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Summary: Due to protein kinase dysregulation, it has become crucial to target this enzyme family in many diseases, especially cancer. There are 72 FDA-approved drugs that target different protein kinases, with three of them receiving approval in 2022. These drugs target various types of protein kinases, and the majority are used to treat neoplasms and inflammatory diseases. This review provides a summary of the physicochemical properties of these drugs, including lipophilic efficiency and ligand efficiency.
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Cell Biology
Miriam Lisci et al.
Summary: Mitochondria, once viewed as ATP factories, have now been recognized as crucial regulators of cellular homeostasis. Recent research has revealed multiple roles of mitochondria in immune system cells, particularly in T cell differentiation and function. This article provides an overview of the diverse functions of mitochondria during T cell development, with a focus on CD8+ cytotoxic T lymphocytes (CTLs), and explores the impact of mitochondrial dysfunction on CTL exhaustion. Additionally, it highlights the newfound role of mitochondria as homeostatic regulators of CTL-mediated killing and discusses the mechanisms linking cytosolic and mitochondrial protein synthesis.
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BIOMEDICINE & PHARMACOTHERAPY
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DRUG DISCOVERY TODAY
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Environmental Sciences
Yasir Qasim Almajidi et al.
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ENVIRONMENTAL RESEARCH
(2023)
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Biochemistry & Molecular Biology
Lianne J. H. C. Jacobs et al.
Summary: Compartmentalisation of eukaryotic cells enables the coexistence of different cellular processes. Small redox molecules, in cooperation with proteins, establish specific subcellular redox compartments that support oxidative protein folding and redox signaling. Dysregulated redox homeostasis is directly linked to various diseases. This review focuses on the mechanisms regulating redox homeostasis in the mitochondrial subcompartments of mammalian cells.
Review
Oncology
Wentao Zeng et al.
Summary: Oncogene-induced hyper-proliferation in cancer cells leads to different stresses, including DNA-replication stress, metabolic stress, and oxidative stress. The excessive accumulation of reactive oxygen species (ROS) plays a crucial role in tumor progression by influencing cell signaling pathways. Cancer cells also rely on oxidative stress and increased iron demands to affect ferroptosis sensitivity. Targeting redox homeostasis and ferroptosis has become a promising approach to overcome drug resistance in cancer treatment. This review summarizes the current understanding of the interplay between redox regulation, ferroptosis, and oncogenic signaling in cancer biology, and discusses strategies for targeting oxidative stress and ferroptosis in cancer treatment.
INTERNATIONAL JOURNAL OF CANCER
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Chemistry, Medicinal
Jiangnan Zhang et al.
Summary: Mitochondrial quality control proteases play a crucial role in maintaining mitochondrial function, regulating cell development, and modulating cancer therapy. They degrade misfolded proteins, regulate mitochondrial morphology, and serve as promising targets for novel antitumor drugs.
MEDICINAL RESEARCH REVIEWS
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Cell Biology
Janeen H. Trembley et al.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
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Shrikant Purushottam Dharaskar et al.
Summary: Understanding cancer cell metabolism reveals hidden information about tumor adaptations. Warburg's theory of aerobic glycolysis in cancer cells is widely accepted, but doesn't explain the role of mitochondria in these cells. Our study shows that intact mitochondria are used for ATP production and anaplerotic functions with the help of TRAP-1, a mitochondrial chaperone, using glutamine. TRAP-1 also promotes aerobic glycolysis by lowering mitochondrial OXPHOS in the presence of glucose. Our findings establish the link between TRAP-1 and enhanced glutamine utilization, and suggest that TRAP-1 inhibitors can be used to target tumor metabolism.
Review
Cell Biology
Maria Parlani et al.
Summary: Energy deprivation in tumors, caused by mutations, malperfusion, hypoxia, and nutrition deficit, leads to adaptive responses in tumor cells, such as changes in migration modes and an enhanced capability for distant metastasis. Understanding the energy requirements of different cancer invasion modes offers possibilities for improving therapeutic targeting of metastatic cancer progression.
TRENDS IN CELL BIOLOGY
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Review
Chemistry, Multidisciplinary
Gan Lin et al.
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Review
Cell & Tissue Engineering
Ayoola O. Ogunleye et al.
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a poor prognosis. PDAC cells rely on various metabolic pathways for growth and metastasis. Cancer stem cells in PDAC tumors are heterogeneous and have specific metabolic dependencies. Understanding these metabolic alterations in cancer stem cells can lead to the development of novel therapeutic strategies.
Review
Cell Biology
Xiao-xia Zheng et al.
Summary: Previous studies have shown that mitochondria play core roles in cancer stem cell (CSC) metabolism, stemness maintenance, and differentiation, which are key regulators of cancer progression and therapeutic resistance. Understanding the regulatory mechanism of mitochondria in CSCs is expected to provide new targets for cancer therapy. This article introduces the roles of mitochondria and related mechanisms in CSC stemness maintenance, metabolic transformation, and chemoresistance and discusses clinical research progress on mitochondria-targeted drugs and their targeted strategies.
TRENDS IN CELL BIOLOGY
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Oncology
Xutong Qiu et al.
Summary: Oxidative phosphorylation (OXPHOS) plays a significant role in cancer progression, providing energy for tumor survival and regulating tumor proliferation, invasion, and metastasis. Alterations in OXPHOS impair immune function, leading to immune evasion. The relationship between OXPHOS and immune escape is crucial in cancer-related research.
Review
Oncology
Qingjing Wang et al.
Summary: Cancer is now recognized as a disease influenced by the tumor microenvironment (TME) rather than just a cellular and genetic disorder. Significant progress has been made in understanding the complexity of the TME and its impact on various anticancer therapies, particularly immunotherapies. Immunotherapy has shown promising therapeutic effects in treating solid tumors and hematological malignancies by leveraging the body's immune system to target and eliminate cancer cells. Recent advancements include the use of PD-1 and PD-L1 inhibitors, CAR-T cell therapy, and tumor vaccines. The TME plays a crucial role in tumor development, progression, and metastasis, making it an important focus for cancer immunotherapy research.
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Pharmacology & Pharmacy
Yang Li et al.
Summary: Cancer treatment is hindered by resistance to conventional therapeutic strategies, and redox homeostasis manipulation can effectively overcome drug resistance. Reactive oxygen species (ROS) regulate multiple signaling pathways and cancer cells upregulate their antioxidant system to cope with elevated ROS levels during therapy, resulting in therapeutic resistance. This review highlights the interplay between redox modification, signaling pathways, and therapeutic resistance, including altered drug efflux, action targets and metabolism, enhanced DNA damage repair, maintained stemness, and reshaped tumor microenvironment. A comprehensive understanding of these interrelationships can improve treatment efficacy.
FRONTIERS IN PHARMACOLOGY
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Article
Chemistry, Multidisciplinary
Yang Liu et al.
Summary: This study designs hybrid drug-loaded nanoliposomes to address the issues of multi-drug resistance and tumor microenvironment immunosuppression in glioblastoma patients. By co-loading TMZ, NO prodrug JS-K, and S1P molecules on the surface, the nanoliposomes exhibit rapid targeting and lysosomal escaping capabilities. Fine-tuned release of TMZ and generation of NO gas in the glioma microenvironment decrease chemoresistance and increase tumor immunogenicity. RNA sequencing analysis demonstrates that NO gas generation reprograms immune and inflammation-related pathways in the glioma microenvironment, effectively enhancing the efficacy of chemotherapy. Therefore, NO gas generated nanoliposomes have promising applications in the treatment of immunosuppressive diseases.
Review
Immunology
Chenicheri Kizhakkeveettil Keerthana et al.
Summary: AMPK is a crucial metabolic sensor involved in maintaining cellular energy homeostasis, with diverse effects on glucose and lipid metabolism. Abnormal AMPK signaling contributes to chronic diseases such as obesity, inflammation, diabetes, and cancer. AMPK activation modulates tumor cellular bioenergetics and has a suppressor role in tumor development and progression. It also plays a central role in the phenotypic and functional reprogramming of immune cells and regulates anti-tumor immune response through metabolic modulation and molecular crosstalk with immune checkpoints.
FRONTIERS IN IMMUNOLOGY
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Review
Genetics & Heredity
Muskan Chaddha et al.
Summary: Circulating cell-free nucleic acids (ccfNAs), including ssNA and dsNA, are released into the blood circulation by various cells through apoptosis, necrosis, and active secretion. They serve as potential biomarkers in assessing clinical conditions. The detection and analysis of ccfNAs, specifically ccf-mRNA, in clinical diagnosis and prognosis of cancer can potentially contribute to precision medicine.
FRONTIERS IN GENETICS
(2023)
Review
Oncology
Ayse Sedef Koeseer et al.
Summary: Tumor cells exhibit functional heterogeneity, and cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation properties. CSCs are found in most solid and hematological tumors and are characterized by various markers. These markers can be used to develop tumor-specific antibodies, immune cells, vaccines, and immune responses to tumor cells, including CSCs. This review discusses CSC-directed immunotherapies, their clinical development, safety and efficacy improvements, and future strategies for enhancing anti-CSC immunotherapy.
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Mauro Viganò et al.
Review
Oncology
Arundhati Mehta et al.
