Magnetic Resonance Imaging in Clinical Trials of Diabetic Kidney Disease

Article Cardiac & Cardiovascular Systems

GLP-1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading

Bryan Haddock et al.

Summary: GLP-1 receptor agonists have beneficial effects on cardiovascular and renal outcomes. GLP-1 can increase renal medullary and cortical perfusion in healthy humans, while maintaining renal oxygenation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2023)

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Review Physiology

Multiparametric magnetic resonance imaging: A robust tool to test pathogenesis and pathophysiology behind nephropathy in humans

Ulrik B. Andersen et al.

Summary: Chronic kidney disease (CKD) is a significant population disease, and kidney disease is a serious complication in diabetes and hypertension. Recent research suggests that chronic hypoxia plays a key role in the development of CKD. This review focuses on how functional magnetic resonance imaging (fMRI) techniques can provide insights into pathogenetic mechanisms and monitor new treatments for CKD.

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING (2023)

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Review Endocrinology & Metabolism

Change in albuminuria as a surrogate endpoint for cardiovascular and renal outcomes in patients with diabetes

Biff F. Palmer

Summary: For predicting clinical outcomes in diabetes and chronic kidney disease patients, albuminuria change is a suitable surrogate marker for cardiovascular events and kidney disease progression. Spot urine albumin/creatinine ratio is a convenient alternative to 24-h urine albumin, but it has limitations. Although it can be used as a surrogate endpoint for renal outcomes in clinical trials, its usage in cardiovascular outcomes is still not established. Nevertheless, the use of albuminuria change should be encouraged.

DIABETES OBESITY & METABOLISM (2023)

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Article Endocrinology & Metabolism

Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial

Soren Gullaksen et al.

Summary: This study examined whether semaglutide (GLP-1ra), empagliflozin (SGLT2i) or their combination improve kidney oxygenation and perfusion. The results showed that empagliflozin reduced medullary kidney oxygenation, while semaglutide decreased kidney perfusion.

DIABETOLOGIA (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Update on state-of-the-art for arterial spin labeling (ASL) human perfusion imaging outside of the brain

Manuel Taso et al.

Summary: This review article provides an overview of the developments and challenges in arterial spin labeling (ASL) perfusion imaging in the body outside of the brain. Specific challenges and developments in various body locations, including kidneys, lungs, heart, placenta, eye, liver, pancreas, and muscle, are discussed. The article also explores the possibilities of wider adoption of body ASL in clinical practice based on standardization efforts and recent advances in high/low-field systems and machine-learning.

MAGNETIC RESONANCE IN MEDICINE (2023)

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Article Transplantation

#4204 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING BIOMARKERS OUTPERFORM LAB BIOMARKERS FOR PREDICTING PROGRESSION OF DIABETIC KIDNEY DISEASE

Paul Hockings et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Review Medicine, General & Internal

The Effect of Metabolic Syndrome and Its Individual Components on Renal Function: A Meta-Analysis

Xu Li et al.

Summary: This meta-analysis examined the relationship between metabolic syndrome (MetS) and renal dysfunction. The results showed that MetS and its components were associated with an increased risk of renal dysfunction, including rapid decline in eGFR, new-onset CKD, and ESRD. Elevated blood pressure had the highest risk, while impaired fasting glucose had the lowest risk.

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap

David L. Raunig et al.

Summary: Multiparametric quantitative imaging biomarkers (QIBs) provide a more comprehensive measure of complex biological systems, especially in disease where structural and functional disturbances occur across multiple subsystems. This paper presents an approach that represents multiple QIBs as a multidimensional vector to capture all relevant disease constructs. The proposed method preserves the sensitivity of each QIB and incorporates correlations among them to create a single, simultaneous measure. The article also discusses metrological methods, reducing the set of QIBs, evaluating the superiority of the multidimensional model, and designing study strategies.

ACADEMIC RADIOLOGY (2023)

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Article Urology & Nephrology

Quantitative Blood Oxygenation Level Dependent Magnetic Resonance Imaging for Estimating Intra-renal Oxygen Availability Demonstrates Kidneys Are Hypoxemic in Human CKD

Pottumarthi V. Prasad et al.

