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LncRNA H19: a novel player in the regulation of diabetic kidney disease

FRONTIERS IN ENDOCRINOLOGY (2023)

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LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

Shao-Hua Wang et al.

Summary: H19 inhibits excessive mitophagy by limiting Pink1 mRNA translation, thus alleviating cardiac defects during obesity. DNA methylation-mediated downregulation of H19 expression plays a crucial role in cardiomyocyte or H9c2 cells metabolic disorders and induces cardiac respiratory dysfunction by promoting mitophagy.

CELL DEATH & DISEASE (2021)

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Article Medicine, Research & Experimental

Knockdown of lncRNA NORAD inhibits the proliferation, inflammation and fibrosis of human mesangial cells under high-glucose conditions by regulating the miR-485/NRF1 axis

Linna Wang et al.

Summary: The study revealed that lncRNA NORAD inhibited the proliferation, inflammation, and fibrosis of high-glucose-induced human mesangial cells in diabetic nephropathy by regulating the miR-485/NRF1 pathway.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Cell Biology

PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

Li Li et al.

Summary: The study reveals the important role of Tug1/PGC1α axis in the progression of diabetic nephropathy by influencing mitochondrial remodeling and altered metabolites. Furthermore, PGC1α is identified as a necessary factor for the renoprotective effect of Tug1.

CELL REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells

Hao Xu et al.

Summary: Aberrant expression of LncRNA H19 and miR-140-5p is associated with ovarian cancer. H19 downregulates miR-140-5p to activate the PI3K/AKT pathway, promoting proliferation, invasion, migration, and EMT of OC cells. Inhibition of H19 expression leads to reduced tumor growth in vitro and in vivo.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Bu-Hui Liu et al.

Summary: The study showed that TFA protected podocytes from pyroptosis and injury induced by high glucose by regulating m(6)A modification, NLRP3 inflammasome activation, and PTEN/PI3K/Akt signaling.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Inhibition of Renal Tubular Epithelial Mesenchymal Transition and Endoplasmic Reticulum Stress-Induced Apoptosis with Shenkang Injection Attenuates Diabetic Tubulopathy

Wen-Wen Wang et al.

Summary: The study confirmed that Shenkang injection (SKI) can alleviate diabetic tubulopathy (DT) in a similar manner as rosiglitazone (ROS), and SKI achieves this effect by inhibiting epithelial-to-mesenchymal transition (EMT) and endoplasmic reticulum (ER) stress-induced apoptosis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Physiology

TRIM18-Regulated STAT3 Signaling Pathway via PTP1B Promotes Renal Epithelial-Mesenchymal Transition, Inflammation, and Fibrosis in Diabetic Kidney Disease

Qi Chen et al.

Summary: DKD is a leading cause of end-stage renal disease worldwide, with inflammation and fibrosis playing important roles in its pathogenesis. TRIM18 has been identified as a key player in DKD, with knockdown of TRIM18 inhibiting HG-induced EMT, inflammation, and fibrosis in kidney cells. The TRIM18/PTP1B/STAT3 signaling pathway could be a promising target for potential therapeutics in DKD treatment.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Physiology

RvD1 Attenuated Susceptibility to Ischemic AKI in Diabetes by Downregulating Nuclear Factor-κ B Signal and Inhibiting Apoptosis

Zheng Li et al.

Summary: Decreased serum RvD1 levels in DKD patients contribute to their susceptibility to ischemic AKI. RvD1 treatment can ameliorate renal function and histological damage in DN mice after ischemic injury, while also inhibiting the inflammatory response.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Urology & Nephrology

Targeting the Pathobiology of Diabetic Kidney Disease

Merlin C. Thomas

Summary: The pathobiology of diabetic kidney disease involves the interplay between different cell types within the kidney in response to chronic hyperglycemia. The characteristic morphological changes accelerate the progression of lesions, ultimately leading to kidney function decline.

ADVANCES IN CHRONIC KIDNEY DISEASE (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis

Bing Chen et al.

Summary: This study revealed that lncRNA H19 is highly expressed in ICH and regulates ferroptosis of BMVECs by modulating the miR-106b-5p/ACSL4 axis.

BIOENGINEERED (2021)

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Article Biochemistry & Molecular Biology

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Peixing Wan et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Medicine, Research & Experimental

LNCRNA CDKN2B-AS1 regulates mesangial cell proliferation and extracellular matrix accumulation via miR-424-5p/HMGA2 axis

Yang Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Medicine, Research & Experimental

LncRNA GAS5 exacerbates renal tubular epithelial fibrosis by acting as a competing endogenous RNA of miR-96-5p

Wei Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway

Yan-Lin Yang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Urology & Nephrology

Innate immunity in diabetic kidney disease

Sydney C. W. Tang et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Environmental Sciences

Long noncoding RNA H19 acts as a miR-340-3p sponge to promote epithelial-mesenchymal transition by regulating YWHAZ expression in paclitaxel-resistant breast cancer cells

Lei Yan et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Article Biochemistry & Molecular Biology

H19/TET1 axis promotes TGF-β signaling linked to endothelial-to-mesenchymal transition

Tiefeng Cao et al.

