4.7 Article

Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and Characterization

Journal

PHARMACEUTICS
Volume 15, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics15102510

Keywords

etodolac; nanoemulsions; topical drug delivery; paw edema; permeation

Ask authors/readers for more resources

This study focuses on the development of innovative topical nanoemulsions for etodolac and optimizes the formulation using a design of experiments approach. The optimized formulation exhibits good hydrophobicity, sustained release profile, and superior anti-inflammatory activity in vivo.
This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of high shear homogenization and ultrasonication methods. The optimization of the formulation components is systematically conducted using the design of experiments methodology. The droplet size (DS), polydispersity index (PDI), and zeta potential (ZP) of the optimized formulation were assessed using the differential light scattering (DLS) technique. Surface morphology examinations were conducted using electron microscopy, while interactions between excipients and the drug were analyzed through FTIR analysis. Additionally, in vitro release and ex vivo permeability studies were carried out. Furthermore, anti-inflammatory activity was evaluated in the context of a carrageenan-induced paw edema model in rats. The DS, PDI, and ZP of the optimal formulation were 163.5 nm, 0.141, and -33.1 mV, respectively. The in vitro release profile was assessed as a sustained release by following a non-Fickian drug transport. The flux of etodolac nanoemulsions and coarse dispersions were 165.7 +/- 11.7 mu g/cm2 h and 59.7 +/- 15.2 mu g/cm2 h, respectively. Enhanced edema inhibition was observed at 13.4%, 36.5%, and 50.65% for the 6th, 8th, and 24th hours, respectively. Taken together, these results confirmed that nanoemulsions are promising carriers for the topical delivery of etodolac.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available