Summary: Kidney BOLD MRI has potential in assessing oxygen availability, but the relationship between R2* value and tissue oxygenation remains uncertain. This study found that fractional blood volume (fBV) was associated with oxygen saturation (StO2) and partial pressure of oxygen in blood (bloodPO2), while R2* value was not.

KIDNEY INTERNATIONAL REPORTS (2023)

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Letter Endocrinology & Metabolism

Effect of glucose regulation on renal parenchyma and sinus fat volume in patients with type 2 diabetes

Ling Lin et al.

DIABETES & METABOLISM (2023)

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Article Pediatrics

Quantitative renal magnetic resonance imaging: magnetic resonance urography

J. Damien Grattan-Smith et al.

Summary: The goal of functional renal imaging is to identify irreversible renal damage and nephron loss, as well as reversible hemodynamic changes. MR urography combines anatomical imaging with functional evaluation without radiation. Quantitative functional MR imaging provides progressive, visible enhancement of the renal parenchyma and urinary tract. The evaluation of contrast agent perfusion, concentration, and excretion can be done using quantitative and qualitative measures.

PEDIATRIC RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of renal fibrosis in various causes of glomerulonephritis by MR elastography: a clinicopathologic comparative analysis

Alper Tuna Guven et al.

Summary: The stiffness of renal tissue derived from MRE is negatively correlated with the extent of fibrosis, with lower values observed in patients with chronic renal injury. Stiffness decreases as glomerulosclerosis and tubulointerstitial fibrosis progress in patients with primary glomerulonephritis and AA amyloidosis. There may be a potential role for MRE to assess renal function in conjunction with conventional markers in the future.

ABDOMINAL RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of renal fibrosis in patients with chronic kidney disease by shear wave elastography: a comparative analysis with pathological findings

Ziman Chen et al.

Summary: Study found that in patients with CKD, the SWE derived elastic values decreased as the grade of renal fibrosis or vessel wall thickening progressed. This may be attributed to renal hypo-perfusion rather than tubulo-interstitial fibrosis progression.

ABDOMINAL RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Bias and Precision in Magnetic Resonance Imaging-Based Estimates of Renal Blood Flow: Assessment by Triangulation

Bashair A. Alhummiany et al.

Summary: This study compared RBF estimates from ASL, DCE, and PC-MRI, showing poor agreement among individual subjects but good average agreement. In healthy volunteers, PC had significantly smaller repeatability error compared to ASL. Poor agreement among individual subjects may be attributed to outlier values from DCE.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2022)

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Review Urology & Nephrology

Glomerular hyperfiltration

Monica Cortinovis et al.

Summary: Glomerular hyperfiltration can be categorized as 'absolute' hyperfiltration and 'relative' hyperfiltration. 'Absolute' hyperfiltration occurs in the context of a normal number of functioning nephrons and can be seen in high protein intake, pregnancy, diabetes, obesity, or polycystic kidney disease. 'Relative' hyperfiltration occurs when the number of functioning nephrons is reduced and can be seen in patients with a congenitally reduced nephron number or acquired reduction in nephron mass due to surgery or kidney disease.

NATURE REVIEWS NEPHROLOGY (2022)

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Article Transplantation

Usefulness of urinary biomarkers to estimate the interstitial fibrosis surface in diabetic nephropathy with normal kidney function

Jorge Gonzalez et al.

Summary: This study successfully developed a model to estimate the extent of interstitial fibrosis (IF) in patients with diabetic nephropathy (DN) and normal kidney function by analyzing a set of biomarkers of tubular injury. The model can be used to assess the progression of IF in patients with normal kidney function.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Review Pharmacology & Pharmacy

Why is diagnosis, investigation, and improved management of kidney stone disease important? Non-pharmacological and pharmacological treatments for nephrolithiasis

Viola D'Ambrosio et al.

Summary: This review emphasizes the broader aspects of kidney stone disease, including recent epidemiological and pathophysiological findings, as well as emerging treatments. Kidney stone disease is associated with important and common comorbidities such as diabetes, hypertension, cardiovascular disease, and chronic kidney disease, suggesting the need for a more holistic approach to its investigation and treatment.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2022)

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Review Endocrinology & Metabolism

Comparison of Nonalbuminuric and Albuminuric Diabetic Kidney Disease Among Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis

Shaomin Shi et al.

Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, but nonalbuminuric diabetic kidney disease (NADKD) has been increasingly reported in diabetic patients. NADKD patients have different clinical characteristics and pathology compared to albuminuric DKD, and require different diagnostic and treatment strategies.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Urology & Nephrology

Epidemiology of chronic kidney disease: an update 2022

Csaba P. Kovesdy

Summary: Chronic kidney disease affects over 800 million individuals worldwide, especially prevalent in older individuals, women, racial minorities, and people with diabetes and hypertension. It has become a major cause of mortality globally, particularly in low- and middle-income countries.

KIDNEY INTERNATIONAL SUPPLEMENTS (2022)

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Article Urology & Nephrology

Multiparametric magnetic resonance imaging allows non-invasive functional and structural evaluation of diabetic kidney disease

Kianoush Makvandi et al.

Summary: A comprehensive and repeatable non-contrast MRI protocol was developed for the functional and structural evaluation of diabetic kidney disease (DKD). This protocol provides valuable insights into the underlying pathophysiology, disease progression, and analysis of therapeutic interventions in DKD.

CLINICAL KIDNEY JOURNAL (2022)

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Letter Cardiac & Cardiovascular Systems

Effect of Empagliflozin on Kidney Biochemical and Imaging Outcomes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF)

Matthew M. Y. Lee et al.

CIRCULATION (2022)

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Article Biotechnology & Applied Microbiology

Level-Set-Based Kidney Segmentation from DCE-MRI Using Fuzzy Clustering with Population-Based and Subject-Specific Shape Statistics

Moumen El-Melegy et al.

Summary: A new and accurate method for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) kidney segmentation is proposed, which combines fuzzy c-means clustering and level set method, and iteratively updates fuzzy memberships during contour evolution. Population-based shape and subject-specific shape statistics are utilized. Experimental results show that the proposed method outperforms several state-of-the-art level set methods and U-Net neural networks, especially on low-contrast and noisy images.

BIOENGINEERING-BASEL (2022)

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Review Urology & Nephrology

KDIGO 2022 CLINICAL PRACTICE GUIDELINE FOR DIABETES MANAGEMENT IN CHRONIC KIDNEY DISEASE

Ian H. de Boer et al.

Summary: The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (CKD) is a focused update of the 2020 guideline, providing treatment recommendations for clinicians treating diabetes and CKD based on systematic reviews of relevant studies.

KIDNEY INTERNATIONAL (2022)

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Article Endocrinology & Metabolism

New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation

Hong Sun et al.

Summary: This study demonstrates that EMPA alleviates diabetic renal tubular cholesterol accumulation by inhibiting the AGEs-RAGE pathway. The results also indicate that EMPA can reduce AGEs levels and renal fat fraction.

DIABETOLOGY & METABOLIC SYNDROME (2022)

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Review Health Care Sciences & Services

The Related Metabolic Diseases and Treatments of Obesity

Ming Yang et al.

Summary: Obesity is a chronic disease affecting over 1 billion people worldwide, characterized by abnormal accumulation of body fat and commonly associated with other metabolic disorders. Factors such as sedentary lifestyle, overnutrition, genetic and environmental conditions contribute to the development of obesity. Various strategies for obesity management and treatment include exercise, dietary changes, surgery, and medications. Psychological management plays a significant role, especially for distressed patients. Gut microbiota has a crucial role in obesity and its associated conditions, and microbial reprogramming through methods like fecal microbiota transplantation shows promise. Prevention and early treatment of obesity are essential in preventing its progression to comorbidities.

HEALTHCARE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

MRI-based quantification of renal fat in obese individuals using different image analysis approaches

Mimoza Gjela et al.

Summary: By evaluating different renal PDFF analysis approaches, it was found that using multiple circular ROIs can provide more accurate renal PDFF values. Obese individuals had significantly higher renal PDFF values compared to lean controls.

ABDOMINAL RADIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI

Anneloes de Boer et al.

