☆ 4.6 Article

Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis

CELLS (2023)

Related references

Note: Only part of the references are listed.

Article Oncology

Cancer-associated fibroblast-dependent and -independent invasion of gastric cancer cells

Ryotaro Kondo et al.

Summary: This study investigated the invasive modes of gastric cancer cells in the presence of cancer-associated fibroblasts (CAFs), and found that gastric cancer cells exhibit both CAF-dependent and -independent modes of invasion, which are determined by intrinsic factors of the cancer cells. By modifying the invasive capacity of CAFs, the invasive mode of gastric cancer cells can be altered.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

Add to Collection

Review Medicine, General & Internal

Systemic sclerosis

Elizabeth R. Volkmann et al.

Summary: Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment options. Early and accurate diagnosis, as well as ongoing risk stratification, play a crucial role in predicting organ involvement and disease progression. Treatment should be tailored to individual patients, considering their goals of care, and balancing side effects with efficacy.

LANCET (2023)

Add to Collection

Review Rheumatology

Improving outcomes in scleroderma: recent progress of cell-based therapies

Dinesh Khanna et al.

Summary: This narrative review examines the evolving cell therapies for the treatment of diffuse cutaneous scleroderma (dcSSc) and other autoimmune diseases, including mesenchymal stem cells, chimeric antigen receptor-based therapy, tolerogenic dendritic cells, and facilitating cells.

RHEUMATOLOGY (2023)

Add to Collection

Review Physiology

Origins of pathological myofibroblasts in lung fibrosis: insights from lineage tracing mouse models in the single-cell RNA sequencing era

Meline Homps-Legend et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a rare interstitial lung disease with a poor prognosis. The origin of fibrosis-associated myofibroblasts in pulmonary fibrosis is not fully understood to date.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2023)

Add to Collection

Review Medicine, General & Internal

Endothelial-to-mesenchymal transition in tumour progression and its potential roles in tumour therapy

Zeli Yin et al.

Summary: Tumour-associated endothelial cells (TECs) are a critical stromal cell type that play important roles in tumour angiogenesis. TECs have the ability to undergo endothelial-to-mesenchymal transition (EndoMT), which influences various malignant properties of tumours, making it a valuable target for tumour treatment. This review comprehensively explores the phenomenon of EndoMT in the tumour microenvironment, identifies the factors and mechanisms responsible for EndoMT induction, and discusses potential therapeutic strategies for targeting EndoMT in tumour treatment.

ANNALS OF MEDICINE (2023)

Add to Collection

Article Physiology

Podoplanin promotes the carcinogenicity of gastric cancer by activating ezrin and mediating the crosstalk between tumour cells and cancer-associated fibroblasts

Yueli Tian et al.

Summary: The role and biological mechanism of PDPN in the progression of gastric cancer were revealed in this study. PDPN acted as a promoter in the progression of gastric cancer through the activation of Ezrin expression and CAFs, providing a new route for gene-targeted therapy. These findings have important implications for the treatment of gastric cancer.

EXPERIMENTAL PHYSIOLOGY (2023)

Add to Collection

Review Physiology

Differential regulation of lymphatic junctional morphology and the potential effects on cardiovascular diseases

Amanda M. Peluzzo et al.

Summary: The lymphatic vasculature is responsible for draining fluid, macromolecules, and immune cells from the interstitium as lymph and returning it to the bloodstream. This process is facilitated by a complex network of lymphatic vessels with differential regulation of cell-cell junctions. Different sections of the lymphatic bed have varying levels of permeability, controlled in part by their junctional morphology. Understanding the regulation of lymphatic junctional morphology is important for studying lymphatic permeability during development and disease, as well as its potential impact on cardiovascular diseases such as atherosclerosis.

FRONTIERS IN PHYSIOLOGY (2023)

Add to Collection

Review Physiology

From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network

Tomohiro Shiiya et al.

Summary: During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. This review discusses the chemotactic factors, LEC-extracellular matrix interactions, and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels, providing insights into the molecular mechanisms underlying physiological lymphatic vascular development and lymphangiogenesis associated with pathological conditions.

FRONTIERS IN PHYSIOLOGY (2023)

Add to Collection

Article Dermatology

Hypoxia-Inducible Factor-1a (HIF-1a) as a Biomarker for Changes in Microcirculation in Individuals with Systemic Sclerosis

Magdalena Maciejewska et al.

Summary: This study investigated the potential abnormalities of HIF-1a plasma concentration and its possible association with disease activity and vascular abnormalities in patients with systemic sclerosis. The results showed a marked increase in HIF-1a levels in patients with systemic sclerosis, especially in those with active disease and no history of digital ulcers. These findings suggest that HIF-1a may serve as a biomarker for assessing microcirculatory changes in individuals with systemic sclerosis.

