Emerging Molecular Determinants and Protective Strategies in Heart Disease: What's New in the Journal of Clinical Medicine? Outlook to the Future

Article Medicine, General & Internal

A Novel Reperfusion Strategy for Primary Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Prospective Case Series

Ji-Fang He et al.

Summary: The VCR strategy for PCI in patients with STEMI is feasible and safe.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Medicine, General & Internal

Growth Differentiation Factor 15 as a Predictor of the No-Reflow Phenomenon in Patients with ST-Segment Elevation Myocardial Infarction

Marcin Kozuch et al.

Summary: This study aimed to assess the relationship between GDF-15 concentration on admission and the occurrence of the no-reflow phenomenon. The results showed a negative correlation between GDF-15 concentration and TIMI flow after PCI. Multivariate logistic regression analysis identified higher age, GDF-15 concentration > 1503 pg/mL, lower systolic blood pressure, and higher troponin I concentration on admission as risk factors for no-reflow.

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Medicine, General & Internal

Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment

Ciro Mauro et al.

Summary: Cardiovascular diseases are a major cause of morbidity and mortality among cancer survivors, particularly breast cancer survivors. The use of certain chemotherapeutics in breast cancer treatment can lead to cardiac dysfunction. Therefore, it is important to have a multidisciplinary approach for preventing, detecting, and treating cardiotoxicity in breast cancer patients.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Medicine, General & Internal

Association of Serum BAFF Levels with Cardiovascular Events in ST-Segment Elevation Myocardial Infarction

Ziyang Wang et al.

Summary: This study suggests that higher BAFF levels in the acute phase are an independent predictor of the incidence of MACEs in patients with STEMI. The impact of high BAFF on MACEs development is stronger in patients without dyslipidemia. BAFF can also improve the predictive value of traditional risk factors and cardiac troponin I in predicting MACEs.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Medicine, General & Internal

Serial Non-Invasive Myocardial Work Measurements for Patient Risk Stratification and Early Detection of Cancer Therapeutics-Related Cardiac Dysfunction in Breast Cancer Patients: A Single-Centre Observational Study

Ana Moya et al.

Summary: This study aims to describe the temporal changes and longitudinal trajectories of Myocardial Work (MW) indices during cardiotoxic treatment. MW indices were calculated through pressure-strain loop (PSL) analysis. Results showed that prior to chemotherapy, MWI, MWE, and CW were significantly lower in patients with moderate Cancer Therapeutics-Related Cardiac Dysfunction (CTRCDmod) than in patients without CTRCD (CTRCDneg) and with mild CTRCD (CTRCDmild). At 6 months, overt cardiac dysfunction in CTRCDmod was accompanied by worse values in MWI, MWE, and WW compared to CTRCDneg and CTRCDmild. MW features such as low baseline CW and a rise in WW at follow-up may indicate risk for CTRCD.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Medicine, General & Internal

Predictive Value of Elevated Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels for Assessment of Cardio-Renal Interactions among ST-Segment Elevation Myocardial Infarction Patients

David Zahler et al.

Summary: Elevated NGAL levels have prognostic utility for renal and clinical outcomes among STEMI patients undergoing primary PCI, independent of traditional inflammatory markers. High NGAL is associated with increased short-term adverse outcomes, such as acute kidney injury, lower left ventricular ejection fraction, higher 30-day mortality, and higher incidence of MACE.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Myocardial Aldosterone Receptor and Aquaporin 1 Up-Regulation Is Associated with Cardiomyocyte Remodeling in Human Heart Failure

Andrea Frustaci et al.

Summary: The study identified that patients with heart failure exhibit overexpression of myocardial aldosterone receptor and aquaporin-1, resulting in intracellular water overloading, cardiomyocyte swelling, and dysfunction. Cardiac recovery is accompanied by down-regulation of hormonal receptors and normalization of cell structure.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Reducing Cardiac Injury during ST-Elevation Myocardial Infarction: A Reasoned Approach to a Multitarget Therapeutic Strategy

Alessandro Bellis et al.

Summary: Reducing myocardial-ischemia reperfusion injury (MIRI) is crucial for improving prognosis in ST elevation myocardial infarction (STEMI) patients. While single interventions have shown benefits, a multitarget therapeutic strategy is needed to effectively reduce mortality.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal