Evolution of Patterns of Care and Outcomes in the Real-Life Setting for Patients with Metastatic GIST Treated in Three French Expert Centers over Three Decades

Simple Summary Gastrointestinal stromal tumors (GIST) are rare digestive mesenchymal tumors, and their treatment strategies have been revolutionized in recent decades with the discovery of tyrosine kinase inhibitors (TKI). This study assesses evolution of real-life treatment strategies for patients with metastatic GIST treated in three French expert centers over 30 years, including access to clinical trials and locoregional procedures to metastasis, and their impact on survival. The main results are the high levels of patient inclusion in clinical trials and locoregional treatments of metastasis, that translate in a benefit in survival, together with the absence of significant differences in the magnitude of benefit from non molecularly driven use of various TKI in later lines since the introduction of imatinib. This study advocates for early referral of metastatic GIST patients to expert centers to orchestrate the best access to future innovative clinical trials together with locoregional strategies and further improve GIST patients' survival.Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors characterized by KIT or PDGFRA mutations. Over three decades, significant changes in drug discovery and loco-regional (LR) procedures have impacted treatment strategies. We assessed the evolution of treatment strategies for metastatic GIST patients treated in the three national coordinating centers of NetSarc, the French network of sarcoma referral centers endorsed by the National Institute of Cancers, from 1990 to 2018. The primary objective was to describe the clinical and biological profiles as well as the treatment modalities of patients with metastatic GIST in a real-life setting, including access to clinical trials and LR procedures in the metastatic setting. Secondary objectives were to assess (1) patients' outcome in terms of time to next treatment (TNT) for each line of systemic treatment, (2) patients' overall survival (OS), (3) evolution of patients' treatment modalities and OS according to treatment access: <2002 (pre-imatinib approval), 2002-2006 (pre-sunitinib approval), 2006-2014 (pre-regorafenib approval), post 2014, and (4) the impact of clinical trials and LR procedures on TNT and OS in the metastatic setting. 1038 patients with a diagnosis of GIST made in one of the three participating centers between 1990 and 2018 were included in the national prospective database. Among them, 492 patients presented metastasis, either synchronous or metachronous. The median number of therapy lines in the metastatic setting was 3 (range 0-15). More than half of the patients (55%) participated in a clinical trial during the course of their metastatic disease and half (51%) underwent additional LR procedures on metastatic sites. The median OS in the metastatic setting was 83.4 months (95%CI [72.7; 97.9]). The median TNT was 26.7 months (95%CI [23.4; 32.3]) in first-line, 10.2 months (95%CI [8.6; 11.8]) in second line, 6.7 months (95%CI [5.3; 8.5]) in third line, and 5.5 months (95%CI [4.3; 6.7]) in fourth line, respectively. There was no statistical difference in OS in the metastatic setting between the four therapeutic periods (log rank, p = 0.18). In multivariate analysis, age, AFIP Miettinen classification, mutational status, surgery of the primary tumor, participation in a clinical trial in the first line and LR procedure to metastatic sites were associated with longer TNT in the first line, whereas age, mitotic index, mutational status, surgery of the primary tumor and LR procedure to metastatic sites were associated with longer OS. This real-life study advocates for early reference of metastatic GIST patients to expert centers to orchestrate the best access to future innovative clinical trials together with LR strategies and further improve GIST patients' survival.

Automated summary

This study assesses the evolution of treatment strategies for patients with metastatic gastrointestinal stromal tumors (GIST) in three French expert centers over 30 years. It highlights the importance of clinical trials and locoregional procedures in improving survival for GIST patients and suggests early referral to expert centers for access to innovative treatments. The study also shows that there is no significant difference in the effectiveness of different tyrosine kinase inhibitors (TKI) in later lines of treatment since the introduction of imatinib.