4.7 Article

Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Clinical Evaluation of Factor XIa Inhibitor Drugs JACC Review Topic of the Week

Josephine Harrington et al.

Summary: FXIa inhibitors have the potential to improve precision in anticoagulation by primarily targeting thrombus formation while sparing clotting and hemostasis. Observational data and small phase 2 trials have shown promising results in terms of bleeding, safety, and prevention of venous thromboembolism. Larger clinical trials are needed to determine the role of FXIa inhibitors in different patient populations.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

Article Hematology

Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis

Mattia Galli et al.

Summary: This meta-analysis indicates that FXI inhibitors are safer and more effective than enoxaparin and have a comparable level of safety to DOACs. However, the use of FXI inhibitors in adjunct to antiplatelet therapy does not show a significant difference in efficacy.

THROMBOSIS AND HAEMOSTASIS (2023)

Article Hematology

Predictive value for increased activated factor XI activity in acute venous thromboembolism

Magdolna Nagy et al.

Summary: This study found that FXIa levels were elevated in patients with acute VTE and were associated with recurrent VTE, suggesting a significant risk contribution of FXI activation to VTE. The findings support the use of FXIa inhibition in the setting of acute VTE.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2023)

Article Peripheral Vascular Disease

Risk Factors for Post-Thrombotic Syndrome in Patients With a First Proximal Deep Venous Thrombosis Treated With Direct Oral Anticoagulants

Luca Spiezia et al.

Summary: The incidence of post-thrombotic syndrome (PTS) in patients with deep vein thrombosis (DVT) treated with direct oral anticoagulants (DOACs) remains significant, and obesity and iliofemoral DVT may be predisposing risk factors for PTS.

ANGIOLOGY (2022)

Article Hematology

Active FXI Can Independently Predict Ischemic Stroke in Anticoagulated Atrial Fibrillation Patients: A Cohort Study

Michal Tomasz Zabczyk et al.

Summary: This study investigates the prognostic value of active coagulation factors in atrial fibrillation (AF) patients. The results show that the presence of FXIa in circulating blood is associated with an increased risk of ischemic stroke and cardiovascular death in AF patients during long-term follow-up.

THROMBOSIS AND HAEMOSTASIS (2022)

Article Medicine, General & Internal

Clinical Pharmacology of Factor XI Inhibitors: New Therapeutic Approaches for Prevention of Venous and Arterial Thrombotic Disorders

Elena Campello et al.

Summary: This review summarizes the clinical pharmacology and evidence from phase 2 clinical trials for drugs targeting FXI in the treatment and prevention of thrombosis, showing the potential effectiveness of FXI inhibitors without impairing hemostasis.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Oncology

Factor XI Deficiency

Magdalena Dorota Lewandowska et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2021)

Article Hematology

Venous thromboembolism risk associated with ABO, F11 and FGG loci

Licinio Manco et al.

BLOOD COAGULATION & FIBRINOLYSIS (2018)

Review Hematology

An update on factor XI structure and function

Bassem M. Mohammed et al.

THROMBOSIS RESEARCH (2018)

Article Hematology

New Prothrombin Mutation (Arg596Trp, Prothrombin Padua 2) Associated With Venous Thromboembolism

Cristiana Bulato et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Article Hematology

F11 is associated with recurrent VTE in women A prospective cohort study

Maria Bruzelius et al.

THROMBOSIS AND HAEMOSTASIS (2016)

Article Hematology

The hemostatic role of factor XI

Cristina Puy et al.

THROMBOSIS RESEARCH (2016)

Review Hematology

Factor XI and contact activation as targets for antithrombotic therapy

D. Gailani et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

Article Hematology

The dimeric structure of factor XI and zymogen activation

Yipeng Geng et al.

BLOOD (2013)

Article Education, Scientific Disciplines

The diagnosis and treatment of venous thromboembolism

Philip Wells et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2013)

Article Hematology

Genetic variants associated with deep vein thrombosis: the F11 locus

Y. Li et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

Article Pathology

Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events

David T. Yang et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2006)

Article Hematology

Elevated levels of Factor XI are associated with cardiovascular disease in women

JI Berliner et al.

THROMBOSIS RESEARCH (2002)

Article Medicine, General & Internal

High levels of coagulation factor XI as a risk factor for venous thrombosis.

JCM Meijers et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)