Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview

Sepsis is a major global health problem that results from a dysregulated and uncontrolled host response to infection, causing organ failure. Despite effective anti-infective therapy and supportive treatments, the mortality rate of sepsis remains high. Approximately 30-80% of patients with sepsis may develop disseminated intravascular coagulation (DIC), which can double the mortality rate. There is currently no definitive treatment approach for sepsis, with etiologic treatment being the cornerstone of therapy for sepsis-associated DIC. Early detection, diagnosis, and treatment are critical factors that impact the prognosis of sepsis-related DIC. Over the past several decades, researchers have made continuous efforts to better understand the mechanisms of DIC in sepsis, as well as improve its quantitative diagnosis and treatment. This article aims to provide a comprehensive overview of the current understanding of sepsis-related DIC, focusing on common causes and diagnoses, with the goal of guiding healthcare providers in the care of patients with sepsis.

Automated summary

Sepsis is a global health problem caused by an uncontrolled host response to infection, leading to organ failure. Disseminated intravascular coagulation (DIC) is a complication of sepsis that significantly increases mortality. Currently, there is no definitive treatment for sepsis, but early detection and treatment of sepsis-related DIC are important for improving prognosis. This article provides a comprehensive overview of sepsis-related DIC, including its causes and diagnoses, to guide healthcare providers in the care of septic patients.