4.8 Article

Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

Leander Witte et al.

Summary: The emergence of SARS-CoV-2 variants with neutralizing antibody resistance mutations has led to waves of infection. However, repeated exposure to antigens has also resulted in the production of broadly neutralizing antibodies against these variants. Through their study, Witte et al found that specific substitutions in the spike protein of SARS-CoV-2 enable the acquisition of resistance to broadly neutralizing antibodies. These findings highlight the importance of understanding the interactions between new and old substitutions in the development of antibody escape.

NATURE COMMUNICATIONS (2023)

Review Immunology

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Yanjia Chen et al.

Summary: This article summarizes neutralizing antibodies targeting four key regions of the SARS-CoV-2 spike protein, which are important for developing antibody therapeutics and designing next-generation vaccines.

NATURE REVIEWS IMMUNOLOGY (2023)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Wanwisa Dejnirattisai et al.

Summary: On November 24, 2021, the sequence of a new SARS-CoV-2 variant, Omicron-B.1.1.529, was announced. Compared to previous variants, Omicron has a higher number of mutations in the Spike (S) protein. Serum neutralization of Omicron by individuals vaccinated or previously infected with Alpha, Beta, Gamma, or Delta variants is significantly reduced or ineffective. Third vaccine doses can boost neutralization titers against Omicron, and high titers are observed in both vaccinated individuals and those infected with the Delta variant. Most potent monoclonal antibodies and antibodies under development are unable to effectively neutralize Omicron due to mutations in its Spike protein. Omicron has structural changes compared to earlier viruses and utilizes mutations that enhance its binding to ACE2, allowing for immune escape. This results in a large number of mutations in the ACE2 binding site and a rebalancing of receptor affinity similar to earlier pandemic viruses.
Article Biochemistry & Molecular Biology

Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Zhen Cui et al.

Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly worldwide due to its increased fitness, with spike structures that maintain stability for receptor recognition but compromise viral fusion efficiency. By altering amino acids and structures, it evades recognition by most antibodies, facilitating immune escape. The research sheds light on conserved regions for the development of broad-spectrum vaccines.
Article Multidisciplinary Sciences

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Delphine Planas et al.

Summary: The Omicron variant of SARS-CoV-2, identified in November 2021, has spread rapidly worldwide and shows resistance to most therapeutic monoclonal antibodies and vaccine-elicited antibodies. However, it can be neutralized by antibodies generated by a booster vaccine dose.

NATURE (2022)

Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

Article Multidisciplinary Sciences

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

Wanchao Yin et al.

Summary: The structures of the Omicron spike trimer and its interactions with ACE2 and an anti-Omicron antibody are reported. Most mutations in Omicron are located on the spike protein surface, altering binding to many existing antibodies. Compensating mutations in the ACE2-binding site enhance binding to ACE2. The therapeutic antibody JMB2002 maintains neutralizing activity against Omicron and inhibits ACE2 binding.

SCIENCE (2022)

Article Multidisciplinary Sciences

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Young-Jun Park et al.

Summary: Understanding broadly neutralizing sarbecovirus antibody responses is crucial for developing countermeasures against SARS-CoV-2 variants and future sarbecoviruses. The human monoclonal antibody S2K146 has been found to broadly neutralize ACE2-binding viruses and shows potential for clinical development. Conserved ACE2-binding residues could be leveraged for developing vaccines that elicit broad immunity.

SCIENCE (2022)

Article Cell Biology

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

David R. Martinez et al.

Summary: Severe acute respiratory syndrome coronaviruses (SARS-CoVs), including SARS-CoV-2 variants, can cause deadly infections. A human antibody called DH1047 has been shown to neutralize SARS-CoV and various coronaviruses, and protect against SARS-CoV-2 B.1.351 infection in mice. The study suggests that DH1047 could be a broadly protective antibody and a potential target for a universal sarbecovirus vaccine.

SCIENCE TRANSLATIONAL MEDICINE (2022)

News Item Infectious Diseases

Research in brief

Sharmila Devi

LANCET INFECTIOUS DISEASES (2022)

Letter Medicine, General & Internal

Neutralization Profile after Recovery from SARS-CoV-2 Omicron Infection

Annika Roessler et al.

Summary: Although some antibodies generated in persons recovering from infection with the omicron variant show cross-reactivity, a group of unvaccinated individuals were found to have largely ineffective antibodies against other viral strains.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Cell Biology

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

Zezhong Liu et al.

