4.7 Article

Ferroptosis triggered by STAT1-IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury

Related references

Note: Only part of the references are listed.
Article Oncology

Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation

Junyan Du et al.

Summary: This study investigated the mechanism of immune response induced by fractionated radiation therapy (FIR) and found that the STING-IFNAR1-STAT1-IRF1 axis regulates immune reactions in cancer cells triggered by FIR, and the STING pathway also contributes to immune cell invasion of cancer cells.

CANCER SCIENCE (2022)

Article Biochemistry & Molecular Biology

Ferroptosis plays an important role in promoting ionizing radiation-induced intestinal injuries

Lei Wang et al.

Summary: This study found the occurrence of ferroptosis in radiation-induced intestinal damage, suggesting its relationship with impairment of intestinal immune function. The ferroptosis inhibitor, Liproxstatin-1, was found to ameliorate radiation-induced ferroptosis and promote the recovery from immune imbalances. These findings provide novel strategies for protection against radiation injury through regulation of the ferroptosis pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

Article Biochemistry & Molecular Biology

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Qing-zhang Tuo et al.

Summary: Ischemic stroke poses a significant threat to human health, especially among the elderly. This study suggests that thrombin, a serine protease, can initiate ferroptotic signaling in ischemic stroke. Inhibiting the thrombin-ACSL4 axis could be a potential therapeutic target for reducing neuronal injury in ischemic stroke.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Immunology

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

Yu Cui et al.

Summary: ACSL4 is an important regulator of neuronal death and neuroinflammation in ischemic stroke, with its suppression protecting mice against brain ischemia and promoting neuronal death via enhancing lipid peroxidation. Additionally, knockdown of ACSL4 can inhibit proinflammatory cytokine production in microglia.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Oncology

SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival

Guoxiang Fu et al.

Summary: Inhibiting SIRT1 can improve the survival of intestinal stem cells, promote stem cell and crypt recovery, and increase mouse survival rate. SIRT1 inhibition increases p53 acetylation, aiding in the survival of intestinal epithelial cells post-radiation.

CANCER LETTERS (2021)

Article Immunology

Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways

Heba A. Mohamed et al.

Summary: The study demonstrates that CoQ10 can protect rats from lethal doses of radiation, promote intestinal epithelial regeneration, alleviate oxidative stress, counteract inflammatory response, and mitigate intestinal fibrosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Cell Biology

Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition

Giuseppina Raspaglio et al.

Summary: Cervical cancer is a common cause of cancer-related death in women, with treatments for locally advanced cancer remaining a challenge. Studies suggest that STAT1 may have a radiosensitizing effect on PARP1 levels, potentially improving the efficacy of chemoradiation therapy.

CELL DEATH & DISEASE (2021)

Article Biochemistry & Molecular Biology

Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis

Yiqing Xu et al.

Summary: Nrf2 plays a protective role in radiation-induced rectal injury by inhibiting necroptosis, which is physiologically significant in this process.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease

Ya-Li Yu et al.

Summary: The study revealed that p-STAT1 and EP300 promote the expression of TNFAIP2 and LCP2 by increasing H3K27ac enrichment on their enhancers, contributing to the pathogenesis of chronic inflammation.

CLINICAL EPIGENETICS (2021)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Cell Biology

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

Minyi Xu et al.

CELL DEATH & DISEASE (2020)

Article Multidisciplinary Sciences

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease

Lisa Mayr et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Emerging Mechanisms and Disease Relevance of Ferroptosis

Brent R. Stockwell et al.

TRENDS IN CELL BIOLOGY (2020)

Review Pharmacology & Pharmacy

The Application of Ferroptosis in Diseases

Yangmin Qiu et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Biochemistry & Molecular Biology

Critical role of AMPK in redox regulation under glucose starvation

Yi Ren et al.

REDOX BIOLOGY (2019)

Review Multidisciplinary Sciences

Arachidonic acid: Physiological roles and potential health benefits - A review

Hatem Tallima et al.

JOURNAL OF ADVANCED RESEARCH (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Cell & Tissue Engineering

The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury

Chang-Kyung Kim et al.

CURRENT STEM CELL REPORTS (2017)

Review Gastroenterology & Hepatology

Radiation enteropathy-pathogenesis, treatment and prevention

Martin Hauer-Jensen et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Gastroenterology & Hepatology

An Association Between Dietary Arachidonic Acid, Measured in Adipose Tissue, and Ulcerative Colitis

Punyanganie S. A. de Silva et al.

GASTROENTEROLOGY (2010)

Review Cell Biology

STAT1 as a key modulator of cell death

Hun Sik Kim et al.

CELLULAR SIGNALLING (2007)

Review Biochemistry & Molecular Biology

STAT1 as a new molecular target of anti-inflammatory treatment

AC de Prati et al.

CURRENT MEDICINAL CHEMISTRY (2005)