4.6 Article

Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Role of Orai3 in the Pathophysiology of Cancer

Jose Sanchez-Collado et al.

Summary: The Orai3 channel in mammals plays a crucial role in cancer pathogenesis by regulating Ca2+ currents and exhibiting different expression and functions in various cancer cells and tissues, affecting cell proliferation, migration, and apoptosis resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms

Mohamed Chamlali et al.

Summary: Orai3 regulates breast cancer cell migration through a Ca2+-dependent modulation of cell adhesive capacities and a Ca2+-independent regulation of the actin cytoskeleton via focal adhesion kinase (FAK).

CELLS (2021)

Article Biochemistry & Molecular Biology

ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma

Charlotte Dubois et al.

Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Oncology

DYRK1A is required for maintenance of cancer stemness, contributing to tumorigenic potential in oral/oropharyngeal squamous cell carcinoma

Charlotte Ellen Martin et al.

Summary: DYRK1A plays a crucial role in maintaining tumor growth and stemness in oral/oropharyngeal squamous cell carcinoma cells. Deletion of DYRK1A suppresses cancer stem-like cell properties, while ectopic expression enhances the CSC phenotype. Additionally, DYRK1A's regulation of CSCs in OSCC is mediated through the FGF2 pathway.

EXPERIMENTAL CELL RESEARCH (2021)

Review Cell Biology

Orai3: Oncochannel with therapeutic potential

Jyoti Tanwar et al.

CELL CALCIUM (2020)

Article Medicine, Research & Experimental

Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling

Anuj Kumar Singh et al.

LIFE SCIENCES (2020)

Review Medicine, General & Internal

Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy

Zhengxiao Zhao et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Review Cell Biology

Store-independent Orail-mediated Ca2+ entry and cancer

C. Cantonero et al.

CELL CALCIUM (2019)

Review Cell Biology

Cancer stem cells (CSCs) in cancer progression and therapy

Masoud Najafi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Pathology

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

Dany Nassar et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Article Gastroenterology & Hepatology

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway

Wei Deng et al.

DIGESTIVE DISEASES AND SCIENCES (2016)

Review Oncology

Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas

Shanaya Saurin Patel et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)

Article Biochemistry & Molecular Biology

Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma

Ji-Hee Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Oncology

In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma

Nobutaka Ota et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Oncology

ID1 Promotes Breast Cancer Metastasis by S100A9 Regulation

Kiranmai Gumireddy et al.

MOLECULAR CANCER RESEARCH (2014)

Review Oncology

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

Anna Lasorella et al.

NATURE REVIEWS CANCER (2014)

Article Oncology

Multiple drug resistant, tumorigenic stem-like cells in oral cancer

Vinitha Richard et al.

CANCER LETTERS (2013)

Article Biochemistry & Molecular Biology

Orai3 is an estrogen receptor alpha-regulated Ca2+ channel that promotes tumorigenesis

Rajender K. Motiani et al.

FASEB JOURNAL (2013)

Article Biochemistry & Molecular Biology

miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

Ki-Hyuk Shin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Pathology

Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis

Huiling Liu et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2011)

Article Immunology

ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival

Kyun-Do Kim et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Oncology

Calcium in tumour metastasis: new roles for known actors

Natalia Prevarskaya et al.

NATURE REVIEWS CANCER (2011)

Article Otorhinolaryngology

SINGLE-MARKER IDENTIFICATION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA CANCER STEM CELLS WITH ALDEHYDE DEHYDROGENASE

Matthew R. Clay et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2010)

Article Biochemistry & Molecular Biology

Anchorage-independent cell growth signature identifies tumors with metastatic potential

S. Mori et al.

ONCOGENE (2009)

Review Cell & Tissue Engineering

Control of Stemness by Fibroblast Growth Factor Signaling in Stem Cells and Cancer Stem Cells

Noriko Gotoh

CURRENT STEM CELL RESEARCH & THERAPY (2009)

Review Oncology

NFAT proteins: emerging roles in cancer progression

Maria Mancini et al.

NATURE REVIEWS CANCER (2009)

Review Dentistry, Oral Surgery & Medicine

Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement

S. Warnakulasuriya et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2008)

Review Oncology

Calcium and cancer:: targeting Ca2+ transport

Gregory R. Monteith et al.

NATURE REVIEWS CANCER (2007)

Article Biochemistry & Molecular Biology

Biochemical and functional characterization of Orai proteins

Yousang Gwack et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Dentistry, Oral Surgery & Medicine

Management of oral epithelial dysplasia:: a review

Michael Brennan et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2007)

Review Biochemistry & Molecular Biology

Fibroblast growth factor signaling in embryonic and cancer stem cells

Petr Dvorak et al.

FEBS LETTERS (2006)

Review Oncology

ID family of helix-loop-helix proteins in cancer

J Perk et al.

NATURE REVIEWS CANCER (2005)

Review Physiology

Store-operated calcium channels

AB Parekh et al.

PHYSIOLOGICAL REVIEWS (2005)

Review Cell Biology

Calcium signalling: Dynamics, homeostasis and remodelling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)