Summary: The newly identified antibody XG014 demonstrates potent neutralizing activity against beta-coronaviruses, with a unique recognition mode and conservation epitope, making it a potential therapeutic candidate for pan-beta-coronavirus treatment. Its single-dose administration shows efficacy in protecting and treating SARS-CoV-2 infection in vivo.

PROTEIN & CELL (2022)

Article Cell Biology

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Kathryn Westendorf et al.

Summary: A monoclonal antibody named LY-CoV1404 has been successfully isolated, which demonstrates highly potent neutralization against multiple variants of the SARS-CoV-2 virus. The binding site of LY-CoV1404 remains relatively conserved, allowing it to maintain its activity. This finding suggests that LY-CoV1404 has the potential to be an effective therapeutic agent against all known variants.

CELL REPORTS (2022)

Article Multidisciplinary Sciences

Omicron's binding to sotrovimab, casirivimab, imdevimab, CR3022, and sera from previously infected or vaccinated individuals

Anna-Lena Mader et al.

Summary: SARS-CoV-2 Omicron is a pandemic variant of concern with mutations in the receptor-binding domain and reduced serum neutralization against it. Booster vaccination can enhance the response, but it is still lower compared to the response against the Wuhan strain. However, some antibodies can still bind and potentially be used in the prevention and treatment of Omicron-induced COVID-19.

ISCIENCE (2022)

Article Multidisciplinary Sciences

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein

Ryota Otsubo et al.

Summary: This study investigated neutralizing antibodies against new variants of the coronavirus and identified two antibodies that were able to neutralize the wild-type virus and the Delta variant, but not the Omicron variant. One of the antibodies targeted the N-terminal domain of the S1 subunit and inhibited S1/S2 cleavage, thus preventing viral entry. The results suggest that neutralizing antibodies targeting S1/S2 cleavage inhibition may have cross-reactivity against multiple virus variants.

SCIENTIFIC REPORTS (2022)

Article Multidisciplinary Sciences

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

Yunlong Cao et al.

Summary: Omicron sublineages BA.2.12.1, BA.4 and BA.5 have higher transmissibility and increased evasion of neutralizing antibodies compared to the BA.2 lineage. They exhibit similar binding affinities to the ACE2 receptor as BA.2. BA.1 infection after vaccination boosts humoral immune memory against wild-type SARS-CoV-2, but these antibodies are largely evaded by BA.2 and BA.4/BA.5 variants.

NATURE (2022)

Article Immunology

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

John E. Bowen et al.

Summary: This study demonstrates that vaccines containing prefusion-stabilizing S mutations can induce enhanced antibody responses in humans, particularly in recognition of the S and S1 subunit. Antibody binding to prefusion S and S1 correlates positively and equivalently with neutralizing activity, with S1-directed antibodies being crucial for plasma neutralization. The study also shows that neutralizing activity is predominantly directed at the S1 subunit and variant cross-neutralization is mediated solely by receptor binding domain-specific antibodies.

SCIENCE IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

A broad and potent neutralization epitope in SARS-related coronaviruses

Meng Yuan et al.

Summary: Therapeutic antibody ADG20 shows effectiveness in neutralizing SARS-CoV-2 variants, including Omicron, by binding to two different sites on the virus. This study has implications for the design of universal vaccines and therapeutic antibodies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

Jun Siong Low et al.

Summary: Researchers have isolated seven monoclonal antibodies that can bind to spike proteins of all human-infecting coronaviruses, including SARS-CoV-2. Some of these antibodies show broad neutralizing activity against different types of coronaviruses and can also neutralize Omicron BA.1 and BA.2 viruses, reducing viral burden and pathology.

SCIENCE (2022)

Article Cell Biology

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

Victoria Stalls et al.

Summary: This study determines the cryoelectron microscopy structures of the Spike (S) protein of the Omicron BA.2 sub-lineage of the SARS-CoV-2 virus and compares it with the BA.1 sub-lineage. The BA.2 S protein exhibits tighter packing and improved thermostability due to mutations in the receptor-binding domain (RBD). The closed state of BA.2 S enhances RBD interactions and shows reduced accessibility of the fusion peptide to antibodies compared to BA.1.

CELL REPORTS (2022)

Article Multidisciplinary Sciences

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Sho Iketani et al.

Summary: The identification of the Omicron variant of SARS-CoV-2 in Botswana in November 2021 sparked concern due to the spike protein alterations that could potentially evade antibodies. Further studies showed that the Omicron sublineages, BA.1+R346K and BA.2, are antigenically similar to the wild-type virus and pose similar risks to the effectiveness of current vaccines. BA.2 also demonstrated resistance to many neutralizing monoclonal antibodies, highlighting the challenges in developing effective therapeutic options.

