☆ 4.6 Review

Recent Insights into the Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis

CANCERS (2023)

Related references

Note: Only part of the references are listed.

Review Biochemistry & Molecular Biology

p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities

Chong Teik Tan et al.

Summary: Sequestosome-1 (SQSTM1), also known as p62, is an autophagy receptor that plays a crucial role in the pathogenesis of liver diseases such as NASH and HCC. Abundance of p62 inclusion bodies has been recognized as a biomarker for these diseases. However, the underlying mechanisms by which p62 regulates and contributes to the development and progression of these diseases remain incompletely understood. This review critically summarizes the findings from preclinical models and explores the potential of p62 as a predictive biomarker and therapeutic target for liver diseases.

FEBS JOURNAL (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis

Eman A. Ahmed et al.

Summary: This study compared the metabolic signatures between NASH and NASH-HCC patients, finding significantly higher levels of triacylglycerol, AFP, AST, and cancer antigen 19-9 in NASH-HCC patients than in NASH patients. Pathway analysis revealed the involvement of several metabolic pathways in HCC development from NASH. Metabolite-protein interaction network analysis identified key protein encoding genes that play important roles in cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Review Gastroenterology & Hepatology

Hepatocellular carcinoma and hepatitis C virus treatments: The bold and the beautiful

Walaa Abdelhamed et al.

Summary: Hepatocellular carcinoma (HCC) is a serious complication of hepatitis C virus (HCV) infection. Effective antiviral medications have made sustained viral response (SVR) or cure a realistic therapeutic goal for most chronic HCV patients. Direct-acting antivirals (DAAs) have changed the treatment landscape, reaching high rates of SVR with few side effects. The likelihood of HCC recurrence after HCV eradication appears to decrease over time following SVR. However, there is a need for markers/scores to predict the long-term risk of HCC in patients with HCV-related liver disease who attain SVR with DAAs.

JOURNAL OF VIRAL HEPATITIS (2023)

Add to Collection

Article Plant Sciences

Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2

Bingyu Shen et al.

Summary: This study provides insights into the mechanism of PTE affecting oxidative stress and autophagy in NAFLD mice.

PHYTOMEDICINE (2023)

Add to Collection

Article Plant Sciences

Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation

Tingting Yang et al.

Summary: This study investigates the effects and mechanism of quercetin on type 2 diabetes-associated non-alcoholic fatty liver disease (NAFLD). The results show that quercetin can bind to mTOR and competitively occupy its binding pocket. Quercetin alleviates hepatic lipid accumulation by downregulating the mTOR/YY1 signaling pathway and restoring cholesterol homeostasis.

PHYTOMEDICINE (2023)

Add to Collection

Article Chemistry, Medicinal

Thymoquinone attenuates hepatic lipid accumulation by inducing autophagy via AMPK/mTOR/ULK1-dependent pathway in nonalcoholic fatty liver disease

Di Zhang et al.

Summary: This study demonstrates the beneficial effects of thymoquinone (TQ) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) and human hepatocellular carcinoma cells. TQ promotes hepatic autophagy through the AMPK/mTOR/ULK1 signaling pathway, reducing lipid accumulation.

PHYTOTHERAPY RESEARCH (2023)

Add to Collection

Article Multidisciplinary Sciences

Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling

Ken Yoshida et al.

Summary: Our study aimed to identify the functional locus involved in NAFLD by investigating the interaction among DNA fragments in association signals with adjacent gene promoters. Knockdown of Gpr180 in mice showed improvement in hepatic lipid storage, and Gpr180 knockout mice exhibited ameliorated hepatic and plasma lipid levels without affecting glucose metabolism. Transcriptome analyses confirmed downregulation of mTORC1 signaling and cholesterol homeostasis. AAV8-mediated hepatic rescue of GPR180 expression in knockout mice restored plasma and hepatic lipid levels.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

Pengfei Liu et al.

Summary: The mechanisms of high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) involve autophagy inhibition, NRF2 suppression, and promotion of ferroptosis. Activation of NRF2 can counteract the NRF2 suppression and ferroptotic cell death caused by HFD. The regulation of NRF2 by saturated fatty acids (SFAs) versus monounsaturated fatty acids (MUFAs) may explain their different effects.

REDOX BIOLOGY (2023)

Add to Collection

Review Oncology

Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug

Hu Li et al.

Summary: Due to its strong biological activity, Tanshinone IIA (TsIIA) extracted from Salvia miltiorrhiza is widely used in Asia to treat cardiovascular and liver diseases. This review explores TsIIA's anti-HCC effects, its liver-protective effect, and its impact on liver fibrosis, NAFLD, and other risk factors for liver cancer. Network pharmacological analysis is also conducted to screen and explore possible targets of TsIIA against hepatocellular carcinoma, providing a theoretical basis for the development of anti-HCC drugs based on TsIIA.

FRONTIERS IN ONCOLOGY (2023)

Add to Collection

Review Gastroenterology & Hepatology

Preventive strategy for nonalcoholic fatty liver disease-related hepatocellular carcinoma

Yuri Cho et al.

Summary: The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) is increasing globally, including Asia. Compared to virus-related HCC, most patients with NAFLD-related HCC are diagnosed at a late stage and older age due to lack of HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLD-related HCC, and surveillance strategies for patients with NAFLD.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

Add to Collection

Article Oncology

Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway

Ganggang Wang et al.

