4.6 Review

Immune regulation in gastric adenocarcinoma is linked with therapeutic efficacy and improved recovery

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

P38 kinase in gastrointestinal cancers

Thuy Phan et al.

Summary: Gastrointestinal cancers are a major cause of cancer-related morbidity and mortality worldwide. The p38 signaling pathway, particularly p38 gamma, plays a crucial role in cancer development and metastasis. This article provides an overview of p38 and p38 gamma in gastrointestinal cancers, as well as discusses the potential of targeting p38 gamma as a therapy.

CANCER GENE THERAPY (2023)

Review Biotechnology & Applied Microbiology

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential

Xinyu Sun et al.

Summary: Head and neck squamous cell carcinoma is the seventh most common malignant tumor worldwide. Despite various treatments available, drug resistance and low survival rates remain a challenge. Identifying diagnostic and prognostic markers is urgently needed to improve treatment outcomes.

CANCER GENE THERAPY (2023)

Review Oncology

Early stage gastric adenocarcinoma: clinical and molecular landscapes

Yuki Hirata et al.

Summary: Gastric adenocarcinoma remains a challenging disease to diagnose and treat, with low cure rates, especially in Western countries. This is due to the impracticality of early diagnosis, regional variations in therapeutic approaches, and the heterogeneity of gastric cancer cells and their microenvironment. Targeted interventions based on molecular subsets of gastric adenocarcinomas identified by genomic and/or multi-omics analyses show promise for improved outcomes. Future strategies involving vaccines, novel antibody technologies, and agents targeting the tumor microenvironment and immune checkpoints, supported by improved diagnostic assays, hold potential for advancements in gastric cancer management.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

Article Multidisciplinary Sciences

The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent

Bente Holm et al.

Summary: This study explored the expression and correlation of RNF43 and LRP1B with clinicopathological characteristics in gastric cancer. The expression of RNF43 and LRP1B was significantly correlated with the Lauren phenotype and with each other. Furthermore, differential effects of RNF43 expression were observed between intestinal and diffuse type gastric cancers. These findings suggest that the expression and biological effects of RNF43 and LRP1B in gastric cancer are context-dependent.

SCIENTIFIC REPORTS (2023)

Review Genetics & Heredity

Microsatellite Instability and Immune Response: From Microenvironment Features to Therapeutic Actionability-Lessons from Colorectal Cancer

Luana Greco et al.

Summary: Microsatellite instability (MSI), a key feature of defective DNA mismatch repair (MMR) system, is found in 15-20% of colorectal cancers (CRC). It has been established as a unique and pivotal biomarker in the diagnosis, prognosis, and treatment of CRC. MSI tumor cells exhibit strong lymphocytic activation and a shift toward a tumor microenvironment that restrains metastasis and shows high responsiveness to immunotherapy.

GENES (2023)

Review Biochemistry & Molecular Biology

Macrophages in immunoregulation and therapeutics

Shanze Chen et al.

Summary: Macrophages are vital to the innate immune system and play a central role in various immune tasks. They possess polarization settings that are crucial for immune regulation, and their clinical importance in cancer and other diseases is increasingly recognized. Macrophages have a significant impact on processes such as angiogenesis, tumor cell proliferation, metastasis, and immune suppression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Review Biochemistry & Molecular Biology

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

Chen Xue et al.

Summary: The JAK-STAT pathway plays a crucial role in cell communication and is associated with various physiological and pathological processes. Drugs targeting this pathway have been developed and approved for clinical treatment of diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Article Oncology

Trastuzumab with trimodality treatment for oesophageal adenocarcinoma with HER2 overexpression (NRG Oncology/RTOG 1010): a multicentre, randomised, phase 3 trial

Howard P. Safran et al.

Summary: The addition of trastuzumab to neoadjuvant chemoradiotherapy did not improve disease-free survival for patients with HER2-overexpressing esophageal cancer. Trastuzumab did not increase toxicities, suggesting the potential for future studies combining it with other agents targeting HER2 in esophageal cancer.