Summary: The immune function of T cells is influenced by lipid metabolism, which is also reprogrammed in T-cell malignancies to support their rapid division and other malignant characteristics. Specific lipid molecules are enriched in T-cell cancer, contributing to survival, migration, and angiogenesis. Lipid metabolic processes like de novo synthesis and lipid uptake provide energy reserves for T-cell cancer cells during metastasis. The balance between fatty acid synthesis and oxidation plays different roles in chemoresistance and rapid division. Additionally, lipid metabolism in T-cell cancer affects immune suppression and immune evasion. Targeting lipid metabolism in T-cell cancer shows promise in enhancing antitumor immunity and improving clinical management.
FRONTIERS IN ONCOLOGY
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Review
Pharmacology & Pharmacy
Tatyana I. Shabatina et al.
Summary: The development of antiviral treatment and anticancer theragnostic agents in recent decades has been closely associated with nanotechnologies, especially inorganic nanoparticles (INPs) made of metal and metal oxides. INPs, with their large specific surface area and high activity, can be easily functionalized for various applications such as targeted drug delivery, magnetic hyperthermia, and plasmonic photothermal therapies. The magnetic properties of iron oxide and ferrite nanoparticles make them ideal for magnetic resonance imaging and targeted cancer therapy. Moreover, gold and silver nanoparticles show promise in plasmonic photothermal and antiviral therapies, respectively.
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Chemistry, Multidisciplinary
Zheng Li et al.
Summary: Subcellular targeted cancer therapy has emerged as a potent anticancer treatment, providing great opportunities for clinical application. This review summarizes two targeting strategies for four main subcellular organelles, including molecule- and nanomaterial-based targeted delivery or therapeutic strategies. Various treatment strategies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, and combination therapy are discussed in detail. The construction of specific materials based on the properties and mechanisms of organelles allows for the elimination of tumors by inducing dysfunction or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. A paradigm for organelle-targeting therapy with enhanced therapeutic efficacy is envisioned.
ADVANCED MATERIALS
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Review
Immunology
Sandra Kannampuzha et al.
Summary: Lung cancer is a major cause of cancer-related deaths. The altered metabolism of cancer cells results in changes in metabolite concentrations, which can be used to identify distinct metabolic patterns for cancer detection. Understanding and analyzing the variations in metabolites can provide early biomarkers and insights into the progression and type of lung cancer.
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Engineering, Biomedical
Zhaoyu Ma et al.
Summary: Mitochondria play critical roles in regulating the proliferation and apoptosis of cancer cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems has attracted increasing attention in recent years. Understanding the mechanisms of mitochondrial dysfunction is important for efficient disease treatment and translating therapeutic strategies into the clinic.
Review
Oncology
Anshika Goenka et al.
Summary: Tumor development and metastasis are influenced by the complex interactions between cancer cells and their microenvironment, which includes stromal cells and extracellular matrix components. Understanding the signaling pathways involved in these interactions is crucial for developing effective intervention strategies. This review provides a comprehensive analysis of the diverse signaling pathways in the tumor microenvironment, highlighting the latest preclinical and clinical studies and their underlying biology.
CANCER COMMUNICATIONS
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Review
Oncology
Steven Tau et al.
Summary: While anti-cancer drug treatments can effectively manage cancer, they often result in drug-tolerant persister cancer cells that can cause recurrence. Understanding how these dormant cancer cells survive and emerge from dormancy is crucial for developing better therapeutic strategies. Metabolic adaptations in cancer cells offer potential vulnerabilities that can be targeted therapeutically. This review discusses the mechanisms of metabolic adaptation in cancer cells during drug treatments and highlights emerging strategies to target dormant cancer cells based on their metabolic features.
CANCER AND METASTASIS REVIEWS
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Article
Cell Biology
Chin-Hsien Tsai et al.
Summary: T cell-mediated immunosurveillance in early-stage tumorigenesis guides metabolic reprogramming in tumor cells through non-canonical interferon gamma (IFNg)-STAT3 signaling, leading to immune evasion and the formation of a suppressive tumor microenvironment.
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Biology
Aisha Farhana et al.
Summary: Breast cancer has a high prevalence in females worldwide, and its treatment poses persistent challenges. This study explores the therapeutic potential of gold nanoparticles (AuNPs) in the regulation of microRNA and the protein MMP-9. The results show that AuNPs inhibit MMP-9 expression through the upregulation of microRNA-204-5p in breast cancer cells. Additionally, AuNPs also inhibit NF-?B activation. These findings demonstrate the novel therapeutic role of AuNPs in breast cancer.
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Chemistry, Multidisciplinary
S. M. Hosseini et al.
Summary: Theranostic is a revolutionary topic in cancer treatment, combining therapeutic and diagnostic. Nanoscale carriers have great potential as platforms in theranostic applications.
MATERIALS TODAY CHEMISTRY
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Engineering, Biomedical
Biao Liu et al.
Summary: Cancer stem cells (CSCs) have been a major challenge due to their resistance to chemotherapy and tumor relapse. Aptamers, as chemical anti-bodies, have emerged as a promising tool to target CSCs. They possess advantages such as lower immunogenicity and smaller size, making them superior to conventional antibodies. This review focuses on recent advances in aptamer-drug conjugates against CSCs and discusses the advantages and limitations of different aptamer-based targeted therapies.
MATERIALS TODAY BIO
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Medicine, Research & Experimental
Shiqi Nong et al.
Summary: Cancer cells require altered metabolic processes to sustain their uncontrolled growth and proliferation. This metabolic reprogramming is mediated by various factors and involves multiple pathways, contributing to the resistance of tumor cells to traditional therapies. Understanding these changes in cancer metabolism can guide the development of new therapeutic approaches. This review provides an overview of the metabolic changes in tumor cells, their regulation, current treatment methods, and potential future treatments.
Review
Biochemistry & Molecular Biology
Yan Zhang et al.
Summary: Lactate is a byproduct of glycolysis that serves as both an energy source for mitochondrial respiration and a precursor for gluconeogenesis. It also acts as a multifunctional signaling molecule through receptor-mediated processes, influencing various biological functions such as lipid metabolism, immune regulation, inflammation, wound healing, and exercise performance. Additionally, lactate has been found to play a role in epigenetic gene regulation through the lactylation of histones, impacting immune modulation and homeostasis. This article summarizes the functions and mechanisms of lactate and lactylation in tumor metabolism and microenvironment.
Review
Oncology
Alexander Ring et al.
Summary: In recent years, advancements in technology have allowed for the identification and study of rare circulating tumor cells (CTCs) from blood samples, leading to new research fields and potential clinical applications in liquid biopsies. Analysis of CTCs has revealed unique biological characteristics, such as the presence of CTC clusters and interactions with immune or stromal cells, impacting metastasis formation and providing insights for cancer vulnerabilities. This review discusses progress in understanding the biological features of CTCs and explores the potential for designing future clinical tools to improve cancer diagnosis and treatment.
NATURE REVIEWS CANCER
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Meeting Abstract
Oncology
Bradley R. Larson et al.
Review
Pharmacology & Pharmacy
Lu Liu et al.
Summary: Macrophages play a dual role in cancer development and are being explored as targets and tools for cancer theranostics. This article provides an overview of the mixed roles of macrophages in cancer pathogenesis and highlights the latest progress in macrophage-based cancer theranostic strategies, focusing on targeting tumor-associated macrophages and engineering adoptive macrophages to enhance immunosuppression and improve therapeutic efficacy.
ADVANCED DRUG DELIVERY REVIEWS
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Review
Oncology
M. Cisneros-Villanueva et al.
Summary: Cell-free DNA analysis is a promising method for the diagnosis and treatment selection of cancer patients. Despite the need for standardization and technical validation, numerous clinical trials have shown its potential in early cancer detection and treatment improvement.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Angelina Tjokrowidjaja et al.
Summary: This study explores the prognostic and predictive value of lactate dehydrogenase (LDH) in advanced non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). The findings suggest that elevated pretreatment LDH is associated with worse prognosis, regardless of treatment. Persistently elevated on-treatment LDH is also associated with decreased overall survival (OS) rates.
Review
Cell Biology
Huan Zhang et al.
Summary: Exosomes play a crucial role in pancreatic cancer by facilitating intercellular communication, promoting cancer progression and metastasis, and serving as potential biomarkers for targeted therapy.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Cell Biology
Natalya N. Pavlova et al.
Summary: The metabolism of cancer cells is highly adaptable, allowing them to sustain growth and proliferation. This adaptation can also influence the behavior of non-transformed cells in the tumor vicinity.
Review
Immunology
Darren R. Heintzman et al.
Summary: T cell metabolism is dynamic and highly regulated, playing a crucial role in differentiation and function patterns; the ability of cells to acquire nutrients and cope with hostile environments can limit metabolic pathways; changes in physical conditions and nutrient availability shape immune responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hardev Singh et al.
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Oncology
Tahere Dadgar et al.
Summary: Cancer stem cells (CSCs) play a significant role in tumor metastasis and resistance to treatment. Their unique metabolic properties make them more sensitive to agents that disrupt cellular homeostasis. Understanding the differences between CSC metabolism and regular cancer cells can help develop effective treatments.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manuela Sollazzo et al.
Summary: Mitochondria play crucial roles in cellular bioenergetics and biosynthetic processes, producing signals that regulate molecular networks governing proliferation and cell death. Even in pathological contexts like tumorigenesis, mitochondrial dysfunction can confer flexibility favoring cancer cell survival. Despite initial growth delays, cancer cells with respiratory complex I impairment may adapt to resume proliferation through molecular mechanisms.
