Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.

Automated summary

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by progressive motor neuron death. Extracellular vesicles (EVs) have been found to play a crucial role in the development of ALS and can be a potential therapeutic strategy. EVs can transport abnormal bioactive cargo and serve as biomarkers for ALS, as well as be used for therapeutic applications such as stem cell-derived exosomes.