Modern Kidney-Sparing Management of Upper Tract Urothelial Carcinoma

Article Urology & Nephrology

Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-Targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma

Wesley Yip et al.

JOURNAL OF UROLOGY (2023)

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Article Urology & Nephrology

Efficacy and safety of mitomycin gel (UGN-101) as an adjuvant therapy after complete endoscopic management of Upper Tract Urothelial Carcinoma.

Craig Labbate et al.

JOURNAL OF UROLOGY (2023)

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Article Urology & Nephrology

Upper Tract Tumor En Bloc Enucleation: A Novel Approach to the Diagnosis and Management of Upper Tract Urothelial Carcinoma

Joshua S. Jue et al.

UROLOGY (2023)

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Review Urology & Nephrology

Oncologic and Safety Outcomes for Endoscopic Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: An Updated Systematic Review and Meta-analysis

Tatsushi Kawada et al.

Summary: We conducted a systematic review and found that endoscopic management (EM) for upper tract urothelial carcinoma (UTUC) had similar survival outcomes to radical nephroureterectomy (RNU), but higher local recurrence rates and the need for long-term surveillance and repeated interventions. Analyses of 13 studies showed that EM had comparable overall survival (OS), cancer-specific survival (CSS), and bladder recurrence-free survival (BRFS) to RNU. However, 28-85% of EM-treated patients experienced upper tract recurrence. EM also required more interventions and had a higher risk of complications and lower likelihood of renal preservation.

EUROPEAN UROLOGY FOCUS (2023)

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Review Urology & Nephrology

Oncologic and Safety Outcomes for Retrograde and Antegrade Endoscopic Surgeries for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis

Ekaterina Laukhtina et al.

Summary: The aim of this study was to compare retrograde and antegrade endoscopic surgery in patients with upper tract urothelial carcinoma (UTUC) regarding oncologic and safety outcomes. The analysis of 20 studies involving 1091 patients showed that antegrade endoscopic surgery had lower rates of bladder and upper urinary tract recurrence compared to retrograde endoscopic surgery. Both approaches had acceptable complication rates, with retrograde endoscopic surgery having slightly higher rates. Overall, the findings suggest that antegrade kidney-sparing surgery may be a promising option for UTUC patients.

EUROPEAN UROLOGY FOCUS (2023)

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Article Surgery

Endoscopic management of upper tract urothelial cancer in a highly endemic area: A Taiwan nationwide collaborative study

Yung Tai Chen et al.

Summary: This study retrospectively reviewed the treatment outcomes of endoscopic management for clinically localized UTUC in Taiwan, and found that endoscopic treatment is safe and effective in this area. Early salvage radical nephroureterectomy (RNU) is necessary for UTUC refractory to endoscopic management in order to prevent UTUC-related mortality.

ASIAN JOURNAL OF SURGERY (2023)

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Article Urology & Nephrology

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline

Jonathan A. Coleman et al.

Summary: The purpose of this guideline is to provide a useful reference on the effective evidence-based diagnoses and management of non-metastatic upper tract urothelial carcinoma (UTUC). By conducting searches and analyzing medical literature, updated evidence-based recommendations regarding diagnosis and treatment of UTUC have been provided. Future studies will further support these recommendations to improve patient outcomes.

JOURNAL OF UROLOGY (2023)

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Article Urology & Nephrology

A Urine-based DNA Methylation Marker Test to Detect Upper Tract Urothelial Carcinoma: A Prospective Cohort Study

Alireza Ghoreifi et al.

JOURNAL OF UROLOGY (2023)

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Article Urology & Nephrology

Segmental ureterectomy for high-risk ureteral carcinoma: a preliminary report

Wei Wei et al.

Summary: This study evaluated the effectiveness and safety of segmental ureterectomy (SU) for patients with high-risk ureteral carcinoma. The results showed that the efficacy and safety of segmental ureterectomy were satisfactory for selected patients with high-risk ureteral carcinoma. However, prospective or randomized studies are still needed to validate the value of SU in patients with high-risk ureteral carcinoma.

BMC UROLOGY (2023)

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Article Oncology

Is Segmental Ureterectomy Associated with Inferior Survival for Localized Upper-Tract Urothelial Carcinoma of the Ureter Compared to Radical Nephroureterectomy?

Marco Paciotti et al.

Summary: According to national cancer registry data, segmental ureterectomy is not associated with inferior survival compared to radical nephroureterectomy in upper-tract urothelial carcinoma patients. Segmental ureterectomy provides a valid surgical approach that does not meaningfully sacrifice survival outcomes within appropriately selected patients of upper urothelial carcinoma of the ureter. It should be considered for selected patients, especially if there is an increased probability of requiring adjuvant chemotherapy.

