4.8 Article

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

Related references

Note: Only part of the references are listed.
Article Obstetrics & Gynecology

Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation

Peter T. Ruane et al.

Summary: Embryo attachment to endometrial epithelium leads to the formation of multinuclear syncytiotrophoblast, which breaches the epithelial layer. This process is crucial for successful implantation and involves gene networks that are potential targets for improving implantation success rates.

HUMAN REPRODUCTION (2022)

Article Biotechnology & Applied Microbiology

Cell2location maps fine-grained cell types in spatial transcriptomics

Vitalii Kleshchevnikov et al.

Summary: Cell2location, a Bayesian model, can resolve the spatial distribution of cell types and create comprehensive cellular maps of tissues. By accounting for technical variation and borrowing statistical strength, cell2location has higher sensitivity and resolution than existing tools. Our results demonstrate that cell2location is a versatile analysis tool for mapping tissue architectures in a comprehensive manner.

NATURE BIOTECHNOLOGY (2022)

Article Developmental Biology

Human implantation: The complex interplay between endometrial receptivity, inflammation, and the microbiome

Jacqueline Sehring et al.

Summary: This review discusses the complexity of human embryo implantation, including the window of implantation, cyclical phases of the endometrium, the implantation process itself, and features of endometrial receptivity. Additionally, it explores new research on inflammatory reproductive biology, epigenetics and microRNA, and the role of the vaginal and endometrial microbiome in implantation.

PLACENTA (2022)

Review Medicine, General & Internal

Clinical tools and biomarkers to predict preeclampsia

Teresa M. MacDonald et al.

Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.

EBIOMEDICINE (2022)

Article Biochemistry & Molecular Biology

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

Ao Chen et al.

Summary: Spatially resolved transcriptomic technologies enable us to study complex biological processes such as mammalian embryogenesis. However, current methods have limitations in resolution, gene capture, and field of view, which hinders their systematic application to large and three-dimensional mid- and late-gestation embryos. In this study, we developed Stereo-seq, a spatially enhanced resolution omics-sequencing method, by combining DNA nanoball-patterned arrays and in situ RNA capture. We used Stereo-seq to generate the mouse organogenesis spatiotemporal transcriptomic atlas, MOSTA, which provides single cell resolution and high sensitivity for mapping the kinetics and directionality of transcriptional variation during mouse organogenesis. By utilizing this atlas, we investigated the molecular basis of spatial cell heterogeneity and cell fate specification in developing tissues like the dorsal midbrain. Our panoramic atlas will facilitate in-depth research into long-standing questions about normal and abnormal mammalian development.
Article Cell Biology

High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae

Mingyue Wang et al.

Summary: This study utilized Stereo-seq technology to analyze the spatiotemporal transcriptome of developing Drosophila with high resolution and sensitivity. The results revealed the spatial transcriptomic characteristics of Drosophila embryos and larvae, and provided key information for the analysis of transcription factor regulons.

DEVELOPMENTAL CELL (2022)

Article Cell Biology

Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

Degong Ruan et al.

Summary: Human placenta trophoblasts and their derivatives are susceptible to SARS-CoV-2 infection, with early syncytiotrophoblasts displaying high infectivity. These findings highlight the potential risk of COVID-19 infection during embryonic implantation.

CELL REPORTS MEDICINE (2022)

Article Biology

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health

Natasha de Alwis et al.

Summary: Preeclampsia affects 2-8% of pregnancies worldwide. This study evaluates the effect of L-NAME in modeling preeclampsia in mice and its long-term effects on maternal cardiovascular health. The results show that L-NAME administration mimics key characteristics of preeclampsia but does not model the increased cardiovascular disease risk seen after preeclampsia.

LIFE SCIENCE ALLIANCE (2022)

Review Biochemistry & Molecular Biology

mRNA-based therapeutics: powerful and versatile tools to combat diseases

Shugang Qin et al.