FASEB JOURNAL (2020)

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Meeting Abstract Biochemistry & Molecular Biology

The Role of Proteoglycans in Glomerular Physiology and Pathophysiology

Kerstin Ebefors et al.

FASEB JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Lucas Opazo-Rios et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis

Xu Jiang et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes

Tengfei Shi et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Oncology

Long non-coding RNA H19 is involved in sorafenib resistance in hepatocellular carcinoma by upregulating miR-675

Yongzi Xu et al.

ONCOLOGY REPORTS (2020)

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Article Cell Biology

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes

Gabriella A. Casalena et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Review Endocrinology & Metabolism

Insights into the Role of Renal Biopsy in Patients with T2DM: A Literature Review of Global Renal Biopsy Results

Xue Tong et al.

DIABETES THERAPY (2020)

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Article Oncology

Enhancement of Breast Cancer Cell Aggressiveness by lncRNA H19 and its Mir-675 Derivative: Insight into Shared and Different Actions

Evodie Peperstraete et al.

CANCERS (2020)

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Article Oncology

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Yuhui Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Urology & Nephrology

Autophagy in kidney homeostasis and disease

Chengyuan Tang et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Review Biochemistry & Molecular Biology

New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease

Jinwen Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Increased long noncoding RNA maternally expressed gene 3 contributes to podocyte injury induced by high glucose through regulation of mitochondrial fission

Qiongxia Deng et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia-reperfusion injury

Zhi Zhao et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

Knockdown of LncRNA-H19 Ameliorates Kidney Fibrosis in Diabetic Mice by Suppressing miR-29a-Mediated EndMT

Sen Shi et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Renal proximal tubular epithelial cells: review of isolation, characterization, and culturing techniques

Matic Mihevc et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Medicine, Research & Experimental

LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network

Yin Zhang et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

Wei Chen et al.

THERANOSTICS (2020)

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Article Cell Biology

A negative feedback loop of H19/miR-675/EGR1 is involved in diabetic nephropathy by downregulating the expression of the vitamin D receptor

WenXing Fan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Urology & Nephrology

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

Mitsuo Kato et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Article Mathematical & Computational Biology

SELER: a database of super-enhancer-associated lncRNA- directed transcriptional regulation in human cancers

Zhi-Wei Guo et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2019)

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Article Endocrinology & Metabolism

Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

Jay C. Jha et al.

DIABETOLOGIA (2019)

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Review Biochemistry & Molecular Biology

Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne's Thread

Anila Duni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

Ji Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Medical Laboratory Technology

Mitochondrial dysfunction in diabetic kidney disease

Pascal Zhongping Wei et al.

CLINICA CHIMICA ACTA (2019)

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Article Endocrinology & Metabolism

Incidences of Severe Hypoglycemia and Diabetic Ketoacidosis and Prevalence of Microvascular Complications Stratified by Age and Glycemic Control in US Adult Patients With Type 1 Diabetes: A Real-World Study

Jeremy H. Pettus et al.

DIABETES CARE (2019)

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Article Biochemistry & Molecular Biology

Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1

Dong-Wei Liu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Editorial Material Transplantation

A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases

Kitty J. Jager et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2019)

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Article Medicine, General & Internal

FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease

Fengjuan Huang et al.

EBIOMEDICINE (2019)

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Article Cell Biology

H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes

Jie Zhu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Urology & Nephrology

Endothelium structure and function in kidney health and disease

Noemie Jourde-Chiche et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Article Medicine, General & Internal

H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway

Haoran Liu et al.

EBIOMEDICINE (2019)

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Article Physiology

Prompt apoptotic response to high glucose in SGLT-expressing renal cells

Linnea M. Nilsson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Victor G. Puelles et al.

JCI INSIGHT (2019)

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Article Medicine, Research & Experimental

LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy

Junjie Gao et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Biochemistry & Molecular Biology

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp et al.

CELL (2018)

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Meeting Abstract Endocrinology & Metabolism

Advanced Glycation End Products (AGEs)-Role in Development and Progression of Kidney Disease in Type 1 Diabetes in DCCT/EDIC

Paul J. Beisswenger et al.

DIABETES (2018)

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Article Endocrinology & Metabolism

Serum level of the autophagy biomarker Beclin-1 in patients with diabetic kidney disease

Mervat Naguib et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Article Biochemistry & Molecular Biology

Genetic Variation in the H19-IGF2 Cluster Might Confer Risk of Developing Impaired Renal Function

Eliecer Coto et al.

DNA AND CELL BIOLOGY (2018)

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Article Genetics & Heredity

shRNA targeting of ferritin heavy chain activates H19/miR-675 axis in K562 cells

M. Di Sanzo et al.

GENE (2018)

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Review Urology & Nephrology

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

Hans-Joachim Anders et al.

NATURE REVIEWS NEPHROLOGY (2018)

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Article Endocrinology & Metabolism

Development of Microvascular Complications and Effect of Concurrent Risk Factors in Type 1 Diabetes: A Multistate Model From an Observational Clinical Cohort Study

Lasse Bjerg et al.

DIABETES CARE (2018)

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Article Oncology

Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice

Jingping Qiu et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

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Article Physiology

Connecting tubule glomerular feedback mediates tubuloglomerular feedback resetting after unilateral nephrectomy

Sumit R. Monu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Endocrinology & Metabolism

Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b

Si F. Sun et al.

DIABETES (2018)

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Article Multidisciplinary Sciences

MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1

Chun-Tao Lei et al.

SCIENTIFIC REPORTS (2017)

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Article Physiology

Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease

Jan Wysocki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

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Article Physiology

Accumulation of worn-out GBM material substantially contributes to mesangial matrix expansion in diabetic nephropathy

Wilhelm Kriz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Diabetes and Kidney Disease: Role of Oxidative Stress

Jay C. Jha et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

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Article Urology & Nephrology

American Society of Nephrology Quiz and Questionnaire 2015: ESRD/RRT

Charmaine E. Lok et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Article Oncology

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

Wen-Tao Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

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Review Genetics & Heredity

Unique features of long non-coding RNA biogenesis and function

Jeffrey J. Quinn et al.

NATURE REVIEWS GENETICS (2016)

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Article Oncology

Long non-coding RNA-H19 antagonism protects against renal fibrosis

Hong Xie et al.

ONCOTARGET (2016)

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Article Endocrinology & Metabolism

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

Ling Li et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

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Review Biochemistry & Molecular Biology

The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory

Eli Raveh et al.

MOLECULAR CANCER (2015)

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Editorial Material Biochemistry & Molecular Biology

Discovery and annotation of long noncoding RNAs

John S. Mattick et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Editorial Material Biochemistry & Molecular Biology

Discovery and annotation of long noncoding RNAs

John S. Mattick et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Medicine, General & Internal

Diabetic kidney disease

Merlin C. Thomas et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Article Endocrinology & Metabolism

Diagnosis and Classification of Diabetes Mellitus

DIABETES CARE (2014)

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Review Neurosciences

Diabetic kidney disease: from physiology to therapeutics

Carmen Mora-Fernandez et al.

JOURNAL OF PHYSIOLOGY-LONDON (2014)

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Article Multidisciplinary Sciences

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

Florian Grahammer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

Pin Wang et al.

SCIENCE (2014)

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Editorial Material Endocrinology & Metabolism

Endothelial-Podocyte Crosstalk: The Missing Link Between Endothelial Dysfunction and Albuminuria in Diabetes

Ferhan S. Siddiqi et al.

DIABETES (2013)

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Review Urology & Nephrology

The role of the glomerular endothelium in albumin handling

Simon Satchell

NATURE REVIEWS NEPHROLOGY (2013)

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Review Endocrinology & Metabolism

Renal progenitors in non-diabetic and diabetic nephropathies

Paola Romagnani et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

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Article Biochemistry & Molecular Biology

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

Thomas Derrien et al.

GENOME RESEARCH (2012)

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Article Cell Biology

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and lgf1r

Andrew Keniry et al.

NATURE CELL BIOLOGY (2012)

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Review Urology & Nephrology

Role of the Podocyte (and Glomerular Endothelium) in Building the GBM

Dale R. Abrahamson

SEMINARS IN NEPHROLOGY (2012)

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Review Urology & Nephrology

Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy

Benjamin D. Humphreys

SEMINARS IN NEPHROLOGY (2012)

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Review Pharmacology & Pharmacy

Mesangial pathology in glomerular disease: targets for therapeutic intervention

Yogesh M. Scindia et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

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Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

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Article Cell Biology

Evidence of apoptosis in human diabetic kidney

D Kumar et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)

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Article Urology & Nephrology

Imprinted mesodermal specific transcript (MEST) and H19 genes in renal development and diabetes

YS Kanwar et al.

KIDNEY INTERNATIONAL (2003)

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