LANCET ONCOLOGY (2022)

Article Biochemical Research Methods

Polarization enhanced laparoscope for improved visualization of tissue structural changes associated with peritoneal cancer metastasis

Robert M. Trout et al.

Summary: A polarization enhanced laparoscopy (PEL) imaging system was developed to improve the visualization of peritoneal cancer metastases. Comparisons using different models and collagen gels showed the enhanced sensitivity of PEL to specific scattering characteristics, demonstrating its potential for improving the visualization of cancerous tissue.

BIOMEDICAL OPTICS EXPRESS (2022)

Article Cell Biology

MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

Mingyu Du et al.

Summary: This study found that the high expression of IGF2BP3 in nasopharyngeal carcinoma (NPC) is positively correlated with late clinical stages, node metastasis, and poor outcomes. Experimental results showed that IGF2BP3 promotes NPC cell proliferation and metastasis by influencing the stability of m6A-modified KPNA2. These findings offer new insights that IGF2BP3 may serve as a new molecular marker and potential therapeutic target for NPC treatment.

CELL DEATH DISCOVERY (2022)

Review Oncology

Molecular pathogenesis and emerging targets of gastric adenocarcinoma

Abby Ivey et al.

Summary: This review discusses the etiology, classification systems, and therapeutic strategies of gastric adenocarcinoma (GC). GC is a devastating disease and the third leading cause of cancer deaths worldwide. Understanding the etiology of GC is crucial, and further exploration of new therapeutic targets is necessary to improve survival rates.

JOURNAL OF SURGICAL ONCOLOGY (2022)

Article Rheumatology

Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One-Year Results of a Double-Blind, Placebo-Controlled Study and Open-Label Extension

Atul Deodhar et al.

Summary: Upadacitinib 15 mg once daily demonstrated sustained and consistent efficacy in patients with ankylosing spondylitis over 1 year. Patients who switched from placebo to upadacitinib at week 14 showed similar efficacy compared to those who received continuous upadacitinib treatment.

ARTHRITIS & RHEUMATOLOGY (2022)

Article Oncology

STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice

Rebekka Bitsch et al.

Summary: STAT3 inhibitor Napabucasin can block the accumulation and activity of MDSC and improve the prognosis of patients with malignant melanoma. Patients with high expression of activated STAT3 in M-MDSC have shorter progression-free survival, indicating that STAT3 may be a promising therapeutic target in the treatment of malignant melanoma.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Oncology

Recent progress and current challenges of immunotherapy in advanced/metastatic esophagogastric adenocarcinoma

Markus Moehler et al.

Summary: Immunotherapy has been successfully implemented in the treatment of metastatic/locally advanced esophagogastric adenocarcinoma. Recent approvals of immune checkpoint inhibitors have enriched the therapeutic options and shown positive clinical outcomes in various treatment lines.

EUROPEAN JOURNAL OF CANCER (2022)

Article Gastroenterology & Hepatology

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

Jaffer A. Ajani et al.

Summary: YAP1 is highly upregulated in peritoneal carcinomatosis tumor cells, contributing to cancer stem cell properties and metastasis. Inhibition of YAP1 can significantly slow tumor growth and eliminate peritoneal carcinomatosis in preclinical models. Pharmacological inhibition of YAP1 can reduce cancer stem cell-like properties and suppress tumor growth, especially in combination with cytotoxic drugs in vivo models.
Review Immunology

Human immunology and immunotherapy: main achievements and challenges

Jezabel Varade et al.

Summary: The immune system is a complex network of cells, soluble factors, membrane molecules, and functionalities, with researchers working to put all pieces of the puzzle together for a more complete understanding. Advances in immunological techniques and the development of new specialized equipment have improved our knowledge of immune-mediated illnesses and how the immune system interacts with other systems. The development of various types of immunotherapies, including vaccines and cellular therapies, is changing the way we approach diseases, particularly cancer.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Oncology

Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment

David A. Wheeler et al.

