Association between inflammatory bowel disease and pancreatic cancer: results from the two-sample Mendelian randomization study

Article Gastroenterology & Hepatology

Inflammatory Bowel Disease and Long-term Risk of Cancer: A Prospective Cohort Study Among Half a Million Adults in UK Biobank

Shanshan Wu et al.

Summary: Regardless of IBD subtype, IBD may be associated with a 17% excess risk of incident overall cancer and a 26% higher risk of death due to cancer compared with non-IBD participants, and the risk seemed even higher in UC patients.

INFLAMMATORY BOWEL DISEASES (2023)

Add to Collection

Article Oncology

Risk of malignancy in patients with inflammatory bowel disease: A population-based cohort study from China

Huimin Zhang et al.

Summary: The increased risks of multiple cancers are particularly prominent in Chinese IBD patients, especially digestive cancers, thyroid cancer, and hematological malignancies, emphasizing the need for more targeted guidance for cancer monitoring.

INTERNATIONAL JOURNAL OF CANCER (2022)

Add to Collection

Review Gastroenterology & Hepatology

Systematic review-Pancreatic involvement in inflammatory bowel disease

Sara Massironi et al.

Summary: This study is the first systematic review of the association between inflammatory bowel disease (IBD) and pancreatic diseases. The study found that pancreatic involvement in IBD commonly presents as acute pancreatitis and chronic pancreatitis, with factors such as gallstones, drugs, and autoimmune processes implicated. Additionally, the study suggests a potential association between IBD and pancreatic exocrine insufficiency, although data on this association is limited and conflicting.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Article Nutrition & Dietetics

Investigating Causal Associations of Diet-Derived Circulating Antioxidants with the Risk of Digestive System Cancers: A Mendelian Randomization Study

Xuening Zhang et al.

Summary: This study used Mendelian randomization to assess the causal associations between diet-derived antioxidants and digestive system cancers. The findings suggest that higher levels of antioxidants are unlikely to be a causal protective factor for most digestive system cancers, except for the suggestive protective effects of ascorbate on colon cancer and of retinol on pancreatic cancer.

NUTRIENTS (2022)

Add to Collection

Review Gastroenterology & Hepatology

The Risk of Extraintestinal Cancer in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Cohort Studies

Bobby Lo et al.

Summary: Patients with Crohn's disease and ulcerative colitis are at increased risk of developing extraintestinal cancers, both overall and at specific sites, even when receiving immunosuppressive treatment. Additional studies with longer follow-up evaluation are needed to more accurately assess the true risk of extraintestinal cancers in patients with inflammatory bowel disease.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement

Veronika W. Skrivankova et al.

Summary: The STROBE-MR Statement was developed to guide the reporting of MR studies by providing a checklist tailored to MR studies, which could improve the evaluation and interpretation of these studies by editors, peer reviewers, researchers, clinicians, and other readers.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

Alice R. Carter et al.

Summary: Mediation analysis aims to explain how an exposure affects an outcome, with Mendelian randomisation (MR) offering improved causal inference. This paper outlines two approaches for mediation analysis with MR: multivariable MR (MVMR) and two-step MR, which are not affected by confounding and measurement errors according to simulations.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

Add to Collection

Review Oncology

Solid extraintestinal malignancies in patients with inflammatory bowel disease

Anastasia Mala et al.

Summary: Malignancies are the second leading cause of death in patients with inflammatory bowel diseases (IBD), with the risk of colorectal cancer decreasing over time while the incidence of extraintestinal cancers (EICs) is increasing. This could be due to systemic inflammation or long-lasting immunosuppression. Proper surveillance is crucial for early diagnosis and better prognosis in IBD patients.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

Alison P. Klein

Summary: Pancreatic cancer is a leading cause of cancer death globally, with significant risk factors including smoking, obesity, diabetes, and genetic factors. Efforts to understand and address these modifiable and inherited risk factors are crucial for early detection and prevention strategies for pancreatic cancer.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational Risks from Mechanisms to Medicines

Ross J. Porter et al.

