Organoid models of the pituitary gland in health and disease

The pituitary gland represents the hub of our endocrine system. Its cells produce specific hormones that direct multiple vital physiological processes such as body growth, fertility, and stress. The gland also contains a population of stem cells which are still enigmatic in phenotype and function. Appropriate research models are needed to advance our knowledge on pituitary (stem cell) biology. Over the last decade, 3D organoid models have been established, either derived from the pituitary stem cells or from pluripotent stem cells, covering both healthy and diseased conditions. Here, we summarize the state-of-the-art of pituitary-allied organoid models and discuss applications of these powerful in vitro research and translational tools to study pituitary development, biology, and disease.

Automated summary

The pituitary gland is essential for the processes of body growth, fertility, and stress regulation. It contains enigmatic stem cells that require appropriate research models for better understanding of pituitary biology. 3D organoid models derived from pituitary stem cells or pluripotent stem cells have been established for studying pituitary development, biology, and disease.