4.6 Review

Unlocking Translational Potential: Conditionally Reprogrammed Cells in Advancing Breast Cancer Research

Related references

Note: Only part of the references are listed.
Article Oncology

Colorectal cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: Colorectal cancer is the second leading cause of cancer death in the United States. The incidence of CRC has slowed down, but it is shifting to a younger age, advanced stage, and left colon/rectum. Mortality from CRC has declined overall, but increased in individuals younger than 50 years and Native Americans younger than 65 years. Uncovering the reasons for rising incidence and improving access to screening and treatment are crucial in combating CRC.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

Review Virology

Conditional Cell Reprogramming and Air-Liquid Interface Modeling Life Cycle of Oncogenic Viruses (HPV and EBV) in Epithelial Cells and Virus-Associated Human Carcinomas

Abdul Qawee Rani et al.

Summary: Oncogenic viruses are linked to around 20% of human cancers, but current cell models have limitations in studying viral life cycle and cancer initiation. There is a need for reliable human physiological cell models. Conditional cell reprogramming (CCR) is a rapid and robust system that can establish cells from minimally invasive specimens and preserve their lineage functions.

VIRUSES-BASEL (2023)

Review Cell Biology

The dual role of microRNA (miR)-20b in cancers: Friend or foe?

Ahmet Ilhan et al.

Summary: MicroRNAs regulate gene expression through RNA silencing and their abnormal expression is associated with tumorigenesis and cancer development. miR-20b, a crucial miRNA, regulates essential biological processes and its deregulated levels contribute to cancer progression. High-throughput strategies have identified potential targets of miR-20b and suggest its effects through various signaling pathways. Restoration of miR-20b expression induces cell apoptosis and reduces invasion and migration, making it a potential biomarker and therapeutic target in cancer.

CELL COMMUNICATION AND SIGNALING (2023)

Review Pathology

Role of cancer stem cell-derived extracellular vesicles in cancer progression and metastasis

Andarz Fazlollahpour Naghibi et al.

Summary: Cancer stem cell-derived extracellular vesicles play a crucial role in cancer treatment failure.

PATHOLOGY RESEARCH AND PRACTICE (2023)

Review Cell Biology

Conditional Reprogramming Modeling of Bladder Cancer for Clinical Translation

Danyal Daneshdoust et al.

Summary: The use of advanced preclinical models is increasingly important in drug development, particularly in bladder cancer. Predictive tools for selecting responsive patients to invasive therapies are largely absent. Patient-derived and clinically relevant models, such as patient-derived xenografts (PDX), organoids, and conditional reprogramming (CR) cells, efficiently generate various models for cancer research. CR technology can reproduce the genomic and histological characteristics of parental tissue, making it a clinically relevant model for drug sensitivity testing and personalized medicine in bladder cancer.

CELLS (2023)

Article Multidisciplinary Sciences

Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells

Sahar J. Alothman et al.

Summary: This study explores the biology and transcriptomes of non-cancerous human mammary epithelial cells at risk for breast cancer development. The findings suggest that high-risk cells exhibit diverse behavioral and gene expression patterns, potentially indicating different risk profiles.

SCIENTIFIC REPORTS (2022)

Article Virology

The First Human Vulvar Intraepithelial Neoplasia Cell Line with Naturally Infected Episomal HPV18 Genome

Ming Wu et al.

Summary: In this study, the first human cell line with naturally infected HPV18 genome from vulvar intraepithelial neoplasia (VIN) was established, offering a valuable model for HPV biology studies, HPV-associated cancer initiation and progression, and drug-screening platforms.

VIRUSES-BASEL (2022)

Article Oncology

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Katrin P. Guillen et al.

Summary: Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. In this study, researchers report a bank of human patient-derived xenografts and organoid cultures from breast cancers that are resistant to treatment and have metastasized. They demonstrate the feasibility and cost-effectiveness of using these models for drug screening, and also show the potential of applying precision oncology in real-time clinical care. The study provides valuable methods and resources for functional precision medicine and drug development for human breast cancer.