CANCERS (2023)

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Article Urology & Nephrology

Route of Administration for UGN-101 and Impact on Oncological and Safety Outcomes

Jennifer Linehan et al.

European Urology Focus (2023)

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Article Urology & Nephrology

Mitomycin Gel (UGN-101) as a Kidney-sparing Treatment for Upper Tract Urothelial Carcinoma in Patients with Imperative Indications and High-grade Disease

Kyle M. Rose et al.

European Urology Focus (2023)

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Review Urology & Nephrology

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update

Morgan Roupret et al.

Summary: The European Association of Urology has updated the guidelines for the management of upper urinary tract urothelial carcinoma. The recommendations are based on a systematic review of the literature and assessed by a panel of experts. However, there is still insufficient high-level evidence in many areas to provide strong recommendations.

EUROPEAN UROLOGY (2023)

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Review Medicine, General & Internal

Endoscopic Conservative Treatment of Upper Urinary Tract Urothelial Carcinoma with a Thulium Laser: A Systematic Review

Luigi Candela et al.

Summary: This article reviews the current evidence on the use of TLs for UTUC treatment. The results suggest that TL is a safe and effective endoscopic treatment for UTUC. However, there is a lack of prospective, multicentric studies with large population sizes and long-term follow-up in the available literature.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Urology & Nephrology

Antegrade Instillation of UGN-101 (Mitomycin for Pyelocalyceal Solution) for Low-Grade Upper Tract Urothelial Carcinoma: Initial Clinical Experience

Geoffrey H. Rosen et al.

Summary: This study presents the technique and early outcomes of antegrade administration of UGN-101 for low-grade upper tract urothelial carcinoma. Adverse events and ureteral strictures are discussed. The method shows potential to improve patient comfort, streamline the procedure, and reduce the risk of adverse events.

JOURNAL OF UROLOGY (2022)

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Article Urology & Nephrology

Durability of Response to Primary Chemoablation of Low-Grade Upper Tract Urothelial Carcinoma Using UGN-101, a Mitomycin-Containing Reverse Thermal Gel: OLYMPUS Trial Final Report

Surena F. Matin et al.

Summary: The study aimed to evaluate the long-term safety and durability of UGN-101 as a primary chemoablative treatment for low-grade upper tract urothelial carcinoma. The results showed that UGN-101 has a clinically meaningful durability of response, providing a kidney-sparing therapeutic alternative for patients with low-grade disease.

JOURNAL OF UROLOGY (2022)

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Article Urology & Nephrology

Bladder Recurrence Following Diagnostic Ureteroscopy in Patients Undergoing Nephroureterectomy for Upper Tract Urothelial Cancer: Is Ureteral Access Sheath Protective?

Antoin Douglawi et al.

Summary: Diagnostic URS in patients undergoing RNU significantly increases the risk of bladder recurrence, but this effect may be mitigated by using a ureteral access sheath.

UROLOGY (2022)

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Article Urology & Nephrology

Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study

Gautier Marcq et al.

Summary: This study aimed to evaluate a new classification for better risk stratification of upper tract urothelial carcinoma patients eligible for kidney-sparing surgery. The study found that several factors were associated with muscle invasion, tumor size and other significant variables defined the high-risk category, and tumor multifocality and a history of radical cystectomy helped classify low-risk and intermediate-risk categories. This classification needs further validation and may be helpful in clinical trial design.

EUROPEAN UROLOGY FOCUS (2022)

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Article Urology & Nephrology

Comparison of Holmium:YAG and Thulium Fiber Lasers on Soft Tissue: An Ex Vivo Study

Steeve Doizi et al.

Summary: This study evaluated the fiber-tissue interaction and degradation of laser fibers during soft tissue treatment using Ho:YAG laser and TFL. The results showed that Ho:YAG laser had greater incision depths and coagulation areas compared to TFL, but TFL had a constant carbonization zone. Additionally, degradation of laser fibers was observed with Ho:YAG laser, but not with TFL.

JOURNAL OF ENDOUROLOGY (2022)

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Article Urology & Nephrology

Endoscopic Management of Low-Grade Upper Tract Urothelial Carcinoma: Characterizing the Long-term Burden of Care in Comparison to Radical Nephroureterectomy

Chen Shenhar et al.

Summary: This study compares the outcomes of radical management (RM) and kidney-sparing endoscopic management (EM) in patients with low-grade upper urothelial cancer (UTUC). The results show similar survival rates and renal function between the two treatment approaches, but EM has a higher procedure burden and cost.

UROLOGY (2022)

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Article Medicine, General & Internal

Outcome of Non-Muscle Invasive Upper Tract Urothelial Carcinoma Receiving Endoscopic Ablation: An Inverse Probability of Treatment Weighting Analysis

Chih-Yu Shen et al.

