4.6 Article

Oral Cavity Cancer Tissues Differ in Isotopic Composition Depending on Location and Staging

Related references

Note: Only part of the references are listed.
Article Oncology

C-13 Natural Isotope Abundance in Urothelium as a New Marker in the Follow-Up of Patients with Bladder Cancer

Adam Madej et al.

Summary: Bladder cancer is characterized by metabolic changes, resulting in differences in the abundance of natural isotopes between normal and cancerous tissues. Analysis of carbon and nitrogen isotopes in bladder cancer samples revealed lower levels compared to normal urothelium. Decreased carbon isotope abundance in normal urothelium was associated with shorter disease-free survival in bladder cancer patients. Isotope analysis can provide important information for predicting bladder cancer recurrence and improving patient management.

CANCERS (2022)

Review Physiology

The role of tumor-associated macrophages in oral squamous cell carcinoma

Yiwen Xue et al.

Summary: This article reviews the role of tumor-associated macrophages (TAMs) in the invasion, metastasis, angiogenesis, and immunosuppression of oral squamous cell carcinoma (OSCC), as well as discusses the therapeutic strategies targeting TAMs for the treatment of OSCC.

FRONTIERS IN PHYSIOLOGY (2022)

Review Oncology

Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews

Miguel Angel Gonzalez-Moles et al.

Summary: Oral cancer is a global problem with a high mortality rate mainly due to late diagnosis. The delay in diagnosis is caused by various factors, and improvement strategies need to be formulated.

CANCERS (2022)

Article Oncology

Human papillomavirus-16 infection and p16 expression in oral squamous cell carcinoma

Norihiko Tokuzen et al.

Summary: The study results suggest that HPV-16 infection is less likely to cause oral squamous cell carcinoma in Japan, and p16 expression is not a suitable marker for HPV infection in oral squamous cell carcinoma.

ONCOLOGY LETTERS (2021)

Review Oncology

Time-to-Treatment in Oral Cancer: Causes and Implications for Survival

Constanza Saka-Herran et al.

Summary: The stage of the disease at diagnosis plays a crucial role in oral cancer prognosis, with early stage diagnosis associated with better survival rates. However, challenges remain in diagnosing oral cancer early, such as patient awareness, delays in diagnosis, and prolonged treatment intervals. Factors influencing time-to-treatment intervals include patient awareness, tumor characteristics, delays in referral, and professional factors. Prolonged pre-treatment and treatment intervals have been linked to poorer survival outcomes in oral cancer patients.

CANCERS (2021)

Article Oncology

Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies

M. Straub et al.

Summary: The study found that using the N-15/N-14 measurement method can distinguish between murine tumors and healthy tissue, potentially providing a new avenue for micro-biopsy diagnosis of malignancy. However, the difference in N-15/N-14 between tumor and healthy tissue may depend on the nitrogen metabolism of the healthy organ involved.

BMC CANCER (2021)

Review Biochemistry & Molecular Biology

Stable Isotope Abundance and Fractionation in Human Diseases

Illa Tea et al.

Summary: The natural abundance of heavy stable isotopes is important in human physiology research, as it can easily identify changes in metabolic fluxes. This suggests the potential for medical diagnosis and prognostic using isotopes at natural abundance.

METABOLITES (2021)

Review Biochemistry & Molecular Biology

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials

Choudhary Harsha et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Cu isotope ratios are meaningful in ovarian cancer diagnosis

B. Toubhans et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

Article Medicine, General & Internal

Characteristic of Oral Squamous Cell Carcinoma Tissues Using Isotope Ratio Mass Spectrometry

Katarzyna Bogusiak et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Dentistry, Oral Surgery & Medicine

The localization and risk factors of squamous cell carcinoma in the oral cavity: A retrospective study of 1501 cases

Britta V. Sundermann et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2018)

Review Genetics & Heredity

Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets

Vera Miranda-Goncalves et al.

FRONTIERS IN GENETICS (2018)

Review Oncology

Rewiring urea cycle metabolism in cancer to support anabolism

Rom Keshet et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Ammonia promotes endothelial cell survival via the heme oxygenase-1-mediated release of carbon monoxide

Xiao-Ming Liu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Multidisciplinary Sciences

13C and 15N natural isotope abundance reflects breast cancer cell metabolism

Illa Tea et al.

SCIENTIFIC REPORTS (2016)

Article Medical Laboratory Technology

The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome

Jong-Ku Park et al.

CLINICA CHIMICA ACTA (2015)

Article Otorhinolaryngology

Prognostic factors in squamous cell carcinoma of the oral cavity

José Raphael de Moura Campos Montoro et al.

Brazilian Journal of Otorhinolaryngology (2015)

Article Dentistry, Oral Surgery & Medicine

A clinical study on survival rate of patients with squamous cell carcinoma of the lower lip in Kosovo

Sami Salihu et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2014)

Review Anthropology

Beyond diet reconstruction: Stable isotope applications to human physiology, health, and nutrition

Laurie J. Reitsema

AMERICAN JOURNAL OF HUMAN BIOLOGY (2013)

Review Medicine, General & Internal

Clinicopathological prognostic implicators of oral squamous cell carcinoma: Need to understand and revise

Kiran B. Jadhav et al.

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES (2013)

Article Biochemical Research Methods

Serial analysis of stable nitrogen and carbon isotopes in hair: monitoring starvation and recovery phases of patients suffering from anorexia nervosa

Anna-Maria Mekota et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2006)

Article Dentistry, Oral Surgery & Medicine

Prognostic factors in intraoral squamous cell carcinoma: The influence of histologic grade

D Kademani et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2005)

Article Biochemical Research Methods

Nitrogen balance and delta N-15: why you're not what you eat during nutritional stress

BT Fuller et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2005)