 antibody isotypes and neutralizing antibodies in serum and breastmilk, especially after the second dose of BNT162b2 vaccination. Transient, low levels of vaccine mRNA were detected in the serum of vaccinated mothers with occasional transfer to their breastmilk, but we did not detect evidence of infant sensitization. Importantly, the presence of breastmilk neutralizing antibodies likely provides a foundation for passive immunization of the breastmilk-fed infant.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles

Darielys Santana-Mederos et al.

Summary: This study explores the use of a SARS-CoV-2 dimeric recombinant RBD combined with Neisseria meningitidis outer membrane vesicles as a promising COVID-19 vaccine candidate, which induces a potent and neutralizing immune response in laboratory animals. The vaccine candidate, named Soberana01, shows high inhibition of the RBD-ACE2 interaction and is the first to evaluate the immunostimulation effect of N. meningitidis OMVs in SARS-CoV-2 vaccine candidates.

RSC CHEMICAL BIOLOGY (2022)

Add to Collection

Article Food Science & Technology

Longitudinal changes of human milk oligosaccharides, breastmilk microbiome and infant gut microbiome are associated with maternal characteristics

Feitong Liu et al.

Summary: The study found a significant association between the levels of HMOs in Chinese breastmilk and maternal characteristics, as well as the infant gut microbiome. As lactation went on, both the diversity of breastmilk and infant gut microbiome significantly increased. Additionally, the concentration of dominant HMOs in the milk of secretors showed a significant decrease over time.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Review Environmental Sciences

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Rekha Khandia et al.

Summary: Since December 2019, SARS-CoV-2 has been rapidly evolving and mutating, leading to various variants with different levels of infectivity and lethality. The most recent variant of concern is Omicron (B.1.1.529), which has raised concerns about its ability to evade pre-existing immunity and overcome antibody-based therapies. Several theories have been proposed to explain the high number of mutations in Omicron. To successfully handle the ongoing pandemic, a multifaceted approach including rapid diagnosis, genome analysis, vaccination, and updated medical facilities is needed.

ENVIRONMENTAL RESEARCH (2022)

Add to Collection

Article Infectious Diseases

Hong Kong's fifth COVID-19 wave—the worst yet

Talha Burki

LANCET INFECTIOUS DISEASES (2022)

Add to Collection

Article Multidisciplinary Sciences

Gut microbiome profiles and associated metabolic pathways in patients of adult-onset immunodeficiency with anti-interferon-gamma autoantibodies

Hui-Shan Hsieh et al.

Summary: This study reveals significant differences in gut microbiome between patients with anti-IFN-gamma AAbs and healthy controls, suggesting a potential association between gut dysbiosis and the immunodeficiency condition caused by anti-IFN-gamma AAbs.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Nutrition & Dietetics

Metataxonomic Analysis of Milk Samples From SARS-CoV-2-Positive and SARS-CoV-2-Negative Women

Natalia Gomez-Torres et al.

Summary: The impact of SARS-CoV-2 viral infection on the metataxonomic profile in breast milk was assessed. The results showed that the structure and diversity of the bacterial population in breast milk remained unchanged and were not affected by SARS-CoV-2 infection, regardless of symptomatic or asymptomatic status.

FRONTIERS IN NUTRITION (2022)

Add to Collection

Article Immunology

COVID-19 vaccination coverage and intent among women aged 18-49 years by pregnancy status, United States, April-November 2021

Hilda Razzaghi et al.

Summary: This study assessed COVID-19 vaccination coverage, intent, and attitudes among women of reproductive age, specifically pregnant and postpartum women, in the United States. The results showed lower vaccination coverage among pregnant women and significantly lower vaccination coverage among non-Hispanic Black pregnant and breastfeeding women compared to non-Hispanic White women.

VACCINE (2022)

Add to Collection

Article Immunology

Humoral response to anti-SARS-CoV-2 vaccine in breastfeeding mothers and mother-to-infant antibody transfer through breast milk

Carlo Pietrasanta et al.

Summary: The extent of transfer of anti-SARS-CoV-2 antibodies from mother to infant through breast milk after maternal vaccination is unclear. A study found that the BNT162b2 vaccine induced long-lasting IgG in maternal serum, but weaker antibody production in saliva and breast milk. The levels of anti-SARS-CoV-2 IgG and IgA in breast milk were 10-150 times lower compared to serum, and only IgA1 was present.

NPJ VACCINES (2022)

Add to Collection

Article Infectious Diseases

Serum and breastmilk SARS-CoV-2 specific antibodies following BNT162b2 vaccine: prolonged protection from SARS-CoV-2 in newborns and older children

Alessandra Ricciardi et al.