Article
Biochemistry & Molecular Biology
Irena Hudecova et al.
Summary: Current evidence suggests that plasma cell-free DNA (cfDNA) is fragmented around 166 bp. A novel population of ultrashort plasma cfDNA fragments centered at 50 bp was discovered, showing higher relative abundance in healthy individuals compared to cancer patients. These ultrashort cfDNA fragments map to accessible chromatin regions of blood cells, particularly in promoter regions with the potential for G-quadruplex DNA secondary structures. G4-positive promoter chromatin accessibility is significantly enriched in ultrashort plasma cfDNA fragments from healthy individuals relative to cancer patients.
Review
Biochemistry & Molecular Biology
Deepa Mundekkad et al.
Summary: This review introduces the application of nanoparticles in cancer therapy, which surpasses the conventional drug delivery methods by encapsulating drug ingredients and delivering them efficiently to the tumor site. The review also discusses the obstacles in bringing nanodrugs from clinic to market, as well as the latest developments in using nanoparticles in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yang-Hsiang Lin et al.
Summary: Mitochondrial DNA plays a significant role as a genetic biomarker in disease, cancer, and evolution. It functions as a modulator for regulating cellular metabolism and its variations and dysregulation are associated with cancer patient survival outcomes. Additionally, nuclear-encoded genes regulate mitochondrial homeostasis by controlling the expression of mitochondria-encoded genes. The crosstalk between nuclear and mitochondrial genomes is crucial for cellular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ornella Morana et al.
Summary: Cancer growth is characterized by an imbalance between cell gain and cell loss, with high-grade cancers often having high levels of apoptosis. While cell-autonomous apoptosis serves as a tumor suppressor mechanism, limited apoptosis can promote cell survival and resistance to therapy by conditioning the tumor microenvironment. Understanding the implications of cell death programs in tumor biology is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Wang et al.
Summary: Gasdermin E (GSDME) is highly expressed in oral squamous cell carcinoma (OSCC) and is associated with better prognosis. Chemotherapy drugs can induce GSDME-mediated pyroptosis, and the loss of GSDME function attenuates the anti-tumor effect of cisplatin.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Jafar Rezaie et al.
Summary: The communication between tumor cells and resident cells in the tissue environment is mediated through the secretion of particles called extracellular vesicles (EVs). These EVs play vital roles in tumorigenesis, including pre-metastatic niche formation and organotropic metastasis, by altering the tissue microenvironment and inducing phenotypic alterations in cells. EVs have potential therapeutic applications in cancer management as targeted therapy, cell-free therapy, drug delivery system, and diagnostic biomarker.
Review
Biochemistry & Molecular Biology
Xin Lian et al.
Summary: Cellular metabolism plays a crucial role in cancer initiation and progression. While the metabolic alterations in cancer cells have been extensively studied, the metabolic states of immune cells in the tumor microenvironment (TME) are less well understood. This review focuses on the impact of oncometabolites on immune cell function and the clinical significance of targeting metabolism in anti-tumor immunotherapy. The metabolic changes in the immune system of TME provide novel therapeutic insights for cancer treatment.
Review
Oncology
Thomas Simon et al.
Summary: This review provides an in-depth description of the cellular heterogeneity of CAF subpopulations in tumors, defines 4 main CAF subpopulations, and introduces a model for the evolution of CAFs during tumor development. Additionally, the molecular characteristics of tumor-inhibitory CAFs in the TME and their potential cellular origins are discussed.
MOLECULAR CANCER RESEARCH
(2022)
Review
Oncology
Lukas Kraehenbuehl et al.
Summary: The discovery and clinical implementation of immune-checkpoint inhibitors like CTLA4, PD-1, and PD-L1 have significantly improved outcomes for patients with advanced-stage cancers. However, a majority of patients do not respond to these agents, emphasizing the need for further research into alternative immunomodulatory pathways and targeting tumor metabolism to enhance treatment efficacy.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Zachary E. Stine et al.
Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Rimsha Munir et al.
Summary: This review discusses the potential anti-tumor therapy targeting fatty acid metabolism, identifying the clinically viable inhibitors or drugs and their significance in inhibiting cancer cell progression. It also assesses the mechanisms of action, limitations, and future perspectives of these compounds.
PROGRESS IN LIPID RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
A. Justin Rucker et al.
Summary: Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 play crucial roles in regulating cell death and inflammation, and tumors have found ways to exploit them for their own benefit. RIPK-driven cell death can enhance antitumor immunity, but it can also induce inflammation and aid tumor progression.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Oncology
Douglas Hanahan
Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.
Article
Cell Biology
Mrittika Chattopadhyay et al.
Summary: This study reveals that mitochondrial DNA in the normal liver plays a role in shaping tumor progression, histology, and immune environment before the acquisition of oncogenic mutations. The activation of oncogenic mutations in the liver with positive mitochondrial unfolded protein response (UPRmt) leads to increased tumor incidence and histological heterogeneity. Additionally, a subset of UPRmt-positive mice develops invasive liver cancers, and the PAPP-A signature of invasion and elevated collagen pre-exist in these mice. The PAPP-A signature also identifies the immune exhausted subset of hepatocellular carcinoma (HCC) in humans.
Review
Geriatrics & Gerontology
Xiaoxian Xie et al.
Summary: Mitochondrial dysfunction plays a crucial role in various diseases, and AKT, as a serine/threonine kinase, exerts important roles in cell metabolism and oxidative state regulation through modulating different mechanisms related to mitochondria.
Review
Immunology
Yuqin Niu et al.
Summary: Tumorigenesis often involves chronic inflammation and the tumor microenvironment (TME) consists of various cells and extracellular components. Tumor cells and other cells undergo genetic and epigenetic alterations in the TME, with macrophages being the most plastic immune cell type and playing a crucial role in these alterations.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Beatrice Aramini et al.
Summary: Cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, and metastasis. They share characteristics with normal stem cells, such as self-renewal and differentiation potential. CSCs establish their niche, a unique microenvironment within the tissue, which sustains their functions. The interactions between CSCs and their niches regulate their self-renewal and tumorigenesis. Understanding the primary mechanisms involved in CSC tumorigenesis is essential for developing targeted therapies. Moreover, CSCs' resistance to standard treatments and their phenotypic plasticity pose challenges in cancer therapeutics.
Article
Oncology
Esther Mettler et al.
Summary: This study demonstrates that the combination of plasma cfDNA concentration, global hypomethylation, and fragment length pattern has the potential to serve as a potent and sensitive prognostic and therapeutic liquid biopsy biomarker for tumor burden and disease progression in patients with neuroendocrine neoplasias.
Review
Cell Biology
Ji-Yong Sung et al.
Summary: Immunometabolism is an emerging discipline in cancer immunotherapy that focuses on the metabolic competition between tumor cells and immune cells for limited nutrients. This competition influences the anticancer immune response and understanding it can aid in developing novel therapeutic approaches for cancer.
Review
Cell Biology
Yu Geon Lee et al.
Summary: Mitochondria, as important organelles, play a vital role in the processes of oncogenesis. Cancer cells activate a stress response to maintain mitochondrial function and survive in harsh environments, which contributes to cancer progression.
Review
Cell Biology
Elizabeth R. Stirling et al.
Summary: This review focuses on the metabolic alterations in immune and cancer cells regulated by currently approved immune checkpoint target proteins and the effect of costimulatory receptor signaling on immunometabolism. Additionally, it explores how diet and the microbiome impact immune checkpoint blockade therapy response.
Review
Pharmacology & Pharmacy
Yang Hao et al.
Summary: Photodynamic therapy (PDT) is a promising method for therapeutically targeting primary tumors. However, it is not sufficient to completely eliminate deep tissue tumors on its own. Therefore, PDT can be combined with other treatment methods based on the characteristics and type of the tumor. Nanoparticles as delivery vehicles can overcome the limitations of traditional photosensitizers and enable the co-delivery of multiple therapeutic drugs.
Review
Cell Biology
Boris Guyot et al.
Summary: Understanding the mechanisms of cancer development is crucial for disease prevention and management. The microenvironment plays a significant role in regulating stem cell fate, and dysregulation of the BMP signaling pathway is associated with the emergence and expansion of cancer stem cells. This review focuses on the dysfunction of stem cells and their microenvironment in cancer, particularly in myeloid leukemia and breast cancers, through the hijacking of BMP signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosamaria Pennisi et al.
Summary: Nanotechnological progress has opened up new possibilities for improving conventional anticancer therapies, and graphene nanoplatforms have proven to be effective carriers for multiple bioactive compounds. The use of graphene engineered with cyclodextrins (GCD) has shown promising results in modulating cancer-related pathways and reducing toxic effects of drugs such as Doxorubicin (DOX).
Review
Biochemistry & Molecular Biology
Baoyi Liu et al.
Summary: The development of brain metastasis in breast cancer patients is a significant contributor to death, with limited effective treatment options available. Metabolic changes associated with cellular metastasis have been observed in primary breast cancer or brain metastases, highlighting the importance of understanding metabolic characteristics at each step of the metastatic cascade for developing efficient treatments.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Biswa Mohan Sahoo et al.
Summary: This article introduces the definition and generation pathways of Reactive Oxygen Species (ROS), as well as their role in the development of cancer. ROS can act as tumor-suppressing or tumor-promoting agents, and their increased levels can inhibit tumor growth or induce apoptosis. However, high levels of ROS can also lead to the formation of malignant tumors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Ibrahim Barnawi et al.