DERMATOLOGY AND THERAPY (2023)

Add to Collection

Article Cell Biology

Single-Cell Analysis of ADSC Interactions with Fibroblasts and Endothelial Cells in Scleroderma Skin

Marvin L. Frommer et al.

Summary: Adipose-derived stem cells (ADSCs) have anti-fibrotic and anti-inflammatory effects, but the mechanisms of action are not well understood. In this study, interactions between ADSCs, fibroblasts, and endothelial cells (EC) from scleroderma (SSc) skin were simulated in silico to investigate these mechanisms. Single-cell RNA sequencing data from patients with SSc and controls were analyzed, and differentially expressed genes and functional enrichment were identified. The study revealed pro-inflammatory and pro-fibrotic transcriptomes of fibroblasts and ECs in SSc, and highlighted the role of ECM proteins in interactions between ADSCs and these cell types. The findings suggest that the secretome of ADSCs may disrupt inflammatory and fibrotic processes in SSc by promoting angiogenesis and lymphangiogenesis.

CELLS (2023)

Add to Collection

Review Medicine, Research & Experimental

The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting

Eloisa Romano et al.

Summary: Systemic sclerosis is a complex connective tissue disorder characterized by multisystem clinical manifestations. Myofibroblasts play a crucial role in the fibrosis of systemic sclerosis, and inhibiting their differentiation and accumulation may be an effective therapeutic strategy.

CURRENT MOLECULAR MEDICINE (2022)

Add to Collection

Article Medicine, General & Internal

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Jia-Mei Chen et al.

Summary: Metastasis via lymphatic or blood vessels is the leading cause of death for breast cancer. However, the research progress for tumor lymphangiogenesis has lagged behind that for angiogenesis due to the lack of specific markers. With the discovery of lymphatic endothelial cell (LEC) markers, it has been shown that LEC plays an active role in various processes related to lymphatic formation, tumor growth, invasion, and antitumor immunity.

DIAGNOSTICS (2022)

Add to Collection

Review Physiology

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Fumiko Itoh et al.

Summary: Transforming growth factor (TGF)-beta and its family members play a crucial role in the development and maintenance of the lymphatic vascular system, which is involved in various physiological and pathological processes such as immune cell trafficking and tumor metastasis.

FRONTIERS IN PHYSIOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

miR-31-5p-Modified RAW 264.7 Macrophages Affect Profibrotic Phenotype of Lymphatic Endothelial Cells In Vitro

Aneta Moskalik et al.

Summary: Cardiac lymphatic vessel remodeling in metabolic syndrome contributes to heart failure. Macrophages modified by miR-31-5p can inhibit LEC-dependent fibrosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Immunology

Emerging roles of inflammation-mediated endothelial-mesenchymal transition in health and disease

Yasuhiro Yoshimatsu et al.

Summary: Inflammatory factors play crucial roles in the induction of EndoMT and related diseases, and additional activation by other inflammatory factors is often required to stabilize the progression of EndoMT, in addition to TGF-beta.

INFLAMMATION AND REGENERATION (2022)

Add to Collection

Review Biology

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy

Eloisa Romano et al.

Summary: In systemic sclerosis (SSc), abnormalities in microvessel morphology evolve into a distinctive vasculopathy that progresses alongside tissue fibrosis orchestrated by myofibroblasts. The endothelial-to-mesenchymal transition (EndoMT) process may play a central role in the pathogenesis of SSc, contributing to both fibrotic vascular lesions and tissue fibrosis. A deeper understanding of the mechanisms underlying myofibroblast differentiation inside vessel walls provides the basis for targeted therapeutic strategies for SSc.

LIFE-BASEL (2021)

Add to Collection

Review Physiology

Role of Podoplanin-Positive Cells in Cardiac Fibrosis and Angiogenesis After Ischemia

Maria Cimini et al.

Summary: New insights into the cellular and extra-cellular composition of scar tissue after myocardial infarction have identified a heterogeneous podoplanin-expressing cell population associated with fibrogenic and inflammatory responses during scar formation. Podoplanin, mainly expressed by cardiac lymphatic endothelial cells in adult mouse hearts, is unexpectedly acquired by different types of cells after MI, suggesting an activation of progenitor cells during post-ischemic myocardial wound repair. Inhibition of the interaction between podoplanin-expressing cells and podoplanin-binding cells using podoplanin-neutralizing antibodies showed reduced inflammation post-MI and improved heart function and scar composition.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Cell Biology

Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement

Juergen Becker et al.

