4.6 Review

The interplay of FLT3 and CXCR4 in acute myeloid leukemia: an ongoing debate

Related references

Note: Only part of the references are listed.
Article Oncology

Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling

Nicholas R. Anderson et al.

Summary: Using a mouse model of FLT3-ITD AML, researchers found that FLT3-ITD AML LSC were enriched within the ST-HSC population and had increased expression of CXCR4. Deletion of CXCL12 from the microenvironment enhanced targeting of AML cells by Flt3-TKI plus chemotherapy treatment, including enhanced LSC targeting. Inhibition of p38 signaling reduced the maintenance of Flt3-ITD AML LSC and enhanced their sensitivity to treatment.

LEUKEMIA (2023)

Article Pharmacology & Pharmacy

The contributory roles of the CXCL12/CXCR4/CXCR7 axis in normal and malignant hematopoiesis: A possible therapeutic target in hematologic malignancies

Mahdieh Mehrpouri

Summary: CXCL12/CXCR4 and CXCL12/CXCR7 axes play a key role in hematopoiesis and their aberrant expression may lead to the development of leukemia. Various therapeutic interventions have been developed to target these axes in leukemic cells, showing promising results in pre-clinical and clinical studies.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Review Oncology

Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

Yiyi Yao et al.

Summary: Despite advances in chemotherapy and targeted therapies, AML's survival rates are still poor due to chemotherapy resistance and high relapse rates caused by leukemia stem cells. The interaction between hematopoietic cells and the bone marrow microenvironment plays a key role in AML pathogenesis and chemotherapy resistance. Targeting this interaction could be a potential therapeutic strategy to eradicate LSCs and improve AML outcomes.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

Review Cell Biology

Role of CXCR4 in the progression and therapy of acute leukaemia

Long Su et al.

Summary: CXCR4 is expressed on leukemia cells and hematopoietic stem cells, and its regulation plays a crucial role in the retention and migration of these cells in the bone marrow microenvironment. While CXCR4 antagonists can mobilize leukemia cells for effective eradication, drug-resistant leukemia cells may not be affected by these antagonists, indicating alternative pathways in leukemia cell migration.

CELL PROLIFERATION (2021)

Review Hematology

Dissecting the role of the CXCL12/CXCR4 axis in acute myeloid leukaemia

Eleni E. Ladikou et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Review Oncology

Significance of CXCL12/CXCR4 Ligand/Receptor Axis in Various Aspects of Acute Myeloid Leukemia

Zinat Yazdani et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Review Oncology

Novel Approaches to Target Mutant FLT3 Leukaemia

Joerg P. Mueller et al.

CANCERS (2020)

Review Physiology

FMS-LIKE TYROSINE KINASE 3/FLT3: FROM BASIC SCIENCE TO CLINICAL IMPLICATIONS

Julhash U. Kazi et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Oncology

FLT3-ITD and its current role in acute myeloid leukaemia

Francisco Alejandro Lagunas-Rangel et al.

MEDICAL ONCOLOGY (2017)

Review Immunology

CXCR4 signaling in health and disease

Tommaso Pozzobon et al.

IMMUNOLOGY LETTERS (2016)

Review Medicine, Research & Experimental

Role of CXCR4 in the Pathogenesis of Acute Myeloid Leukemia

Amnon Peled et al.

THERANOSTICS (2013)

Article Anatomy & Morphology

The Prognostic Value of CXCR4 in Acute Myeloid Leukemia

Jeong Yeal Ahn et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2012)

Review Oncology

Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

Guido Marcucci et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Hematology

Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts

Angela Jacobi et al.

EXPERIMENTAL HEMATOLOGY (2010)

Editorial Material Oncology

CXCR4 in acute myelogenous leukemia (AML): When too much attraction is bad for you

Jan A. Burger

LEUKEMIA RESEARCH (2009)

Article Oncology

Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia

Emmanuelle Tavernier-Tardy et al.

LEUKEMIA RESEARCH (2009)

Article Hematology

CXCR4 is a prognostic marker in acute myelogenous leukemia

Anke C. Spoo et al.

BLOOD (2007)

Review Oncology

The role of FLT3 in haematopoietic malignancies

DL Stirewalt et al.

NATURE REVIEWS CANCER (2003)