☆ 4.6 Article

Drug Resistance Profile Among HIV-1 Infections Experiencing ART with Low-Level Viral Load in Guangdong China During 2011-2022: A Retrospective Study

INFECTION AND DRUG RESISTANCE (2023)

Related references

Note: Only part of the references are listed.

Review Public, Environmental & Occupational Health

Virological failure and adherence to antiretroviral therapy in adolescents and young adults living with human immunodeficiency virus

Adeilton Cleison Borges Daltro et al.

Summary: This systematic review aims to identify factors associated with virologic failure and adherence to drug therapy in adolescents and young adults living with HIV. The results showed that factors such as gender, alcohol use, low education, medication side effects, lack of social support, HIV/AIDS stigma, transportation barriers, and forgetfulness were linked to poor adherence to therapy. On the other hand, sufficient nutrition, good social support, confidence in therapy use, and fewer ART side effects were associated with good adherence. Additionally, factors such as low CD4 levels, alcohol use, substance abuse, low education, medication non-adherence, and forgetfulness were linked to virological failure.

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2023)

Add to Collection

Review Microbiology

Strategies to overcome HIV drug resistance-current and future perspectives

Aura Temereanca et al.

Summary: The availability of cART has greatly improved the course of HIV infection and the quality of life of patients, but drug resistant and multidrug resistant strains still pose a significant threat to treatment effectiveness. HIV drug resistance has been increasing exponentially in recent years, hindering efforts to end the HIV epidemic. New strategies for drug development focus on improving safety and resistance profiles, discovering drugs with novel mechanisms of action, and simplifying treatment. This review discusses the progress in salvage therapy for patients with multidrug-resistant HIV-1 infection and highlights the development of new antiretroviral agents and drug targets.

FRONTIERS IN MICROBIOLOGY (2023)

Add to Collection

Article Virology

Transcriptome analysis of CD4+T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity

Jingliang Chen et al.

Summary: Some HIV-infected individuals receiving antiretroviral therapy (ART) develop low-level viremia (LLV), which is associated with virologic failure. The characteristics of CD4+ T cells in LLV are largely unknown. In this study, we analyzed the transcriptome profiling of CD4+ T cells from healthy controls, HIV-infected patients with virologic suppression, and those with LLV. We found that CD4+ T cells in LLV expressed higher levels of Th1 signature transcription factors, toll-like receptors, anti-HIV entry chemokines, and antiIL-1& beta; factors compared to virologic suppression. We also identified pathways that could promote HIV-1 replication in LLV. Finally, we evaluated the effects of upregulated transcription factors on HIV-1 promoter activity and found that CXXC5 increased, while SOX5 suppressed HIV-1 transcription.

VIROLOGICA SINICA (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

A Concentration Method for HIV Drug Resistance Testing in Low-Level Viremia Samples

Qun Li et al.

Summary: This study assessed the performance of lentivirus concentration reagent (LCR) combined with Sanger sequencing (SS) in detecting drug resistance mutations (DRMs) in low-level HIV-1 viral load samples. The results showed that LCR can be an effective alternative method for monitoring DRMs in HIV-1 patients, especially in small- and medium-sized laboratories that cannot afford an ultracentrifuge.

BIOMED RESEARCH INTERNATIONAL (2022)

Add to Collection

Article Infectious Diseases

HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads

Ontlametse Bareng et al.

Summary: This study evaluated the performance of an in-house HIV drug resistance genotyping assay using plasma for detecting DRM in low-level viremia (LLV) samples, successfully genotyping 72% of LLV samples and detecting DRM in 17% of them.

INFECTION AND DRUG RESISTANCE (2022)

Add to Collection

Article Infectious Diseases

HIV-1 Genotypic Resistance Testing Using Sanger and Next-Generation Sequencing in Adults with Low-Level Viremia in China

Qun Li et al.

Summary: In this study, the performance of next-generation sequencing (NGS) in detecting HIV drug-resistance mutations (DRMs) in patients with low-level viremia (LLV) was explored. The results showed the presence of drug-resistance mutations in LLV patients and suggested the need for genotyping resistance testing to guide antiretroviral therapy optimization.

INFECTION AND DRUG RESISTANCE (2022)

Add to Collection

Article Public, Environmental & Occupational Health

HIV-1 Drug Resistance Profiles of Low-Level Viremia Patients and Factors Associated With the Treatment Effect of ART-Treated Patients: A Cross-Sectional Study in Jiangsu, China

Defu Yuan et al.

Summary: This study evaluated the drug resistance profiles and influencing factors of treatment effects in LLV patients in Jiangsu Province. The results showed that patients treated with the 2NRTIs+PIs regimen had a higher risk of drug resistance, and married or cohabiting patients had lower drug resistance. Smoking history, clinical stage, and treatment regimen may influence the therapeutic effect.

FRONTIERS IN PUBLIC HEALTH (2022)

Add to Collection

Article Infectious Diseases

Complicated genotypes circulating among treatment naive HIV-1 patients in Guangzhou, China

Yun Lan et al.

Summary: This study aimed to explore the characteristics of HIV-1 genotypes among treatment naive HIV/AIDS patients living in Guangzhou, China. Various CRFs and URFs were identified, with CRF07_BC, CRF01_AE, and CRF55_01B being the main circulating genotypes in Guangzhou. Analysis also revealed the presence of transmission networks among different risk populations, with a small percentage of patients showing pre-treatment drug resistance.

INFECTION GENETICS AND EVOLUTION (2021)

Add to Collection

Review Immunology

Persistent low-Level viremia in persons living with HIV undertreatment: An unresolved status

Celia Crespo-Bermejo et al.

