☆ 4.6 Review

Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial-Mesenchymal Transition

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Small Molecule NF-κB Pathway Inhibitors in Clinic

Venkataramanan Ramadass et al.

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NRP1 regulates radiation-induced EMT via TGF-β/Smad signaling in lung adenocarcinoma cells

ZhiYuan Chen et al.

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MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

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ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma

Emerson Soares Veloso et al.

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Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

Valeria Capaci et al.

NATURE COMMUNICATIONS (2020)

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Selective antagonism of cJun for cancer therapy

Andrew Brennan et al.

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Targeting STAT3 in Cancer Immunotherapy

Sailan Zou et al.

MOLECULAR CANCER (2020)

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Porphyromonas gingivalis promotes progression of esophageal squamous cell cancer via TGFβ-dependent Smad/YAP/TAZ signaling

Yi-Jun Qi et al.

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The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

Dionysios V. Chartoumpekis et al.

ANTIOXIDANTS (2020)

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LINC01235-TWIST2 feedback loop facilitates epithelial–mesenchymal transition in gastric cancer by inhibiting THBS2

Yu-En Tan et al.

Aging-US (2020)

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Expression of the miR-200 family in tumor tissue, plasma and urine of epithelial ovarian cancer patients in comparison to benign counterparts

Kalle Savolainen et al.

BMC RESEARCH NOTES (2020)

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SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA

Ruiyan Wu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Role of SOX Protein Groups F and H in Lung Cancer Progression

Mateusz Olbromski et al.

CANCERS (2020)

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Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Androgen receptor in bladder cancer: A promising therapeutic target

Abhishek Tripathi et al.

ASIAN JOURNAL OF UROLOGY (2020)

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Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10

Lili Fan et al.

THERANOSTICS (2020)

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microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells

Zheqing Cui et al.

BMC CANCER (2019)

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RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

Christopher P. Mill et al.

BLOOD (2019)

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Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease

Gillian A. Durham et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

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Retinoic acid signaling pathways

Norbert B. Ghyselinck et al.

DEVELOPMENT (2019)

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TGF--Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

Yang Hao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway

Hongchao Zhao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

Qingyuan Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Epithelial mesenchymal transition and resistance in endocrine-related cancers

Zoran Culig

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

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miR-186 Suppresses the Progression of Cholangiocarcinoma Cells Through Inhibition of Twist1

Ming Zhang et al.

ONCOLOGY RESEARCH (2019)

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T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma

Sheng Zhong et al.

AGING-US (2019)

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Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex

Xingrong Zheng et al.

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The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

Paul Laissue

MOLECULAR CANCER (2019)

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New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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The effect of sodium butyrate and cisplatin on expression of EMT markers

Alena Mrkvicova et al.

PLOS ONE (2019)

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JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

Katie L. Owen et al.

CANCERS (2019)

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Glucocorticoid receptor-IRS-1 axis controls EMT and the metastasis of breast cancers

Weiwei Shi et al.

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Molecular regulation of Snai2 in development and disease

Wenhui Zhou et al.

JOURNAL OF CELL SCIENCE (2019)

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TFClass: expanding the classification of human transcription factors to their mammalian orthologs

Edgar Wingender et al.

NUCLEIC ACIDS RESEARCH (2018)

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Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA

Fang Bai et al.

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Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone-sensitive prostate cancer

Heather H. Cheng et al.

PROSTATE (2018)

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Protective effect of retinoic acid receptor on hypoxia-induced epithelial to mesenchymal transition of renal tubular epithelial cells associated with TGF-/MMP-9 pathway

Ling Gong et al.

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Targeting the IL-6/JAK/STAT3 signalling axis in cancer

Daniel E. Johnson et al.

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Role of the NFκB-signaling pathway in cancer

Longzheng Xia et al.

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Silencing of c-jun decreases cell migration, invasion, and EMT in radioresistant human nasopharyngeal carcinoma cell line CNE-2R

Guoxiang Lin et al.

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Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition

Kendra A. Williams et al.

Oncotarget (2018)

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CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target

Rajkumar S. Kalra et al.

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Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ

Tong Zhou et al.

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Elevation of androgen receptor promotes prostate cancer metastasis by induction of epithelial-mesenchymal transition and reduction of KAT5

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The Dominant Role of Forkhead Box Proteins in Cancer

Duc-Hiep Bach et al.

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EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-B and Erk1/2 pathways

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Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers

Thu H. Truong et al.

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EMT in cancer

Thomas Brabletz et al.

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Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial

Derek J. Jonker et al.

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Up-regulation of Transcription Factor 3 Is Correlated With Poor Prognosis in Cervical Carcinoma

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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2017)

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EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells

Ming Han et al.

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Targeting Twist expression with small molecules

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SR 11302, an AP-1 Inhibitor, Reduces Metastatic Lesion Formation in Ex Vivo 4D Lung Cancer Model

Dhruva Kumar Mishra et al.

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Putting p53 in Context

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CELL (2017)

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Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression

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Oncogenic retinoic acid receptor γ knockdown reverses multi-drug resistance of human colorectal cancer via Wnt/β-catenin pathway

Gui-Li Huang et al.

