4.7 Review

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Comparative efficacy and safety of disease-modifying therapies in patients with relapsing multiple sclerosis: A systematic review and network meta-analysis

Chaoyang Chen et al.

Summary: This study conducted a systematic review and network meta-analysis to evaluate the efficacy and safety of disease-modifying therapies (DMTs) in patients with relapsing forms of multiple sclerosis (RMS), and found that alemtuzumab and ofatumumab had the highest efficacy among DMTs. Clinical shared decision making is recommended when formulating treatment plans.

JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION (2023)

Letter Clinical Neurology

MicroRNAs 181a and 125a are highly expressed in naive RRMS: a pilot case-control study

Emanuele D'Amico et al.

JOURNAL OF NEUROLOGY (2023)

Article Health Care Sciences & Services

Characterizing fatigue phenotypes with other symptoms and clinically relevant outcomes among people with multiple sclerosis

Matthew Plow et al.

Summary: This study aimed to identify fatigue phenotypes in multiple sclerosis (MS) patients and examine their stability over time. The results suggest that considering the severity of fatigue experienced may be more important than considering the type of fatigue when characterizing fatigue phenotypes. Future research should explore interventions targeting environmental factors, self-efficacy, and fatigue catastrophizing to reduce the likelihood of transitioning to more severe fatigue phenotypes.

QUALITY OF LIFE RESEARCH (2023)

Review Pediatrics

Premorbid Personality Traits as Risk Factors for Behavioral Addictions: A Systematic Review of a Vulnerability Hypothesis

Daniela Smirni et al.

Summary: Recent research suggests that behavioral addictions may be an epiphenomenon of a pre-existing personality structure, which is more likely to occur in vulnerable individuals with emotional instability, negative affects, and unsatisfactory relationships. Therefore, in clinical and educational contexts, it is crucial to focus on vulnerability factors and at-risk personality traits, as well as protective and moderating traits such as extroversion, agreeableness, conscientiousness, and openness to experience. Meanwhile, the treatment of behavioral addictions often emphasizes overt pathological behaviors.

CHILDREN-BASEL (2023)

Article Neurosciences

Treatment of multiple sclerosis fatigue with the synthetic psychoactive drug modafinil

Eleonora Cocco et al.

Summary: Multiple sclerosis is a complex disorder with a wide range of symptoms, categorized as visible and invisible. Fatigue is a common symptom in MS patients that significantly impacts daily living and quality of life, and it does not improve with rest.

EXPERIMENTAL NEUROLOGY (2022)

Article Environmental Sciences

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Carmen Concerto et al.

Summary: This scoping review evaluated the association between vitamin D levels and depressive symptoms in patients with Multiple Sclerosis (MS). Among the 11 studies included, 7 studies showed a potential correlation between low vitamin D levels and depressive symptoms.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Immunology

Immunological Subsets Characterization in Newly Diagnosed Relapsing-Remitting Multiple Sclerosis

Emanuele D'Amico et al.

Summary: This study characterized the immune cell phenotypes of patients recently diagnosed with relapsing-remitting multiple sclerosis who had not received disease-modifying therapies. The results revealed differences in myeloid, B, and T cells between these patients and healthy controls.

FRONTIERS IN IMMUNOLOGY (2022)

Review Clinical Neurology

Co-occurrence of Fatigue and Depression in People With Multiple Sclerosis: A Mini-Review

Joanna Tarasiuk et al.

Summary: Fatigue and depression are common symptoms in patients with multiple sclerosis (MS). Primary fatigue and depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes. Secondary fatigue and depression may be caused by emotional factors, sleep disorders, pain, coexisting diseases, and medication use.

FRONTIERS IN NEUROLOGY (2022)

Review Clinical Neurology

Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes

Michael K. Racke et al.

Summary: Neuropathic pain and other pain syndromes are common in patients with multiple sclerosis. These pain syndromes can vary from central neuropathic pain to trigeminal neuralgia and optic neuritis pain. Strategies are available to help manage these symptoms.

FRONTIERS IN NEUROLOGY (2022)

Review Psychology, Clinical

Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies

Paula M. Ellison et al.

Summary: This systematic review and meta-analysis examined the neurobiology of fatigue in people with multiple sclerosis, finding that fatigue in MS is characterized by greater cortico-subcortical grey matter atrophy and neural lesions, accompanied by neurophysiological decrements such as reduced strength and voluntary activation.

NEUROPSYCHOLOGY REVIEW (2022)

Review Biochemistry & Molecular Biology

Current and Future Biomarkers in Multiple Sclerosis

Jennifer Yang et al.

