☆ 4.6 Article

Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma

CELLS (2023)

Related references

Note: Only part of the references are listed.

Review Oncology

DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies

Ola Rominiyi et al.

Summary: Glioblastoma is the most common primary brain tumor in adults with limited treatment options and low survival rates. The presence of treatment-resistant stem cell-like subpopulations with heightened expression of DNA damage response factors contributes to the difficulty in treating the disease. Studying the role of DDR in glioblastoma biology and treatment is crucial for improving patient survival rates.

MOLECULAR ONCOLOGY (2022)

Add to Collection

Review Oncology

The Role of Hypoxia in Glioblastoma Radiotherapy Resistance

Agathe L. Chedeville et al.

Summary: Glioblastoma (GB) is the deadliest type of primary brain tumor with a median survival time of 16 months post-diagnosis, and radiotherapy remains the most effective treatment despite the common resistance observed in GB patients. Understanding the role of low tumor oxygenation (hypoxia) in radioresistance is crucial for developing novel strategies to improve tumor cell sensitivity to radiotherapy.

CANCERS (2021)

Add to Collection

Review Cell Biology

The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma

Anshika Goenka et al.

Summary: GBM is the most lethal type of primary brain cancer, with therapy resistance attributed to both intrinsic factors like tumor heterogeneity and altered metabolomics, as well as extrinsic factors like hypoxia and an immune-suppressive tumor microenvironment. The escape mechanisms of tumor cells during therapy also contribute to treatment failure in GBM.

CELLS (2021)

Add to Collection

Article Medicine, Research & Experimental

N-cadherin upregulation mediates adaptive radioresistance in glioblastoma

Satoru Osuka et al.

Summary: Glioblastoma is composed of heterogeneous tumor cell populations, including glioma stem cells (GSCs) with stem cell properties. GSCs, which are less radiation sensitive, drive tumor formation and recurrence. Increase in N-cadherin expression enhances radioresistance and stemness in GSCs, while targeting N-cadherin can reverse the radiation resistance phenotype in these cells.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cadherin Expression and EMT: A Focus on Gliomas

Carolina Noronha et al.

Summary: Cadherins play a crucial role in cell adhesion and tissue homeostasis, with implications in cancer cell invasiveness and dissemination. Cadherin switch signifies the epithelial to mesenchymal transition, a key process in cancer progression.

BIOMEDICINES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

Wei Wu et al.

Summary: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with highly infiltrative nature and treatment resistance, highlighting the importance of innovative treatment strategies. The standard treatment for GBM is surgical resection followed by chemoradiotherapy, but the robust DNA repair and self-renewing capabilities of GBM cells lead to resistance against current therapies.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Oncology

DNA Damage Response in Glioblastoma Mechanism for Treatment Resistance and Emerging Therapeutic Strategies

Alipi Bonm et al.

Summary: This review discusses the role of DDR pathways in treatment resistance in GBM and summarizes the current preclinical and clinical evidence for DDR inhibitors in GBM.

CANCER JOURNAL (2021)

Add to Collection

Review Cell Biology

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

Joseph Sia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Nucleobindin 2 expression is an independent prognostic factor for bladder cancer

Jeong Man Cho et al.

MEDICINE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

NUCB2/nesfatin-1-Inhibitory effects on food intake, body weight and metabolism

Martha A. Schalla et al.

PEPTIDES (2020)

Add to Collection

Review Oncology

Radioresistance in Glioblastoma and the Development of Radiosensitizers

Md Yousuf Ali et al.

CANCERS (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

High expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion

Jingzhu Zhao et al.

ONCOTARGETS AND THERAPY (2019)

Add to Collection

Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016

Quinn T. Ostrom et al.

NEURO-ONCOLOGY (2019)

Add to Collection

Article Oncology

Prognostic significance of E-cadherin and N-cadherin expression in Gliomas

Myung-Giun Noh et al.

BMC CANCER (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Peripheral and central localization of the nesfatin-1 receptor using autoradiography in rats

Philip Prinz et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Add to Collection

Article Endocrinology & Metabolism

Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration

Kiyoshi Takagi et al.

ENDOCRINE JOURNAL (2016)

Add to Collection

Article Oncology

Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer

Jung-Yu Kan et al.

ONCOTARGET (2016)

Add to Collection

Article Endocrinology & Metabolism

Nesfatin-1 inhibits proliferation and enhances apoptosis of human adrenocortical H295R cells

Manjunath Ramanjaneya et al.

JOURNAL OF ENDOCRINOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Nesfatin-1 inhibits ovarian epithelial carcinoma cell proliferation in vitro

Yang Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Add to Collection

Article Endocrinology & Metabolism

Nesfatin-1 in Human and Murine Cardiomyocytes: Synthesis, Secretion, and Mobilization of GLUT-4

Sandra Feijoo-Bandin et al.

ENDOCRINOLOGY (2013)

Add to Collection

Article Neurosciences

Expression of β-catenin and E- and N-cadherin in human brainstem gliomas and clinicopathological correlations

Wenhao Wu et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2013)

Add to Collection

Article Oncology

Clinical significance of NUCB2 mRNA expression in prostate cancer

Hongtuan Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)

Add to Collection

Article Oncology

Adult glioblastoma multiforme survival in the temozolomide era: A population-based analysis of Surveillance, Epidemiology, and End Results registries

Amy S. Darefsky et al.

CANCER (2012)

Add to Collection

Article Oncology

Nucleobindin 2 in human breast carcinoma as a potent prognostic factor

Shiho Suzuki et al.

CANCER SCIENCE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

The anti-inflammatory and anti-apoptotic effects of nesfatin-1 in the traumatic rat brain

Chong-Hui Tang et al.

PEPTIDES (2012)

Add to Collection

Article Oncology

High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

R. Stupp et al.

ANNALS OF ONCOLOGY (2010)

Add to Collection

Article Neurosciences

Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice

Kaori Atsuchi et al.

NEUROREPORT (2010)

Add to Collection

Article Multidisciplinary Sciences

Identification of nesfatin-1 as a satiety molecule in the hypothalamus

Shinsuke Oh- et al.

NATURE (2006)

Add to Collection

Article Oncology

Genetic pathways to glioblastoma:: A population-based study

H Ohgaki et al.

CANCER RESEARCH (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.