Summary: Recent studies have shown an increase in the incidence of NAFLD-HCC. This study investigates the relationship between S1PR2 expression and prognosis in NAFLD-HCC patients through bioinformatics techniques. The study also explores the impact of S1PR2 on HCC cell behaviors and the potential mechanism by conducting cell assays and in vivo experiments. Additionally, the study reveals the activation of the PI3K/AKT/mTOR pathway by GCDA in CBAs, which may affect the activity of hepatocellular carcinoma cells.

DISCOVER ONCOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Magnesium Supplementation Stimulates Autophagy to Reduce Lipid Accumulation in Hepatocytes via the AMPK/mTOR Pathway

Shiyan Chen et al.

Summary: MAFLD is a globally prevalent disease with limited therapeutic interventions. This study found that magnesium supplementation can reduce lipid deposition in hepatocytes by activating the AMPK-mTOR pathway, thereby alleviating the occurrence and development of MAFLD.

BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

Add to Collection

Article Endocrinology & Metabolism

with type 2 diabetes mellitus

Szu-Yuan Wu et al.

Summary: This study investigated the association between H1-antihistamine use and hepatocellular carcinoma (HCC) risk in type 2 diabetes mellitus (T2DM) patients without hepatitis B or C virus infection. The results showed that the use of antihistamines significantly reduced the risk of HCC in these patients, and a dose-response relationship was observed.

DIABETES & METABOLISM (2023)

Add to Collection

Article Immunology

Leucine aminopeptidase 3:a promising serum biomarker candidate for nonalcoholic steatohepatitis diagnosis

Lina Feng et al.

Summary: In this study, LAP3 was found to be significantly upregulated in the serum and hepatocytes of patients with NASH, and it was strongly correlated with clinical indicators of NASH. Therefore, LAP3 could be a promising serum biomarker candidate for NASH diagnosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Article Oncology

Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling

Fanghui Chen et al.

Summary: Ufl1 and Ufbp1 play a role in preventing liver fibrosis, steatohepatitis and hepatocellular carcinoma (HCC) development by inhibiting the mTOR pathway.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

Add to Collection

Article Biochemistry & Molecular Biology

The Anti-Obesity and Anti-Steatotic Effects of Chrysin in a Rat Model of Obesity Mediated through Modulating the Hepatic AMPK/mTOR/lipogenesis Pathways

Ghaleb Oriquat et al.

Summary: This study investigated the therapeutic effects of the flavonoid chrysin on obesity and NAFLD in rats, and the role of AMPK/mTOR pathways in mediating these effects. Results showed that chrysin treatment significantly improved histological changes and dose-dependently reduced weight gain, hyperglycemia, and insulin resistance in obese rats. Chrysin activated the AMPK pathway, suppressed the mTOR and lipogenic pathways, and stimulated mitochondrial biogenesis gene expression in the liver tissues. This suggests that chrysin could be a promising candidate for the treatment of obesity and associated NAFLD.

MOLECULES (2023)

Add to Collection

Review Plant Sciences

Therapeutic application of natural products: NAD+ metabolism as potential target

Chen Guo et al.

Summary: This research provides a summary of the latest findings on the prevention and treatment of various diseases through the regulation of NAD(+) metabolism by natural products. The natural products mainly include phenols, flavonoids, glycosides, quinones, terpenoids, pyrazines, alkaloids, and phenylpropanoids, which have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic, and anti-aging effects.

PHYTOMEDICINE (2023)

Add to Collection

Article Anatomy & Morphology

AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice

U. Ajay Krishnan et al.

Summary: The activation of AMPK by AICAR has been found to alleviate symptoms of NAFLD. In a mouse model, AICAR reduced lipid levels in the liver, improved oxidative stress, and upregulated FOXO3 and p-AMPK expression while downregulating p-mTOR expression. These findings reveal the crosstalk between AMPK, mTOR, and FOXO3, providing new insights into the treatment of NAFLD.

TISSUE & CELL (2023)

Add to Collection

Review Gastroenterology & Hepatology

Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis

Min Yao et al.

Summary: Nonalcoholic fatty liver disease (NAFLD), characterized by lipid accumulation and hepatocyte injury, has become one of the most common chronic liver diseases worldwide. The dysfunction of carnitine palmitoyltransferase-II (CPT-II) on the inner mitochondrial membrane has been identified as a possible novel pathogenesis for NAFLD in hepatocarcinogenesis. Abnormalities in CPT-II, including gene mutations, deficiency, enzymatic thermal instability, and circulating carnitine level, affect its catalytic activity and contribute to the formation of NAFLD.

WORLD JOURNAL OF GASTROENTEROLOGY (2023)

Add to Collection

Article Nutrition & Dietetics

Identification and Evaluation of Hub Long Noncoding RNAs and mRNAs in High Fat Diet Induced Liver Steatosis

Jing Sui et al.

Summary: The study aimed to explore the key long noncoding RNAs (lncRNAs) and mRNAs and pathological processes in high-fat diet (HFD)-induced and lycopene-intervened liver steatosis. Differential expression analysis and coexpression network analysis were performed using the GSE146627 dataset from the GEO database. Functional enrichment analysis revealed the involvement of hub lncRNAs in the regulation of inflammatory and metabolic pathways in nonalcoholic fatty liver disease (NAFLD). The establishment of an NAFLD mouse model confirmed the attenuating effect of lycopene on hepatic steatosis. Hub lncRNAs provide potential biomarkers and therapeutic targets for NAFLD, and lycopene has the potential to prevent HFD-induced liver steatosis.

