☆ 4.7 Review

SIRT6's function in controlling the metabolism of lipids and glucose in diabetic nephropathy

FRONTIERS IN ENDOCRINOLOGY (2023)

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Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases

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FASEB JOURNAL (2019)

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SIRT6 as a potential target for treating insulin resistance

Wei Tang et al.

LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

Su Myung Jung et al.

MOLECULAR CELL (2019)

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Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Ann-Katrin Hopp et al.

CELLS (2019)

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Sitagliptin inhibits vascular inflammation via the SIRT6-dependent signaling pathway

Yanhao He et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Regulation of PTEN/AKT/FAK pathways by PPARγ impacts on fibrosis in diabetic nephropathy

Rui Yan et al.

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Adipogenesis and metabolic health

Alexandra L. Ghaben et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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PKCζ Phosphorylates SIRT6 to Mediate Fatty Acid β-Oxidation in Colon Cancer Cells

Tian Gao et al.

NEOPLASIA (2019)

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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman et al.

CELL REPORTS (2019)

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Metabolic Messengers: adiponectin

Leon G. Straub et al.

NATURE METABOLISM (2019)

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Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation

Yanqin Fan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Editorial Material Urology & Nephrology

Update on Diabetic Nephropathy: Core Curriculum 2018

Kausik Umanath et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2018)

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Article Endocrinology & Metabolism

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

Kunhua Qin et al.

DIABETOLOGIA (2018)

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Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6

Pengcheng Luo et al.

HEPATOLOGY (2018)

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Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress

Alec G. Trub et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

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Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Zhuoran Wang et al.

AGING-US (2018)

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Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy

Susan B. Gurley et al.

DIABETES (2018)

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Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

Sara Iachettini et al.

CELL DEATH & DISEASE (2018)

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Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program)

Mikhail Kosiborod et al.

CARDIOVASCULAR DIABETOLOGY (2018)

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ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease

Bernhard Luescher et al.

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High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Takeshi Yamamoto et al.

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Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential

Dongqing Zha et al.

ENDOCRINOLOGY (2017)

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High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

Toshiyuki Imasawa et al.

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Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

Giovanna Sociali et al.

FASEB JOURNAL (2017)

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Lipotoxicity-Induced PRMT1 Exacerbates Mesangial Cell Apoptosis via Endoplasmic Reticulum Stress

Min-Jung Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Weier Qi et al.

NATURE MEDICINE (2017)

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Mitochondrial energetics in the kidney

Pallavi Bhargava et al.

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Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Michael B. Stout et al.

PHYSIOLOGY (2017)

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A global perspective on FOXO1 in lipid metabolism and lipid-related diseases

Yue Li et al.

PROGRESS IN LIPID RESEARCH (2017)

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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Min Liu et al.

NATURE COMMUNICATIONS (2017)

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Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300

Feng Ling et al.

ONCOTARGET (2017)

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Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

Lu Yao et al.

CELL REPORTS (2017)

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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

Xiaoyu Zhang et al.

ELIFE (2017)

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The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat

David Long et al.

SCIENTIFIC REPORTS (2017)

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Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

Jiangying Kuang et al.

DIABETES (2017)

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Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiwen Xiong et al.

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A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes

Wesley Wei Wang et al.

ACS CHEMICAL BIOLOGY (2016)

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Altered lipid metabolism in the aging kidney identified by three layered omic analysis

Fabian Braun et al.

AGING-US (2016)

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Podocytes: the Weakest Link in Diabetic Kidney Disease?

Jamie S. Lin et al.

CURRENT DIABETES REPORTS (2016)

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SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis

Xiwen Xiong et al.

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Thematic Review Series: Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death Lipids, lysosomes, and autophagy

Bharat Jaishy et al.

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Lipotoxicity as a trigger factor of renal disease

Adriana Izquierdo-Lahuerta et al.

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High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects

Jingwen Yu et al.

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Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Manoela Mota et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

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Identifying the functional contribution of the defatty-acylase activity of SIRT6

Xiaoyu Zhang et al.

Nature Chemical Biology (2016)

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SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

Luisa Tasselli et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

J. Cai et al.

ONCOGENE (2016)

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SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

Jing Lu et al.

