Journal
CELLS
Volume 12, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/cells12141879
Keywords
enzymes; exosomes; extracellular vesicles; hepatocellular carcinoma; liver cancer; metastasis; circular RNAs
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Liver cancer is a global health challenge and the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC), the most common type of liver cancer, is associated with high morbidity and mortality rates. Recent studies have shown that extracellular vesicles (EVs) secreted by HCC cells play a critical role in HCC progression and metastasis by transferring oncogenic factors to surrounding cells. This review summarizes the roles of EVs and their cargos in HCC progression and metastasis, and identifies potential therapeutic targets for HCC treatment.
Liver cancer is a global health challenge as it is the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is often found in liver cells, where it is associated with high morbidity and mortality rates. Recent studies have shown that extracellular vesicles (EVs) secreted by HCC cells play a critical role in HCC progression and metastasis. EVs contain proteins, nucleic acids, lipids, and metabolites as cargos. EVs derived from HCC cells can transfer oncogenic factors to surrounding cells leading to increased tumor growth, cell invasion, and angiogenesis. In this review, we summarize the roles that EVs play and the specific effects of their cargos on HCC progression and metastasis and identify potential therapeutic targets for HCC treatment.
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