Summary: This study investigated the sensitivity and resistance of breast cancer and glioma cells to chemotherapy drugs, as well as the expression of nitric oxide synthase and apoptosis-regulating proteins. The results showed that A172 cancer cells had higher resistance to chemotherapy drugs and this resistance might be related to the expression of endothelial nitric oxide synthase.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Adeleh Sahebnasagh et al.
Summary: This review focuses on the immunomodulatory role of nitric oxide (NO) in cancer and recent advancements in the use of NO donors in immunotherapy. It is suggested that low/moderate levels of NO may promote tumorigenesis, while higher levels have anti-tumor effects. The use of NO donors in immunotherapy shows therapeutic potential, although clinical trials are lacking.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Katerina Honigova et al.
Summary: Metabolic plasticity is an important characteristic of cancer cells in tumorigenesis, allowing them to reshape metabolic pathways to support increased energy demands. The selective pressures in the tumor microenvironment force cancer cells to adapt by reorganizing their metabolism. Understanding metabolic reprogramming is crucial for developing targeted therapies for cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Medicine, Research & Experimental
Huixiao Yuan et al.
Summary: This study verified circFARSA as a novel target for pancreatic cancer treatment and prepared a novel anti-pancreatic cancer agent. The agent effectively inhibited the proliferation and migration of pancreatic cancer cells and showed good biological safety and anti-cancer effects in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Engineering, Environmental
Duc Dung Nguyen et al.
Summary: ITNPs are a special class of nanomaterials with intrinsic therapeutic capabilities, which can be utilized to treat diseases associated with oxidative stress, inflammation, angiogenesis, and infection. Recent advancements in the field of nanotherapeutics have been significantly influenced by ITNPs.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Oncology
Pierre L. Triozzi et al.
Summary: In this study, the bioenergetics of circulating immune cells and the metabolomic profiles of plasma were compared in melanoma patients treated with anti-PD-1 therapy. It was found that patients who responded to the therapy had higher respiratory capacity and glycolytic activity compared to nonresponders. Metabolomic analysis also revealed differences in metabolic signatures between responder and nonresponder patient samples. The study suggests that blood bioenergetics and metabolomics can be used as predictive biomarkers for patient response to immune checkpoint inhibitor therapy.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Adriana Romo-Perez et al.
Summary: Gastric cancer causes significant metabolic alterations including high rates of glycolysis, glutaminolysis, de novo fatty acid synthesis, and cholesterol synthesis. Blocking these pathways simultaneously may reduce metabolic flexibility and enhance treatment efficacy.
CURRENT CANCER DRUG TARGETS
(2022)
Review
Chemistry, Medicinal
Shivaputra A. Patil et al.
Summary: This review summarizes the use of different classes of citrate transporter inhibitors for anticancer activity, either individually or as part of a chemotherapy strategy.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Wenzhen Du et al.
Summary: With the rapid growth of nanomedicine research, subcellular-delivery nanosystems (SDNSs) have become a research focus in the field of cancer treatment. Nuclear-targeted SDNSs, which deliver therapeutic agents and assist various treatment methods, may have the potential for precise cancer treatment. This review summarizes the latest progress of nuclear-targeted SDNSs for cancer treatment, discusses the possible mechanisms of SDNSs entering the nucleus, its applications in cancer treatment, and highlights the promising future of SDNSs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Gastroenterology & Hepatology
Pai-Chi Teng et al.
Summary: Serum alpha-fetoprotein and radiologic imaging are commonly used tests for early diagnosis and treatment monitoring of hepatocellular carcinoma (HCC), but their accuracy is limited. Developing novel HCC biomarkers reflecting tumor biology is an unmet need. Circulating tumor cells (CTCs) have potential as a noninvasive biomarker for HCC, offering molecular and functional data that can reflect the underlying tumor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Kosuke Miyakuni et al.
Summary: The study revealed the role of DNA hypermethylation in ccRCC progression, including identifying DNMT targets, regulating cell apoptosis, affecting mitochondrial complex III components, and enhancing treatment efficacy to impact tumor progression.
MOLECULAR ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritama Paul et al.
Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Physiology
Eva Crosas-Molist et al.
Summary: This review examines the role of Rho GTPase signaling in different stages of cancer progression, highlighting its importance in tumor initiation, proliferation, and metastasis, as well as its involvement in cell migration, interaction with the tumor microenvironment, and inflammation regulation.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Oncology
Abbas Salihi et al.
Summary: Nitric oxide, carbon monoxide, and hydrogen sulfide, serving as endogenous gasotransmitters, can disrupt the interactions between cancer cells and drug treatments, providing potential for developing effective cancer therapies.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Conglian Yang et al.
Summary: This article discusses the design principles and strategies of bioreactor-based drug delivery systems and summarizes their advantages and applications in various fields. It emphasizes the applications of bioreactor-based drug delivery systems in the treatment and diagnosis of cancer, inflammatory bowel disease, Alzheimer's disease, and other diseases.
Article
Multidisciplinary Sciences
Jarred W. Rensvold et al.
Summary: Mitochondria, as the epicentres of eukaryotic metabolism and bioenergetics, are linked to numerous diseases. However, the functions of many mitochondrial proteins are still unclear, and the genetic basis of many mitochondrial disorders remains unresolved. Through mass spectrometry-based multiomics analyses, we have established a comprehensive functional compendium of human mitochondrial proteins, providing a foundation for mechanistic investigations and genetic diagnosis of mitochondrial diseases. Our findings have identified specific proteins associated with mitochondrial function and disorders, and defined a rich cell signature of mitochondrial dysfunction.
Article
Biotechnology & Applied Microbiology
Mohammad Shahrokh Esfahani et al.
Summary: EPIC-seq is a method that predicts gene expression levels at individual genes from cfDNA. We demonstrate the potential of EPIC-seq in cancer subtype classification and prediction of clinical response.
NATURE BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Di Zhu et al.
Summary: Mitochondrial changes associated with aging play a crucial role in the aging process by modulating epigenomes through communication with the nucleus.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Brittany Rupp et al.
Summary: The mutational and phenotypic landscape of tumors is dynamic, and constant monitoring of cancer patients using liquid biopsy can provide important tumor information for diagnosis, prognosis, and treatment.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Lin Zhao et al.
Summary: Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells. Reprogrammed energy metabolism affects the development of tumor suppressive immune microenvironment and the progression of gastric cancer (GC). The tumor microenvironment (TME) has important clinical and pathological significance in predicting prognosis and therapeutic efficacy. Understanding the targeted metabolism of metabolic reprogramming can enhance anti-tumor immune responses and provide direction for the treatment and prognosis of GC.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Chandler D. Gatenbee et al.
Summary: Integration of mathematical modeling, ecological analyses, and neoantigen prediction suggests that recruitment of immunosuppressive cells is crucial for the transformation from adenoma to carcinoma in colorectal cancer. The dynamics of tumor initiation remain unknown, but the interaction between neoplastic cells and the immune system is believed to play a critical role in this process.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Adam E. Hall et al.
Summary: This study identifies dysregulated RNA splicing as a key driver of tumour cell plasticity in colorectal cancer. The splicing factor SRSF1 controls Kras splicing and maintains stemness in CRC cells, and its expression correlates with cancer stem cell markers in human tumours.
NATURE COMMUNICATIONS
(2022)
Review
Cell & Tissue Engineering
Feng Ju et al.
Summary: This review summarizes the latest findings on the morphology, signaling pathways, and interactions of cancer stem cell (CSC) niches, as well as the genetic and epigenetic modulations involved in CSC maintenance. The crosstalk between CSCs and their niche plays a crucial role in therapy resistance and recurrence.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Song Yan et al.
Summary: Cellular metabolism affects the function of decidual NK cells, with glycolysis blockage enhancing VEGF-A production but restraining proliferation, and inhibition of glycolysis or oxidative phosphorylation decreasing secretion of IFN-γ and TNF-α. Furthermore, disruption of metabolic processes has minimal effects on secretion and degranulation of dNK cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Pauline Gilson et al.
Summary: Malignant tumors exhibit high levels of heterogeneity at both molecular and phenotypic levels, which poses challenges for patient management. This heterogeneity exists between patients and even within a single patient over space and time. Current treatment decision-making often only considers the molecular characteristics of a limited tumor tissue sample, without taking into account the complexity and continuous evolution of bulk tumors. This review explores the extent of tumor heterogeneity, focusing on intra-tumor heterogeneity (ITH), and discusses the mechanisms that promote and sustain this diversity in cancers. The clinical implications of ITH in the management of cancer patients are summarized, along with discussions on current approaches to adequately appreciate ITH.
Review
Oncology
Yangjing Zhao et al.
Summary: This review summarizes and discusses the relationship between GPX1 genetic polymorphisms and cancer susceptibility, as well as the dichotomous roles of GPX1 aberrant expressions in tumorigenesis. It highlights the importance of GPX1 as a potential prognostic biomarker and novel therapeutic target in various malignancies.
Review
Cell Biology
Giovanni Luca Beretta et al.
Summary: Necroptosis is a cell death mechanism characterized by inflammatory reactions and is involved in viral defense, inflammatory diseases, and drug response of tumors such as prostate cancer.
Article
Cell Biology
Gloria Campioni et al.
