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Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives

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Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017

Gregory A. Roth et al.

LANCET (2018)

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Article Cardiac & Cardiovascular Systems

Potent P2Y12 Inhibitors in Men Versus Women A Collaborative Meta-Analysis of Randomized Trials

Emily S. Lau et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Multidisciplinary Sciences

Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts

Qin Shao et al.

PLOS ONE (2017)

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Article Cardiac & Cardiovascular Systems

Outcomes of Women and Men With Acute Coronary Syndrome Treated With and Without Percutaneous Coronary Revascularization

Jacob A. Udell et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Treatments, Relative Survival, and Excess Mortality Following Acute Myocardial Infarction: National Cohort Study Using the SWEDEHEART Registry

Oras A. Alabas et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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Review Endocrinology & Metabolism

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

Andrea Iorga et al.

BIOLOGY OF SEX DIFFERENCES (2017)

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Review Pharmacology & Pharmacy

Progress in Therapies for Myocardial Ischemia Reperfusion Injury

Hong-jie Chi et al.

CURRENT DRUG TARGETS (2017)

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Article Biochemistry & Molecular Biology

Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis

Hao Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

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Review Cardiac & Cardiovascular Systems

Gender differences in the effects of cardiovascular drugs

J. Tamargo et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2017)

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Article Cardiac & Cardiovascular Systems

Medical Therapy for Secondary Prevention and Long-Term Outcome in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease

Bertil Lindahl et al.

CIRCULATION (2017)

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Review Cardiac & Cardiovascular Systems

Roles of Testosterone Replacement in Cardiac Ischemia-Reperfusion Injury

Wanpitak Pongkan et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2016)

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Article Cardiac & Cardiovascular Systems

Impact of Bleeding and Bivalirudin Therapy on Mortality Risk in Women Undergoing Percutaneous Coronary Intervention (from the REPLACE-2, ACUITY, and HORIZONS-AMI Trials)

Vivian G. Ng et al.

AMERICAN JOURNAL OF CARDIOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Characterization of the sex-dependent myocardial S-nitrosothiol proteome

Qin Shao et al.

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Review Cardiac & Cardiovascular Systems

The Biological Basis for Cardiac Repair After Myocardial Infarction From Inflammation to Fibrosis

Sumanth D. Prabhu et al.

CIRCULATION RESEARCH (2016)

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Article Physiology

The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome

H. L. Brooks et al.

PHYSIOLOGY (2016)

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Review Cardiac & Cardiovascular Systems

Estrogenic Impact on Cardiac Ischemic/Reperfusion Injury

Sivaporn Sivasinprasasn et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2016)

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Article Medicine, General & Internal

Lifelong Gender Gap in Risk of Incident Myocardial Infarction The Tromso Study

Grethe Albrektsen et al.

JAMA INTERNAL MEDICINE (2016)

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Article Multidisciplinary Sciences

Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106

Tao Luo et al.

PLOS ONE (2016)

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Article Physiology

Changes in Activities of Circulating MMP-2 and MMP-9 in Patients Suffering From Heart Failure in Relation to Gender, Hypertension and Treatment: a Cross-Sectional Study

E. Giannakos et al.

PHYSIOLOGICAL RESEARCH (2016)

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Article Cardiac & Cardiovascular Systems

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1 937 360 People

Julie George et al.

CIRCULATION (2015)

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Article Cardiac & Cardiovascular Systems

Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011 Evidence for Stagnation in Young Adults, Especially Women

Kobina A. Wilmot et al.

CIRCULATION (2015)

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Article Biochemistry & Molecular Biology

β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells

Amanda E. Starr et al.