TRANSLATIONAL RESEARCH (2016)

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SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

Luisa Tasselli et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

Jiaxiang Shao et al.

PROTEIN & CELL (2016)

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Review Geriatrics & Gerontology

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

Xiaoting Luo et al.

AGING AND DISEASE (2016)

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Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy

Anna Czajka et al.

REDOX BIOLOGY (2016)

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Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease

Janaka Karalliedde et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

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Article Multidisciplinary Sciences

p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

Eun Sun Jung et al.

SCIENTIFIC REPORTS (2016)

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Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

Mi-Young Song et al.

SCIENTIFIC REPORTS (2016)

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The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

Dionne E. M. Maessen et al.

CLINICAL SCIENCE (2015)

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Excess Mortality among Persons with Type 2 Diabetes

Mauro Tancredi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Deubiquitinase inhibition as a cancer therapeutic strategy

Padraig D'Arcy et al.

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Diabetic kidney disease

Merlin C. Thomas et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Emerging role of microRNAs in lipid metabolism

Zhihong Yang et al.

ACTA PHARMACEUTICA SINICA B (2015)

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Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

Tae-Hyun Yoo et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Lipotoxicity Augments Glucotoxicity-Induced Mitochondrial Damage in the Development of Diabetic Retinopathy

Binit Kumar et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

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What We Talk About When We Talk About Fat

Evan D. Rosen et al.

CELL (2014)

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Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

Stephan Hardiville et al.

CELL METABOLISM (2014)

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Lipid droplet biogenesis

Florian Wilfling et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

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Molecular mechanisms of diabetic kidney disease

Kimberly Reidy et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

Michal Herman-Edelstein et al.

JOURNAL OF LIPID RESEARCH (2014)

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Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

Gregory R. Wagner et al.

MOLECULAR CELL (2014)

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Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

Ping Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Biochemistry & Molecular Biology

Chromatin and beyond: the multitasking roles for SIRT6

Site Kugel et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Michael Van Meter et al.

NATURE COMMUNICATIONS (2014)

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Site-specific mapping and quantification of protein S-sulphenylation in cells

Jing Yang et al.

NATURE COMMUNICATIONS (2014)

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Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

Liang-Jun Yan

JOURNAL OF DIABETES RESEARCH (2014)

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Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Jessica L. Feldman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Gastroenterology & Hepatology

Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity

Alexander R. Moschen et al.

JOURNAL OF HEPATOLOGY (2013)

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Article Biochemistry & Molecular Biology

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

Rongya Tao et al.

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Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

Kumar Sharma et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

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Article Biochemistry & Molecular Biology

The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination

Sarah M. Ronnebaum et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

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SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

Debra Toiber et al.

MOLECULAR CELL (2013)

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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

Hong Jiang et al.

NATURE (2013)

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Brown and beige fat: development, function and therapeutic potential

Matthew Harms et al.

NATURE MEDICINE (2013)

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SIRT6 exhibits nucleosome-dependent deacetylase activity

Reuven Gil et al.

NUCLEIC ACIDS RESEARCH (2013)

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The NAD ratio redox paradox: why does too much reductive power cause oxidative stress?

Joao Soeiro Teodoro et al.

TOXICOLOGY MECHANISMS AND METHODS (2013)

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Multiple Regulatory Layers of SREBP1/2 by SIRT6

Sivan Elhanati et al.

CELL REPORTS (2013)

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Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

Volker Vallon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

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Renal Function in Diabetic Disease Models: The Tubular System in the Pathophysiology of the Diabetic Kidney

Volker Vallon et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)

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Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

Norma Frizzell et al.

BIOCHEMICAL JOURNAL (2012)

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Caries Canto et al.

CELL METABOLISM (2012)

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The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

John E. Dominy et al.

MOLECULAR CELL (2012)

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Kidney: Its impact on glucose homeostasis and hormonal regulation

Asimina Mitrakou

DIABETES RESEARCH AND CLINICAL PRACTICE (2011)

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Structure and Biochemical Functions of SIRT6

Patricia W. Pan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

Yuki Tanaka et al.

KIDNEY INTERNATIONAL (2011)

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miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

Alberto Davalos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Zhiyong Mao et al.