Summary: The therapeutic use of mRNA has shown great potential in combating incurable diseases. Recent advances in biotechnology and molecular medicine have allowed for the production of functional proteins/peptides in the human body through mRNA vaccines or therapeutic agents. mRNA vaccines offer the quickest response to large-scale infectious disease outbreaks, such as the current COVID-19 pandemic. Scientists have been working on improving the stability, immunogenicity, translation efficiency, and delivery system of mRNA to achieve efficient and safe delivery. This review comprehensively describes mRNA-based therapeutics, their principles, manufacturing, application, effects, and limitations.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Obstetrics & Gynecology

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics

Natasha Pritchard et al.

Summary: Nanomedicine technology in reproductive medicine and obstetrics holds promise for targeted therapeutic strategies that enhance efficacy and minimize off-target effects. Through nanoparticle delivery systems, interventions can effectively address various issues in reproductive medicine, providing new treatment options for women's health and reproductive capacity.

HUMAN REPRODUCTION UPDATE (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Biochemistry & Molecular Biology

Irisin Protects the Human Placenta from Oxidative Stress and Apoptosis via Activation of the Akt Signaling Pathway

Hamid-Reza Kohan-Ghadr et al.

Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Acoustics

First-trimester diagnosis of congenital cytomegalovirus infection after maternal primary infection in early pregnancy: feasibility study of viral genome amplification by PCR on chorionic villi obtained by CVS

V Faure-Bardon et al.

Summary: PCR analysis of trophoblast samples obtained by CVS is feasible for diagnosing CMV infection in early pregnancy, with a potential role in excluding CMV-related embryopathy leading to sequelae. Long-term follow-up evaluation is needed to confirm the diagnostic value of this method.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2021)

Review Genetics & Heredity

Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models

Vanessa Chenouard et al.

Summary: This review discusses the extensive use of rats as small animal models in genetic engineering, focusing on their application in human genetic diseases and immune system analysis. It also highlights the competitive advantages of rat models over mouse models, particularly in addressing specific scientific questions.

FRONTIERS IN GENETICS (2021)

Review Medicine, General & Internal

Pre-eclampsia

Lucy C. Chappell et al.

Summary: Pre-eclampsia is a pregnancy disorder characterized by placental malperfusion, leading to hypertension and multi-organ injury, with potential fetal growth restriction and stillbirth. While prophylactic low-dose aspirin can reduce the risk of preterm pre-eclampsia, there are currently no curative treatments once pre-eclampsia is diagnosed except for delivery. Ongoing studies are evaluating various strategies and drugs to prevent and manage pre-eclampsia.

LANCET (2021)

Article Multidisciplinary Sciences

Construction of a human cell landscape at single-cell level

Xiaoping Han et al.

NATURE (2020)

Article Cardiac & Cardiovascular Systems

Preeclampsia Pathophysiology, Challenges, and Perspectives

Sarosh Rana et al.

CIRCULATION RESEARCH (2019)

Article Cell Biology

Establishment of porcine and human expanded potential stem cells

Xuefei Gao et al.

NATURE CELL BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Daehwan Kim et al.

NATURE BIOTECHNOLOGY (2019)

Review Developmental Biology

Development of the human placenta

Margherita Y. Turco et al.

DEVELOPMENT (2019)

Article Obstetrics & Gynecology

First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume

Jiri Sonek et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

Article Cell & Tissue Engineering

Derivation of Human Trophoblast Stem Cells

Hiroaki Okae et al.

CELL STEM CELL (2018)

Review Endocrinology & Metabolism

The first-trimester of pregnancy - A window of opportunity for prediction and prevention of pregnancy complications and future life

Liona C. Poon et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Developmental Biology

Investigating human placentation and pregnancy using first trimester chorionic villi

Roberta L. Hannibal et al.

PLACENTA (2018)

Article Medicine, Research & Experimental

Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice

Baozhen Zhang et al.

THERANOSTICS (2018)

Article Multidisciplinary Sciences

Placentation defects are highly prevalent in embryonic lethal mouse mutants

Vicente Perez-Garcia et al.

NATURE (2018)

Review Endocrinology & Metabolism

Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models

Laura Woods et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

Single-cell reconstruction of the early maternal-fetal interface in humans

Roser Vento-Tormo et al.