FEBS JOURNAL (2015)

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Article Cardiac & Cardiovascular Systems

Matrix metalloproteinases and their tissue inhibitor after reperfused ST-elevation myocardial infarction treated with doxycycline. Insights from the TIPTOP trial

Giampaolo Cerisano et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration

Tuncay Yetgin et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2015)

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Cardiovascular Disease Associated With Androgen-Deprivation Therapy: Time to Give It Due Respect

Shehzad Basaria

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Article Cardiac & Cardiovascular Systems

Temporal Trends and Sex Differences in Revascularization and Outcomes of ST-Segment Elevation Myocardial Infarction in Younger Adults in the United States

Sahil Khera et al.

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Article Cardiac & Cardiovascular Systems

Sex-Based Differences in Bleeding and Long Term Adverse Events After Percutaneous Coronary Intervention for Acute Myocardial Infarction: Three Year Results From the HORIZONS-AMI Trial

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CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2015)

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Article Multidisciplinary Sciences

Chronic Testosterone Replacement Exerts Cardioprotection against Cardiac Ischemia-Reperfusion Injury by Attenuating Mitochondrial Dysfunction in Testosterone-Deprived Rats

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PLOS ONE (2015)

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Article Hematology

G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism Cellular and Population Genetic Studies

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Age and sex differences in inhospital complication rates and mortality after percutaneous coronary intervention procedures: Evidence from the NCDR®

Judith H. Lichtman et al.

AMERICAN HEART JOURNAL (2014)

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Sex differences of leukocyte-platelet interactions and on-treatment platelet reactivity in patients with atherosclerosis

Thomas Gremmel et al.

ATHEROSCLEROSIS (2014)

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Targeting MMP-2 to treat ischemic heart injury

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BASIC RESEARCH IN CARDIOLOGY (2014)

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The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two

Jingyuan Li et al.

CARDIOVASCULAR RESEARCH (2014)

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Article Cardiac & Cardiovascular Systems

Gender Differences in Coronary Artery Diameter Are Not Related to Body Habitus or Left Ventricular Mass

Amit K. Hiteshi et al.

CLINICAL CARDIOLOGY (2014)

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Article Endocrinology & Metabolism

Role of Androgens in Sex Differences in Cardiac Damage During Myocardial Infarction

Thi Y. L. Le et al.

ENDOCRINOLOGY (2014)

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Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study

Maarten J. G. Leening et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

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Sex Differences in Short-term and Long-term All-Cause Mortality Among Patients With ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Intervention A Meta-analysis

Samir Bipin Pancholy et al.

JAMA INTERNAL MEDICINE (2014)

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Article Medicine, General & Internal

Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels

Rebecca Vigen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Myocardial ischemia-reperfusion injury: a neglected therapeutic target

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Patterns of Use and Comparative Effectiveness of Bleeding Avoidance Strategies in Men and Women Following Percutaneous Coronary Interventions An Observational Study From the National Cardiovascular Data Registry

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The P-Glycoprotein Transport System and Cardiovascular Drugs

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

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Article Medicine, Research & Experimental

Apoptosis and autophagy contribute to gender difference in cardiac ischemia-reperfusion induced injury in rats

Chen Chen et al.

LIFE SCIENCES (2013)

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B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

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NATURE MEDICINE (2013)

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Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies

Pauline M. Maki

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2013)

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Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction

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NEW ENGLAND JOURNAL OF MEDICINE (2013)

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P-glycoprotein Inhibition for Optimal Drug Delivery

Md. Lutful Amin

DRUG TARGET INSIGHTS (2013)

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Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

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Article Cardiac & Cardiovascular Systems

Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice

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BASIC RESEARCH IN CARDIOLOGY (2012)

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The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL

Carsten Mueller et al.

BLOOD (2012)

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Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response

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HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)

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Transcriptome Characterization of Estrogen-Treated Human Myocardium Identifies Myosin Regulatory Light Chain Interacting Protein as a Sex-Specific Element Influencing Contractile Function

Georgios Kararigas et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

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Females Live Longer than Males: Role of Oxidative Stress

Jose Vina et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

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INHIBITION OF MITOCHONDRIAL Na+-DEPENDENT Ca2+ EFFLUX BY 17β-ESTRADIOL IN THE RAT HIPPOCAMPUS

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Article Cardiac & Cardiovascular Systems

Sex-related resistance to myocardial ischemia-reperfusion injury is associated with high constitutive ARC expression

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury

Jean Chrisostome Bopassa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Article Physiology

Estrogen improves TIMP-MMP balance and collagen distribution in volume-overloaded hearts of ovariectomized females

Tetyana G. Voloshenyuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)

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17β-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts

Shokoufeh Mahmoodzadeh et al.