NATURE (2022)

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Adaptive immunity to SARS-CoV-2 and COVID-19

Alessandro Sette et al.

Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.
Article Microbiology

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Allison J. Greaney et al.

Summary: Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are key in neutralizing antibody responses, and a deep mutational scanning method was used to assess the impact of all amino-acid mutations in the RBD on antibody binding with 10 human monoclonal antibodies. The study identified the clustered escape mutations in different surfaces of the RBD that correspond to structurally defined antibody epitopes, showing that even antibodies targeting the same surface can have distinct escape mutations.

CELL HOST & MICROBE (2021)

Article Multidisciplinary Sciences

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

C. Garrett Rappazzo et al.

Summary: The engineered antibody ADG-2 shows enhanced neutralization breadth and potency against a wide range of sarbecoviruses, providing complete protection in SARS and COVID-19 mouse models. Structural and biochemical studies reveal that ADG-2 targets a highly conserved epitope through a unique angle of approach.

SCIENCE (2021)

Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

Article Multidisciplinary Sciences

Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia

Supaporn Wacharapluesadee et al.

Summary: A study identified a SARS-CoV-2-related coronavirus (SC2r-CoV), RacCS203, in Rhinolophus acuminatus bats from Thailand, with 91.5% genome similarity to SARS-CoV-2, and demonstrated that sera obtained from bats and Malayan pangolin can neutralize SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Deborah Delaune et al.

Summary: The study identified SARS-CoV-2 related coronaviruses in bats sampled in Cambodia, indicating a wider geographic distribution than previously reported. The findings suggest that Southeast Asia may be a key area to consider for future coronavirus surveillance.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Renhong Yan et al.

Summary: This study investigated the structural basis for the potent neutralizing activity of nAbs against SARS-CoV-2, finding that the bivalent binding of full-length IgG associates with more RBDs in the up conformation, leading to enhanced neutralization and shedding of the S1 subunit from the S protein. Comparing a large number of nAbs revealed common and unique structural features associated with their potent neutralizing activities.

CELL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Tackling COVID-19 with neutralizing monoclonal antibodies

Davide Corti et al.

Summary: Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity, and infectious diseases. Lessons learned from the COVID-19 pandemic have paved the way for the development of more monoclonal antibody-based therapeutics.
Article Biochemical Research Methods

Mechanistic Insights to the Binding of Antibody CR3022 Against RBD from SARS-CoV and HCoV-19/SARS-CoV-2: A Computational Study

Wei Yu et al.

Summary: The study utilized molecular dynamics simulation to investigate the binding mechanism of the CR3022 antibody against SARS-CoV and HCoV-19, revealing common conservative amino acids in both systems and highlighting the deficiency of crucial hydrogen bonds and salt bridges in the HCoV-19-RBD system, resulting in a loss of affinity.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2021)

Article Multidisciplinary Sciences

Broad sarbecovirus neutralization by a human monoclonal antibody

M. Alejandra Tortorici et al.

Summary: The emergence of SARS-CoV-2 variants and recurrent spillovers of coronaviruses into the human population emphasize the need for broadly neutralizing antibodies to prevent future zoonotic infections. The human monoclonal antibody S2X259 has shown promising results in neutralizing various forms of SARS-CoV-2 and potentially zoonotic sarbecoviruses by inhibiting the binding of ACE2 to the receptor-binding domain. This antibody targets a key antigenic site and may guide the design of vaccines effective against all sarbecoviruses.

NATURE (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Tyler N. Starr et al.

Summary: An ideal therapeutic anti-SARS-CoV-2 antibody should have resistance to viral escape, activity against diverse sarbecoviruses, and provide high protection through viral neutralization and effector functions. Studies have found a trade-off between in vitro neutralization potency and breadth of sarbecovirus binding in SARS-CoV-2 antibodies targeting the RBD, but identified some antibodies with exceptional sarbecovirus breadth and resistance to SARS-CoV-2 escape.

NATURE (2021)

Article Medicine, General & Internal

Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

Chee-Wah Tan et al.

Summary: Survivors of SARS-CoV-1 infection who received the BNT162b2 mRNA vaccine produced potent cross-clade pan-sarbecovirus neutralizing antibodies, capable of neutralizing various variants of concern and potential human-infecting coronaviruses, indicating the feasibility of a pan-sarbecovirus vaccine strategy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Lingshu Wang et al.

Summary: The study identified four receptor binding domain-targeting antibodies with potent neutralizing activity against 23 variants, including two ultrapotent antibodies. Combinations of these antibodies reduced the in vitro generation of escape mutants, showing potential in mitigating resistance development.