Summary: Multiple sclerosis (MS) is a debilitating autoimmune disorder with a lack of effective treatment for the progressive form. Neurofilament light chain (NfL) has emerged as a potential biomarker for predicting MS disease activity and progression, but it is not specific to MS and can be influenced by age, BMI, and blood volume. Other biomarkers of axonal damage, neuronal damage, glial dysfunction, demyelination, and inflammation have also been studied, but they may face similar limitations as NfL. A comprehensive panel including cellular studies, miRNAs, EVs, metabolomics, metabolites, and the microbiome could provide a more useful approach. Further research using advanced technology and statistical approaches is needed to identify novel and useful biomarkers for MS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

Personality and fatigue: meta-analysis of seven prospective studies

Yannick Stephan et al.

Summary: This study examined the associations between five major personality traits and fatigue using cross-sectional and longitudinal analyses. The results showed that higher neuroticism and lower extraversion, openness, agreeableness, and conscientiousness were associated with a higher risk of fatigue. Self-rated health and physical inactivity partially explained these associations. Age and gender did not moderate these associations.

SCIENTIFIC REPORTS (2022)

Article Clinical Neurology

Association of personality traits with physical function, cognition, and mood in multiple sclerosis

Anne Kever et al.

Summary: This cross-sectional study investigated the association between personality traits and physical function, cognition, and depression in persons with multiple sclerosis (pwMS). The findings demonstrated that higher extraversion was associated with better physical function and cognition, while higher neuroticism was associated with worse depression.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Article Immunology

Fatigue, Depression, and Anxiety Among Ambulating Multiple Sclerosis Patients

Safanah AlSaeed et al.

Summary: This study aims to assess the prevalence of depression, anxiety, and fatigue among pwMS who have no physical disability in Saudi Arabia and demonstrate any correlation between these factors and physical activity as well as the QoL. The results revealed that depression, anxiety, and fatigue tend to be correlated and clustered together among pwMS in our cohort.

FRONTIERS IN IMMUNOLOGY (2022)

Article Clinical Neurology

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial

Bardia Nourbakhsh et al.

Summary: The study compared the efficacy of amantadine, modafinil, and methylphenidate in alleviating fatigue in multiple sclerosis patients. Results showed that none of the medications were superior to placebo in improving fatigue and had more frequent adverse events.

LANCET NEUROLOGY (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Multiple Sclerosis A Review

Marisa P. McGinley et al.

Summary: Multiple sclerosis is a neurodegenerative disease that affects the central nervous system, leading to physical disability, cognitive impairment and decreased quality of life. Current disease-modifying therapies can reduce relapse rates by 29% to 68% compared to placebo or active comparators.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Clinical Neurology

Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study

Aurora Zanghi et al.

Summary: This study evaluated the efficacy and safety of OCR, RTX, and CLA as NTZ exit strategies in RRMS patients, finding that patients on OCR had lower ARR and less MRI activity. The three groups showed similar rates of adverse events. Anti-CD20 drugs were deemed effective and safe options for NTZ exit strategies, with all investigated DMTs demonstrating a good safety profile.

NEUROTHERAPEUTICS (2021)

Article Clinical Neurology

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study A Randomized Clinical Trial

Ludwig Kappos et al.

Summary: In the OPTIMUM trial, ponesimod showed superiority over teriflunomide in reducing annualized relapse rate, fatigue, MRI activity, brain volume loss, and NEDA status, but not in confirmed disability accumulation. The safety profile was consistent with previous observations and known S1P receptor modulators.

JAMA NEUROLOGY (2021)

Review Clinical Neurology

Clinical Features of Late-Onset Multiple Sclerosis: a Systematic Review and Meta-analysis

Amirreza Naseri et al.

Summary: Late-onset multiple sclerosis (LOMS) commonly occurs in patients above 50 years old, with a higher proportion in females than males. Spinal cord involvement and relapsing-remitting multiple sclerosis (RRMS) are frequently observed in LOMS cases.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Article Clinical Neurology

First-line therapies in late-onset multiple sclerosis: An Italian registry study

Aurora Zanghi et al.

Summary: The study compared the effectiveness of injectable and oral first-line therapies in patients with late-onset relapsing remitting multiple sclerosis (LORRMS), and found no significant differences in controlling outcomes between the two treatments. This suggests that both injectables and oral first-line therapies are similarly effective in managing LORRMS.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

Article Clinical Neurology

Ethical considerations in the treatment of multiple sclerosis fatigue

Bardia Nourbakhsh et al.

Summary: Fatigue is a common symptom in MS, and many medications prescribed for its treatment may only work due to placebo effect. Ethical concerns have been raised regarding the initiation and discontinuation of these medications, with non-pharmacological approaches like exercise and cognitive behavioral therapy now being recommended. Novel study designs may be needed in future clinical trials evaluating interventions for fatigue in MS.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Article Neurosciences

Autistic Traits and Attention-Deficit Hyperactivity Disorder Symptoms Predict the Severity of Internet Gaming Disorder in an Italian Adult Population

Carmen Concerto et al.