CARDIOVASCULAR RESEARCH (2010)

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Article Cardiac & Cardiovascular Systems

Sex Differences in the Phosphorylation of Mitochondrial Proteins Result in Reduced Production of Reactive Oxygen Species and Cardioprotection in Females

Claudia J. Lagranha et al.

CIRCULATION RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence

Danielle Duma et al.

SCIENCE SIGNALING (2010)

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Article Surgery

Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury

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SURGERY (2010)

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Comparison of Primary Percutaneous Coronary Intervention and Fibrinolytic Therapy in ST-Segment-Elevation Myocardial Infarction Bayesian Hierarchical Meta-Analyses of Randomized Controlled Trials and Observational Studies

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CIRCULATION (2009)

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Review Biochemistry & Molecular Biology

Gender Differences in P-Glycoprotein Expression and Function: Effects on Drug Disposition and Outcome

M. Bebawy et al.

CURRENT DRUG METABOLISM (2009)

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Gender Differences in Cardiac Ischemic Injury and Protection-Experimental Aspects

Bohuslav Ostadal et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

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Sex Differences in Medical Care and Early Death After Acute Myocardial Infarction

Hani Jneid et al.

CIRCULATION (2008)

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Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone

Dianxin Liu et al.

ENDOCRINOLOGY (2008)

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Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs

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JOURNAL OF CLINICAL PHARMACOLOGY (2008)

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Article Peripheral Vascular Disease

Both estrogen receptor subtypes, α and β, attenuate cardiovascular remodeling in aldosterone salt-treated rats

Paula-Anahi Arias-Loza et al.

HYPERTENSION (2007)

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Explaining the decrease in US deaths from coronary disease, 1980-2000

Earl S. Ford et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage

Bartomeu Colom et al.

CARDIOVASCULAR RESEARCH (2007)

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Article Cardiac & Cardiovascular Systems

Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors - Results from the CRUSADE (can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) initiative

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CIRCULATION (2006)

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Article Cardiac & Cardiovascular Systems

17β-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts

James A. Stewart et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat

Micah S. Johnson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function

MA Cavasin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor necrosis factor-α

Y Xu et al.

CARDIOVASCULAR RESEARCH (2006)

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Article Cardiac & Cardiovascular Systems

17-β-estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia

MJ Wang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)

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Letter Cardiac & Cardiovascular Systems

Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults

BL Stauffer et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

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Article Cardiac & Cardiovascular Systems

Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion

MJ Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

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Article Clinical Neurology

Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke - A pooled analysis of randomized clinical trials

DM Kent et al.

STROKE (2005)

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Platelets of female mice are intrinsically more sensitive to agonists than are platelets of males

XH Leng et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

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Article Medicine, Research & Experimental

Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice

MA Cavasin et al.

LIFE SCIENCES (2004)

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Article Oncology

Human CYP1B1 is regulated by estradiol via estrogen receptor

Y Tsuchiya et al.

CANCER RESEARCH (2004)

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Myocardial antioxidant and oxidative stress changes due to sex hormones

J Barp et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2002)

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Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

JM Maglich et al.

MOLECULAR PHARMACOLOGY (2002)

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Greater oxidative stress in healthy young men compared with premenopausal women

T Ide et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

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Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A2A receptor agonists

GW Sullivan et al.

BRITISH JOURNAL OF PHARMACOLOGY (2001)

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Article Cardiac & Cardiovascular Systems

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

PY Zhai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)

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