Summary: Through a systematic consensus process, technical recommendations were established for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and result comparability. The international panel of experts reached consensus and provided specific recommendations on data acquisition, processing, and reporting. These recommendations may encourage widespread adoption of renal PC-MRI and provide reference values for multicenter studies.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study

Anneloes de Boer et al.

Summary: The study assessed the intrasubject test-retest repeatability of renal MRI measurements in 19 healthy subjects, with most MRI measures showing good repeatability below 13%, except for perfusion fraction and perfusion as measured by DCE, which were above 13%.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2021)

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Review Urology & Nephrology

Risks and Options With Gadolinium-Based Contrast Agents in Patients With CKD: A Review

Michael R. Rudnick et al.

Summary: Gadolinium-based contrast agents improve diagnostic capabilities of MRI, but can cause nephrogenic systemic fibrosis in severe chronic kidney disease patients. Restrictive policies and selective use of GBCAs with higher free gadolinium affinity have reduced NSF cases, yet physicians remain concerned about GBCA use in severe CKD. Recent observations of gadolinium deposition in the brain and a possible systemic syndrome attributed to GBCAs have magnified these concerns.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Nutrition & Dietetics

The Effect of Glycemic Control on Renal Triglyceride Content Assessed by Proton Spectroscopy in Patients With Type 2 Diabetes Mellitus: A Single-Center Parallel-Group Trial

Ilona A. Dekkers et al.

Summary: This study found that 26 weeks of glycemic control resulted in lower renal triglyceride content, particularly in the liraglutide treatment group. Larger clinical studies are needed to further assess the impact of glycemic control on fatty kidney.

JOURNAL OF RENAL NUTRITION (2021)

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Article Urology & Nephrology

Assessing Risk of Rapid Progression in Autosomal Dominant Polycystic Kidney Disease and Special Considerations for Disease-Modifying Therapy

Fouad T. Chebib et al.

Summary: ADPKD is the most common inherited cause of kidney failure, and predicting which patients will progress rapidly to kidney failure is essential. Various factors have been studied as prognostic markers, with age-adjusted TKV and the drug tolvaptan being key in clinical management. Individualized approaches and ongoing clinical trials aim to identify patients at risk of rapid progression and provide targeted treatment.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Chemistry, Analytical

Healthy Kidney Segmentation in the Dce-Mr Images Using a Convolutional Neural Network and Temporal Signal Characteristics

Artur Klepaczko et al.

Summary: This study proposed an automatic kidney segmentation framework for DCE-MR images, utilizing a convolutional neural network to generate kidney masks and classifying mask voxels based on signal intensity time courses. The results indicated high accuracy in kidney segmentation and classification.

SENSORS (2021)

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Review Cell Biology

Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge

Jorge Gutierrez-Cuevas et al.

Summary: Obesity-induced cardiovascular disease pathophysiology is primarily due to a series of abnormal physiological and metabolic responses caused by excessive lipid accumulation in the body. The multiple factors triggered by obesity can lead to inflammation and oxidative stress, affecting myocardial function. PPARs play a crucial role in improving metabolic abnormalities and oxidative stress.

CELLS (2021)

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Article Multidisciplinary Sciences

Comparison of multiparametric magnetic resonance imaging sequences with laboratory parameters for prognosticating renal function in chronic kidney disease

Tsutomu Inoue et al.

Summary: MRI plays a crucial role in evaluating chronic kidney disease and predicting disease course. Among various MRI sequences examined, T2* values from the BOLD sequence emerged as a good predictor of disease progression, independent of proteinuria levels. Further research is warranted to explore the potential of using BOLD-derived T2* values in the management of CKD.

SCIENTIFIC REPORTS (2021)

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Review Gastroenterology & Hepatology

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Emmanuel Anandraj Selvaraj et al.

Summary: Non-invasive tests measuring liver stiffness or using MRI have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these tests cannot be fully assessed due to lack of intention-to-diagnose analyses and validation of pre-specified thresholds.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Native T1 Mapping in Assessing Kidney Fibrosis for Patients With Chronic Glomerulonephritis

Jianhua Wu et al.

