Analysis of complete blood count and derived inflammatory indicators for bipolar disorder patients with different states

Article Clinical Neurology

Predictive Value of the Systemic Immune Inflammation Index for Adverse Outcomes in Patients With Acute Ischemic Stroke

Yun-Xiang Zhou et al.

Summary: The systemic immune-inflammation index (SII) is associated with short-term adverse outcomes in patients with acute ischemic stroke, and the nomogram can predict the risk of adverse outcomes in these patients.

FRONTIERS IN NEUROLOGY (2022)

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Article Psychiatry

Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder

Yanyan Wei et al.

Summary: This study compares the predictive ability of various inflammation and lipid metabolism markers in patients with schizophrenia and bipolar disorder using large-scale clinical data. The results highlight the association between these markers and the pathophysiology of these psychiatric disorders as well as the role of inflammation and lipid metabolism in disease progression.

FRONTIERS IN PSYCHIATRY (2022)

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Article Neurosciences

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte, Platelet-to-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Different States of Bipolar Disorder

Katerina Dadouli et al.

Summary: The study found that patients with BD had higher NLR, MLR, and SII index compared to healthy controls during manic and depressive episodes, indicating a higher level of inflammation in BD patients.

BRAIN SCIENCES (2022)

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Article Psychiatry

A comparison of inflammatory markers in manic and euthymic states of bipolar disorder

Selcuk Ozdin et al.

Summary: This study found that in the manic phases of bipolar disorder, inflammatory biomarkers NLR, PLR, and MLR values were higher, but decreased during the remission period after treatment. However, in the euthymic phase of bipolar disorder, platelet and monocyte counts as well as MLR values were higher than the control group.

NORDIC JOURNAL OF PSYCHIATRY (2021)

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Review Pharmacology & Pharmacy

Update on the neurodevelopmental theory of depression: is there any 'unconscious code'?

Malgorzata Galecka et al.

Summary: Depression is a common psychiatric disorder with increasing numbers of patients receiving antidepressant treatment yearly. Stress is considered the main factor leading to changes in functioning, such as apathy, anhedonia, lack of motivation, and sleep disturbances, which are associated with the higher prevalence of depression in modern society. Dysregulation of immune and nervous system interactions, particularly involving proinflammatory cytokines like interleukin 17 (IL-17), may play a significant role in the development of depressive disorders, with influences starting even during prenatal development.

PHARMACOLOGICAL REPORTS (2021)

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Article Geriatrics & Gerontology

Association Between Systemic Immune-Inflammation Index and Diabetic Depression

Jie Wang et al.

Summary: The study investigated the relationship between diabetic depression and SII levels, finding that high SII level is an independent risk factor for diabetic depression. The study also suggests that SII may be an easily accessible and cost-effective strategy for identifying depression in patients with diabetes.

CLINICAL INTERVENTIONS IN AGING (2021)

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Article Health Care Sciences & Services

Inflammatory versus Anti-Inflammatory Profiles in Major Depressive Disorders-The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3

Malgorzata Galecka et al.

Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Oncology

Systemic immune-inflammation index: a prognostic tiebreaker among all in advanced pancreatic cancer

Alessandro Bittoni et al.

Summary: Elevated systemic immune-inflammation index (SII) was found to be an independent negative prognostic factor for both overall survival (OS) and progression-free survival (PFS) in advanced pancreatic ductal adenocarcinoma (PDAC) patients undergoing first-line chemotherapy, highlighting the crucial role of systemic inflammation in PDAC progression and patient outcomes.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Medicine, General & Internal

Gamma-glutamyl transpeptidase-platelet ratio, systemic immune inflammation index, and system inflammation response index in invasive Aspergillosis

Nuri Cakir et al.

Summary: The study found that the Gamma-glutamyl transpeptidase-platelet ratio, system inflammation response index, and systemic immune inflammation index have diagnostic value in invasive aspergillosis. The gamma-glutamyl transpeptidase-platelet ratio performed better in diagnosing inflammation in invasive aspergillosis compared to other markers.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2021)

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Review Immunology