Summary: Three-dimensional cancer models provide a more accurate representation of tumor architecture for studying cancer metabolism. However, the application of Seahorse XFe96 technology to three-dimensional cultures needs optimization. The researchers developed an optimized workflow for Seahorse metabolic analysis of three-dimensional cultures, ensuring regular and uniform spheroid formation and reducing variability in metabolic parameters. High-resolution imaging allowed for quantitative analysis and comparison of spheroids.
Review
Oncology
Anthony J. Murphy et al.
Summary: Alternative splicing plays a crucial role in diversifying the proteome and has significant implications in cancer development. Recent studies have highlighted the important roles of SR proteins in cancer progression. Understanding the spliceosome and its relationship to cancer has opened up new opportunities for therapeutic interventions based on alternative splicing.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Dillon P. Boulton et al.
Summary: Mitochondria are highly dynamic organelles that change their shape through fission and fusion processes to adapt to different environments and developmental contexts. Dysregulated fission and fusion promote tumor progression, affecting tumor cell growth, metabolism, motility, and invasion, and impacting metastasis. It has been found that mitochondrial fission positively influences metastatic potential in various types of tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Peter B. Gahan et al.
Summary: This article discusses the early structure of DNA, its involvement in gene structure, and the mobility of cfDNA within and between cells and tissues. It then provides an overview of the current status of cfDNA studies and the clinical applications of ctDNA. The future developments and roles of ctDNA are also considered.
Review
Oncology
Xueman Chen et al.
Summary: Cancer cells interact with cellular and non-cellular components in the host internal environment to create a self-sustainable tumor ecosystem. Recent evidence suggests that targeting the vulnerability of this ecosystem could revolutionize cancer therapy. This review comprehensively examines the interaction between cancer cells and the local tumor microenvironment, distant organ niches, immune, nervous and endocrine systems, with a focus on material and energy flow.
CANCER COMMUNICATIONS
(2022)
Review
Oncology
Rongbin Ge et al.
Summary: This review discusses the heterogeneity of prostate cancer, focusing on how non-genetic factors and treatment methods contribute to tumor heterogeneity, as well as the challenges of targeting the tumor environment. The author emphasizes the importance of continued research on tumor heterogeneity in order to offer personalized therapy for prostate cancer.
NPJ PRECISION ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Pratibha Pandey et al.
Summary: Immunotherapy has made significant progress in cancer treatment through blocking immunological checkpoint pathways. Recent studies have shown that combining immune checkpoint inhibitors with other anticancer drugs can improve their effectiveness. Immune checkpoint blockade also aids in inhibiting angiogenesis and enhancing the immune system's efficacy.
Review
Andrology
Xinyu Geng et al.
Summary: Prostate cancer is a common tumor in the male genitourinary system, with bone metastasis being a significant complication. Exosomes and integrins have been found to be closely related to bone metastasis of prostate cancer, and their role in prevention, monitoring, and treatment is of great importance.
Review
Biochemistry & Molecular Biology
Lourdes Sainero-Alcolado et al.
Summary: The research field of cancer metabolism has been based on the Warburg effect for decades, but recently the key role of mitochondria in cancer development has been demonstrated. Mutations in oncogenes, tumor suppressor genes, and metabolic enzymes alter various mitochondrial pathways in tumors, leading to metabolic reprogramming that sustains rapid cell proliferation and the utilization of reactive oxygen species by cancer cells. The knowledge acquired on mitochondrial cancer metabolism is now being translated into clinical practice, where detailed analysis of tumors is necessary to develop more precise treatments. Drugs targeting metabolic mitochondrial enzymes have shown potential in precision medicine, but efficient personalized drugs remain challenging to develop and may require combination with other strategies.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Engineering, Environmental
Xinzhu Shan et al.
Summary: This review discusses the application of prodrug-engineered nanomedicines in synergistic chemo-phototherapy. They offer advantages of synergistic treatment effect and dosage reduction, but also face challenges in design rationale.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Oncology
Sameer Ullah Khan et al.
Summary: Anchorage-independent survival of cancer cells is crucial for metastasis and understanding the molecular events leading to anoikis resistance can help identify therapeutic targets against cancer cell dissemination and secondary tumor formation.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Biophysics
Urushi Rehman et al.
Summary: Ovarian cancer is a major cause of death in women, and there is a need for innovative treatment approaches. RNA interference and nanotechnology can improve ovarian cancer therapy and overcome chemo-resistance. Nanoparticles are used to transport siRNA molecules to the targeted site, enhancing the therapeutic potential.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Oncology
Elisa Fontana et al.
Summary: Circulating tumour DNA (ctDNA) is a minimally invasive tool with significant therapeutic and diagnostic potential in gastrointestinal malignancies. Recent studies have shown its value in assessing prognosis, guiding intervention, and detecting early responses and resistances to therapies. Its utility in early cancer detection is particularly relevant in gastrointestinal cancers with limited screening programs and poor outcomes for metastatic patients.
CURRENT OPINION IN ONCOLOGY
(2022)
Review
Immunology
Kota Itahashi et al.
Summary: Treg cells play a crucial role in maintaining self-tolerance and preventing the development of autoimmune diseases. However, in tumors, there is an abundance of Treg cells that suppress antitumor immunity, promoting tumor development and growth. Therefore, understanding tumor-infiltrating Treg cells is essential for the development of Treg cell-targeted therapies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Laura Urbanski et al.
Summary: This study identifies a network of co-expressed splicing factors in MYC-active breast tumors, including a pan-cancer splicing factor module that correlates with MYC activity. It demonstrates that MYC activation leads to upregulation of pan-cancer module splicing factors and changes in splicing events in breast cancer models. Additionally, a MYC-activity pan-cancer splicing signature is associated with survival across tumor types.
Review
Biochemistry & Molecular Biology
Alexandra Wagner et al.
Summary: Mitochondria play a crucial role in cellular metabolism and bioenergetics, and are involved in cancer development and treatment response. Studying the genetic and epigenetic control of mitochondria can provide insights into cancer therapy response and aid in the development of new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Changduo Wang et al.
Summary: The development of a targeted gene/drug co-delivery nano system provides a potential strategy to combat multidrug resistance by suppressing drug efflux pumps and modulating autophagy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Peng He et al.
Summary: This review presents recent advances in the biomolecule-mimetic synthesis of functional nanomaterials for photothermal therapy (PTT) and photodynamic therapy (PDT) of cancers. It introduces different biomimetic synthesis methods and discusses the advantages of each method. The review also explores the synthesis of nanomaterials using biomolecules and discusses how to regulate the structure and functions of the obtained biomimetic nanomaterials. Additionally, potential applications of biomimetic nanomaterials for both PTT and PDT of cancers are demonstrated and discussed.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Oncology
Yuheng Yan et al.
Summary: This article reviews the metabolic characteristics of Treg cells, discusses the differences in metabolism between Treg cells and other conventional T cells, and explores the critical roles of different metabolic programs in regulating Treg cell function. These studies provide new insights into Treg cell-targeted antitumor immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Haohao Li et al.
Summary: Reversing T-cell exhaustion in the tumor microenvironment through metabolic reprogramming is found to be closely related to the therapeutic efficacy of immune checkpoint inhibitors (ICIs). Targeting T-cell metabolism holds promise in improving drug tolerance and enhancing anti-tumor effects. Developing methods to alter T-cell metabolism could significantly contribute to the clinical effectiveness of ICI therapy and predicting treatment responsiveness in patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Andras Telekes et al.
Summary: The review evaluates the current status of cell-free DNA and its ctDNA fraction in cancer patients, highlighting their potential utility in diagnosis, prognosis, treatment selection, and monitoring disease progression. Despite ongoing research and clinical validations, ctDNA testing has the potential to become a routine part of patient care in the future.
Review
Oncology
Eva Kocianova et al.
Summary: This review discusses the role and significance of lactate in cancer, as well as recent findings on lactate metabolism and signaling pathways in cancer.
Review
Oncology
Styliani Papadaki et al.
Summary: Cancer cells rely on glycolysis for energy production, while cancer stem cells have the ability to switch between glycolysis and oxidative phosphorylation depending on their energy needs and stimuli from the microenvironment, with this metabolic plasticity being associated with therapy resistance.
Review
Oncology
Anna L. M. Smith et al.
Summary: Advancing age and cancer development are both associated with mitochondrial dysfunction, and mtDNA mutations may play a significant role in age-related cancer development. However, the specific mechanisms by which mtDNA mutations contribute to tumor progression remain unclear.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chang Ying et al.
Summary: This study reveals that interfering cellular pH may provide a valuable approach to treat cancer.
Review
Geriatrics & Gerontology
Yu Pan et al.
Summary: Senescent cells secrete SASP factors, which have both beneficial and deleterious effects on biological processes. The underlying mechanisms of SASP's pleiotropic influence are still largely unknown, but it can alter cellular states through regulating stem cell differentiation. Cells undergo behavioral changes when exposed to SASP, contributing to various senescence-associated physiological and pathological phenomena.
REJUVENATION RESEARCH
(2022)
Review
Multidisciplinary Sciences
Hiroshi Kobayashi
Summary: This review summarizes the metabolic profiles and adaptation of epithelial ovarian cancer (EOC) to the dynamic tumor microenvironment, and discusses potential therapeutic strategies. EOC cells rely on glycolysis, oxidative phosphorylation (OXPHOS), or both for survival. Environmental stresses can reprogram metabolic pathways to adapt. Interaction between tumors and stromal cells allows cancer cells to enhance mitochondrial energy metabolism.
