Journal
JOURNAL OF CLINICAL MEDICINE
Volume 12, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/jcm12144848
Keywords
systemic lupus erythematosus; safety; biologic treatment; efficacy; meta-analysis
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This study analyzed the efficacy and safety of new B cell-targeted drug therapies for SLE, such as belimumab and tabalumab, through systematic review and meta-analysis of randomized controlled trials. The findings suggest that belimumab and tabalumab therapies are effective and safe in the treatment of SLE, with lower risks of adverse events and serious adverse events in the treatment group.
Background: B cells are central to the pathogenesis of systemic lupus erythematosus (SLE). We aimed to analyze the efficacy and safety of new B cell-targeted drug therapies for SLE. Methods: A systematic review of randomized controlled trials (RCTs) and reference lists of relevant articles published from inception to 2022 were selected from PubMed, Scopus and Web of Science databases. Random effects meta-analyses were performed to estimate an overall effect size for the risk of adverse events (AEs) and serious adverse events (SAEs) with belimumab and tabalumab treatment. Heterogeneity was assessed using the I-2 statistic and meta-regression. Funnel asymmetry was evaluated using Egger's test. Results: This study included 13 RCTs, of which three showed high risk of bias. Egger's test showed no asymmetry. The risk of SAEs and AEs was lower in the treatment group with belimumab treatment. The risk of AEs for tabalumab treatment was lower in the treatment group and lower for SAEs. Conclusion: Belimumab and tabalumab therapies are effective and safe in the treatment of SLE, although tabalumab does not show sufficient statistical power. Advances in understanding the underlying mechanisms of SLE will be directed towards correlating clinical manifestations with specific pathogenic pathways and the development of precision medicine.
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