NATURE (2018)

Article Multidisciplinary Sciences

Trophoblast organoids as a model for maternal-fetal interactions during human placentation

Margherita Y. Turco et al.

NATURE (2018)

Article Multidisciplinary Sciences

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Nuphar Veiga et al.

NATURE COMMUNICATIONS (2018)

Article Biotechnology & Applied Microbiology

SCANPY: large-scale single-cell gene expression data analysis

F. Alexander Wolf et al.

GENOME BIOLOGY (2018)

Article Critical Care Medicine

MR-proADM: A New Biomarker for Early Diagnosis of Sepsis in Burned Patients

Jochen Gille et al.

JOURNAL OF BURN CARE & RESEARCH (2017)

Article Cell Biology

Embryo-epithelium interactions during implantation at a glance

John D. Aplin et al.

JOURNAL OF CELL SCIENCE (2017)

Review Cardiac & Cardiovascular Systems

Pre-eclampsia: its pathogenesis and pathophysiolgy

P. Gathiram et al.

CARDIOVASCULAR JOURNAL OF AFRICA (2016)

Review Medicine, General & Internal

Pre-eclampsia

Ben W. J. Mol et al.

LANCET (2016)

Article Medicine, General & Internal

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Harald Zeisler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Editorial Material Anatomy & Morphology

Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ

Ellen C. Jensen

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Biomarkers and diagnostics in heart failure

Hanna K. Gaggin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Article Medicine, Research & Experimental

Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta

Manyu Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Developmental Biology

Review: Biochemical markers to predict preeclampsia

U. D. Anderson et al.

PLACENTA (2012)

Review Endocrinology & Metabolism

Adrenomedullin and pregnancy: perspectives from animal models to humans

Patricia M. Lenhart et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

Article Obstetrics & Gynecology

Regulation by hypoxia of adrenomedullin output and expression in human trophoblast cells

Emanuela Marinoni et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2011)

Article Multidisciplinary Sciences

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

Damayanti Chakraborty et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast

Anne Dupressoir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemical Research Methods

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

Likun Wang et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Developmental Biology

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation

Lindsey N. Kent et al.

BMC DEVELOPMENTAL BIOLOGY (2010)

Article Multidisciplinary Sciences

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

Anne Dupressoir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Peripheral Vascular Disease

Early and Late Preeclampsia Two Different Maternal Hemodynamic States in the Latent Phase of the Disease

Herbert Valensise et al.

HYPERTENSION (2008)

Article Medicine, Research & Experimental

Adrenomedullin signaling is necessary for murine lymphatic vascular development

Kimberly L. Fritz-Six et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Biochemistry & Molecular Biology

Impaired cytotrophoblast cell-cell fusion is associated with reduced syncytin and increased apoptosis in patients with placental dysfunction

Manuela Langbein et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2008)

Article Developmental Biology

Animal models of human placentation - A review

A. M. Carter

PLACENTA (2007)

Article Medical Laboratory Technology

Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay

NG Morgenthaler et al.

CLINICAL CHEMISTRY (2005)

Article Medicine, General & Internal

Circulating angiogenic factors and the risk of preeclampsia

RJ Levine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Obstetrics & Gynecology

Pathophysiology of preeclampsia: links with implantation disorders

P Merviel et al.

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2004)

Article Hematology

Growth and function of the normal human placenta

NM Gude et al.

THROMBOSIS RESEARCH (2004)

Article Endocrinology & Metabolism

Adrenomedullin in perinatal medicine

R Di Iorio et al.

REGULATORY PEPTIDES (2003)

Review Anatomy & Morphology

Regulation of adrenomedullin expression and release

N Minamino et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2002)

Review Anatomy & Morphology

Adrenomedullin in mammalian embryogenesis

M Garayoa et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2002)

Article Endocrinology & Metabolism

Immunoreactive adrenomedullin (AM) concentration in maternal plasma during human pregnancy and AM expression in placenta

K Kobayashi et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000)