Article
Biochemistry & Molecular Biology
Shreya Bandopadhyay et al.
Summary: SIRT6 plays a crucial oncogenic role in ovarian cancer by enhancing glycolysis and oxidative phosphorylation in cancer cells, promoting migration and invasion. Its mechanism involves promoting ERK1/2-driven activatory phosphorylation of DRP1 at serine-616, inducing mitochondrial fission and facilitating cell movement important for metastasis. The downregulation of SIRT6 leads to decreased cellular invasion through compromised mitochondrial fragmentation and reduction in stress fiber formation in ovarian cancer cells.
Article
Biochemistry & Molecular Biology
Kelly Ascencao et al.
Summary: The expression of the reverse transsulfuration enzyme cystathionine-beta-synthase (CBS) varies in different types of cancer, and is associated with survival rates. CBS and its product hydrogen sulfide (H2S) play various roles in tumor growth, cell protection, and angiogenesis in high-CBS expressing tumor cells. This article reviews the potential of CBS silencing and pharmacological CBS inhibition as potential cancer therapies, and discusses the identification of biomarkers for future targeted treatments.
Editorial Material
Oncology
Paul C. McDonald et al.
Summary: Tumor hypoxia is a significant problem in cancer treatment, as hypoxic tumor cells are resistant to most therapies and display aggressive behavior. Carbonic Anhydrase IX (CAIX) has attracted attention as a therapeutic target because of its selective expression on hypoxic tumor cells. This article discusses the current status and future strategies for targeting CAIX in cancer therapy.
Review
Oncology
Roumaissa Gouasmi et al.
Summary: The kynurenine pathway plays important roles in tumor development by protecting organs from immune reactions and providing essential metabolites to cells. Abnormal activation of this pathway promotes tumor growth, metastasis, and chemoresistance. The complex regulation of this pathway poses challenges for clinical interventions.
Review
Cell Biology
Muhammad Bilal Ahmed et al.
Summary: Cancer, one of the leading causes of death globally, remains unclear in its fundamental principles. Understanding the key signaling mechanisms that cause cancer cell malignancy may help uncover new pharmaco-targets. Targeting cAMP and its effectors, crucial for tumor growth and development, may serve as a useful cancer treatment strategy.
Review
Cell Biology
Yu'e Liu et al.
Summary: Mitochondria play a crucial role in both energy supply and regulation of key metabolites involved in epigenetic regulation. Tumorigenesis is influenced by gene mutations and the tumor microenvironment, with mitochondria and epigenetics being essential for tumor initiation, evolution, metastasis, and recurrence. Targeting mitochondrial metabolism and epigenetics holds promise for cancer treatment.
Review
Oncology
Caitlin M. Tilsed et al.
Summary: Chemotherapy response in cancer patients is not solely determined by the proliferation rate of tumor cells, but also influenced by other cellular mechanisms and the composition of the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Gabor Valcz et al.
Summary: The conventional gene-centric view on tumor evolution states that vertically inherited mutations largely define the properties of tumor cells. However, accumulating evidence shows that tumor cells and their microenvironment may acquire external genetic properties through horizontal gene transfer, particularly via small extracellular vesicles.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Vida Ungerer et al.
Summary: Unique genetic, biological, and pathological information is present in differently sized cell-free DNA (cfDNA) populations. Investigating cfDNA fragmentation patterns in human bone cancer cells revealed that different analysis methods generate diverse size profiles, and the laddering pattern of cfDNA may extend beyond the detection range of commonly used methods.
Review
Medicine, General & Internal
Angela Oberhofer et al.
Summary: Cell and tissue types release DNA fragments into body fluids through various mechanisms, and cfDNA in plasma or serum has been used for non-invasive molecular diagnostics. Analysis of epigenetic features of cfDNA can infer tissue-of-origin. Research has shown that analysis of methylation patterns, nucleosome occupancy, and fragmentomics can determine the tissue-of-origin of cfDNA molecules.
Review
Biology
Aleksandra Bozyk et al.
Summary: Scientists worldwide have been studying the biology of cancer, revealing that its development is not only caused by genetic mutations but also by complex interactions between molecules and cells. Understanding the tumor microenvironment is crucial in developing effective anti-cancer treatments and combating immune system evasion by cancer cells.
Review
Chemistry, Multidisciplinary
Chendi Ding et al.
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Article
Engineering, Biomedical
Han Jiang et al.
Summary: This study proposes a novel immunogenic cell death (ICD) modality based on mitochondrial heat stress by magnetic hyperthermia treatment (MHT), which effectively evokes tumor-associated macrophages (TAMs) against cancer cells. A nanomedicine named MRT is synthesized for mitochondria-targeted heat stress-induced oxidative damage of tumor cells, leading to the release of damage-associated molecular patterns (DAMPs) and the activation of TAMs-mediated immune response against cancer cells.
Article
Oncology
Qian Wang et al.
Summary: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide, and enhanced mitochondrial fragmentation (MF) is associated with poor prognosis in HCC patients. Although MF activates certain immune cells, it decreases the number and cytotoxicity of natural killer cells in the HCC immune microenvironment, leading to immune escape. Moreover, MF contributes to maintaining stemness by promoting the asymmetric division of liver cancer stem cells. MF may promote tumor progression through autophagy, oxidative stress, and metabolic reprogramming.
Review
Chemistry, Inorganic & Nuclear
Jinxing Liu et al.
Summary: Two-dimensional (2D) nanomaterials have attracted much attention due to their unique properties and wide range of applications in cancer treatments. They can be utilized for chemotherapy, immunotherapy, gene therapy, and imaging-guided cancer treatments. This review provides an overview of the synthesis strategies and surface modifications of 2D nanomaterials, and comprehensively summarizes the recent progress in their applications for cancer treatments and imaging.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jinman Xiao et al.
Summary: Mitochondrial dynamics play a crucial role in cancer progression, and an imbalance of mitochondrial fusion and fission can greatly affect cancer cell behavior. This study found that the expression of Cav-1 is higher in highly metastatic breast cancer cells compared to low-metastatic or normal breast cells. Downregulation of Cav-1 reduces the migratory and invasive abilities of breast cancer cells by affecting mitochondrial dynamics and intracellular ROS generation. These findings suggest that Cav-1 may be a potential target for inhibiting breast cancer metastasis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Oncology
Giuseppina Claps et al.
Summary: High serum lactate dehydrogenase (LDH) levels are typically associated with a poor prognosis in many cancer types. It serves as a complex biomarker with various physiological functions, including activation of oncogenic signaling pathways, metabolic activity, invasiveness, and immunogenicity of tumors. It is an attractive target for cancer therapy.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sara G. Pelaz et al.
Summary: This review summarizes recent progress in understanding the role of Src in glucose metabolism in cancer cells and discusses its link with metabolic plasticity and tumor progression. The opportunities and challenges in this field are also discussed.
Article
Multidisciplinary Sciences
Sujun Chen et al.
Summary: The authors used cell-free DNA methylation analysis to demonstrate changes in hypermethylation in metastatic prostate cancer, and its impact on immune features and clinical outcomes. The results showed that the cell-free DNA methylome can capture variations beyond the tumor, and has a high accuracy in predicting disease types.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Angela Llop-Hernandez et al.
Summary: This study investigated the survival mechanisms of therapy-induced senescent cells under limited nutrient conditions, identifying key metabolites that support cell survival and observing a correlation between the intensity of pro-inflammatory response induced by different aging-inducing interventions and the compensatory nutritional utilization ability of cells.
Editorial Material
Biochemistry & Molecular Biology
Colin Sheehan et al.
Summary: A new study reveals that primary and metastatic tumors have divergent metabolic requirements.
Review
Medicine, General & Internal
Navin Kumar Verma et al.
Summary: The tumour microenvironment (TME) imposes obstacles to infiltrating T-lymphocytes and suppresses their function. Immune checkpoint proteins and metabolic factors within the TME contribute to the exhaustion of tumour-infiltrating T-cells. Overcoming these obstacles and developing new therapeutic strategies can harness the full potential of the immune system in combating cancer.
Review
Oncology
Edoardo Francini et al.
Summary: Early diagnosis and predicting recurrence of renal cell carcinoma (RCC) are challenging, with no established predictive biomarkers yet. Circulating cell-free DNA (cfDNA) shows potential to be a non-invasive, cost-effective method for cancer detection, including RCC, offering contemporary mutational profiling of the tumor and potentially improving prognosis.
Article
Oncology
Lin Wang et al.
Summary: In this study, we found that overexpression of succinate dehydrogenase (SDHA) in ovarian carcinoma leads to enhanced mitochondrial metabolism and increased energy requirements. These SDHA overexpressing tumor cells heavily rely on both glycolysis and oxidative phosphorylation for energy production. We also discovered that these cells are highly vulnerable to nutrient deprivation, such as glucose and glutamine, resulting in a significant reduction in ATP production. Additionally, we identified an anti-metabolic compound, shikonin, which exhibits potent anti-tumor effects against SDHA overexpressing ovarian cancer cells. Our findings highlight the previously unknown role of SDHA in the reprogramming of ovarian cancer metabolism and provide new opportunities for therapeutic intervention.
Review
Oncology
Yunong Xie et al.