Summary: The study compared the outcomes of early-stage upper tract urothelial carcinoma (UTUC) patients receiving endoscopic ablation (EA) with radical nephroureterectomy (RNU). The results showed that EA preserves renal function without compromising oncological outcome in selected UTUC patients.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Oncology

Liquid Biopsy Landscape in Patients with Primary Upper Tract Urothelial Carcinoma

Stephanie N. Shishido et al.

Summary: Liquid biopsy can detect circulating tumor cells and large extracellular vesicles in patients with upper tract urothelial carcinoma, providing important information for understanding the biology of the disease and potentially improving patient outcomes.

CANCERS (2022)

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Article Urology & Nephrology

Thulium:YAGVersusHolmium:YAG Laser Effect on Upper Urinary Tract Soft Tissue: Evidence from anEx VivoExperimental Study

Silvia Proietti et al.

Summary: This study compared the effects of Holmium laser (Ho:YAG) and Thulium laser (Tm:YAG) on upper urinary tract soft tissues in an ex vivo experimental study. The results showed that Ho:YAG produced deeper incisions, while Tm:YAG led to larger coagulation areas and total laser areas. Future in vivo studies are needed to confirm these findings.

JOURNAL OF ENDOUROLOGY (2021)

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Article Urology & Nephrology

Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study

Beat Foerster et al.

Summary: This study developed a risk-stratification model to better identify patients for endoscopic kidney-sparing surgery in upper tract urothelial carcinoma. The model showed higher accuracy in identifying patients with higher disease stage and additional clinical net reduction compared to existing models.

EUROPEAN UROLOGY (2021)

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Article Urology & Nephrology

Higher than expected and significantly increasing incidence of upper tract urothelial carcinoma. A population based study

Bjarte Almas et al.

Summary: The incidence of UTUC was higher than expected and increasing, with patient age at diagnosis increasing as well. The cancer-specific survival rate has improved over the years.

WORLD JOURNAL OF UROLOGY (2021)

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Article Multidisciplinary Sciences

Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

Yung-Tai Chen et al.

Summary: The study aimed to compare the clinical and survival differences between patients who underwent endoscopic ablation and radical nephroureterectomy for UTUC in Taiwan. The results showed that endoscopic management of UTUC was as safe as radical nephroureterectomy in an endemic region for UTUC.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Segmental Ureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis of Comparative Studies

Alessandro Veccia et al.

CLINICAL GENITOURINARY CANCER (2020)

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Article Urology & Nephrology

Adjuvant Single-Dose Upper Urinary Tract Instillation of Mitomycin C After Therapeutic Ureteroscopy for Upper Tract Urothelial Carcinoma: A Single-Centre Prospective Non-Randomized Trial

Andrea Gallioli et al.

JOURNAL OF ENDOUROLOGY (2020)

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Article Oncology

Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial

Nir Kleinmann et al.

LANCET ONCOLOGY (2020)

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Review Andrology

Outcomes of endoscopic management of upper tract urothelial carcinoma

John J. Knoedler

TRANSLATIONAL ANDROLOGY AND UROLOGY (2020)

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Review Andrology

Endoscopic management of upper tract urothelial carcinoma-tips and tricks

Asaf Shvero et al.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2020)

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Review Oncology

UGN-101 (mitomycin gel): a novel treatment for low-grade upper tract urothelial carcinoma

Andrea Kokorovic et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

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Article Urology & Nephrology

Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma: results of a multicentre study

Alberto Abrate et al.

BJU INTERNATIONAL (2019)

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Review Oncology

Endocavitary treatment for upper tract urothelial carcinoma: A meta-analysis of the current literature

Beat Foerster et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2019)

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Article Urology & Nephrology

Which flexible ureteroscope is the best for upper tract urothelial carcinoma treatment?

Etienne Xavier Keller et al.

WORLD JOURNAL OF UROLOGY (2019)

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Article Urology & Nephrology

Robotic radical nephroureterectomy and segmental ureterectomy for upper tract urothelial carcinoma: a multi-institutional experience

Riccardo Campi et al.

WORLD JOURNAL OF UROLOGY (2019)

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Article Biochemistry & Molecular Biology

Role of lasers in urology

Stephan M. Korn et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2019)

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Article Oncology

Treatment of upper tract urothelial carcinoma with ureteroscopy and thulium laser: a retrospective single center study

Jin Wen et al.

BMC CANCER (2018)

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Article Urology & Nephrology

Long-term outcomes of total ureterectomy with ileal-ureteral substitution treatment for ureteral cancer: a single-center experience

Yin-Chien Ou et al.

BMC UROLOGY (2018)

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Article Urology & Nephrology

Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)

Francesco Soria et al.