NUTRIENTS (2023)

Add to Collection

Article Endocrinology & Metabolism

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

Daniel Ferguson et al.

Molecular Metabolism (2023)

Add to Collection

Review Oncology

Non-Parenchymal Cells and the Extracellular Matrix in Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

Koen C. van Son et al.

Summary: The incidence of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD) has increased. NAFLD-related HCC is often detected late and is more advanced at diagnosis, leading to limited treatment options. In addition to hepatocytes, immune cells and cells involved in connective tissue formation also play important roles in the development of NAFLD-related HCC.

CANCERS (2023)

Add to Collection

Review Cell Biology

Emerging role of aging in the progression of NAFLD to HCC

Yongyuan He et al.

Summary: With the global aging population, nonalcoholic fatty liver disease (NAFLD) has dramatically increased in recent decades. It is a progressive disease that ranges from simple fatty liver to liver cirrhosis and hepatocellular carcinoma (HCC). Aging plays a crucial role in the development and progression of NAFLD, HCC, and other age-related liver diseases. The involvement of senescent cells and aging-related factors, such as NAD+, sirtuins, and mTOR, in the development of NAFLD has been explored, although their significance remains underestimated. This review summarizes current research on the roles of aging, cellular senescence, and aging-related factors in the evolution of NAFLD to HCC, with the aim of identifying potential therapeutic targets for aging-related NAFLD and its progression.

AGEING RESEARCH REVIEWS (2023)

Add to Collection

Article Medicine, Research & Experimental

Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice

Chunbin Sun et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common lipid metabolism disorder. Autophagy plays a crucial role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active components of Pueraria lobata, have antioxidant and anti-inflammatory effects. This study demonstrates that Pueraria flavonoids can reduce intracellular lipid accumulation and inflammation levels in NAFLD by stimulating autophagy through the PI3K/Akt/mTOR signaling pathway.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Add to Collection

Review Oncology

Perspectives on the Underlying Etiology of HCC and Its Effects on Treatment Outcomes

Takanori Ito et al.

Summary: Hepatocellular carcinoma (HCC) is a serious medical problem with changing etiologies, including viral hepatitis, non-alcoholic liver disease (NAFLD), and alcohol-associated liver disease (ALD). Antiviral treatments for hepatitis B and C viruses have improved prognosis, while NAFLD and ALD are increasing causes of HCC. Nucleoside/nucleotide analogues (NAs) and direct-acting antivirals (DAAs) have shown effectiveness in slowing disease progression and improving survival. Lifestyle modification and prevention of complications are important for NAFLD treatment. ALD has become a significant cause of HCC-related deaths, especially during the COVID-19 pandemic.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2023)

Add to Collection

Review Gastroenterology & Hepatology

The Global Burden of Liver Disease

Zobair M. Younossi et al.

Summary: Chronic liver disease and its associated complications cause significant mortality, morbidity, and economic burden. The burden of CLD is large and increasing globally, with nonalcoholic fatty liver disease and alcohol-related liver disease being major contributors. Different regions of the world are affected by different etiologies, with HBV-related HCC cases being highest in Asia and NAFLD-related HCC cases highest in the United States. The impact of CLD is influenced by sociodemographic factors.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms of autophagic responses to altered nutritional status

Zhipeng Tao et al.

Summary: Autophagy is a crucial process for cellular remodeling and organelle quality control. It is regulated by various signaling pathways in response to changes in nutritional status. However, nutrient oversupply can disrupt autophagic regulation and is associated with chronic diseases in humans.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

Add to Collection

Article Medicine, Research & Experimental

Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice

Kota Yano et al.

Summary: FGF21, an endocrine growth factor mainly secreted by the liver in response to a ketogenic diet and alcohol consumption, has pleiotropic metabolic effects including inducing hepatic fatty acid oxidation and ketogenesis. Continuous induction of FGF21-induced lipolysis by a high-fat diet may lead to liver damage, but hepatic fatty acid oxidation and ketone body synthesis can improve liver steatosis. Liver-derived ketone bodies may be utilized for energy in skeletal muscle, showing potential in treating nonalcoholic fatty liver disease.

LABORATORY INVESTIGATION (2022)

Add to Collection

Article Multidisciplinary Sciences

Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis

Chanbin Lee et al.

Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is higher in men than premenopausal women. This study demonstrates that formyl peptide receptor 2 (FPR2) levels are regulated by estrogen, and that FPR2 contributes to NAFLD resistance in female mice.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin

Dandan Shan et al.

Summary: This study found that NP can induce steatosis in HepG2 cells and inhibit the ROS-dependent AMPK/mTOR pathway, while curcumin can effectively ameliorate the NAFLD-like changes induced by NP. This provides a new research direction for the prevention and treatment of non-alcoholic fatty liver disease.

FOOD & FUNCTION (2022)

Add to Collection

Article Physiology

MicroRNA-122-5p Inhibition Improves Inflammation and Oxidative Stress Damage in Dietary-Induced Non-alcoholic Fatty Liver Disease Through Targeting FOXO3

Yiyi Hu et al.