Summary: This study investigated the prevalence of Internet Gaming Disorder among adult video game players, finding that daily spare time, autistic traits, and ADHD symptoms were positively associated with the severity of IGD in adults. Future research is needed to explore factors linked to IGD in adults.

BRAIN SCIENCES (2021)

Article Psychology, Clinical

Cognitive Fatigue Predicts Cognitive Failure in Multiple Sclerosis Patients and Healthy Controls: A Case-Control Study

Nora Spiegelberg et al.

Summary: Cognitive fatigue is the only significant predictor of cognitive mistakes in both MS patients and healthy controls, explaining additional variance in the MS group. Physical fatigue does not impact cognitive mistakes. Age and depression show differing impacts on cognitive mistakes in healthy controls compared to MS patients. Depression is significantly correlated with cognitive mistakes and cognitive fatigue in MS patients.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2021)

Review Clinical Neurology

Comprehensive Approach to Management of Multiple Sclerosis: Addressing Invisible Symptoms-A Narrative Review

Lynsey Lakin et al.

Summary: Multiple sclerosis is a chronic autoimmune inflammatory disease that can cause a variety of invisible symptoms, impacting patient quality of life. Despite gaps in awareness and management, a team-based approach is recommended for comprehensive care that addresses these hidden symptoms. Open communication, stigma mitigation, and shared decision-making are key strategies for managing invisible symptoms effectively.

NEUROLOGY AND THERAPY (2021)

Review Geriatrics & Gerontology

Neuroimaging markers of chronic fatigue in older people: a narrative review

Davide Angioni et al.

Summary: Currently, there is limited research on the associations between fatigue and neuroimaging markers in older adults. Studies suggest that fatigue is linked to changes in the hippocampus, basal ganglia networks, and white matter integrity. Further research is needed to explore these associations in depth.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2021)

Article Environmental Sciences

Perfectionism and a Healthy Attitude toward Oneself: Could Humor Be a Resource?

Annamaria Di Fabio et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Review Pharmacology & Pharmacy

Pharmacotherapeutic management of lower urinary tract symptoms

Aurora Zanghi et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

Article Clinical Neurology

Physical disability and personality traits in multiple sclerosis

Mar Estrada-Lopez et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Article Clinical Neurology

Dimethyl fumarate vs Teriflunomide: an Italian time-to-event data analysis

Emanuele D'Amico et al.

JOURNAL OF NEUROLOGY (2020)

Review Clinical Neurology

How personality traits affect functional outcomes in patients with multiple sclerosis: A scoping review on a poorly understood topic

Maria Grazia Maggio et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Article Medicine, Research & Experimental

Biomarkers in Multiple Sclerosis

Anu Paul et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2019)

Review Clinical Neurology

Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

Zina-Mary Manjaly et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Clinical Neurology

Cancer Risk and Multiple Sclerosis: Evidence From a Large Italian Cohort

Emanuele D'Amico et al.

FRONTIERS IN NEUROLOGY (2019)

Review Immunology

The Role of Inflammation in Depression and Fatigue

Chieh-Hsin Lee et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Gastroenterology & Hepatology

Management of dysphagia in multiple sclerosis: current best practice

Emanuele D'Amico et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Health Care Sciences & Services

The burden of multiple sclerosis and patients' coping strategies

Lorena Lorefice et al.

BMJ SUPPORTIVE & PALLIATIVE CARE (2018)

Article Behavioral Sciences

High anxiety trait: A vulnerable phenotype for stress-induced depression

Meltem Weger et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Article Psychology, Clinical

Personality and Primary Emotional Traits: Disentangling Multiple Sclerosis Related Fatigue and Depression

Cornelia Sindermann et al.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2018)

Article Psychology, Social

Vulnerable Narcissism Is (Mostly) a Disorder of Neuroticism

Joshua D. Miller et al.

JOURNAL OF PERSONALITY (2018)

Article Psychiatry

The Relationship Between Narcissism and Personality Traits of the Five-Factor-Model in Adolescents and Young Adults A Comparative Study

Marc Allroggen et al.

ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE (2018)

Article Clinical Neurology

Treatment choices and neuropsychological symptoms of a large cohort of early MS

Olga von Bismarck et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

Review Clinical Neurology

Safety concerns and risk management of multiple sclerosis therapies

P. Soelberg Sorensen

ACTA NEUROLOGICA SCANDINAVICA (2017)

Article Public, Environmental & Occupational Health

Personality in multiple sclerosis (MS): impact on health, psychological well-being, coping, and overall quality of life

L. B. Strober

PSYCHOLOGY HEALTH & MEDICINE (2017)

Review Clinical Neurology

Fatigue in multiple sclerosis - Insights into evaluation and management

Samar S. Ayache et al.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Muscle fatigue: general understanding and treatment

Jing-jing Wan et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Review Psychiatry

The neurobiology of depression: An integrated view

Jason Dean et al.

