4.7 Article

Crosstalk between oxidative stress and epigenetic marks: New roles and therapeutic implications in cardiac fibrosis

Related references

Note: Only part of the references are listed.
Article Cell Biology

miR-340-5p Mediates Cardiomyocyte Oxidative Stress in Diabetes-Induced Cardiac Dysfunction by Targeting Mcl-1

Yinghong Zhu et al.

Summary: This study aimed to elucidate the mechanism underlying the potential role of microRNA-340-5p in diabetic cardiomyopathy (DCM). The results showed that miR-340-5p expression was significantly increased under diabetic conditions and overexpression of miR-340-5p exacerbated DCM. Inhibition of miR-340-5p was beneficial for preventing DCM.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Review Biochemistry & Molecular Biology

Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging

Hyun Jung Hwang et al.

Summary: Aging leads to a decline in organ structure and function, and the accumulation of senescent endothelial cells (ECs) contributes to the development of vascular dysfunction and cardiovascular diseases. Senescent ECs undergo changes in protein expression, morphology, and function, which have been associated with vascular impairments. This review summarizes the molecular players and signaling pathways involved in EC senescence and identifies potential therapeutic targets for age-related vascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

Review Biochemistry & Molecular Biology

Exercise, redox homeostasis and the epigenetic landscape

Ivan Dimauro et al.

REDOX BIOLOGY (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Physiology

ROLE OF THE EPIGENOME IN HEART FAILURE

Roberto Papait et al.

PHYSIOLOGICAL REVIEWS (2020)

Review Cardiac & Cardiovascular Systems

Treating oxidative stress in heart failure: past, present and future

Atze van der Pol et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Pharmacology & Pharmacy

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

Thomas Kietzmann et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Readers, Writers, and Erasers Chromatin as the Whiteboard of Heart Disease

Thomas G. Gillette et al.

CIRCULATION RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

Sirt1 regulates aging and resistance to oxidative stress in the heart

Ralph R. Alcendor et al.

CIRCULATION RESEARCH (2007)

Review Multidisciplinary Sciences

The biochemistry of apoptosis

MO Hengartner

NATURE (2000)