Summary: In this study, the researchers investigated the role of miR-122-5p in non-alcoholic fatty liver disease (NAFLD). They found that miR-122-5p expression was upregulated in response to a high-fat diet and palmitic acid. Inhibiting miR-122-5p reduced lipid-induced inflammation and oxidative stress damage in liver cells and fatty liver. The researchers discovered that miR-122-5p targets FOXO3 to attenuate the inflammatory response and oxidative stress in dietary-induced NAFLD. This study provides insights into the physiological role of miR-122-5p in NAFLD.

FRONTIERS IN PHYSIOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du et al.

Summary: Hepatocellular carcinoma is an aggressive cancer with increasing incidence worldwide. Targeting abnormal metabolism has emerged as a new strategy for HCC treatment. This review highlights metabolic targets and discusses current pharmaceutical agents and studies in this field.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection

Article Cell Biology

Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy

Kunpeng Liu et al.

Summary: The study identified a novel regulatory loop between STING1 and MTORC1, explaining how hepatic inflammation regulates lipid accumulation. The findings may facilitate the development of new strategies for clinical treatment of hepatic steatosis.

AUTOPHAGY (2022)

Add to Collection

Review Cell Biology

Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

Vojo Deretic et al.

Summary: Autophagy is both a metabolic process and a quality control process, involving specific receptors that selectively remove various intracellular targets. It is regulated by master regulators of cellular metabolism such as MTOR and AMPK, making the system responsive to amino acid and glucose starvation.

AUTOPHAGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway

Junhan Li et al.

Summary: This study found that aerobic exercise can reverse the abnormal lipid metabolism, liver function injury, and overexpression of CNPY2-PERK pathway induced by high-fat diet in NAFLD. This suggests that aerobic exercise is an effective method to improve NAFLD.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis

Zi-Xin Xu et al.

Summary: The study identified the involvement of the circ608-miR222-PINK1 pathway in NASH-related liver fibrosis, specifically in regulating mitophagy. Circ608 was found to inhibit the expression of miR222, thereby promoting PINK1-mediated mitophagy.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Article Medicine, Research & Experimental

Purendan alleviates non-alcoholic fatty liver disease in aged type 2 diabetic rats via regulating mTOR/S6K1/SREBP-1c signaling pathway

Lu Fan et al.

Summary: The study found that PRD has significant therapeutic effects on aged type 2 diabetes mellitus with non-alcoholic fatty liver disease. After treatment, insulin sensitivity and insulin resistance were improved, and lipid metabolism indexes in the blood and lipid accumulation in the liver tissue were significantly reduced.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Gastroenterology & Hepatology

S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

Komal Ramani et al.

Summary: Our study identified a SAMe-sensitive mechanism of LARP1 phosphorylation that may be involved in the progression from NASH to HCC.

HEPATOLOGY (2022)

Add to Collection

Article Cell Biology

Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis

Shogo Kawaguchi et al.

Summary: The study revealed that MDA5 expression is associated with the development of NASH in a diet-induced mouse model, and MDA5-positive macrophages are commonly found in NASH patients, suggesting MDA5 may be involved in the inflammation of the disease.

INFLAMMATION (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A new preclinical model of western diet-induced progression of non-alcoholic steatohepatitis to hepatocellular carcinoma

Christopher D. Green et al.

Summary: This study develops a new mouse model that mimics the progression of non-alcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC) observed in humans. The model, created through feeding mice a Western high-fat diet and sugar water, shows metabolic disorders, liver injury, fibrosis, and spontaneous development of HCC. The model exhibits molecular markers and gene signatures associated with NASH-driven HCC in humans, making it a valuable tool for future studies on the disease's molecular mechanisms.

FASEB JOURNAL (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting the lysosome: Mechanisms and treatments for nonalcoholic fatty liver disease

Jing Pu

Summary: This review summarizes the role of lysosomes in regulating lipid metabolism and discusses the alterations of lysosome functions in the livers affected by NAFLD. Targeting lysosomes shows promise as a strategy for preventing and treating NAFLD progression. The review also provides insights into potential future directions for manipulating lysosome functions in NAFLD.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

Add to Collection

Article Biochemical Research Methods

Serum Glycoprotein Markers in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

Prasanna Ramachandran et al.

Summary: This study investigates the use of circulating serum glycoproteins as potential prognostic markers for the progression of liver diseases. The analysis of healthy, NASH, and HCC serum samples reveals significant differences in the abundance of certain glycopeptides in NASH and HCC compared to controls.

JOURNAL OF PROTEOME RESEARCH (2022)

Add to Collection

Article Clinical Neurology

Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model

Pablo Ranea-Robles et al.

Summary: Research showed that RIP140 is modulated through a redox-dependent mechanism in X-ALD models, and genetic inactivation of RIP140 can prevent various axonal degeneration-related abnormalities, highlighting its potential as a therapeutic target in neurodegeneration.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway

Li-Shan Yan et al.

Summary: This study found that Schisandrin B inhibits hepatic steatosis and promotes fatty acid oxidation (FAO) through the activation of autophagy via the AMPK/mTOR pathway. These findings provide new insights into the potential application of Schisandrin B in the management of non-alcoholic fatty liver disease (NAFLD).