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Role of RUNX1 in hematological malignancies

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Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model

Daisuke Kamide et al.

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M. Angela Nieto et al.

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TGF-β Signaling in Cancer

Viqar Syed

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Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis

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Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma

Aparna Jayachandran et al.

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Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

Bowen Du et al.

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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Dawid Walerych et al.

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Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC

Shen-Nien Wang et al.

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SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

Yi-Jing Hsiao et al.

ONCOTARGET (2016)

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Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation

Ioannis A. Voutsadakis

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An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers

H. M. Tang et al.

CELL DEATH DISCOVERY (2016)

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SOX family transcription factors involved in diverse cellular events during development

Zhen-Yu She et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2015)

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Attenuation of EMT in RPE cells and subretinal fibrosis by an RAR-γ agonist

Kazuhiro Kimura et al.

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Retinoic acid receptors: From molecular mechanisms to cancer therapy

Alessandra di Masi et al.

MOLECULAR ASPECTS OF MEDICINE (2015)

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Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing

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Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression

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CELL DEATH AND DIFFERENTIATION (2015)

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Mechanisms of Jak/STAT Signaling in Immunity and Disease

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Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures

Ayano Doi et al.

MOLECULAR ONCOLOGY (2015)

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TFClass: a classification of human transcription factors and their rodent orthologs

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Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition

Yifeng Jing et al.

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Celecoxib Suppresses the Phosphorylation of STAT3 Protein and Can Enhance the Radiosensitivity of Medulloblastoma-Derived Cancer Stem-Like Cells

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Oncogenic roles of EMT-inducing transcription factors

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Molecular mechanisms of epithelial-mesenchymal transition

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Signaling mechanisms of the epithelial-mesenchymal transition

David M. Gonzalez et al.

SCIENCE SIGNALING (2014)

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Sox2 acts as a rheostat of epithelial to mesenchynnal transition during neural crest development

Nikolaos Mandalos et al.

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Cancer genetics and genomics of human FOX family genes

Masuko Katoh et al.

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The Role of Snail in EMT and Tumorigenesis

Yifan Wang et al.

CURRENT CANCER DRUG TARGETS (2013)

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Targeting transcription factors: promising new strategies for cancer therapy

Jennifer E. Yeh et al.

CURRENT OPINION IN ONCOLOGY (2013)

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Wild-type p53 suppresses the epithelial-mesenchymal transition and sternness in PC-3 prostate cancer cells by modulating miR-145

Dong Ren et al.

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Therapeutic modulators of STAT signalling for human diseases

Gabriella Miklossy et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

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Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses

Michael J. Bolt et al.

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Twist: a molecular target in cancer therapeutics

Md Asaduzzaman Khan et al.

TUMOR BIOLOGY (2013)

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CRITERIA FOR AN UPDATED CLASSIFICATION OF HUMAN TRANSCRIPTION FACTOR DNA-BINDING DOMAINS

Edgar Wingender

JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY (2013)

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Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

Sabine Stolzenburg et al.

NUCLEIC ACIDS RESEARCH (2012)

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c-Jun, at the crossroad of the signaling network

Qinghang Meng et al.

PROTEIN & CELL (2011)

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The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer?

Simone Brabletz et al.

EMBO REPORTS (2010)

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FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance

J. Millour et al.

ONCOGENE (2010)

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Cancer Metastasis Is Accelerated through Immunosuppression during Snail-induced EMT of Cancer Cells

Chie Kudo-Saito et al.

CANCER CELL (2009)

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Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

Jose Miguel Lopez-Novoa et al.

EMBO MOLECULAR MEDICINE (2009)

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Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15,15′-Monooxygenase (Bcmo1) expression

Yusuke Seino et al.

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Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy

M. Schmitz et al.

BRITISH JOURNAL OF CANCER (2007)

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HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

Paola Gallinari et al.

CELL RESEARCH (2007)

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Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia:: results of the prospective multicenter LALA-94 study

N. Vey et al.

LEUKEMIA (2006)

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Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis

Craig Slattery et al.

FEBS LETTERS (2006)

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c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer

Marije M. Vleugel et al.

HUMAN PATHOLOGY (2006)

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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

J-C Marine et al.

CELL DEATH AND DIFFERENTIATION (2006)

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The antiproliferative agent MLN944 preferentially inhibits transcription

SA Byers et al.

MOLECULAR CANCER THERAPEUTICS (2005)

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The fallacy of epithelial mesenchymal transition in neoplasia

D Tarin

CANCER RESEARCH (2005)

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The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer

CJ Sweeney et al.

MOLECULAR CANCER THERAPEUTICS (2005)

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The effects of steroid hormones on the transcription of genes encoding enzymes of oxidative phosphorylation

K Scheller et al.

EXPERIMENTAL PHYSIOLOGY (2003)

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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

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EMBO JOURNAL (2002)

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Expression of Jun family members in human colorectal adenocarcinoma

HL Wang et al.

CARCINOGENESIS (2000)

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