Mitochondrial Properties in Skeletal Muscle Fiber

Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties.

Automated summary

Mitochondria are crucial for energy production and play a vital role in various biological processes in eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplementation and also relies on them for maintaining calcium and reactive oxygen species levels. This review summarizes recent studies on mitochondria function and quality control in skeletal muscle, focusing on in vivo studies of rodents and human subjects. The interplay between mitochondrial functions and muscle fiber type-specific phenotypes, as well as the impact of aging and exercise on skeletal muscle and mitochondria properties, is also discussed.