4.6 Article

Molecular Subtypes and Tumor Microenvironment Characteristics of Small-Cell Lung Cancer Associated with Platinum-Resistance

Related references

Note: Only part of the references are listed.
Article Oncology

Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer

Ying Jin et al.

Summary: This study investigates treatment resistance mechanisms in small cell lung cancer (SCLC) by comparing the genotype and phenotype in tumor samples of treatment-resistant and treatment-sensitive SCLC. The results suggest that activation of the PI3K/AKT pathway may be a potential mechanism underlying therapeutic resistance of SCLC, and provides a possible approach to reverse resistance to chemo/radiotherapy.

CLINICAL CANCER RESEARCH (2022)

Article Oncology

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Carl M. Gay et al.

Summary: Despite the heterogeneity of small cell lung cancer (SCLC), four subtypes have been identified based on tumor expression data, each showing different responses to treatment. SCLC-I subtype benefits the most from immunotherapy, while other subtypes have vulnerabilities to different inhibitors. Matching tumor subtype to therapy and manipulating subtype switching during treatment may enhance response depth and duration for SCLC patients.

CANCER CELL (2021)

Article Oncology

Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

Joseph M. Chan et al.

Summary: The study reveals a greater tumor diversity in SCLC compared to lung adenocarcinoma, with a PLCG2-high SCLC phenotype showing stem-like, pro-metastatic features and predicting worse overall survival. Furthermore, SCLC demonstrates greater immune sequestration and less immune infiltration than lung adenocarcinoma.

CANCER CELL (2021)

Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Multidisciplinary Sciences

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Alexandre F. Aissa et al.

Summary: Tyrosine kinase inhibitors have clinical effectiveness in treating certain subsets of cancers with receptor tyrosine kinase somatic mutations, but limited duration of response and development of drug resistance are common issues. Single-cell RNA sequencing revealed multiple cancer cell subpopulations with epigenetic changes and variable therapeutic sensitivity. Overrepresented gene ontologies associated with drug tolerance include epithelial-to-mesenchymal transition, drug metabolism, and vesicle transport. Combination therapy targeting specific drug tolerant cell subpopulations shows promise in inhibiting drug resistance.

NATURE COMMUNICATIONS (2021)

Article Cardiac & Cardiovascular Systems

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung

Jonas C. Schupp et al.

Summary: This study provides a comprehensive reference atlas of endothelial cells in the lungs, identifying over 15,000 vascular endothelial cells from 73 individuals. The research reveals previously unrecognized subpopulations of lung endothelial cells and confirms the maintenance of endothelial diversity in pulmonary hypertension.

CIRCULATION (2021)

Article Oncology

Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation

Alvaro Quintanal-Villalonga et al.

Summary: Lineage plasticity plays a role in treatment resistance in various cancers, with transformation to SCLC in LUAD being a recognized mechanism. NE transformation in lung cancer is primarily driven by transcriptional reprogramming rather than mutational events. Identifying genomic contexts and pathways involved in NE transformation could lead to potential therapeutic targets in lung cancer.

CANCER DISCOVERY (2021)

Review Oncology

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

John T. Poirier et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

Article Multidisciplinary Sciences

Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi et al.

NATURE (2019)

Review Oncology

Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

A. Pavan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Article Cell Biology

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

Yu-Han Huang et al.

GENES & DEVELOPMENT (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Medicine, General & Internal

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

L. Horn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Biochemical Research Methods

Single-cell mRNA quantification and differential analysis with Census

Xiaojie Qiu et al.

NATURE METHODS (2017)

Article Oncology

The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma

Hemant K. Bid et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Multidisciplinary Sciences

Comprehensive genomic profiles of small cell lung cancer

Julie George et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Hematology

A Role for Partial Endothelial-Mesenchymal Transitions in Angiogenesis?

Katrina M. Welch-Reardon et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Biochemical Research Methods

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

Daryl Waggott et al.

BIOINFORMATICS (2012)

Article Multidisciplinary Sciences

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)