Journal
CELLS
Volume 12, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/cells12202446
Keywords
febrile seizure; autism spectrum disorder; CA2 region; inflammation; gliosis
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Research suggests a link between febrile seizures and the development of autism spectrum disorder (ASD), with the inflammatory response triggered by febrile seizures potentially contributing to social cognitive impairments.
Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on neuropsychiatric disorders and hippocampal inflammatory changes following febrile seizure occurrences is very limited. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that the inflammatory response triggered by febrile seizures in young children could potentially serve as a mediator of social cognitive impairments.
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