Journal
SCIENCE ADVANCES
Volume 9, Issue 34, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.add3643
Keywords
-
Categories
Ask authors/readers for more resources
By using dissolution dynamic nuclear polarization (dDNP), the sensitivity of magnetic resonance imaging is enhanced by over 10,000 times, allowing for noninvasive real-time in vivo metabolic imaging. Here, a group of dDNP polarized tracers based on nicotinamide (NAM) are being developed.
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be performed noninvasively in real time. Here, we are developing a group of dDNP polarized tracers based on nicotinamide (NAM). We synthesized 1-N-15-NAM and 1-N-15 nicotinic acid and hyperpolarized them with dDNP, reaching (13.0 +/- 1.9)% N-15 polarization. We found that the lifetime of hyperpolarized 1-N-15-NAM is strongly field- and pH-dependent, with T1 being as long as 41 s at a pH of 12 and 1 T while as short as a few seconds at neutral pH and fields below 1 T. The remarkably short 1-N-15 lifetime at low magnetic fields and neutral pH drove us to establish a unique pH neutralization procedure. Using N-15 dDNP and an inexpensive rodent imaging probe designed in-house, we acquired a N-15 MRI of 1-N-15-NAM (previously hyperpolarized for more than an hour) in less than 1 s.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available