4.6 Article

Primary tumour category, site of metastasis, and baseline serum S100B and LDH are independent prognostic factors for survival in metastatic melanoma patients treated with anti-PD-1

Related references

Note: Only part of the references are listed.
Article Oncology

Development and Validation of a Prognostic Risk Model for Patients with Advanced Melanoma Treated with Immune Checkpoint Inhibitors

Igor Stukalin et al.

Summary: This study developed a new prognostic model associated with overall survival in advanced melanoma patients treated with immune checkpoint inhibitors (ICI), focusing on clinically accessible parameters at the start of ICI therapy.

ONCOLOGIST (2023)

Article Oncology

Regional variability of melanoma incidence and prevalence in Hungary. Epidemiological impact of ambient UV radiation and socioeconomic factors.

Eszter A. Janka et al.

Summary: The incidence and prevalence of cutaneous melanoma in Hungary have been increasing, with higher rates among women and elderly individuals. There appears to be no significant correlation between geographical variations in ambient UV radiation and epidemiologic indicators, but socioeconomic factors may play a role in melanoma rates.

EUROPEAN JOURNAL OF CANCER PREVENTION (2022)

Review Oncology

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022

Claus Garbe et al.

Summary: A unique collaboration of multidisciplinary experts has provided recommendations on diagnosis and treatment of cutaneous melanoma. The recommendations cover excision of melanomas, sentinel lymph node dissection, and systemic treatments.

EUROPEAN JOURNAL OF CANCER (2022)

Article Medical Laboratory Technology

Diagnostic performance of early increase in S100B or LDH as outcome predictor for non-responsiveness to anti-PD-1 monotherapy in advanced melanoma

Elisa A. Rozeman et al.

Summary: This study evaluated if early increases in S100B or lactate dehydrogenase (LDH) could predict non-responsiveness to anti-PD-1 therapy in advanced melanoma patients. The findings revealed that early increases in S100B or LDH serve as strong parameters for non-responsiveness to anti-PD-1 in advanced melanoma patients.

CLINICA CHIMICA ACTA (2022)

Article Immunology

Nomogram for predicting prognosis of patients with metastatic melanoma after immunotherapy: A Chinese population-based analysis

Jingjing Zhao et al.

Summary: This study found that baseline biomarkers can predict the response to immunotherapy and prognosis in patients with metastatic melanoma. Personalized treatment regimens can be developed based on these biomarkers.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

Systemic Therapy in Advanced Nodular Melanoma versus Superficial Spreading Melanoma: A Nation-Wide Study of the Dutch Melanoma Treatment Registry

Daan Jan Willem Rauwerdink et al.

Summary: This study aimed to compare the efficacy of immunotherapy and BRAF/MEK inhibitors in metastatic nodular melanoma and metastatic superficial spreading melanoma. The results showed no difference in efficacy between the two treatments for patients with either type of melanoma. However, patients with nodular melanoma had shorter distant metastasis-free survival and worse overall survival, suggesting that the poorer overall survival of nodular melanoma is mainly due to the propensity for metastatic spread after the primary diagnosis.

CANCERS (2022)

Article

Double Trouble: Immunotherapy Doublets in Melanoma—Approved and Novel Combinations to Optimize Treatment in Advanced Melanoma

Florentia Dimitriou et al.

American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting (2022)

Article Cell Biology

Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma

Ke-Jia Wu et al.

Summary: The study identified a CRAF inhibitor that can suppress melanoma cell proliferation and tumor growth in murine models by blocking the S100B and RAF pathways, showing potential for melanoma therapy. Inhibiting BRAF together with S100B was found to significantly restore p53 transcription activity and inhibit melanoma cell proliferation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Oncology

Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: A Systematic Review and Meta-Analysis

Eszter Anna Janka et al.

Summary: In a systematic review and meta-analysis involving 1,033 patients with resected melanoma, serum S100B showed significantly better discriminative ability for disease relapse compared to serum LDH. However, in a risk of death analysis with 1,987 patients included, the prognostic performance of serum S100B was independent but not superior to serum LDH.