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

Add to Collection

Article Multidisciplinary Sciences

Complex regulation of fatty liver disease

Henry N. Ginsberg et al.

SCIENCE (2022)

Add to Collection

Review Cell Biology

Interleukin-6 at the Host-Tumor Interface: STAT3 in Biomolecular Condensates in Cancer Cells

Pravin B. Sehgal

Summary: This article provides an overview of the role of interleukin-6 (IL-6) at the host-tumor interface and its regulation in cancer. IL-6 can promote cancer cell migration, proliferation, and transformation, and it exerts effects on tumor progression by modulating immune cell activity. The article also discusses the impact of gender on IL-6 expression and tumor development, as well as the challenges in measuring IL-6 during immunotherapy.

CELLS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases

Shengmin Yan

Summary: TFEB is a key regulator of lysosomal function and autophagy, and its dysregulation is associated with lipid metabolism and several diseases. It has emerged as a potential therapeutic target for diseases, including non-alcoholic fatty liver disease.

BIOMOLECULES (2022)

Add to Collection

Editorial Material Health Care Sciences & Services

Forgetting: The New Normal

Suzanne K. Powell

Summary: Research has found that forgetting is valuable for enhancing long-term memory. Normal forgetting can help the brain eliminate unnecessary information, allowing us to better remember the most relevant information. Furthermore, there are molecular nano-machines within the brain for both remembering and forgetting.

PROFESSIONAL CASE MANAGEMENT (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Alternate-day fasting prevents non-alcoholic fatty liver disease and working memory impairment in diet-induced obese mice

Wentong Zhang et al.

Summary: Alternate-day fasting (ADF) regimen shows potential benefits in reducing obesity, improving non-alcoholic fatty liver disease (NAFLD), and alleviating cognitive decline. These effects may be mediated through the regulation of autophagy, energy metabolism, and inflammatory responses.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

LncNONMMUG027912 alleviates lipid accumulation through AMPKa/ mTOR/SREBP1C axis in nonalcoholic fatty liver

Kaifei Chu et al.

Summary: This study reveals the regulatory role of the long noncoding RNA lnc027912 in lipid metabolism and its ability to reduce lipid accumulation and liver inflammation through the AMPKa/mTOR/SREBP1C signaling axis. This finding highlights the potential of lnc027912 as a new treatment target for lipid disorder diseases.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease

Jiayao Feng et al.

Summary: This paper explores the various mechanisms by which mTOR regulates lipid metabolism, insulin resistance, oxidative stress, intestinal microbiota, autophagy, inflammation, genetic polymorphisms, and epigenetics in NAFLD. The research suggests that mTOR plays a crucial role in the development of NAFLD and provides new therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR

Chen-Yu Zhang et al.

Summary: This study found that restoring the balance of sEH/COX-2-mediated ARA metabolism attenuated NAFLD by inhibiting hepatocyte senescence. PTUPB, a dual inhibitor of sEH and COX-2, significantly improved liver injury and reduced lipid accumulation in NAFLD mice. It also decreased the expression of senescence-related molecules and enhanced autophagy in hepatocytes. These findings suggest that PTUPB has a protective effect against NAFLD through its anti-senescence and pro-autophagy properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma

Meenakshi Vachher et al.

Summary: The incidence of hepatocellular carcinoma (HCC) is increasing globally, and it is associated with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Understanding the pathogenesis and risk factors of NAFLD/NASH related HCC is crucial for early diagnosis and prognosis.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Shuangyu Tiaozhi decoction alleviates non-alcoholic fatty liver disease by improving lipid deposition, insulin resistance, and inflammation in vitro and in vivo

Guoliang Yin et al.

Summary: This study investigated the potential mechanism of Shuangyu Tiaozhi Decoction (SYTZD) against non-alcoholic fatty liver disease (NAFLD) through network pharmacology and experimental verification. The results showed that SYTZD may exert multiple anti-NAFLD mechanisms through a multi-component, multi-target, and multi-pathway mechanism of action, including improvements in lipid deposition, inflammation, and insulin resistance. These findings provide insights into the therapeutic potential of SYTZD for NAFLD.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high- fat diet in the mouse model

Ernest C. Lynch et al.

Summary: The Osr1 gene plays an important role in regulating lipid homeostasis and hepatic inflammation, and its disruption contributes to the progression of NAFLD.

PLOS ONE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

NAFLD: Mechanisms, Treatments, and Biomarkers

Fatiha Nassir

Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic-associated fatty liver disease (MAFLD), is a common liver disease worldwide that is closely linked to the obesity epidemic. Currently, there is no specific pharmacological treatment available for NAFLD due to incomplete understanding of its mechanisms, lack of accurate and inexpensive imaging tools, and inadequate non-invasive biomarkers. NAFLD can lead to metabolic-associated steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma.

BIOMOLECULES (2022)

Add to Collection

Article Cell Biology

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

Dong Cheng et al.

Summary: The MGAT2 inhibitor BMS-963272 shows promise as a potential treatment for NASH. It decreases inflammation and fibrosis, improves blood biomarkers, increases gut hormone levels, and reduces body weight, as demonstrated in rodent and primate models as well as in obese human subjects.

CELL METABOLISM (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis

You Lan et al.