SCIENCE (2011)

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Reactive oxygen species and insulin resistance: the good, the bad and the ugly

Tony Tiganis

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

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Pathophysiology of the Diabetic Kidney

Volker Vallon et al.

COMPREHENSIVE PHYSIOLOGY (2011)

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SIRT6 protects against pathological damage caused by diet-induced obesity

Yariv Kanfi et al.

AGING CELL (2010)

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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong et al.

CELL (2010)

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Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

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Hyperglycemia Impairs Proteasome Function by Methylglyoxal

Markus A. Queisser et al.

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E-Cadherin Expression Is Regulated by miR-1921215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β

Bo Wang et al.

DIABETES (2010)

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Review Endocrinology & Metabolism

O-GlcNAc modification, insulin signaling and diabetic complications

T. Issad et al.

DIABETES & METABOLISM (2010)

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SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

Cuiying Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Multidisciplinary Sciences

被撤回的出版物: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation (Publication with Expression of Concern. See vol. 364, pg. 247, 2019) (Publication with Expression of Concern. See vol. 361, pg. 1322, 2018) (Retracted article. See vol. 364, pg. 247, 2019)

Abderrahmane Kaidi et al.

SCIENCE (2010)

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Review Medicine, Research & Experimental

Role of PPAR alpha in Hepatic Carbohydrate Metabolism

Annelies Peeters et al.

PPAR RESEARCH (2010)

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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Tiara L. A. Kawahara et al.

CELL (2009)

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Letter Cell Biology

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

Eriko Michishita et al.

CELL CYCLE (2009)

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Oxygen Sensors at the Crossroad of Metabolism

Julian Aragones et al.

CELL METABOLISM (2009)

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Activation of PPARα and PPARγ reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1

Bettina Koenig et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

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Article Multidisciplinary Sciences

Autophagy regulates lipid metabolism

Rajat Singh et al.

NATURE (2009)

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

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Regulation of SIRT6 protein levels by nutrient availability

Yariv Kanfi et al.

FEBS LETTERS (2008)

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita et al.

NATURE (2008)

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Article Biochemistry & Molecular Biology

Involvement of glomerular SREBP-1c in diabetic nephropathy

Naomi Ishigaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Article Endocrinology & Metabolism

Reactive oxygen species, PKC-β1, and PKC-ξ mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells

Ling Xia et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

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Review Cell Biology

Adipocyte differentiation from the inside out

Evan D. Rosen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

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Transcriptional control of adipocyte formation

Stephen R. Farmer

CELL METABOLISM (2006)

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Review Endocrinology & Metabolism

PGC-1α:: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

S. Soyal et al.

DIABETOLOGIA (2006)

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Article Cell Biology

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

JW Kim et al.

CELL METABOLISM (2006)

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Article Biochemistry & Molecular Biology

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

R Mostoslavsky et al.

CELL (2006)

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Insulin resistance in diabetic nephropathy - cause or consequence?

Maria Svensson et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2006)

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Article Endocrinology & Metabolism

Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes

H Rahmoune et al.

DIABETES (2005)

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Article Cell Biology

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

E Michishita et al.

MOLECULAR BIOLOGY OF THE CELL (2005)

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Article Biochemistry & Molecular Biology

Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway

T Jiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

G Liszt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Cardiac & Cardiovascular Systems

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

Rangnath Mishra et al.

CARDIOVASCULAR DIABETOLOGY (2005)

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Article Genetics & Heredity

NADH-reductive stress in Saccharomyces cerevisiae induces the expression of the minor isoform of glyceraldehyde-3-phosphate dehydrogenase (TDH1)

H Valadi et al.

CURRENT GENETICS (2004)

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Protein kinase Cδ is required for P47phox phosphorylation and translocation in activated human monocytes

EA Bey et al.

JOURNAL OF IMMUNOLOGY (2004)

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Review Anatomy & Morphology

Diabetic vascular dysfunction: Links to glucose-induced reductive stress and VEGF

RG Tilton

MICROSCOPY RESEARCH AND TECHNIQUE (2002)

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Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

RA Frye

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

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Review Physiology

Leptin

RS Ahima et al.

ANNUAL REVIEW OF PHYSIOLOGY (2000)

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