Summary: Persistent low-level viremia (pLLV) has been observed in some persons living with HIV (PLWH) undergoing antiretroviral therapy (ART), leading to higher virological failure, viral genotype resistance, immune activation, inflammation, and adverse clinical outcomes. The true cause(s) and origin(s) of pLLV remain unclear, with molecular mechanisms related to viral reservoir size and clonal expansion suggested as a possible explanation.

VIRULENCE (2021)

Add to Collection

Article Infectious Diseases

Persistent Low-Level Viremia is an Independent Risk Factor for Virologic Failure: A Retrospective Cohort Study in China

Qun Li et al.

Summary: The study showed an association between persistent low-level viremia (pLLV) and virologic failure (VF) in HIV-1 patients, while there was no significant correlation between intermittent low-level viremia (blip) and VF. Therefore, monitoring and corresponding measures should be strengthened for patients with pLLV to prevent subsequent VF.

INFECTION AND DRUG RESISTANCE (2021)

Add to Collection

Article Infectious Diseases

Feasibility and clinical relevance of HIV-1 drug resistance testing in patients with low-level viraemia in South Africa

Avania Bangalee et al.

Summary: The study aimed to determine the feasibility of HIV genotyping at low-level viremia in a South African population and found a high prevalence of drug resistance mutations in this population, suggesting a need for adjustments to current virological failure guidelines in South Africa.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Add to Collection

Article Virology

Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study

Yun Lan et al.

Summary: There is a high genetic heterogeneity of HIV-1 among patients in Guangdong. Although the overall prevalence of TDR is low, it is still necessary to remain vigilant regarding some important SDRMs.

VIROLOGY JOURNAL (2021)

Add to Collection

Article Infectious Diseases

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019

Yun Lan et al.

Summary: The study in Guangdong province found that drug resistance mutations were more common in NNRTIs among MSM with ART failure. The transmission network analysis revealed a complex transmission pattern, with younger HIV-1-infected MSM with multiple links requiring more attention.

INFECTION AND DRUG RESISTANCE (2021)

Add to Collection

Article Virology

Characterization of HIV-1 subtypes and drug resistance mutations in Henan Province, China (2017-2019)

Zhaojie Yang et al.

ARCHIVES OF VIROLOGY (2020)

Add to Collection

Article Infectious Diseases

Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains

Yongjian Liu et al.

BMC INFECTIOUS DISEASES (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016

Jiayi Chen et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Add to Collection

Article Immunology

The relative contributions of HIV drug resistance, nonadherence and low-level viremia to viremic episodes on antiretroviral therapy in sub-Saharan Africa

Seth C. Inzaule et al.

AIDS (2020)

Add to Collection

Review Immunology

HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates

Soo-Yon Rhee et al.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2020)

Add to Collection

Article Immunology

Burden of Disease in PWH Harboring a Multidrug-Resistant Virus: Data From the PRESTIGIO Registry

Laura Galli et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Add to Collection

Article Infectious Diseases

Rapid and complicated HIV genotype expansion among high-risk groups in Guangdong Province, China

Ping-Ping Zhou et al.

BMC INFECTIOUS DISEASES (2019)

Add to Collection

Article Immunology

Management of Virologic Failure and HIV Drug Resistance

Suzanne M. McCluskey et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2019)

Add to Collection

Article Infectious Diseases

Evolution of transmitted HIV-1 drug resistance and viral subtypes circulation in Italy from 2006 to 2016

B. Rossetti et al.

HIV MEDICINE (2018)

Add to Collection

Article Infectious Diseases

Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL: a 2014 French nationwide study

L. Assoumou et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

Add to Collection

Article Infectious Diseases

A single untimed plasma drug concentration measurement during low-level HIV viremia predicts virologic failure

A. Gonzalez-Serna et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

Add to Collection

Article Immunology

Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013

Theppharit Panichsillapakit et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2016)

Add to Collection

Article Immunology

HIV drug resistance detected during low-level viraemia is associated with subsequent virologic failure

Luke C. Swenson et al.

AIDS (2014)

Add to Collection

Article Immunology

Performance of HIV-1 Drug Resistance Testing at Low-Level Viremia and Its Ability to Predict Future Virologic Outcomes and Viral Evolution in Treatment-Naive Individuals

A. Gonzalez-Serna et al.

CLINICAL INFECTIOUS DISEASES (2014)

Add to Collection

Article Immunology

Reliability and Clinical Relevance of the HIV-1 Drug Resistance Test in Patients With Low Viremia Levels

Maria Mercedes Santoro et al.

CLINICAL INFECTIOUS DISEASES (2014)

Add to Collection

Article Infectious Diseases

Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

George L. Melikian et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification

Daniel Struck et al.

NUCLEIC ACIDS RESEARCH (2014)

Add to Collection

Article Infectious Diseases

Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: Performance evaluation of the new REGA version 3 and seven other tools

Andrea-Clemencia Pineda-Pena et al.

INFECTION GENETICS AND EVOLUTION (2013)

Add to Collection

Article Multidisciplinary Sciences

A Comprehensive Mapping of HIV-1 Genotypes in Various Risk Groups and Regions across China Based on a Nationwide Molecular Epidemiologic Survey

Xiang He et al.

PLOS ONE (2012)

Add to Collection

Article Evolutionary Biology

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

Stephane Guindon et al.

SYSTEMATIC BIOLOGY (2010)

Add to Collection

Article Immunology

Web resources for HIV type 1 genotypic-resistance test interpretation

TF Liu et al.

CLINICAL INFECTIOUS DISEASES (2006)

Add to Collection

Article Medicine, General & Internal

Intermittent HIV-1 viremia (blips) and drug resistance in patients receiving HAART

RE Nettles et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.