Summary: The study found that antibodies against SARS-CoV-2 can be detected in both breastmilk and serum after mRNA vaccination. The levels of these antibodies vary at different time points after vaccination, with a decrease in breastmilk antibodies after 6 months. This suggests that breastfeeding may provide protection to newborns through the transmission of secretory antibodies, which emphasizes its importance.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Entero-Mammary Pathway and Perinatal Transmission of Gut Microbiota and SARS-CoV-2

Carmen Josefina Juarez-Castelan et al.

Summary: This study provides insights into the gut microbiota of pregnant women during SARS-CoV-2 infection, revealing a high abundance of the Firmicutes phylum. Some bacteria belonging to the Firmicutes phylum have been associated with anti-inflammatory effects, which may explain the ability of women to overcome the infection. Furthermore, the presence of certain bacterial diversity in colostrum suggests a potential association between the gut microbiota and a better outcome.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Infectious Diseases

The early-life gut microbiome and vaccine efficacy

Anne Jordan et al.

Summary: This article evaluates the impact of gut microbiota on early life immunity, focusing on the roles of Bifidobacterium and Bacteroides, and discusses their effects on vaccine responses and efficacy in infants. It also presents microbiota-based approaches to enhance vaccine outcomes and explores novel microbe-derived components that could lead to safer, more effective vaccines and adjuvants.

LANCET MICROBE (2022)

Add to Collection

Article Medicine, General & Internal

Comparing the human milk antibody response after vaccination with four COVID-19 vaccines: A prospective, longitudinal cohort study in the Netherlands

Hannah G. Juncker et al.

Summary: This study compares the antibody response in human milk after vaccination with mRNA and vector-based vaccines. The findings show that lactating women who received mRNA-based vaccines had a higher SARS-CoV-2 antibody response in their breast milk compared to those who received vector-based vaccines.

ECLINICALMEDICINE (2022)

Add to Collection

Editorial Material Obstetrics & Gynecology

Considerations for COVID-19 Vaccination in Lactation

Alison Stuebe

BREASTFEEDING MEDICINE (2021)

Add to Collection

Review Medicine, General & Internal

The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases

Anujit Sarkar et al.

Summary: The gut microbiota in early life plays a crucial role in human health and diseases, influenced by factors including gestational age, delivery mode, birth weight, feeding types, antibiotic exposure, maternal microbiome, and diet. These microbes assist in digestion, immune regulation, and disease risk modulation.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Immunology

The changes of respiratory microbiome between mild and severe asthma patients

Qunzhi Wang et al.

Summary: This study found that there were significant changes in the components and the function of the microbiome when asthma changed from mild to severe, which can help us better understand the relationship between asthma and the respiratory microbiome.

MICROBIOLOGY AND IMMUNOLOGY (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention

H. Knight et al.

Summary: This study developed a scalable digital intervention to address COVID-19 vaccine hesitancy and enhance uptake of COVID-19 vaccines in the UK, guided by motivational interviewing principles. The intervention includes therapeutic dialogues addressing 10 key concerns of vaccine-hesitant individuals. The study was conducted in four stages: identifying reasons, qualitative interviews, developing dialogues, and digitisation pilot testing.

PUBLIC HEALTH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The multifaceted roles of breast milk antibodies

Caroline Atyeo et al.

Summary: Neonates rely on maternal antibodies transferred via the placenta and breast milk for protection, with breast milk antibodies playing important roles in preventing infections, supporting the selection of commensals, and promoting tolerizing immunity.

CELL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Acceptive Immunity: The Role of Fucosylated Glycans in Human Host-Microbiome Interactions

Svetlana Kononova et al.

Summary: This article mainly discusses the impact of the relationship between the human body and symbiotic microbiota on the growth of chronic non-communicable diseases, emphasizing the importance of the balance between the immune system and the microbiota on disease mechanisms, as well as the role of milk glycans, mucins, and secretory immunoglobulins in maintaining homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Cell Biology

Microbiome Analysis of Mucosal Ileoanal Pouch in Ulcerative Colitis Patients Revealed Impairment of the Pouches Immunometabolites

Orazio Palmieri et al.

Summary: The study explored mucosal microbiota of UC patients who underwent IPAA, revealing specific bacterial signatures of dysbiosis that could serve as potential biomarkers in IPAA patients. This may aid in the development of novel treatments by modulating gut microbiota through probiotic immunometabolites-producing bacterial strains, specific prebiotics, and fecal microbiota transplantation.

CELLS (2021)

Add to Collection

Article Virology

SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland

Sarah Stuckelberger et al.