Summary: The study demonstrated that non-contrast enhanced native T1 mapping of the renal cortex is a useful and effective method for evaluating renal fibrosis in patients with chronic glomerulonephritis. The T1 value was found to be significantly correlated with chronic kidney disease stage and various clinical parameters, making it a valuable tool for diagnosing renal fibrosis.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, General & Internal

Perirenal Adipose Tissue-Current Knowledge and Future Opportunities

Adriana Grigoras et al.

Summary: Perirenal adipose tissue (PRAT) as a component of visceral adipose tissue, plays an important role in maintaining cardiovascular system and kidney balance. PRAT is a complex microenvironment consisting of various adipocytes, nerve endings, and inflammatory cells. It may also be involved in hypertension, obesity, chronic renal diseases, and tumor progression.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Canagliflozin could improve the levels of renal oxygenation in newly diagnosed type 2 diabetes patients with normal renal function

Saijun Zhou et al.

Summary: The study showed that canagliflozin improved renal oxygenation in newly diagnosed type 2 diabetes mellitus patients with normal renal function, independently of changes in renal blood perfusion.

DIABETES & METABOLISM (2021)

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Article Endocrinology & Metabolism

Renal sinus fat volume in type 2 diabetes mellitus is associated with glycated hemoglobin and metabolic risk factors

Ling Lin et al.

Summary: This study compared renal sinus fat volume assessed by MRI between patients with type 2 diabetes and healthy volunteers, and investigated the association between renal sinus fat and metabolic traits. The results showed that in type 2 diabetes patients, renal sinus fat volume is positively associated with several metabolic risk factors including HbA1c level and urinary albumin-to-creatinine ratio, indicating a potential role of renal sinus fat in the development of diabetic nephropathy.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

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Review Transplantation

Precision medicine in diabetic nephropathy and chronic kidney disease

Danilo Fliser et al.

Summary: Progressive chronic kidney disease in individuals with type 2 diabetes mellitus is a global public health issue with challenges in predicting the individual course of the disease progression. Patterns of progression in CKD patients include both linear and nonlinear trajectories of GFR loss, with kidney function potentially remaining stable for years in the elderly.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Review Medicine, General & Internal

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

Luis D'Marco et al.

Summary: Adipose tissues around the heart and kidneys play a significant role in cardiovascular and renal diseases, especially in chronic kidney disease patients. Epicardial fat and perirenal fat may influence atherosclerosis and kidney diseases through the secretion of inflammatory factors and fatty acids, serving as modulators of cardiorenal dysfunction.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: A randomised, double-blind, placebo-controlled crossover trial

Jens Christian Laursen et al.

Summary: A single 50 mg dose of dapagliflozin acutely improved renal cortical oxygenation without affecting renal perfusion or blood flow, suggesting a potential mechanism through reducing tubular transport workload. Further studies are needed to determine if these effects can be achieved with chronic treatment, at lower doses, and in individuals with type 2 diabetes.

ECLINICALMEDICINE (2021)

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Article Computer Science, Information Systems

Kidney Segmentation in Renal Magnetic Resonance Imaging-Current Status and Prospects

Frank G. Zoellner et al.

Summary: Magnetic resonance imaging plays an increasingly important role in the clinical diagnosis of renal diseases such as CKD, with TKV being considered a biomarker. Volume estimation in renal MRI is based on image segmentation, which also supports quantification of other MR parameters. However, limitations in existing renal image segmentation techniques may hinder clinical translation, and open source software resources can be helpful in this field.

IEEE ACCESS (2021)

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Article Transplantation

Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease

Kei Sugiyama et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Article Transplantation

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging

Charlotte E. Buchanan et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Article Urology & Nephrology

Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency

Andrew S. Levey et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Article Anatomy & Morphology

What Makes the Kidney Susceptible to Hypoxia?

Roger G. Evans et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Renal sinus fat and renal hemodynamics: a cross-sectional analysis

Karlinde A. Spit et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Phase-contrast magnetic resonance imaging to assess renal perfusion: a systematic review and statement paper

Giulia Villa et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Article Nutrition & Dietetics

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics

Christopher R. Bradley et al.