Summary: The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases predisposes to the development of IBD-CRC. Inflammation can induce mutagenesis, and the molecular pathogenesis of IBD-CRC is well described, while the immunopathogenesis is less understood. The impact of novel immunosuppressive therapies on achieving deep remission in IBD-CRC remains mostly unknown.

JOURNAL OF CROHNS & COLITIS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer

Lifang Liang et al.

Summary: This review briefly summarizes the expression of CypA, CypB, and CypD in IBD and CRC, their relationship with the development of these two intestinal diseases, as well as the possible pathogenesis, providing a modest reference for future clinical research and treatments.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Add to Collection

Review Oncology

Risk of colorectal cancer in inflammatory bowel diseases

Muhammad Shahid Nadeem et al.

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Cancer Risk in Inflammatory Bowel Disease: A 6-Year Prospective Multicenter Nested Case-Control IG-IBD Study

Livia Biancone et al.

INFLAMMATORY BOWEL DISEASES (2020)

Add to Collection

Article Gastroenterology & Hepatology

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sudabeh Alatab et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Inflammatory bowel disease and pancreatic cancer: a Scandinavian register-based cohort study 1969-2017

Asa H. Everhov et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Add to Collection

Editorial Material Gastroenterology & Hepatology

Editorial: pancreatic cancer risk in inflammatory bowel diseases-it's all relative

Ariela K. Holmer et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Add to Collection

Article Gastroenterology & Hepatology

Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer

Dianbo Yao et al.

INFLAMMATORY BOWEL DISEASES (2019)

Add to Collection

Review Medicine, General & Internal

Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement

Douglas K. Owens et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Add to Collection

Article Gastroenterology & Hepatology

Malignancies in Inflammatory Bowel Disease: Frequency, Incidence and Risk Factors-Results from the Swiss IBD Cohort Study

Sylvie Scharl et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

Add to Collection

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Add to Collection

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Add to Collection

Article Biology

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani et al.

ELIFE (2018)

Add to Collection

Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

Add to Collection

Article Gastroenterology & Hepatology

Cancer Risk in the Early Stages of Inflammatory Bowel Disease in Korean Patients: A Nationwide Population-based Study

Yoon Suk Jung et al.

JOURNAL OF CROHNS & COLITIS (2017)

Add to Collection

Review Gastroenterology & Hepatology

Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis

Sawan Bopanna et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2017)

Add to Collection

Article Biochemical Research Methods

PhenoScanner: a database of human genotype-phenotype associations

James R. Staley et al.

BIOINFORMATICS (2016)

Add to Collection

Article Gastroenterology & Hepatology

Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study

Livia Biancone et al.

JOURNAL OF CROHNS & COLITIS (2016)

Add to Collection

Review Urology & Nephrology

Mendelian Randomization as an Approach to Assess Causality Using Observational Data

Peggy Sekula et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment

Jordan E. Axelrad et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Add to Collection

Review Gastroenterology & Hepatology

Epidemiology of pancreatic cancer

Milena Ilic et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Add to Collection

Article Public, Environmental & Occupational Health

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2015)

Add to Collection

Article Genetics & Heredity

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Jimmy Z. Liu et al.

NATURE GENETICS (2015)

Add to Collection

Article Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

Gilaad G. Kaplan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Add to Collection

Article Public, Environmental & Occupational Health

Avoiding bias from weak instruments in Mendelian randomization studies

Stephen Burgess et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)

Add to Collection

Article Gastroenterology & Hepatology

Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study

Konstantinos H. Katsanos et al.

JOURNAL OF CROHNS & COLITIS (2011)

Add to Collection

Review Gastroenterology & Hepatology

Risk of Extra-Intestinal Cancer in Inflammatory Bowel Disease: Meta-Analysis of Population-Based Cohort Studies

Natalia Pedersen et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

Add to Collection

Article Multidisciplinary Sciences

A map of human genome variation from population-scale sequencing

David Altshuler et al.

NATURE (2010)

Add to Collection

Article Genetics & Heredity

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Laufey Amundadottir et al.

NATURE GENETICS (2009)

Add to Collection

Association between inflammatory bowel disease and pancreatic cancer: results from the two-sample Mendelian randomization study

Related references

Export Citation

Share Paper