SCIENCE (2021)

Article Multidisciplinary Sciences

Broad betacoronavirus neutralization by a stem helix-specific human antibody

Dora Pinto et al.

Summary: The study identified five monoclonal antibodies from COVID-19 convalescent individuals that cross-react with multiple betacoronavirus spike glycoproteins, with one antibody (S2P6) showing broad neutralization of viruses from three different subgenera. This antibody reduced viral burden in hamsters challenged with SARS-CoV-2 by inhibiting membrane fusion, providing a framework for the design of pan-betacoronavirus vaccines for broad protection.

SCIENCE (2021)

Article Cell Biology

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

Claudia A. Jette et al.

Summary: This study characterizes two class 4 anti-RBD antibodies derived from COVID-19 donors that exhibit breadth and potent neutralization of zoonotic coronaviruses and SARS-CoV-2 variants. These antibodies work by occluding the ACE2 binding site and reducing sensitivity to variations in the protein structure.

CELL REPORTS (2021)

Article Cell Biology

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Federico Bertoglio et al.

Summary: Researchers have developed a human neutralizing antibody against SARS-CoV-2, which shows promising efficacy in animal models and is currently undergoing clinical trials for the treatment of moderate to severe COVID-19. The antibody binds to the receptor-binding domain (RBD) of the spike protein to inhibit the virus, and is not affected by many known RBD mutations.

CELL REPORTS (2021)

Article Immunology

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

Benjamin Israelow et al.

Summary: Research demonstrates that both humoral and cellular immunity play a role in clearing SARS-CoV-2, and convalescent mice or mice vaccinated with mRNA are protected from infection with both the wild type virus and the B.1.351 variant. This protection is mainly mediated by antibody response rather than cellular immunity.

SCIENCE IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Ester Lopez et al.

Summary: This study introduces a new rapid multiplex assay for measuring SARS-CoV-2 antibodies that can evaluate multiple RBD natural variants, filling a major gap in SARS-CoV-2 research and providing a method for selecting complementary monoclonal antibody candidates and rapidly identifying immune escape to emerging RBD variants following vaccination or natural infection.

JCI INSIGHT (2021)

Article Multidisciplinary Sciences

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

Alexander A. Cohen et al.

Summary: The study developed nanoparticles displaying the receptor binding domain (RBD) of SARS-CoV-2 and other animal coronaviruses, which induced cross-reactive antibody responses in mice. Immunization with mosaic RBD nanoparticles resulted in superior neutralization of heterologous viruses, providing a potential strategy for simultaneous protection against multiple coronaviruses.

SCIENCE (2021)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Article Multidisciplinary Sciences

Cross-neutralization ofSARS-CoV-2 by a human monoclonal SARS-CoV antibody

Dora Pinto et al.

NATURE (2020)

Article Multidisciplinary Sciences

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Tommy Tsan-Yuk Lam et al.

NATURE (2020)

Article Multidisciplinary Sciences

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Lihong Liu et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structural basis of a shared antibody response to SARS-CoV-2

Meng Yuan et al.

SCIENCE (2020)

Review Multidisciplinary Sciences

SARS-CoV-2 vaccines in development

Florian Krammer

NATURE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

Review Medicine, Research & Experimental

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

Marco Tuccori et al.

Article Biochemical Research Methods

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Dorothee Liebschner et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)

Article Biochemical Research Methods

Real-time cryo-electron microscopy data preprocessing with Warp

Dimitry Tegunov et al.

NATURE METHODS (2019)

Article Chemistry, Multidisciplinary

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

Jasenko Zivanov et al.

IUCRJ (2019)

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

Thomas D. Goddard et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

Alexis Rohou et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Deciphering key features in protein structures with the new ENDscript server

Xavier Robert et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres

JOURNAL OF STRUCTURAL BIOLOGY (2012)

Article Medicine, General & Internal

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

Ali Moh Zaki et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

Fabian Sievers et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

Kenneth Smith et al.

NATURE PROTOCOLS (2009)

Article Medicine, General & Internal

Human monoclonal antibody combination against SARS coronavirus: Synergy and coverage of escape mutants

Jan ter Meulen et al.

PLOS MEDICINE (2006)

Article Multidisciplinary Sciences

Bats are natural reservoirs of SARS-like coronaviruses

WD Li et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Automated electron microscope tomography using robust prediction of specimen movements

DN Mastronarde

JOURNAL OF STRUCTURAL BIOLOGY (2005)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)