SARS-CoV-2 specific plasma cells acquire long-lived phenotypes in human bone marrow

Article Multidisciplinary Sciences

Germinal centre-driven maturation of B cell response to mRNA vaccination

Wooseob Kim et al.

Summary: SARS-CoV-2 mRNA vaccination induces a persistent germinal center reaction in humans, resulting in affinity-matured long-term antibody responses that potently neutralize the virus.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Humoral and cellular immune memory to four COVID-19 vaccines

Zeli Zhang et al.

Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.

CELL (2022)

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Letter Infectious Diseases

Dynamics of humoral and T-cell immunity after three BNT162b2 vaccinations in adults older than 80 years

Addi J. Romero-Olmedo et al.

LANCET INFECTIOUS DISEASES (2022)

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Article Immunology

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Andrea Cossarizza et al.

Summary: The third edition of Flow Cytometry Guidelines provides comprehensive information on phenotypes and functional assays of major human and murine immune cell subsets, as well as clinical sample analysis and applications in various diseases. It also includes expert tips, tricks, and pitfalls to avoid, making it an essential handbook for researchers.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Jackson S. Turner et al.

Summary: The study found that individuals who had recovered from mild SARS-CoV-2 infections showed rapid decline of serum anti-SARS-CoV-2 spike protein antibodies in the first 4 months after infection, followed by a more gradual decrease over the following 7 months but remaining detectable at least 11 months after infection. This suggests that mild infection with SARS-CoV-2 can induce robust antigen-specific, long-lived humoral immune memory in humans.

NATURE (2021)

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Article Immunology