Summary: Genomic analysis has identified molecular mechanisms for exceptional responses to cancer therapy in a small fraction of patients with advanced disease, including DNA damage response, intracellular signaling, immune engagement, and genetic alterations. These analyses have revealed synthetic lethal relationships and rare genetic lesions that favor therapeutic success, providing valuable insights into oncogenic mechanisms influencing the response to cancer therapy.

CANCER CELL (2021)

Article Oncology

Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids

Vivien Koh et al.

Summary: The study shows that PD-L1 expression in gastric cancer is mediated by Hh and mTOR signaling pathways. Patient-derived organoid/immune cell co-cultures can be used to study immunosuppressive MDSC function. DSP analysis reveals infiltration of immunosuppressive MDSCs in gastric cancer tissues.

CANCER LETTERS (2021)

Article Oncology

First-line pembrolizumab/placebo plus trastuzumab and chemotherapy in HER2-positive advanced gastric cancer: KEYNOTE-811

Hyun Cheol Chung et al.

Summary: Current treatment options for patients with HER2-positive advanced gastric cancer are limited, with poor prognosis. Pembrolizumab in combination with trastuzumab and chemotherapy may provide a benefit for these patients.

FUTURE ONCOLOGY (2021)

Article Multidisciplinary Sciences

The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer

Yelena Y. Janjigian et al.

Summary: The study results demonstrate that adding pembrolizumab to trastuzumab and chemotherapy significantly reduces tumor size, induces complete responses in some patients, and improves objective response rate in HER2-positive gastric or gastro-oesophageal junction adenocarcinoma.

NATURE (2021)

Review Pharmacology & Pharmacy

Advances and challenges in the treatment of esophageal cancer

Shiming He et al.

Summary: Esophageal cancer is a common and deadly cancer with two histological subtypes - esophageal squamous cell carcinoma and esophageal adenocarcinoma. Available treatment strategies include surgery, chemotherapy, and molecular targeted therapy, with poor prognosis. This review discusses the latest developments in chemotherapy, molecular targeted therapy, and immunotherapy for esophageal cancer.

ACTA PHARMACEUTICA SINICA B (2021)

Review Biochemistry & Molecular Biology

PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects

Rosalin Mishra et al.

Summary: The PI3K pathway is crucial in cancer development and is a promising therapeutic target. Clinical trials are ongoing to evaluate the efficacy and potential risks associated with PI3K inhibitors in overcoming resistance to current therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer

Kohei Shitara et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon et al.

NATURE (2019)

Review Gastroenterology & Hepatology

Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

Zachary J. Brown et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Biotechnology & Applied Microbiology

Targeting macrophages: therapeutic approaches in cancer

Luca Cassetta et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Oncology

Microsatellite Instability as a Biomarker for PD-1 Blockade

Jonathan C. Dudley et al.

CLINICAL CANCER RESEARCH (2016)

Article Medicine, Research & Experimental

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Kipp Weiskopf et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Biochemistry & Molecular Biology

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

Razvan Cristescu et al.

NATURE MEDICINE (2015)

Article Oncology

Inflammation and cancer: advances and new agents

Shanthini M. Crusz et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Article Plant Sciences

Cytotoxic activity of hirsutanone, a diarylheptanoid isolated from Alnus glutinosa leaves

A. J. Leon-Gonzalez et al.

PHYTOMEDICINE (2014)

Article Gastroenterology & Hepatology

Causes and consequences of microsatellite instability in gastric carcinogenesis

Sergia Velho et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Pathology of Gastric Cancer and Its Precursor Lesions

Evgeny Yakirevich et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2013)

Review Multidisciplinary Sciences

Genetic Aspects of Gastric Cancer Instability

Petra Hudler

SCIENTIFIC WORLD JOURNAL (2012)

Article Oncology

Oncogenic mutations in gastric cancer with microsatellite instability

Giovanni Corso et al.

EUROPEAN JOURNAL OF CANCER (2011)

Article Medicine, General & Internal

Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer

David Cunningham et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Biochemistry & Molecular Biology

Deficient DNA mismatch repair:: a common etiologic factor for colon cancer

P Peltomäki

HUMAN MOLECULAR GENETICS (2001)