Summary: After the first wave of the pandemic, a study in Switzerland found that only a small percentage of pregnant and breastfeeding women were willing to receive the SARS-CoV-2 vaccine, with factors such as older age, higher education, prior influenza vaccination, having an obstetrician as the primary healthcare provider, and being in the third trimester of pregnancy associated with higher vaccine acceptance. This emphasizes the importance of identifying and reducing barriers to immunization in this population, particularly among younger individuals and those with lower education levels.

VIRUSES-BASEL (2021)

Add to Collection

Review Nutrition & Dietetics

The Breast Milk Immunoglobulinome

Karla Rio-Aige et al.

Summary: Breast milk contains various immunoglobulins, including IgA, IgM, and IgG. The concentrations and proportions of these immunoglobulins change during lactation, but the results of various studies show significant differences and are influenced by multiple factors.

NUTRIENTS (2021)

Add to Collection

Article Immunology

Codominant IgG and IgA expression with minimal vaccine mRNA in milk of BNT162b2 vaccinees

Jia Ming Low et al.

Summary: Lactating mothers who received the BNT162b2 vaccine secreted SARS-CoV-2-specific antibodies into milk, providing protective immunity. Minimal transfer of vaccine mRNA was detected, and no adverse effects were reported in recipients.

NPJ VACCINES (2021)

Add to Collection

Article Ecology

Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem

Melissa A. E. Lawson et al.

ISME JOURNAL (2020)

Add to Collection

Article Multidisciplinary Sciences

DNA extraction approaches substantially influence the assessment of the human breast milk microbiome

Chloe A. Douglas et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Ecological Importance of Cross-Feeding of the Intermediate Metabolite 1,2-Propanediol between Bacterial Gut Symbionts

Christopher C. Cheng et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)

Add to Collection

Review Immunology

Vertically Transferred Immunity in Neonates: Mothers, Mechanisms and Mediators

Marie Albrecht et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Letter Biotechnology & Applied Microbiology

PICRUSt2 for prediction of metagenome functions

Gavin M. Douglas et al.

NATURE BIOTECHNOLOGY (2020)

Add to Collection

Article Immunology

Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

J. Stewart New et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Influence of gut microbiota on mucosal IgA antibody response to the polio vaccine

Ting Zhao et al.

NPJ VACCINES (2020)

Add to Collection

Review Nutrition & Dietetics

Lactobacillus Bacteria in Breast Milk

Katarzyna Lubiech et al.

NUTRIENTS (2020)

Add to Collection

Article Microbiology

The Composition and Concordance of Lactobacillus Populations of Infant Gut and the Corresponding Breast-Milk and Maternal Gut

Xuyao Zhang et al.

FRONTIERS IN MICROBIOLOGY (2020)

Add to Collection

Article Food Science & Technology

The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

Alia H. Al-Khafaji et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

Add to Collection

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Add to Collection

Article Pediatrics

Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age

M. Nazmul Huda et al.

PEDIATRICS (2019)

Add to Collection

Review Immunology

The influence of probiotics on vaccine responses - A systematic review

Petra Zimmermann et al.

VACCINE (2018)

Add to Collection

Review Multidisciplinary Sciences

Microbial tryptophan catabolites in health and disease

Henrik M. Roager et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Microbiology

Human milk oligosaccharide categories define the microbiota composition in human colostrum

J. Aakko et al.

BENEFICIAL MICROBES (2017)

Add to Collection

Review Immunology

Innate Immunity and Breast Milk

Nicole Theresa Cacho et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study

Kiera Murphy et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Microbiology

Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense

Vera Bunesova et al.

BMC MICROBIOLOGY (2016)

Add to Collection

Article Medicine, Legal

Safety evaluation of the human-identical milk monosaccharide, L-fucose

Sharon S. H. Choi et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2015)

Add to Collection

Article Obstetrics & Gynecology

Human Breast Milk and the Gastrointestinal Innate Immune System

Brett M. Jakaitis et al.

CLINICS IN PERINATOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

Eric W. Rogier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Glucocorticoids and microbiota regulate ontogeny of intestinal fucosyltransferase 2 requisite for gut homeostasis

N. Nanda Nanthakumar et al.

GLYCOBIOLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia et al.

NATURE (2013)

Add to Collection

Article Pediatrics

Changes in immunomodulatory constituents of human milk in response to active infection in the nursing infant

Arieh Riskin et al.

PEDIATRIC RESEARCH (2012)

Add to Collection

Review Multidisciplinary Sciences

Interactions Between the Microbiota and the Immune System

Lora V. Hooper et al.

SCIENCE (2012)

Add to Collection

© Peeref 2019-2024. All rights reserved.