4.7 Article

Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Related references

Note: Only part of the references are listed.
Article Physiology

Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney

Signe S. Tofteng et al.

Summary: COX-2 activity protects against fibrosis and preserves microvasculature in injured kidney. In the study, it was found that fibrosis markers increased significantly in COX-2(-/-) mice and human kidney tissue with obstruction-induced kidney disease. Fibroblasts from COX-2(-/-) kidneys also showed increased matrix synthesis. Additionally, obstructed human kidneys showed increased PGE2-EP2 receptor levels, which could contribute to protection.

ACTA PHYSIOLOGICA (2022)

Article Cell Biology

The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Laia Caja et al.

Summary: The study suggests that LKB1 plays a role in regulating cell metabolism and promoting invasiveness in glioblastoma. Immunohistochemistry for LKB1 can help identify subpopulations of stem-like cells, and loss of LKB1 function may lead to mitochondrial dysfunction and enhanced cell invasion.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model

Aastha Arora et al.

Summary: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that increases cardiovascular disease risk. In a study using mice, it was found that deficiency of the enzyme IDO1 worsened atherosclerosis but had no effect on liver disease. The overexpression of the enzyme TDO2 may play a role in balancing the kynurenine pathway and inflammation in the liver during NASH development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells

Pedro Garcia-Gomez et al.

Summary: This study investigates the crucial roles of TGF beta and ROS in GSC biology, revealing the key regulatory function of NOX4 in GSCs.

MOLECULAR ONCOLOGY (2022)

Article Cell Biology

Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase

Mirca S. Saurty-Seerunghen et al.

Summary: Cell motility is critical for tumor malignancy. Analysis of transcriptomes from glioblastoma patients identified metabolic weaknesses shared by motile cells, characterized by enhanced mitochondrial load, oxidative stress, and dependence on increased ROS production and MPST activity for their motility.

CELL DEATH & DISEASE (2022)

Review Oncology

World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas A Review

Tamar R. Berger et al.

Summary: The 2021 World Health Organization central nervous system tumor classification is a major advance toward improving the diagnosis of brain tumors, providing more accurate guidance on prognosis and therapy selection, and facilitating the development of more effective treatments through enrollment of homogeneous patient populations in clinical trials.

JAMA ONCOLOGY (2022)

Review Oncology

World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas A Review

Tamar R. Berger et al.

Summary: The fifth edition of the Classification of Tumors of the Central Nervous System published by the World Health Organization in 2021 represents a significant improvement in the classification of brain tumors, incorporating molecular pathogenesis and histopathology to provide more accurate guidance on prognosis and therapy. This revision, particularly for gliomas, separates adult and pediatric tumors based on molecular differences and prognosis, consolidates adult-type diffuse gliomas into 3 types, and emphasizes the importance of IDH mutation status in tumor classification.

JAMA ONCOLOGY (2022)

Article Clinical Neurology

H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish

Weiqing Jiang et al.

Summary: Through experiments in larval zebrafish, it was found that H2S promotes brain vascular development via the NOS/NO pathway. Additionally, deficiency of H2S can affect the normal development of brain vasculature, while using H2S donors can alleviate these defects.

STROKE AND VASCULAR NEUROLOGY (2021)

Review Pharmacology & Pharmacy

The Association between Tumor-associated Macrophages and Glioblastoma: A Potential Target for Therapy

Arash Heidari et al.

Summary: Glioblastoma multiforme (GBM) is a common malignant brain tumor in adults with a poor prognosis. Previous treatments targeting cancerous cells have shown high recurrence rates, leading to a shift towards novel methods targeting the tumor microenvironment components and immune cells.

CURRENT PHARMACEUTICAL DESIGN (2021)

Article Cell Biology

NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma

Xiangsheng Su et al.