Summary: This study reveals the mechanism by which HBx protein causes imbalanced macrophage polarization, leading to NASH. It provides a basis for screening potential biomarkers and evaluating interventions for HBx-associated NASH.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Genetics & Heredity

Transcription factor EB inhibits non-alcoholic fatty liver disease through fibroblast growth factor 21

Qi Gong et al.

Summary: We explored the potential role of transcription factor EB (TFEB) in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), and found that fibroblast growth factor 21 (FGF21) has a significantly positive effect on NAFLD. Starvation led to an increase in liver lipids, which was reversed by re-feeding. Phosphorylated mTOR, ribosomal S6 kinase, TFEB, and FGF21 are involved in this process. The increased expression of TFEB in NAFLD mice by tail vein injection of Ad-TFEB could reverse lipid deposition and metabolic changes in NAFLD mice. TFEB upregulated FGF21 expression by targeting the promoter of FGF21. This study adds to our understanding of the potential role of TFEB in the progression of NAFLD, and may lay a basis for identifying new drug targets for NAFLD treatment.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

Add to Collection

Review Medicine, Research & Experimental

The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions

Salah Alshehade et al.

Summary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease and hepatic failure worldwide. This article discusses the key role of protein kinases in the pathogenesis of MAFLD and predicts potential therapeutic targets. Moreover, it presents recent research on molecules that improve MAFLD condition by regulating oxidation and inflammation signaling.

LIFE SCIENCES (2022)

Add to Collection

Article Multidisciplinary Sciences

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Aveline Filliol et al.

Summary: The shift in HSC subpopulations during chronic liver disease is associated with a switch from HCC protection to promotion. Quiescent and cytokine-producing HSCs prevent hepatocyte death and HCC development, while activated myofibroblastic HSCs promote proliferation and tumor development through increased stiffness and TAZ and discoidin domain receptor 1 activation.

NATURE (2022)

Add to Collection

Article Nutrition & Dietetics

Red Pepper Seeds Inhibit Hepatic Lipid Accumulation by Inducing Autophagy via AMPK Activation

Young-Hyun Lee et al.

Summary: This study investigated the inhibitory effect of red pepper seed extract (RPS) on hepatic lipid accumulation. The results showed that RPS treatment suppressed lipogenesis and induced hepatic autophagy, leading to a reduction in lipid accumulation. This effect was mediated through the AMPK-dependent pathway. In vitro experiments also demonstrated the ability of RPS to decrease lipid accumulation and downregulate lipogenesis-associated proteins in an oleic acid-induced hepatic steatosis cell model.

NUTRIENTS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Empagliflozin activates Sestrin2-mediated AMPK/mTOR pathway and ameliorates lipid accumulation in obesity-related nonalcoholic fatty liver disease

Yuting Ma et al.

Summary: Empagliflozin (EMPA) therapy has been shown to improve non-alcoholic fatty liver disease (NAFLD) patients. This study investigated the functional implications of EMPA on the pathogenesis of NAFLD and identified the underlying molecular mechanisms. The results showed that EMPA treatment reversed liver damage by upregulating Sestrin2 and activating the AMPK-mTOR pathway, leading to the inhibition of lipogenesis and inflammation. These findings suggest that EMPA therapy could target Sestrin2 to alleviate lipogenesis and inflammation in obesity-related NAFLD.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway

Junlu Tong et al.

Summary: The study revealed that hepatic FST expression is increased in NAFLD patients compared to normal samples. FST can alleviate hepatic steatosis by regulating the Akt/mTOR signaling pathway, suggesting that gene therapy for FST may be a promising treatment option for NAFLD.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2022)

Add to Collection

Article Medicine, General & Internal

Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs

Shereen A. A. El Sobky et al.

Summary: This study demonstrates the impact of miR-615-5p and H19 on the mTOR/SREBP1c axis and their functional effects on LDs and TG accumulation.

FRONTIERS IN MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Fangzhou Liu et al.

Summary: Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. The long non-coding RNA SNHG6 is found to be an important player in this process, linking cholesterol sensing with cancer cell growth through mTORC1 signaling. SNHG6 modulates cholesterol-induced mTORC1 activation by forming a SNHG6-FAF2-mTOR complex, enhancing cholesterol-dependent mTORC1 lysosomal recruitment and activation. Loss of SNHG6 inhibits mTORC1 signaling and impairs liver cancer tumor growth, suggesting SNHG6 as a potential target for liver cancer treatment.

NATURE METABOLISM (2022)

Add to Collection

Article Immunology

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

Wenshu Tang et al.

Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Add to Collection

Article Medicine, Research & Experimental

Metabolomic-proteomic combination analysis reveals the targets and molecular pathways associated with hydrogen sulfide alleviating NAFLD

Zhangnan Liu et al.

Summary: This study demonstrated that H2S can alleviate NAFLD by reducing liver weight, body weight, and lipid accumulation, and improving liver pathology and serum biochemical parameters. Metabolomics and proteomics analysis revealed potential molecular targets and mechanisms of H2S in mitigating NAFLD.

LIFE SCIENCES (2021)

Add to Collection

Article Endocrinology & Metabolism

Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis

Mario Masarone et al.

Summary: The study utilized metabolomics analysis to differentiate metabolic profiles of different stages in NAFLD patients, revealing key metabolites that could potentially serve as biomarkers for disease progression. Additionally, the use of an ensemble machine learning model demonstrated high accuracy in predicting clinical stages of NAFLD.

METABOLOMICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression

Lilian H. Lo et al.

Summary: A forward genetic Sleeping Beauty insertional mutagenesis screen combined with high-throughput transcriptome sequencing identified two novel candidate genes, Cnpy2 and Actn2, potentially involved in HCC-associated metastatic progression, shedding light on their roles in the metastatic evolution process of liver cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Prognostic Value of Peroxiredoxin-1 Expression in Patients with Solid Tumors: a Meta-Analysis of Cohort Study

Lianghe Jiao et al.

Summary: This meta-analysis found that positive PRDX1 expression is associated with poor overall survival and disease-free survival in patients with solid tumors. Additionally, high PRDX1 expression is correlated with larger tumor size, advanced TNM stage, and poor tumor differentiation.

DISEASE MARKERS (2021)

Add to Collection

Article Oncology

Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis

Anna Kakehashi et al.

Summary: In this study, novel early molecular biomarkers of liver neoplasms in non-alcoholic steatohepatitis (NASH) were discovered using the STAM mouse model. The protein CACHD1 was found to be significantly elevated in hepatocellular carcinomas, suggesting its potential as a biomarker and molecular target in NASH-associated hepatocarcinogenesis involving cell proliferation, autophagy, and apoptosis. The research highlights CACHD1 as an early biomarker of liver preneoplastic and neoplastic lesions in the context of NASH, with implications for potential therapeutic targets in diabetes mellitus/NASH-associated hepatocarcinogenesis.

CANCERS (2021)

Add to Collection

Article Multidisciplinary Sciences

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways

Mathieu Paquette et al.

Summary: FLCN protein activity could be a promising target for small molecule drugs to treat liver fibrosis by specifically activating autophagy, promoting the degradation of intracellular lipid stores, ultimately resulting in reduced hepatocellular damage and inflammation. These results show an unexpected role for Flcn in fatty liver disease progression and highlight new potential treatment strategies.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.

CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways

Noriko Suzuki-Kemuriyama et al.

Summary: The study found that a high-fat diet with insufficient methionine can induce nonobese mice to develop NASH and insulin sensitivity, while a high-fat diet with sufficient methionine can lead to steatosis, obesity, and insulin resistance. Gene profile analysis revealed possible mechanisms behind the disease severity, providing insights for future research on NASH regulation, particularly its 'nonobese' subtype.

FEBS OPEN BIO (2021)

Add to Collection

Article Oncology

Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis

Anna Kakehashi et al.

Summary: Protein canopy homolog 2 (CNPY2) plays a crucial role in controlling neurite outgrowth and is significantly associated with cell cycle progression, proliferation, survival, and invasion in liver cancer cells. Its elevation in HCV-associated HCC patients is positively correlated with survival, suggesting it as a potential prognostic marker for liver cancer.

CANCERS (2021)

Add to Collection

Review Gastroenterology & Hepatology

Systematic review with meta-analysis: bariatric surgery reduces the incidence of hepatocellular carcinoma

Daryl Ramai et al.

Summary: Bariatric surgery is associated with a decreased risk of hepatocellular carcinoma (HCC), as indicated by meta-analysis of multiple studies.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Article Surgery

Bariatric surgery is associated with reduction in non-alcoholic steatohepatitis and hepatocellular carcinoma: A propensity matched analysis

Minyoung Kwak et al.

AMERICAN JOURNAL OF SURGERY (2020)

Add to Collection

Review Gastroenterology & Hepatology

Role of gut microbiota in liver disease

Somaya A. M. Albhaisi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Add to Collection

Article Chemistry, Analytical

Novel Strategy for Validating the Existence and Mechanism of the Gut-Liver Axis in Vivo by a Hypoxia-Sensitive NIR Fluorescent Probe

Yang Tian et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Suppression of miR-30a-3p Attenuates Hepatic Steatosis in Non-alcoholic Fatty Liver Disease

De-Run Wang et al.

BIOCHEMICAL GENETICS (2020)

Add to Collection

Article Immunology

MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway

Zhiyuan Chen et al.

IMMUNOLOGY LETTERS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis

Anna Kakehashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy

Yu Gao et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells

Maria Jose Lopez-Grueso et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Pathology

Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model

Momoka Hayashida et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2019)

Add to Collection

Review Gastroenterology & Hepatology

From NASH to HCC: current concepts and future challenges

Quentin M. Anstee et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection

Review Gastroenterology & Hepatology

Mechanisms of hepatocellular carcinoma progression

Olorunseun O. Ogunwobi et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)

Jessica Min-DeBartolo et al.

PLOS ONE (2019)

Add to Collection

Review Cell Biology

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Haojie Wang et al.

CELLS (2019)

Add to Collection

Review Immunology

Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: An increasing concern

Ekta Dhamija et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2019)

Add to Collection

Article Gastroenterology & Hepatology

Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future

Ana Ruth Araujo et al.

LIVER INTERNATIONAL (2018)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of hepatic integrin avβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET

Takemi Rokugawa et al.

EJNMMI RESEARCH (2018)

Add to Collection

Article Neurosciences

CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity

Graeme S. Cottrell et al.

JOURNAL OF NEUROSCIENCE (2018)

Add to Collection

Article Cell Biology

The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1

Shehrazade Dahimene et al.