ASIAN JOURNAL OF PSYCHIATRY (2017)

Article Clinical Neurology

Lateral and escalation therapy in relapsing-remitting multiple sclerosis: a comparative study

Emanuele D'Amico et al.

JOURNAL OF NEUROLOGY (2016)

Article Medicine, General & Internal

Major depressive disorder

Christian Otte et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Psychology, Social

Traits, cognitive processes and adaptation: An elegy for Hans Eysenck's personality theory

Gerald Matthews

PERSONALITY AND INDIVIDUAL DIFFERENCES (2016)

Article Education & Educational Research

Perfectionism, Coping, and Underachievement in Gifted Adolescents: Avoidance vs. Approach Orientations

Emily Mofield et al.

EDUCATION SCIENCES (2016)

Article Clinical Neurology

A Preliminary Investigation of Abnormal Personality Traits in MS Using the MCMI-III

Chiara C. Incerti et al.

APPLIED NEUROPSYCHOLOGY-ADULT (2015)

Review Clinical Neurology

Is personality profile a relevant determinant of fatigue in multiple sclerosis?

Herbert Schreiber et al.

FRONTIERS IN NEUROLOGY (2015)

Review Medicine, General & Internal

Depressive symptoms in neurodegenerative diseases

Miquel Baquero et al.

WORLD JOURNAL OF CLINICAL CASES (2015)

Article Public, Environmental & Occupational Health

Personality Traits and Personality Disorders in Older Women: An Explorative Study Between Normal Development and Psychopathology

Joana Henriques-Calado et al.

HEALTH CARE FOR WOMEN INTERNATIONAL (2014)

Review Clinical Neurology

Pain and Multiple Sclerosis: Pathophysiology and Treatment

Claudio Solaro et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2013)

Article Psychiatry

Perfectionism and physical disability predict depression in multiple sclerosis

Megan M. Smith et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2013)

Article Geriatrics & Gerontology

Personality Traits and Chronic Disease: Implications for Adult Personality Development

Angelina R. Sutin et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2013)

Review Psychology

Personality Processes: Mechanisms by Which Personality Traits Get Outside the Skin

Sarah E. Hampson

ANNUAL REVIEW OF PSYCHOLOGY, VOL 63 (2012)

Article Psychiatry

Personality traits in multiple sclerosis: Association with mood and anxiety disorders

Jared M. Bruce et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2011)

Article Public, Environmental & Occupational Health

Perfectionism and fatigue in multiple sclerosis

Mohammad Ali Besharat et al.

PSYCHOLOGY & HEALTH (2011)

Article Clinical Neurology

Fatigue in MS is associated with specific clinical features

C. Colosimo et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

Article Geriatrics & Gerontology

Trait Neuroticism, Depression, and Cognitive Function in Older Primary Care Patients

Lisa L. Boyle et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2010)

Article Pharmacology & Pharmacy

Modafinil for the Treatment of Multiple Sclerosis-Related Fatigue

Jamie N. Brown et al.

ANNALS OF PHARMACOTHERAPY (2010)

Review Health Care Sciences & Services

Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems

Floortje Mols et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2010)

Review Clinical Neurology

Fatigue in Multiple Sclerosis: Mechanisms, Evaluation, and Treatment

Tiffany J. Braley et al.

SLEEP (2010)

Review Psychiatry

The psychology of fatigue in patients with multiple sclerosis: A review

Yvonne Bol et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2009)

Review Neurosciences

From inflammation to sickness and depression: when the immune system subjugates the brain

Robert Dantzer et al.

NATURE REVIEWS NEUROSCIENCE (2008)

Article Psychology, Social

The international personality item pool and the future of public-domain personality measures

LR Goldberg et al.

JOURNAL OF RESEARCH IN PERSONALITY (2006)

Article Clinical Neurology

Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?

N Tellez et al.

MULTIPLE SCLEROSIS JOURNAL (2005)

Article Psychology, Social

The effect of daily stress, personality, and age on daily negative affect

DK Mroczek et al.

JOURNAL OF PERSONALITY (2004)

Article Clinical Neurology

Personality traits in multiple sclerosis (MS) patients with and without fatigue experience

S Merkelbach et al.

ACTA NEUROLOGICA SCANDINAVICA (2003)

Article Public, Environmental & Occupational Health

Fatigue among working people:: validity of a questionnaire measure

AJHM Beurskens et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2000)

Article Psychology, Educational

Reliability generalization of the NEO personality scales

JC Caruso

EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT (2000)