FRONTIERS IN ONCOLOGY (2021)

Article Medicine, General & Internal

Association Between Sex and Immune Checkpoint Inhibitor Outcomes for Patients With Melanoma

Se Ryeong Jang et al.

Summary: This study examined the effectiveness of cancer immunotherapy in male and female patients with advanced melanoma and found that women may not benefit as much from combination ICIs as men would. Tumor mutation burden or estrogen level may serve as important biomarkers associated with ICI response in metastatic melanoma.

JAMA NETWORK OPEN (2021)

Review Oncology

Immune Responses against Disseminated Tumor Cells

Ling Peng et al.

Summary: The ability of cancer cells to metastasize and interact with the immune system plays a crucial role in cancer progression. Failed immune surveillance leads to the reappearance and growth of cancer cells in the body, while immune checkpoint inhibitors show promising clinical activity.

CANCERS (2021)

Review Medicine, General & Internal

Unraveling the Wide Spectrum of Melanoma Biomarkers

Antonios Revythis et al.

Summary: The use of biomarkers in medicine is crucial for diagnosis, prognostication, and prediction of treatment response. With advancements in understanding DNA mutational profiles, new gene targets and proteins are being identified. Currently, only a small number of available biomarkers are being utilized, but this could change with more research being published.

DIAGNOSTICS (2021)

Article Oncology

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Lisa Haas et al.

Summary: The study reveals that tumors relapsing after targeted therapy show cross-resistance to immunotherapies due to an immunosuppressive tumor microenvironment lacking CD103(+) dendritic cells. Cross-resistance is not a result of immune response pressure during resistance evolution, but stems from the MAPK pathway's increased transcriptional output driving immune evasion. Restoring CD103(+) dendritic cells can resensitize tumors to immunotherapy.

NATURE CANCER (2021)

Review Biochemistry & Molecular Biology

Significance of 5-S-Cysteinyldopa as a Marker for Melanoma

Kazumasa Wakamatsu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

RAGE Signaling in Melanoma Tumors

Olamide T. Olaoba et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy

Michael Lattanzi et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Oncology

Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy

Michael Lattanzi et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Review Biochemistry & Molecular Biology

The S100B story: from biomarker to active factor in neural injury

Fabrizio Michetti et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

S100 proteins: Diagnostic and prognostic biomarkers in laboratory medicine

Claus W. Heizmann

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Dermatology

Baseline laboratory parameters predicting clinical outcome in melanoma patients treated with ipilimumab: a single-centre analysis

T. Gambichler et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

Article Biochemistry & Molecular Biology

Ultraviolet radiation-mediated development of cutaneous melanoma: An update

Gabriella Emri et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2018)

Review Oncology

Biomarkers for immune Checkpoint inhibitors in Melanoma

Shigehisa Kitano et al.

FRONTIERS IN ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

Ming Yi et al.

MOLECULAR CANCER (2018)

Article Oncology

Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade

Jun Zhou et al.

CANCER IMMUNOLOGY RESEARCH (2017)

Article Dermatology

Biomarker value and pitfalls of serum S100B in the follow-up of high-risk melanoma patients

Christoffer Gebhardt et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2016)

Article Medical Laboratory Technology

Relevance of MIA and S100 serum tumor markers to monitor BRAF inhibitor therapy in metastatic melanoma patients

Miguel F. Sanmamed et al.

CLINICA CHIMICA ACTA (2014)

Review Biochemistry & Molecular Biology

Protein and non-protein biomarkers in melanoma: a critical update

Nadine Tandler et al.

AMINO ACIDS (2012)

Article Biochemistry & Molecular Biology

Importance of glycolysis and oxidative phosphorylation in advanced melanoma

Jonhan Ho et al.

MOLECULAR CANCER (2012)

Review Dermatology

A Synopsis of Serum Biomarkers in Cutaneous Melanoma Patients

Pierre Vereecken et al.

DERMATOLOGY RESEARCH AND PRACTICE (2012)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Review Medical Laboratory Technology

S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma

R Hatpio et al.

CLINICAL BIOCHEMISTRY (2004)

Letter Medical Laboratory Technology

Reference values for serum S-100B protein depend on the race of individuals

O Ben Abdesselam et al.

CLINICAL CHEMISTRY (2003)