NATURE CANCER (2022)

Review Cell Biology

The molecular basis of mammary gland development and epithelial differentiation

Priscila Ferreira Slepicka et al.

Summary: This article reviews recent advances in understanding molecular events underlying mammalian organ system development, focusing on genes and pathways involved in mammary gland development and the use of single-cell genomics and 3D organoid cultures as tools to study these processes. Additionally, it highlights the potential of this research in predicting breast cancer risk and developing new therapies.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Competitive Endogenous Role of the LINC00511/miR-185-3p Axis and miR-301a-3p From Liquid Biopsy as Molecular Markers for Breast Cancer Diagnosis

Marwa M. Mahmoud et al.

Summary: Breast cancer is the leading cause of female cancer-related mortalities. This study investigated the expression patterns and diagnostic values of LINC00511 and its downstream microRNAs in BC patients. Results showed that LINC00511 and miR-301a-3p were overexpressed, while miR-185-3p was downregulated in BC patients' blood.These findings contribute to our understanding of BC pathogenesis, with implications for potential therapeutic targets.

FRONTIERS IN ONCOLOGY (2021)

Review Biotechnology & Applied Microbiology

Current Status of Breast Organoid Models

Srivarshini Cherukupalli Mohan et al.

Summary: Breast cancer is the most frequently diagnosed malignancy among women globally, and human breast models are needed to elucidate the underlying mechanisms of breast cancer risk factors. Three-dimensional breast organoids accurately recapitulate the in vivo breast microenvironment and are crucial for studying signaling transduction, gene expression, and tissue remodeling.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Review Pharmacology & Pharmacy

Current State of Breast Cancer Diagnosis, Treatment, and Theranostics

Arya Bhushan et al.

Summary: Breast cancer is a leading cause of cancer-related morbidity and mortality in women worldwide, with early diagnosis and effective treatment being crucial for positive outcomes. Theranostics has emerged as a new paradigm for simultaneous diagnosis, imaging, and treatment of cancers, offering potential for personalized therapy. Nanotheranostics, embedding specific targeting moieties, imaging agents, and therapeutic agents within a single formulation, is an effective treatment approach for breast cancer.

PHARMACEUTICS (2021)

Review Cell Biology

Long-term differentiating primary human airway epithelial cell cultures: how far are we?

Zuzanna Bukowy-Bieryllo

Summary: Human airway epithelial (HAE) cellular models are widely used in respiratory research, with the conditionally reprogrammed cell (CRC) models showing promising results for longer in vitro proliferation of HAE cells. The limitations of primary HAE models due to their limited proliferative lifespan have led to the exploration of CRC HAE cultures as a useful alternative.

CELL COMMUNICATION AND SIGNALING (2021)

Review Cell Biology

Conditional Cell Reprogramming in Modeling Digestive System Diseases

Ruihua Zhao et al.

Summary: Digestive diseases are a significant source of morbidity and mortality, highlighting the importance of extensive research. Traditional models have limitations, so the development of reliable new technologies is crucial for understanding disease mechanisms.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell & Tissue Engineering

Organoids: Past Learning and Future Directions

Lauren O'Connell et al.

STEM CELLS AND DEVELOPMENT (2020)

Review Gastroenterology & Hepatology

Culture and application of conditionally reprogrammed primary tumor cells

Mengjun Zhong et al.

GASTROENTEROLOGY REPORT (2020)

Review Oncology

Conditional reprogramming: Modeling urological cancer and translation to clinics

Wei Liu et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors

Michela Piezzo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools

Erin D. Giles et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2020)

Review Oncology

Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer

Neil Portman et al.

ENDOCRINE-RELATED CANCER (2019)

Review Genetics & Heredity

Induced pluripotent stem cells in disease modelling and drug discovery

R. Grant Rowe et al.

NATURE REVIEWS GENETICS (2019)

Article Oncology

Cancer treatment and survivorship statistics, 2019

Kimberly D. Miller et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Medicine, Research & Experimental

Highlight article: Long-term culture and characterization of patient-derived primary hepatocytes using conditional reprogramming

Shan Su et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Review Biotechnology & Applied Microbiology

Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations

Silvia Codenotti et al.