CLINICAL NUTRITION (2020)

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Article Urology & Nephrology

Multiparametric magnetic resonance imaging shows promising results to assess renal transplant dysfunction with fibrosis

Octavia Bane et al.

KIDNEY INTERNATIONAL (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Image registration in dynamic renal MRI-current status and prospects

Frank G. Zoellner et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Octavia Bane et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

Michael Pedersen et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Alexandra Ljimani et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Ilona A. Dekkers et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Editorial Material Urology & Nephrology

Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators

Frank Holtkamp et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Editorial Material Urology & Nephrology

Change in Estimated GFR and Albuminuria as End Points in Clinical Trials: A Viewpoint From the FDA

Aliza Thompson et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Article Transplantation

Validation of the corticomedullary difference in magnetic resonance imaging-derived apparent diffusion coefficient for kidney fibrosis detection: a cross-sectional study

Lena Berchtold et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Editorial Material Urology & Nephrology

Visualizing fibrosis-hope for ideal markers beyond imaging

Yosuke Hirakawa et al.

KIDNEY INTERNATIONAL (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Consensus-based technical recommendations for clinical translation of renal ASL MRI

Fabio Nery et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparing the interobserver reproducibility of different regions of interest on multi-parametric renal magnetic resonance imaging in healthy volunteers, patients with heart failure and renal transplant recipients

Alastair J. Rankin et al.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2020)

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Article Multidisciplinary Sciences

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Mike Notohamiprodjo et al.

PLOS ONE (2020)

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Article Urology & Nephrology

Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD

Anand Srivastava et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Review Urology & Nephrology

Pathophysiology of AKI to CKD progression

Yuki Sato et al.

SEMINARS IN NEPHROLOGY (2020)

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Review Urology & Nephrology

The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

Anne C. Hesp et al.

KIDNEY INTERNATIONAL (2020)

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Article Transplantation

Diffusion magnetic resonance imaging detects an increase in interstitial fibrosis earlier than the decline of renal function

Lena Berchtold et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Review Physiology

Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond

Alemayehu H. Jufar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Advances in Magnetic Resonance Elastography of Liver

Jiahui Li et al.

MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA (2020)

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Article Urology & Nephrology

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

Kim M. Gooding et al.

BMC NEPHROLOGY (2020)

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Review Endocrinology & Metabolism

NAFLD as a continuum: from obesity to metabolic syndrome and diabetes

Amelio F. Godoy-Matos et al.

DIABETOLOGY & METABOLIC SYNDROME (2020)

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Article Multidisciplinary Sciences

Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease

Christopher M. Ferguson et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, General & Internal

HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol

Kieran Mccafferty et al.

BMJ OPEN (2020)

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Review Urology & Nephrology

The Nephrologist as an Ultrasonographer

Abhilash Koratala et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2020)

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Article Urology & Nephrology

Gadolinium-Based Contrast Agent Use, Their Safety, and Practice Evolution

Catherine Do et al.

KIDNEY360 (2020)

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Article Transplantation

Magnetic Resonance Imaging for Evaluation of Interstitial Fibrosis in Kidney Allografts

Andrea Beck-Toelly et al.

TRANSPLANTATION DIRECT (2020)

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Article Psychiatry

Relationship of para- and perirenal fat and epicardial fat with metabolic parameters in overweight and obese subjects

Carlo Manno et al.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2019)

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Article Peripheral Vascular Disease

Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease: a randomized clinical trial

Dinah S. Khatir et al.

JOURNAL OF HYPERTENSION (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

A prospective comparison of dynamic contrast-enhanced MRI and 51Cr-EDTA clearance for glomerular filtration rate measurement in 42 kidney transplant recipients

Benjamin Taton et al.

EUROPEAN JOURNAL OF RADIOLOGY (2019)

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Article Endocrinology & Metabolism

Acute hyperglycemia increases renal tissue oxygenation as measured by BOLD-MRI in healthy overweight volunteers

Nima Vakilzadeh et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

The Accuracy of Renal Function Measurements in Obstructive Hydronephrosis Using Dynamic Contrast-Enhanced MR Renography

Yuan-Cheng Wang et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2019)

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