Summary: Lymphedema is a chronic disease affecting millions globally, with no pharmacological treatment available. The disease is characterized by swelling, fibrosis, and collagen accumulation in affected tissues. This study found that hypoxia may contribute to fibrosis in lymphatic endothelial cells (LECs), with hypoxic LECs showing a high ability to alter the extracellular matrix.

CELLS (2021)

Add to Collection

Article Oncology

The expression profiling of microRNA in systemic sclerosis-associated pulmonary arterial hypertension

Yu-Xia Huang et al.

Summary: The study identified a number of upregulated and downregulated miRNAs in the lung tissue of SSc-PAH patients, which were found to be closely associated with biological processes such as nervous system development and cellular metabolism. High-throughput sequencing and qRT-PCR confirmed the differential expression of hsa-miR-205-5p and hsa-miR-539-3p in SSc-PAH tissue. Target genes IRF1 and ADCYAP1 were validated as potential therapeutic targets in SSc-PAH patients.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Cell Biology

Endothelium-mediated contributions to fibrosis

Xuetao Sun et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals

Yasuhiro Yoshimatsu et al.

PLOS ONE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Cell Fate Determination of Lymphatic Endothelial Cells

Young Jae Lee

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Medicine, General & Internal

The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies

Yoshihide Asano

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Review Rheumatology

The contribution of mesenchymal transitions to the pathogenesis of systemic sclerosis

Irene Rosa et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2020)

Add to Collection

Article Cell Biology

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Rachel Evans et al.

CELL REPORTS (2019)

Add to Collection

Letter Rheumatology

Decreased circulating lymphatic endothelial progenitor cells in digital ulcer-complicated systemic sclerosis

Mirko Manetti et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Systemic Sclerosis Serum Significantly Impairs the Multi-Step Lymphangiogenic Process: In Vitro Evidence

Mirko Manetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Roles of the TGF-β-VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis

Hiroshi Kinashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Review Immunology

Vascular Leaking, a Pivotal and Early Pathogenetic Event in Systemic Sclerosis: Should the Door Be Closed?

Cosimo Bruni et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Review Immunology

Unraveling SSc Pathophysiology; The Myofibroblast

Arjan van Caam et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancerassociated fibroblasts in breast cancer progression

Jaroslaw Suchanski et al.

PLOS ONE (2017)

Add to Collection

Article Multidisciplinary Sciences

Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients

Bin Zhou et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Review Rheumatology

Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities

John Varga et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2017)

Add to Collection

Review Oncology

The optimum marker for the detection of lymphatic vessels

Ling-Ling Kong et al.

MOLECULAR AND CLINICAL ONCOLOGY (2017)

Add to Collection

Article Rheumatology

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis

Mirko Manetti et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Add to Collection

Article Rheumatology

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease

Fabian A. Mendoza et al.

ARTHRITIS & RHEUMATOLOGY (2016)

Add to Collection

Article Pathology

Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90

Banafsheh Nazari et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

Sergio A. Jimenez et al.

MATRIX BIOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)

Sandra D. Scherer et al.

PLOS ONE (2016)

Add to Collection

Article Pathology

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

Robert B. Good et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

Add to Collection

Article Cell Biology

MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation

Sanjukta Chakraborty et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

Add to Collection

Article Peripheral Vascular Disease

Decline of lymphatic vessel density and function in murine skin during aging

Sinem Karaman et al.

ANGIOGENESIS (2015)

Add to Collection

Article Rheumatology

2013 Classification Criteria for Systemic Sclerosis An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

Frank van den Hoogen et al.

ARTHRITIS AND RHEUMATISM (2013)

Add to Collection

Review Pathology

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

Sonsoles Piera-Velazquez et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Add to Collection

Article Microbiology

KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

Fang Cheng et al.

CELL HOST & MICROBE (2011)

Add to Collection

Article Rheumatology

Progressive Loss of Lymphatic Vessels in Skin of Patients with Systemic Sclerosis

Mirko Manetti et al.

JOURNAL OF RHEUMATOLOGY (2011)

Add to Collection

Article Cell Biology

Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-β1-mediated tissue fibrosis

Tomer Avraham et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Add to Collection

Article Rheumatology

Decreased Lymphatic Vessel Counts in Patients With Systemic Sclerosis Association With Fingertip Ulcers

Alfiya Akhmetshina et al.

ARTHRITIS AND RHEUMATISM (2010)

Add to Collection

Article Pathology

Lymphatic and blood vessels in scleroderma skin, a morphometric analysis

Antonella Rossi et al.

HUMAN PATHOLOGY (2010)

Add to Collection

Letter Dermatology

Reduction of lymphatic vessels in photodamaged human skin

Kentaro Kajiya et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.