Summary: Accumulating evidence suggests that cancer stem cells (CSCs) use reprogrammed metabolic strategies to adapt to a hostile tumor microenvironment (TME) for survival and maintenance of stemness. This metabolic alteration is facilitated by microenvironmental cues, including metabolites such as glucose, amino acids, and lipids, as well as environmental properties like hypoxia and acidity in the TME. Additionally, interactions between CSCs and tumor-infiltrating cells promote cancer stemness, contributing to tumor development and progression.
Review
Oncology
Funto A. Akindona et al.
Summary: This article reviews the development mechanisms of the cancer stem cell niche, with a focus on glioblastoma. By studying nonmalignant stem cell niches, important parallels can be drawn to the malignant environment. Understanding the cancer stem cell niche may provide new insights for therapeutic approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mode Al Ojaimi et al.
Summary: Mitochondrial fusion and fission are dynamic processes crucial for cellular metabolism. Defects in mitochondrial proteins disrupt the balance between fusion and fission, leading to mitochondrial disorders.
Review
Oncology
Shadia Hamoud Alshahrani et al.
Summary: MicroRNAs (miRNAs) have emerged as important regulators of immunity, playing a significant role in cancer and immune cell metabolism. Recent studies have shown that miRNAs can modulate tumor-associated immune cells and signaling cascades through regulating metabolic processes. Additionally, immunometabolism also affects the immune system and inflammatory processes. Current research focuses on modifying miRNAs to intervene in cancer, providing new insights for cancer therapeutic strategies based on immunometabolism.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Aadhya Tiwari et al.
Summary: Tumor microenvironment (TME) is a specialized ecosystem designed by tumor cells for successful development and metastasis. Advanced bioinformatic methodologies and 3D culture have allowed for the study of TME components and their interplay. Understanding TME diversity and immune therapeutic interventions could potentially overcome immunotherapeutic resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Li Song et al.
Summary: Sonodynamic therapy (SDT) is a more preferable therapeutic modality than photodynamic therapy (PDT) due to its deeper tissue penetration. However, SDT still suffers from low ROS production efficiency and insufficient systematic immune activation. Efforts have been made to overcome these challenges, including the development of inorganic sonosensitizers and the modulation of the tumor microenvironment (TME) to enhance SDT. More research is needed to further improve the understanding and application of TME modulation in SDT.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Oncology
Hyang Joo Ryu et al.
Summary: This study investigated the expression of glucose and glutamine metabolism-related proteins in breast ductal carcinoma in situ (DCIS) and found that it is associated with molecular subtypes and stromal features.
Review
Biotechnology & Applied Microbiology
Daria S. Chulpanova et al.
Summary: Tumor-cell-derived extracellular vesicles (EVs) have the ability to alter the metabolism and morphology of normal cells, leading to malignant transformation. These EVs can also transfer oncogenes and induce epigenetic changes in normal cells, resulting in genomic instability and subsequent oncogenic transformation of normal cells.
BIOENGINEERING-BASEL
(2022)
Review
Oncology
Liwei Pang et al.
Summary: Cav-1 plays a central role in various diseases and has both positive and negative effects through different regulation pathways.
Review
Oncology
Eric C. Cheung et al.
Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Amma Asare et al.
Summary: This study identifies genomic changes in African American patients with gynecologic malignancies and suggests a framework for identifying novel therapeutic targets.
CANCER RESEARCH COMMUNICATIONS
(2022)
Review
Immunology
Catherine C. Hedrick et al.
Summary: Neutrophils have emerged as important regulators of cancer, revealing their diverse and plastic contributions in tumor development and growth, influencing positively and negatively depending on time, place, and disease context. Their functional importance in cancer has been overlooked due to their short-lived, terminally differentiated, and non-proliferative characteristics, but recent studies have led to a paradigm shift in understanding their roles.
NATURE REVIEWS IMMUNOLOGY
(2022)
Review
Biology
Karla Santos-de-Frutos et al.
Summary: This review article discusses the implication of dormant cancer cells in tumor relapse and the roles that quiescent and senescent cells may play in this process.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Svenja Michalek et al.
Summary: LRH-1, an orphan nuclear receptor, plays a crucial role in regulating development, metabolism, and cancer by targeting mitochondria and associated activities. Its balanced expression contributes to maintaining physiological equilibrium, while deregulation may lead to inflammation and cancer. Researchers are exploring its potential as a pharmacological target for cancer therapy.
Review
Cell Biology
Keywan Mortezaee
Summary: Tumor cells need to acquire characteristics more potent than normal cells in order to survive and grow in the host environment. This includes having stronger redox tolerance and adaptive metabolic processes. Without these characteristics, tumors are prone to disruption.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Immunology
Wolf Herman Fridman et al.
Summary: Recent studies have suggested that B cells in the tumor microenvironment may play a significant role in presenting tumor-associated antigens to T cells and producing antibodies that enhance antigen presentation, ultimately impacting cancer clinical outcomes. Immune complexes formed by B cells can also have deleterious effects through inflammation, angiogenesis, and immunosuppression via macrophage and complement activation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Karuna Ganesh et al.
Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.
Review
Biochemistry & Molecular Biology
Katrin Pansy et al.
Summary: The TME plays a crucial role in regulating tumor growth and metastasis, with immune escape enabling tumor cells to maintain their proliferation. Novel immunotherapies have been successfully developed based on intensive study of the mechanisms involved in immune evasion, such as membrane-bound and soluble factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Luana Greco et al.
Summary: Cancer metastasis involves multiple steps, including local invasion, intravasation, colonization at distant sites, and outgrowth of lesions. Epithelial to mesenchymal transition (EMT) enables cancer cells to overcome barriers and have plasticity during transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mostafa Mostafazadeh et al.
Summary: Exosomes play potential roles in tumor initiation, progression, and chemoresistance by mediating cell-to-cell communication and affecting drug resistance. Studies have shown that the content of exosomes released from tumor cells may be associated with the clinical outcomes of cancer patients.
CELL AND BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Suliman Khan et al.
Summary: Heterocyclic compounds are commonly used in anticancer drug development, and there is a need for cost-effective alternatives to complex chemical catalysts for their production. Researchers have explored the use of magnetic nanoparticles (NPs) as catalysts for synthesizing heterocyclic compounds with anticancer properties and as smart agents for targeting cancer cells. Current studies focus on the application of magnetic NPs in cancer therapy and their potential role in synthesizing heterocyclic compounds.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Chemistry, Medicinal
Hye-Young Min et al.
Summary: Non-small cell lung cancer (NSCLC) accounts for a majority of lung cancer cases and is typically treated with a combination of therapies, such as radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, chemoresistance remains a significant obstacle in the management of NSCLC, necessitating a better understanding of the underlying mechanisms to develop effective treatment strategies.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Logan P. Poole et al.
Summary: Cells utilize mitophagy to remove dysfunctional or excess mitochondria in response to external stresses, with mechanisms including mitochondrial cargo receptors induced by these stresses, mitochondrial protein targets of PINK1/Parkin phospho-ubiquitination, and mitochondrial lipid signaling. These pathways play a crucial role in tumorigenesis, metastasis, cell cycle control, survival pathways, and therapy responses in cancer. Mitophagy also impacts tissue atrophy during cancer cachexia and clinical therapy responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pritpal Kaur et al.
Summary: Heme synthesis influences cellular energy and anabolism pathways, potentially leading to oxidative stress. Exogenous supplementation of heme precursor ALA can suppress oxidative metabolism and glycolysis in cancer cells, reducing proliferation and destabilizing the transcription regulator Bach1, indicating a promising anti-cancer strategy.
Article
Oncology
Hanna Leister et al.
Summary: The immunoproteasome has opposing roles in the tumor microenvironment, promoting colitis-associated carcinogenesis while exhibiting antitumorigenic activity in melanoma. This suggests that immunoproteasomes may have context-dependent pro- or antitumoral properties.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Chien-Liang Liu et al.
Summary: This study demonstrated that upregulated QPRT expression in breast cancer enhances invasiveness through purinergic signaling, indicating that QPRT could potentially serve as a prognostic indicator and therapeutic target in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Toxicology
Javier De las Rivas et al.
Summary: This review explores the important clinical benefits achieved in cancer patients through drug-targeting strategies, but drug resistance remains a major issue. The impact of epithelial-mesenchymal plasticity and tumor microenvironment on treatment effectiveness is discussed, along with the use of bioinformatics and pharmacogenomics to study the biological effects of epithelial-to-mesenchymal transition on drug resistance and develop novel pharmacological approaches in the future.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Aisha Farhana et al.
Summary: This study highlights the potential therapeutic target in colon cancer cells by utilizing a newly formulated camptothecin encapsulated in nanoparticles, which shows specific regulatory effects on gene expression, cellular components, and metabolic functions. The findings suggest a dual effect on epigenetic control and metabolic modulation, providing new pathways for targeting deregulated genes for potential treatment in colon cancer.
Review
Pharmacology & Pharmacy
Moein Ala
Summary: The kynurenine pathway plays a crucial role in promoting T Reg differentiation, leading to an immunosuppressive microenvironment for mutant cells in cancers. Overactivation of this pathway is associated with poor prognosis in various cancers and increased invasion, metastasis, and chemoresistance of cancer cells, although IDO inhibitors have shown promising therapeutic efficacy in clinical trials for certain cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Tomas Duraj et al.