Summary: Current research shows that TGF-beta 1 plays a critical role in tumor development and malignant transformation by inducing metabolic reprogramming and promoting EMT through NOX4/ROS signaling pathways in glioblastoma cells. Inhibition of glycolysis reverses EMT, suggesting a causal relationship between TGF-beta 1-induced metabolic changes and tumorigenesis. The PI3K/AKT/HIF-1 alpha signaling pathways are involved in mediating the effects of TGF-beta 1 on metabolic reprogramming and EMT in glioblastoma, providing potential strategies for cancer therapy.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Biochemistry & Molecular Biology

NADPH Oxidases: Redox Regulators of Stem Cell Fate and Function

Tullia Maraldi et al.

Summary: This review highlights the role of NOX-derived ROS in stem cell biology and functions, focusing on the positive and negative effects triggered by the activity of different NOX isoforms. Recent findings on downstream molecular targets of NOX-ROS signaling that can modulate stem cell homeostasis and lineage commitment are discussed, along with implications in ex vivo expansion and in vivo engraftment, function, and longevity. The pivotal role of NOX as a regulator of several stem cell populations is underscored, and further studies on the effects of pharmacological modulation of NOX in human stem cells are deemed imperative.

ANTIOXIDANTS (2021)

Article Medicine, Research & Experimental

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

Daniel J. Silver et al.

Summary: Research shows that consuming a high-fat diet may worsen glioblastoma (GBM), mainly by inhibiting the production of hydrogen sulfide (H2S) and increasing the enrichment of cancer stem cells (CSC). Increasing the bioavailability of H2S may help suppress the development of GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Biochemistry & Molecular Biology

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Maria Peleli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis

Yi-Hsiang Wang et al.

EMBO REPORTS (2019)

Review Pharmacology & Pharmacy

Current Challenges and Opportunities in Treating Glioblastoma

Andrea Shergalis et al.

PHARMACOLOGICAL REVIEWS (2018)

Article Cell Biology

Mechanisms of invasion and motility of high-grade gliomas in the brain

Devin B. Mair et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

Review Oncology

Angiogenesis inhibitors in tackling recurrent glioblastoma

Thomas Hundsberger et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

Review Biotechnology & Applied Microbiology

Gasotransmitters in cancer: from pathophysiology to experimental therapy

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2016)

Editorial Material Oncology

Reactive Oxygen Species in Cancer: A Dance with the Devil

Paul T. Schumacker

CANCER CELL (2015)

Review Cell Biology

Cancer stem cells in glioblastoma

Justin D. Lathia et al.

GENES & DEVELOPMENT (2015)

Review Oncology

Mouse models of glioblastoma: lessons learned and questions to be answered

Loury Janbazian et al.

JOURNAL OF NEURO-ONCOLOGY (2014)

Article Oncology

Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

Naoharu Takano et al.

MOLECULAR CANCER RESEARCH (2014)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Clinical Neurology

CD133 as a Marker for Regulation and Potential for Targeted Therapies in Glioblastoma Multiforme

Winward Choy et al.

NEUROSURGERY CLINICS OF NORTH AMERICA (2012)

Article Pharmacology & Pharmacy

Glioma Stem Cell Maintenance: The Role of the Microenvironment

John M. Heddleston et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Review Neurosciences

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

Manfred Westphal et al.

NATURE REVIEWS NEUROSCIENCE (2011)

Article Urology & Nephrology

Angiotensin II Promotes Development of the Renal Microcirculation through AT1 Receptors

Kirsten Madsen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Multidisciplinary Sciences

Hydrogen sulfide is an endogenous stimulator of angiogenesis

Andreas Papapetropoulos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell & Tissue Engineering

SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

Rosaria Maria Rita Gangemi et al.

STEM CELLS (2009)

Article Biochemical Research Methods

In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

Chun-Chi Liang et al.

NATURE PROTOCOLS (2007)

Article Biochemistry & Molecular Biology

A functional transsulfuration pathway in the brain links to glutathione homeostasis

Victor Vitvitsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Oncology

Temozolomide as first-line agent in treating high-grade gliomas:: phase II study

S Chibbaro et al.

JOURNAL OF NEURO-ONCOLOGY (2004)