CELL REPORTS (2018)

Add to Collection

Article Oncology

mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans

Takahiro Okuno et al.

CANCERS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors

Jingjing Jiao et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas

Anna Kakehashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response

Feng Hong et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Add to Collection

Article Oncology

Overexpression of RIP140 suppresses the malignant potential of hepatocellular carcinoma by inhibiting NF-κB-mediated alternative polarization of macrophages

Ying-Chun Hu et al.

ONCOLOGY REPORTS (2017)

Add to Collection

Article Oncology

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity

Tze Mun Loo et al.

CANCER DISCOVERY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response

Feng Hong et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Add to Collection

Article Oncology

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Yakir Guri et al.

CANCER CELL (2017)

Add to Collection

Article Physiology

Pathophysiological Analysis of the Progression of Hepatic Lesions in STAM Mice

T. Saito et al.

PHYSIOLOGICAL RESEARCH (2017)

Add to Collection

Article Medicine, Research & Experimental

Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis

Delin Zhang et al.

BIOMARKERS IN MEDICINE (2017)

Add to Collection

Article Biochemical Research Methods

Analysis of fucosylation in liver-secreted N-glycoproteins from human hepatocellular carcinoma plasma using liquid chromatography with tandem mass spectrometry

Eun Sun Ji et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2016)

Add to Collection

Article Oncology

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

Atsushi Umemura et al.

CANCER CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor

Yanhong He et al.

FEBS LETTERS (2015)

Add to Collection

Article Gastroenterology & Hepatology

A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers

Yoshihiro Kamada et al.

HEPATOLOGY (2015)

Add to Collection

Review Endocrinology & Metabolism

Leptin in nonalcoholic fatty liver disease: A narrative review

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

Add to Collection

Article Multidisciplinary Sciences

Proteomic Analysis of Mice Fed Methionine and Choline Deficient Diet Reveals Marker Proteins Associated with Steatohepatitis

Su Jin Lee et al.

PLOS ONE (2015)

Add to Collection

Article Oncology

Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells

Dexiang Zhang et al.

TUMOR BIOLOGY (2015)

Add to Collection

Article Oncology

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

Hayato Nakagawa et al.

CANCER CELL (2014)

Add to Collection

Article Multidisciplinary Sciences

Expression of CNPY2 in Mouse Tissues: Quantification and Localization

Kota Hatta et al.

PLOS ONE (2014)

Add to Collection

Article Multidisciplinary Sciences

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Shin Yoshimoto et al.

NATURE (2013)

Add to Collection

Review Endocrinology & Metabolism

Distinct functions for RIP140 in development, inflammation, and metabolism

Jaya Nautiyal et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

Add to Collection

Article Oncology

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens

Anna Kakehashi et al.

Cancers (2013)

Add to Collection

Review Gastroenterology & Hepatology

S-adenosylmethionine metabolism and liver disease

Jose M. Mato et al.

ANNALS OF HEPATOLOGY (2013)

Add to Collection

Article Endocrinology & Metabolism

The Influence of Diabetes in the Pathogenesis and the Clinical Course of Hepatocellular Carcinoma: Recent Findings and New Perspectives

Antonio Facciorusso

CURRENT DIABETES REVIEWS (2013)

Add to Collection

Article Cell Biology

Branched-chain amino acids prevent insulin-induced hepatic tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2-dependent mechanisms

Asami Hagiwara et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Add to Collection

Article Toxicology

Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model

Jin-Sook Lee et al.

TOXICOLOGY LETTERS (2012)

Add to Collection

Article Biochemistry & Molecular Biology

MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators

Akemi Takata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Add to Collection

Article Cell Biology

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

Brian F. Teske et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Add to Collection

Article Medicine, General & Internal

Role of autophagy in the pathogenesis of liver diseases

Klára Werling

ORVOSI HETILAP (2011)

Add to Collection

Review Endocrinology & Metabolism

The metabolic coregulator RIP140: an update

Asmaa Fritah et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

Add to Collection

Article Chemistry, Medicinal

DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications

Kazuaki Kawai et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Add to Collection

Article Gastroenterology & Hepatology

Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study

Ariel E. Feldstein et al.

HEPATOLOGY (2009)

Add to Collection

Review Medicine, Research & Experimental

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease

James P. Hardwick et al.

PPAR RESEARCH (2009)

Add to Collection

Article Oncology

The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis

Angeles Duran et al.

CANCER CELL (2008)

Add to Collection

Article Cell Biology

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

D. Thomas Rutkowski et al.

DEVELOPMENTAL CELL (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140

Tomas Jakobsson et al.

BIOCHEMICAL JOURNAL (2007)

Add to Collection

Article Oncology

High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: Comparison to C3H and C57 mice

Shuji Iwai et al.

CANCER LETTERS (2007)

Add to Collection

Article Gastroenterology & Hepatology

Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases

S Seki et al.

HEPATOLOGY RESEARCH (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II

K Yamamoto et al.

JOURNAL OF BIOCHEMISTRY (2004)

Add to Collection

Article Multidisciplinary Sciences

Nuclear receptor corepressor RIP140 regulates fat accumulation

G Leonardsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Add to Collection

Article Biochemistry & Molecular Biology

MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain

BC Bornhauser et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.