WORLD JOURNAL OF UROLOGY (2017)

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Review Oncology

Anatomical templates of lymph node dissection for upper tract urothelial carcinoma: a systematic review of the literature

Riccardo Campi et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

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Review Urology & Nephrology

Early repeated ureteroscopy within 6-8 weeks after a primary endoscopic treatment in patients with upper tract urothelial cell carcinoma: preliminary findings

Luca Villa et al.

WORLD JOURNAL OF UROLOGY (2016)

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Review Oncology

A systematic review and meta-analysis of oncological and renal function outcomes obtained after segmental ureterectomy versus radical nephroureterectomy for upper tract urothelial carcinoma

D. Fang et al.

EJSO (2016)

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Review Urology & Nephrology

Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel

Thomas Seisen et al.

EUROPEAN UROLOGY (2016)

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Article Urology & Nephrology

The Expanded Use of Percutaneous Resection for Upper Tract Urothelial Carcinoma: A 30-Year Comprehensive Experience

Piruz Motamedinia et al.

JOURNAL OF ENDOUROLOGY (2016)

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Article Urology & Nephrology

Oncologic Outcomes of Kidney Sparing Surgery versus Radical Nephroureterectomy for the Elective Treatment of Clinically Organ Confined Upper Tract Urothelial Carcinoma of the Distal Ureter

Thomas Seisen et al.

JOURNAL OF UROLOGY (2016)

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Article Urology & Nephrology

Survival Comparison Between Endoscopic and Surgical Management for Patients With Upper Tract Urothelial Cancer: A Matched Propensity Score Analysis Using Surveillance, Epidemiology and End Results-Medicare Data

Goutham Vemana et al.

UROLOGY (2016)

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Review Urology & Nephrology

Kidney-sparing surgery for upper tract urothelial cancer

Ilaria Lucca et al.

CURRENT OPINION IN UROLOGY (2015)

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Article Urology & Nephrology

Patterns of Lymphatic Metastases in Upper Tract Urothelial Carcinoma and Proposed Dissection Templates

Surena F. Matin et al.

JOURNAL OF UROLOGY (2015)

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Article Oncology

Distal ureterectomy is a safe surgical option in patients with urothelial carcinoma of the distal ureter

Orietta Dalpiaz et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

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Article Urology & Nephrology

Oncologic results of Nephron sparing endoscopic approach for upper tract low grade transitional cell carcinoma in comparison to nephroureterectomy - a case control study

Azik Hoffman et al.

BMC UROLOGY (2014)

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Article Urology & Nephrology

Endoscopic Versus Laparoscopic Management of Noninvasive Upper Tract Urothelial Carcinoma: 20-Year Single Center Experience

Mark L. Cutress et al.

JOURNAL OF UROLOGY (2013)

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Article Urology & Nephrology

Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience

Harun Fajkovic et al.

WORLD JOURNAL OF UROLOGY (2013)

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Article Urology & Nephrology

Combining imaging and ureteroscopy variables in a preoperative multivariable model for prediction of muscle-invasive and non-organ confined disease in patients with upper tract urothelial carcinoma

Ricardo L. Favaretto et al.

BJU INTERNATIONAL (2012)

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Article Urology & Nephrology

Ureteroscopic and extirpative treatment of upper urinary tract urothelial carcinoma: a 15-year comprehensive review of 160 consecutive patients

Michael Grasso et al.

BJU INTERNATIONAL (2012)

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Article Urology & Nephrology

The Impact of Tumor Multifocality on Outcomes in Patients Treated With Radical Nephroureterectomy

Thomas F. Chromecki et al.

EUROPEAN UROLOGY (2012)

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Article Urology & Nephrology

Transurethral endoscopic treatment of patients with upper tract urothelial carcinomas using neodymium-YAG and/or holmium-YAG laser ablation

Yasuhiro Tada et al.

BJU INTERNATIONAL (2010)

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Article Urology & Nephrology

Preoperative Hydronephrosis, Ureteroscopic Biopsy Grade and Urinary Cytology Can Improve Prediction of Advanced Upper Tract Urothelial Carcinoma

James C. Brien et al.

JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Long-Term Outcomes of Nephroureterectomy Versus Endoscopic Management for Upper Tract Urothelial Carcinoma

Adam J. Gadzinski et al.

JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Conservative management in selected patients with upper tract urothelial carcinoma compares favourably with early radical surgery

Steven M. Lucas et al.

BJU INTERNATIONAL (2008)

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Article Urology & Nephrology

Comparison of open nephroureterectomy and ureteroscopic and percutaneous management of upper urinary tract transitional cell carcinoma

Morgan Roupret et al.

UROLOGY (2006)

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Modern Kidney-Sparing Management of Upper Tract Urothelial Carcinoma

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