Age has a U-shaped relationship with breast cancer outcomes in women: a cohort study

Article Oncology

The impact of young age (< 40 years) on the outcome of a cohort of patients with primary non-metastatic breast cancer: analysis of 10-year survival of a prospective study

Youssef Bouferraa et al.

Summary: Young age at diagnosis is an independent risk factor for adverse outcomes in female breast cancer patients. Compared to patients aged ≥40, those aged <40 have lower 10-year overall survival and disease-free survival rates.

BMC CANCER (2022)

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Article Oncology

The impact of young age at diagnosis (age <40 years) on prognosis varies by breast cancer subtype: A US SEER database analysis

Hee Jeong Kim et al.

Summary: Women under 40 years old are at increased risk for developing breast cancer and have worse prognoses. This study found that young age is independently associated with worse outcomes in HR-positive, lower grade disease.

BREAST (2022)

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Article Oncology

Association between age at initial diagnosis and post-metastasis mortality among women with recurrent metastatic breast cancer in China

Yuxin Xie et al.

Summary: This study found that elderly breast cancer patients at initial diagnosis face a higher risk of post-metastasis mortality.

BMC CANCER (2022)

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Article Cell Biology

Comparisons of Metastatic Patterns, Survival Outcomes and Tumor Immune Microenvironment Between Young and Non-Young Breast Cancer Patients

Hengwen Sun et al.

Summary: This study compared the metastatic patterns, survival outcomes, and tumor immune microenvironment between young and non-young breast cancer patients, finding that young patients had significantly higher metastatic rates and poorer prognosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Oncology

Breast cancer in the oldest old (> 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review

Simona Di Lascio et al.

Summary: This study reviewed and analyzed the clinical characteristics, treatment, and outcomes of breast cancer patients aged 89 and older, highlighting the importance of sub-stratifying this heterogeneous group for tailored treatment. Most patients did not receive adjuvant treatment, and a small percentage experienced relapse.

EJSO (2021)

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Article Oncology

10-Year Breast Cancer Outcomes in Women ≤35 Years of Age

Cole Billena et al.

Summary: Breast cancer patients aged 35 and below have worse survival and recurrence outcomes, making breast conservation therapy appropriate for this group. Concerns about second malignancies should not affect the indication for postoperative radiation therapy.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer

Meng-Ting He et al.

Summary: The therapeutic effect of postmastectomy radiotherapy (PMRT) on T3N0M0 breast cancer patients is related to age. PMRT significantly improves survival time for patients over 65 years old, while offering little benefit to younger patients. Individualized treatment decisions for T3N0M0 patients should take age into consideration.

BREAST (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Multidisciplinary Sciences

Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients

Hikmat Abdel-Razeq et al.

Summary: In developing countries, younger patients with breast cancer showed more aggressive pathological features compared to older patients, but had a better overall survival rate. There was no significant difference in disease-free survival between the two groups, indicating that older women were more likely to die from non-cancer related causes.

SCIENTIFIC REPORTS (2021)

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Article Surgery