Summary: Aberrant cancer metabolism, characterized by a preference for various metabolites including aerobic glycolysis and glutaminolysis, challenges the traditional static metabolic profile. Metabolic plasticity, often overlooked in therapeutic strategies, is crucial for understanding cancer bioenergetics. Standardization of metabolic readouts can provide a comprehensive metabolic picture in cancer research.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Tatjana Kleele et al.
Summary: Mitochondrial fission is a highly regulated process that can impact cell function and health. Depending on the location and manner of division, mitochondria can be divided into two types, one for clearing damaged material and undergoing mitophagy, and the other for mitochondrial proliferation.
Review
Biochemistry & Molecular Biology
Joseph Eniafe et al.
Summary: The tricarboxylic acid cycle plays a vital role in cancer initiation and progression by modulating cellular activities through its intermediates. Understanding the roles and molecular mechanisms of TCA metabolites in oncogenesis could lead to the development of novel metabolite-based cancer therapy in the future.
Review
Pharmacology & Pharmacy
Zhongmin Tang et al.
Summary: The field of 2D nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines and focuses on the biological interactions of nanomaterials for improved treatment of cancer and other immune dysregulation syndromes.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Oncology
Christiana M. Neophytou et al.
Summary: The tumor microenvironment (TME) plays a crucial role in cancer progression, influencing tumor aggressiveness, dissemination, and immune evasion. Interactions between cellular and structural TME components enable cancer cells to invade and spread, and the extracellular matrix (ECM) also affects cancer cell migration and therapy response. Current and future strategies aim to target these components to block metastasis.
Review
Oncology
Funmilayo O. Adeshakin et al.
Summary: Cancer cells develop mechanisms to resist anoikis, promoting invasion and metastasis. Understanding the mechanisms driving anoikis resistance is crucial for preventing tumor progression and metastasis, with metabolic pathways playing a key role in helping cells evade anoikis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Xiaodong Hao et al.
Summary: Hypoxia is a common phenomenon in pancreatic cancer, leading to metabolic reprogramming of cancer cells and contributing to immunotherapy resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Inorganic & Nuclear
Karolina Wieszczycka et al.
Summary: This review discusses the latest innovations and trends in surface functionalization of various nanomaterials, focusing on smart materials fabrication protocols and challenges in improving their performance. Attention is given to the properties enhancement of polymer, silica, inorganic, and hybrid nanomaterials, as well as their potential applications in multiple fields.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Carlos Jhovani Perez-Amado et al.
Summary: Analysis of mitochondrial genome is important in studying human diseases, including cancer, as mutations and variants in tumors impact tumor growth and invasion. Heteroplasmy-shifting is suggested to play a role in tumor progression and treatment response, but further research is needed to fully understand its clinical implications in treating human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Zhe Cheng et al.
Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aisha Farhana et al.
Summary: The molecular crosstalk between the cellular epigenome and genome serves as a synergistic driver of oncogenic transformations, with epigenetic regulatory circuits influencing cancer progression through DNA repair deficiencies. Treatment with CPT-CEF may alleviate the repression of genes involved in DNA repair mechanisms by modulating epigenetic pathways, representing a potential method to correct DNA repair deficiencies in cancer cells.
Article
Multidisciplinary Sciences
Joerg Bredno et al.
Summary: Analysis of circulating tumor DNA in oncology applications is limited by the amount of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a blood sample. Linear models revealed that tumor mitotic volume, excessive lesion glycolysis, and tumor invasion depth are significant correlates of circulating tumor fraction. The identified correlates suggest that faster growing tumors have higher fractions of circulating tumor DNA.
Article
Cell Biology
Chengxian Xu et al.
Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.
Review
Cell Biology
Ruipu Sun et al.
Summary: Pericytes play a crucial role in regulating blood vessels and the formation of leaky vasculature in tumors. Recent research shows that they can also directly interact with stromal cells/cancer cells to modulate the tumor microenvironment and have immunomodulatory effects. Targeting pericyte functions may offer new strategies for cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fabian den Brave et al.
Summary: Mitochondria import thousands of precursor proteins from cytosolic ribosomes, with defects in this process leading to proteotoxic stress. The cell uses molecular chaperones, quality control factors, protein translocases, and W proteases to monitor protein transport into mitochondria, ensuring efficiency and quality control.
BIOCHEMICAL JOURNAL
(2021)
Article
Oncology
Anna Jakabova et al.
Summary: This study characterized circulating tumor cells (CTCs) in early and locally advanced breast cancer patients during neoadjuvant chemotherapy. The response to anthracyclines and taxanes varied, with CTCs presence and HER2 status showing significant associations. Monitoring CTCs may help predict patient outcomes during treatment.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Zhenzhen Li et al.
Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.
Review
Biochemistry & Molecular Biology
Delin Liu et al.
Summary: Mitochondria, crucial for cell metabolism and tissue survival, undergo morphological changes and can be transferred intercellularly. The phenomenon of mitochondrial transfer plays a key role in tissue homeostasis, damaged tissue repair, tumor progression, and immunoregulation, functioning under both physiological and pathological conditions. Various mechanisms contributing to this process, such as trigger factors and transfer routes, are summarized in order to explore potential therapeutic strategies for rescuing tissue damage and inhibiting tumor progression through mitochondria-targeted applications.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Oncology
Gabriele Bergers et al.
Summary: This review discusses the metabolic rewiring in cancer cells during the metastatic cascade and the distinct metabolic features of primary tumors and metastases. Metastasis is the leading cause of death in most cancer patients, and targeting metastatic seeding and colonization remains a significant challenge. Adjusting metabolism may provide therapeutic opportunities to prevent or reduce metastasis, and targeting the new metabolic traits in established metastases could lead to their eradication.
NATURE REVIEWS CANCER
(2021)
Review
Pathology
David C. Chan
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020
(2020)
Article
Oncology
Xiang Zhuang et al.
Review
Oncology
Vittoria Raimondi et al.
BRITISH JOURNAL OF CANCER
(2020)
Review
Oncology
Du-Bois Asante et al.
Review
Genetics & Heredity
Zaka Abbaszadeh et al.
Review
Biochemistry & Molecular Biology
Shamir Cassim et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Immunology
Takayuki Imanishi et al.
TRENDS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Nobu Oshima et al.
Review
Oncology
Sen Wang et al.
Review
Biochemical Research Methods
Nathan Basisty et al.
EXPERT REVIEW OF PROTEOMICS
(2020)
Review
Biochemistry & Molecular Biology
Ilenia Aversa et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Multidisciplinary Sciences
Brandon Faubert et al.
Review
Chemistry, Physical
Xi Yang et al.
Review
Oncology
Charles Pottier et al.
Review
Cell Biology
Fuming Li et al.
DEVELOPMENTAL CELL
(2020)
Review
Biochemistry & Molecular Biology
Anthony M. Battram et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Patrick M. Perrigue et al.
Review
Medicine, Research & Experimental
Xiaoyu Sun et al.
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Biochemistry & Molecular Biology
Bruno M. F. Goncalves et al.
Article
Biochemistry & Molecular Biology
Nicole M. Anderson et al.
Review
Chemistry, Multidisciplinary
Sarkar Siddique et al.
Article
Oncology
Aikaterini Poulaki et al.
Review
Oncology
Sonam Mittal et al.
Review
Oncology
Jiun- Lai et al.
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Sonu Kumar Gupta et al.
Review
Oncology
Emmanuel N. Kontomanolis et al.
ANTICANCER RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Andrew N. Lane et al.
Review
Medicine, Research & Experimental
Yun Liu et al.
Review
Immunology
Seongju Jeong et al.
Review
Oncology
Gerta Hoxhaj et al.
NATURE REVIEWS CANCER
(2020)
Article
Surgery
Yuki Kiyozumi et al.
Review
Pharmacology & Pharmacy
Jordan F. Hastings et al.
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Review
Chemistry, Medicinal
Min-Kyue Shin et al.
ARCHIVES OF PHARMACAL RESEARCH
(2019)
Review
Medicine, Research & Experimental
Zahra Ghanbari Movahed et al.
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Review
Immunology
Fatemeh Vahidian et al.
IMMUNOLOGY LETTERS
(2019)
Article
Multidisciplinary Sciences
Stephen Cristiano et al.
Review
Oncology
Eva Rodriguez-Aznar et al.
Article
Oncology
Fangxuan Li et al.
Article
Multidisciplinary Sciences
Federico Bocci et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Cell Biology
Jonathan K. M. Lim et al.
CELL DEATH & DISEASE
(2019)
Article
Medicine, Research & Experimental
Denise P. Munoz et al.
Review
Cell Biology
Veronica Eisner et al.
NATURE CELL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Lynnea R. Waters et al.
Review
Cell Biology
Patrick G. Hogan
Review
Biochemistry & Molecular Biology
Emilie Schrepfer et al.
Review
Biochemistry & Molecular Biology
Maria V. Liberti et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2016)
Review
Pharmacology & Pharmacy
Zhi Fang et al.
EXPERT OPINION ON DRUG DELIVERY
(2015)
Article
Endocrinology & Metabolism
Laura D. Osellame et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Biochemistry & Molecular Biology
A. K. Iyer et al.
CURRENT MEDICINAL CHEMISTRY
(2012)
Review
Biochemistry & Molecular Biology
Douglas Hanahan et al.
Review
Genetics & Heredity
AS Reichert et al.
TRENDS IN GENETICS
(2004)