ONCOTARGETS AND THERAPY (2019)

Review Oncology

Circulating tumor DNA analysis in breast cancer: Is it ready for prime-time?

Giuseppe Buono et al.

CANCER TREATMENT REVIEWS (2019)

Article Oncology

BRCA1 mutation influences progesterone response in human benign mammary organoids

Batzaya Davaadelger et al.

BREAST CANCER RESEARCH (2019)

Review Cell Biology

Humanized mouse models: Application to human diseases

Ryoji Ito et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

A system for detecting high impact-low frequency mutations in primary tumors and metastases

M. Anjanappa et al.

ONCOGENE (2018)

Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

Article Biochemistry & Molecular Biology

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

Minan Wang et al.

FASEB JOURNAL (2018)

Review Oncology

The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

Jaeyun Jung et al.

CANCER RESEARCH AND TREATMENT (2018)

Article Genetics & Heredity

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben-David et al.

NATURE GENETICS (2017)

Article Biochemical Research Methods

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

Xuefeng Liu et al.

NATURE PROTOCOLS (2017)

Article Multidisciplinary Sciences

Proof of region-specific multipotent progenitors in human breast epithelia

Agla J. Fridriksdottir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Medicine, Research & Experimental

Ex vivo tumor culture systems for functional drug testing and therapy response prediction

Titia G. Meijer et al.

FUTURE SCIENCE OA (2017)

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

Article Oncology

Primary cancer cell culture: mammary-optimized vs conditional reprogramming

Ahmad M. Alamri et al.

ENDOCRINE-RELATED CANCER (2016)

Article Cell & Tissue Engineering

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

Manuela Voelkner et al.

STEM CELL REPORTS (2016)

Article Oncology

Developing in vitro models of human ductal carcinoma in situ from primary tissue explants

Daniel D. Brown et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Article Medicine, General & Internal

Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer

Sandra M. Swain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization

Harikrishna Nakshatri et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Multidisciplinary Sciences

Identification of multipotent mammary stemcells by protein C receptor expression

Daisong Wang et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

Wouter R. Karthaus et al.

Review Oncology

Genetically engineered ERα-positive breast cancer mouse models

Sarah A. Dabydeen et al.

ENDOCRINE-RELATED CANCER (2014)

Article Cell & Tissue Engineering

Lgr5+ liver stem cells, hepatic organoids and regenerative medicine

Meritxell Huch et al.

REGENERATIVE MEDICINE (2013)

Review Oncology

Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines

Nandita Barnabas et al.

INTERNATIONAL JOURNAL OF BREAST CANCER (2013)

Article Pathology

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

Xuefeng Liu et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

Review Oncology

Patient-derived tumour xenografts as models for oncology drug development

John J. Tentler et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Multidisciplinary Sciences

Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

Frank A. Suprynowicz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemical Research Methods

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al.

BIOINFORMATICS (2011)

Article Multidisciplinary Sciences

Distinct stem cells contribute to mammary gland development and maintenance

Alexandra Van Keymeulen et al.

NATURE (2011)

Review Cell Biology

The essence of senescence

Thomas Kuilman et al.

GENES & DEVELOPMENT (2010)

Article Cell Biology

Hormone Action in the Mammary Gland

Cathrin Brisken et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Multidisciplinary Sciences

Tumours with PI3K activation are resistant to dietary restriction

Nada Y. Kalaany et al.

NATURE (2009)

Article Biochemical Research Methods

Three-dimensional culture models of normal and malignant breast epithelial cells

Genee Y. Lee et al.

NATURE METHODS (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Cell Biology

Information networks in the mammary gland

L Hennighausen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Oncology

Epithelial-stromal interactions in the mouse and human mammary gland in vivo

H Parmar et al.

ENDOCRINE-RELATED CANCER (2004)

Article Multidisciplinary Sciences

Gene expression profiling predicts clinical outcome of breast cancer

LJ van't Veer et al.

NATURE (2002)

Article Multidisciplinary Sciences

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

T Sorlie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Molecular portraits of human breast tumours

CM Perou et al.

NATURE (2000)